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  1. Article ; Online: Reply to C. Murray et al and V. Martin et al.

    Wolff, Antonio C / Hammond, M Elizabeth Hale / Allison, Kimberly H / Harvey, Brittany E / McShane, Lisa M / Dowsett, Mitchell

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2018  , Page(s) JCO1801163

    Language English
    Publishing date 2018-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.18.01163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  2. Book ; Online: Martin Mere

    Hale, W. G / Coney, Audrey

    Lancashire's lost lake

    2005  

    Abstract: ... because in the seventeenth century this was the site of the largest lake in England. Martin Mere began as a depression ...

    Institution ebrary, Inc
    Author's details W.G. Hale and Audrey Coney; with contributions from Bill Pick and Alan Whittaker
    Abstract A drive through the area of Lancashire inland from the seaside resort of Southport takes you through miles of fertile agricultural land dotted with farms and smallholdings. Road signs pointing to such places as 'Mereside', 'Mere Brow' and 'Mere Sands Wood' suggest the origin of these peaty soils, because in the seventeenth century this was the site of the largest lake in England. Martin Mere began as a depression in the glacial drift which filled with water as the ice from the last Ice Age retreated, and over its long history the land and the lake have contested the area as water levels have r
    Keywords Geomorphology ; Landscape archaeology ; Wetlands/History ; Lancashire (England) ; Martin Mere (England)
    Language English
    Size Online-Ressource (xvi, 264 p), ill. (some col.), maps, ports
    Publisher Liverpool University Press
    Publishing place Liverpool
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 0853237492 ; 9780853237495
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article: Recent developments in humanized MAbs for immunotherapy: a personal tribute to Dr. Martin Lockwood.

    Hale, G

    Transfusion science

    1999  Volume 21, Issue 3, Page(s) 181–184

    MeSH term(s) Alemtuzumab ; Animals ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/history ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Antibodies, Neoplasm/history ; Antibodies, Neoplasm/therapeutic use ; Antineoplastic Agents/history ; Antineoplastic Agents/therapeutic use ; Antirheumatic Agents/history ; Antirheumatic Agents/therapeutic use ; History, 20th Century ; Humans ; Immunotherapy/history ; Vasculitis/drug therapy ; Vasculitis/history
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neoplasm ; Antineoplastic Agents ; Antirheumatic Agents ; Alemtuzumab (3A189DH42V)
    Language English
    Publishing date 1999-12
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1038644-0
    ISSN 1879-3126 ; 0955-3886
    ISSN (online) 1879-3126
    ISSN 0955-3886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1739: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Book ; Collection: Handbook of exploration and environmental geochemistry

    Hale, Martin

    2004  

    Author's details M. Hale (ed.)
    Language English
    Dates of publication 2004-9999
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Collection (display volumes)
    Old title Bis Bd. 7 u.d.T. Handbook of exploration geochemistry
    HBZ-ID HT013899687
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  5. Article: Genes Impacting Grain Weight and Number in Wheat (

    Tillett, Brandon J / Hale, Caleb O / Martin, John M / Giroux, Michael J

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 13

    Abstract: The primary goal of common wheat ( ...

    Abstract The primary goal of common wheat (
    Language English
    Publishing date 2022-07-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11131772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Short Course Training on a Quality Management System for Pathologists, Trainees, and Histotechnologists During the African Pathology Assembly.

    Guarner, Jeannette / Hale, Martin John / Milner, Danny A / Nelson, Ann Marie

    American journal of clinical pathology

    2023  Volume 160, Issue 5, Page(s) 450–454

    Abstract: Objectives: Provide quality management training in anatomic pathology so that slides are of adequate quality and can be interpreted.: Methods: During the first African Pathology Assembly, we performed a needs assessment and knowledge quizzes, then ... ...

    Abstract Objectives: Provide quality management training in anatomic pathology so that slides are of adequate quality and can be interpreted.
    Methods: During the first African Pathology Assembly, we performed a needs assessment and knowledge