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  1. Article ; Online: 1,2,3-Thiadiazole as a Modifiable and Scalable Directing Group for

    Jia, Xiaoyan / Xing, Donghui / Shen, Jiayi / Li, Bo / Zeng, Yue / Jiang, Huanfeng / Huang, Liangbin

    Organic letters

    2024  Volume 26, Issue 8, Page(s) 1544–1549

    Abstract: In the last few decades, directed C-H bond functionalization has had enormous applicability in academia and industry. The development of a novel, readily accessible, and scalable directing group with modifiable ability is highly desirable in C-H ... ...

    Abstract In the last few decades, directed C-H bond functionalization has had enormous applicability in academia and industry. The development of a novel, readily accessible, and scalable directing group with modifiable ability is highly desirable in C-H functionalization. Herein, we report the 1,2,3-thiadiazole as a modifiable directing group for C-H amidation and alkynylation with dioxazolones,
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c04075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Investigation of Molecular Mechanism of Cobalt Porphyrin Catalyzed CO

    Wu, Feng / Jiang, Fengshuo / Yang, Jiahao / Dai, Weiyan / Lan, Donghui / Shen, Jing / Fang, Zhengjun

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 6

    Abstract: This study explores the electrochemical reduction in ... ...

    Abstract This study explores the electrochemical reduction in CO
    Language English
    Publishing date 2023-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28062747
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article ; Online: Autophagy modulation in multiple sclerosis and experimental autoimmune encephalomyelitis.

    Shen, Donghui / Liu, Kang / Wang, Hongyan / Wang, Haifeng

    Clinical and experimental immunology

    2022  Volume 209, Issue 2, Page(s) 140–150

    Abstract: Multiple sclerosis (MS), a white matter demyelinating disease of the central nervous system (CNS), is characterized by neuroinflammatory and neurodegenerative. Experimental autoimmune encephalomyelitis (EAE) is a commonly used animal model for ... ...

    Abstract Multiple sclerosis (MS), a white matter demyelinating disease of the central nervous system (CNS), is characterized by neuroinflammatory and neurodegenerative. Experimental autoimmune encephalomyelitis (EAE) is a commonly used animal model for investigating pathogenic mechanisms of MS, representing the destruction of the blood-brain barrier (BBB), the activation of T cells, and the infiltration of myeloid cells. An increasing number of studies have documented that autophagy plays a critical role in the pathogenesis of both MS and EAE. Autophagy maintains CNS homeostasis by degrading the damaged organelles and abnormal proteins. Furthermore, autophagy is involved in inflammatory responses by regulating the activation of immune cells and the secretion of inflammatory factors. However, the specific mechanisms of autophagy involved in MS and EAE are not completely understood. In this review, we will summarize the complex mechanisms of autophagy in MS and EAE, providing potential therapeutic approaches for the management of MS.
    MeSH term(s) Animals ; Autophagy ; Blood-Brain Barrier/pathology ; Central Nervous System/pathology ; Encephalomyelitis, Autoimmune, Experimental ; Mice ; Mice, Inbred C57BL ; Multiple Sclerosis
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1093/cei/uxac017
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 337: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Magnetite enhancing sludge anaerobic fermentation to improve wastewater biological nitrogen removal: Pilot-scale verification.

    Jiang, Binbin / Lu, Donghui / Shen, Xiaojia / Zhang, Fan / Xu, Xiangyang / Zhu, Liang

    Chemosphere

    2023  Volume 336, Page(s) 139197

    Abstract: Alkaline anaerobic fermentation for acids production has been considered as an effective method to recover resources from waste activated sludge, and magnetite could improve the quality of fermentation liquid. Here, we have constructed a pilot-scale ... ...

    Abstract Alkaline anaerobic fermentation for acids production has been considered as an effective method to recover resources from waste activated sludge, and magnetite could improve the quality of fermentation liquid. Here, we have constructed a pilot-scale sludge alkaline anaerobic fermentation process enhanced by magnetite to produce short chain fatty acids (SCFAs), and used them as external carbon sources to improve the biological nitrogen removal of municipal sewage. Results showed that the addition of magnetite could significantly increase the production of SCFAs. The average concentration of SCFAs in fermentation liquid reached 3718.6 ± 101.5 mg COD/L, and the average concentration of acetic acid reached 2368.8 ± 132.1 mg COD/L. The fermentation liquid was used in the mainstream A
    MeSH term(s) Wastewater ; Sewage/microbiology ; Fermentation ; Ferrosoferric Oxide ; Anaerobiosis ; Denitrification ; Nitrogen ; Bioreactors ; Fatty Acids, Volatile
    Chemical Substances Wastewater ; Sewage ; Ferrosoferric Oxide (XM0M87F357) ; Nitrogen (N762921K75) ; Fatty Acids, Volatile
    Language English
    Publishing date 2023-06-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.139197
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A Review of Numerical Research on the Pressure Swing Adsorption Process

    Runye Zhang / Yuanhui Shen / Zhongli Tang / Wenbin Li / Donghui Zhang

    Processes, Vol 10, Iss 812, p

    2022  Volume 812

    Abstract: The pressure swing adsorption (PSA) process has been considered a promising method for gas separation and purification. However, experimental methods are time-consuming, and it is difficult to obtain the detailed changes in variables in the PSA process. ... ...

    Abstract The pressure swing adsorption (PSA) process has been considered a promising method for gas separation and purification. However, experimental methods are time-consuming, and it is difficult to obtain the detailed changes in variables in the PSA process. This review focuses on the numerical research developed to realize the modelling, optimization and control of the cyclic PSA process. A complete one-dimensional mathematical model, including adsorption bed, auxiliary devices, boundary conditions and performance indicators, is summarized as a general modelling approach. Key simplified assumptions and special treatments for energy balance are discussed for model reliability. Numerical optimization models and control strategies are reviewed for the PSA process as well. Relevant attention is given to the combination of deep-learning technology with artificial-intelligence-based optimization algorithms and advanced control strategies. Challenges to further improvements in the adsorbent database establishment, multiscale computational mass transfer model, large-scale PSA facility design, numerical computations and algorithm robustness are identified.
    Keywords PSA ; numerical modelling ; optimization ; control ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Subject code 660
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  6. Article ; Online: Data storage and encryption with a high security level based on molecular configurational isomers.

    Liu, Yang / Shen, Jinghui / Dong, Yu / Zhu, Lijuan / Li, Caicong / Wang, Donghui / Huang, Weiguo

    Soft matter

    2022  Volume 18, Issue 35, Page(s) 6599–6606

    Abstract: Developing advanced materials for highly secure data-encryption is crucial but very challenging, as most data-encryption materials (the message area) are chemically different from the substrates (the background) on which they are being written, leading ... ...

    Abstract Developing advanced materials for highly secure data-encryption is crucial but very challenging, as most data-encryption materials (the message area) are chemically different from the substrates (the background) on which they are being written, leading to high risks of data leakage by deciphering
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d2sm00890d
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  7. Article ; Online: Identification of lysosome-related genes in connection with prognosis and immune cell infiltration for drug candidates in head and neck cancer.

    Shen, Ye / Chen, Haibin / Gong, Xiaoyang / Wang, Ziyi / Chen, Mengjie / Chen, Donghui

    Open life sciences

    2023  Volume 18, Issue 1, Page(s) 20220660

    Abstract: Lysosome dysfunction has been shown to play an important role in cancer progression. However, few research studies have reported the role of lysosomes in head and neck squamous cell carcinoma (HNSCC) progression. Lysosome-related genes (LRGs) were ... ...

    Abstract Lysosome dysfunction has been shown to play an important role in cancer progression. However, few research studies have reported the role of lysosomes in head and neck squamous cell carcinoma (HNSCC) progression. Lysosome-related genes (LRGs) were collected from the Molecular Signatures Database. Differentially expressed lysosome-related genes (DELRGs) were identified from the TCGA-HNSCC dataset. The least absolute shrinkage and selection operator and multivariate Cox regression analysis were used to identify the prognostic genes. The prognostic values and expression of hub DELRGs were further validated by GEO datasets. Estimation of STromal and Immune cells in MAlignant Tumors using Expression data and the single-sample gene set enrichment analysis were applied to evaluate the correlation between cathepsin G (CTSG) and immune infiltrates. Twenty-two DELRGs were identified. Among them, CTSG was an independent prognostic biomarker for HNSCC patients. Gene set enrichment analysis indicated that the potential mechanism of CTSG in regulating HNSCC was associated with the immune- and inflammation-related pathways. CTSG expression was highly correlated with immune cell infiltration. Finally, two potential compounds (CH and MAN) targeting CTSG protein were identified, and their reliability was validated through molecular docking analysis. CTSG was associated with immune infiltration and had prognostic value in HNSCC patients, which may be a potential biomarker for predicting the outcome of immunotherapy.
    Language English
    Publishing date 2023-08-09
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2817958-4
    ISSN 2391-5412 ; 2391-5412
    ISSN (online) 2391-5412
    ISSN 2391-5412
    DOI 10.1515/biol-2022-0660
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  8. Article ; Online: Investigation of Molecular Mechanism of Cobalt Porphyrin Catalyzed CO 2 Electrochemical Reduction in Ionic Liquid by In-Situ SERS

    Feng Wu / Fengshuo Jiang / Jiahao Yang / Weiyan Dai / Donghui Lan / Jing Shen / Zhengjun Fang

    Molecules, Vol 28, Iss 2747, p

    2023  Volume 2747

    Abstract: This study explores the electrochemical reduction in CO 2 using room temperature ionic liquids as solvents or electrolytes, which can minimize the environmental impact of CO 2 emissions. To design effective CO 2 electrochemical systems, it is crucial to ... ...

    Abstract This study explores the electrochemical reduction in CO 2 using room temperature ionic liquids as solvents or electrolytes, which can minimize the environmental impact of CO 2 emissions. To design effective CO 2 electrochemical systems, it is crucial to identify intermediate surface species and reaction products in situ. The study investigates the electrochemical reduction in CO 2 using a cobalt porphyrin molecular immobilized electrode in 1- n -butyl-3-methyl imidazolium tetrafluoroborate (BMI.BF4) room temperature ionic liquids, through in-situ surface-enhanced Raman spectroscopy (SERS) and electrochemical technique. The results show that the highest faradaic efficiency of CO produced from the electrochemical reduction in CO 2 can reach 98%. With the potential getting more negative, the faradaic efficiency of CO decreases while H 2 is produced as a competitive product. Besides, water protonates porphyrin macrocycle, producing pholorin as the key intermediate for the hydrogen evolution reaction, leading to the out-of-plane mode of the porphyrin molecule. Absorption of CO 2 by the ionic liquids leads to the formation of BMI·CO 2 adduct in BMI·BF 4 solution, causing vibration modes at 1100, 1457, and 1509 cm −1 . However, the key intermediate of <semantics> CO 2 − · </semantics> radical is not observed. The υ (CO) stretching mode of absorbed CO is affected by the electrochemical Stark effect, typical of CO chemisorbed on a top site.
    Keywords SERS ; cobalt protoporphyrin ; pholorin ; ionic liquid ; Organic chemistry ; QD241-441
    Subject code 290 ; 660
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: General Analysis of Heat Shock Factors in the

    Zheng, Ruiyue / Chen, Jiemin / Peng, Yukun / Zhu, Xuanyi / Niu, Muqi / Chen, Xiuming / Xie, Kai / Huang, Ruiliu / Zhan, Suying / Su, Qiuli / Shen, Mingli / Peng, Donghui / Ahmad, Sagheer / Zhao, Kai / Liu, Zhong-Jian / Zhou, Yuzhen

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Heat shock factors ( ...

    Abstract Heat shock factors (
    MeSH term(s) Temperature ; Phylogeny ; Cold Temperature ; Heat-Shock Response/genetics ; Binding Sites
    Language English
    Publishing date 2024-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021002
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  10. Article ; Online: Measuring the topological charge of optical vortices with a twisting phase.

    Shen, Donghui / Zhao, Daomu

    Optics letters

    2019  Volume 44, Issue 9, Page(s) 2334–2337

    Abstract: We analyzed the propagation characteristics of the intensity of a vortex beam after it passes through a twisting phase. It was found that the doughnut-like intensity pattern of a vortex beam would separate into several bright and dark fringes. The number ...

    Abstract We analyzed the propagation characteristics of the intensity of a vortex beam after it passes through a twisting phase. It was found that the doughnut-like intensity pattern of a vortex beam would separate into several bright and dark fringes. The number of dark fringes between two bright spots is equal to the topological charge (TC) of the vortex beam. Meanwhile, the intensity pattern varies with the sign of the TC. Based on this property, we proposed a convenient method to measure the TC of a vortex beam by observing its intensity pattern after passing through a twisting phase. This detection technique is mainly based on the use of a twisting phase, and the effect of parameters in the twisting phase is demonstrated and clearly studied. By choosing proper parameters in the twisting phase, the separation speed of a vortex beam's intensity could be controlled in the experiment. The experimental results are in good agreement with the theoretical analyses.
    Language English
    Publishing date 2019-05-01
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.44.002334
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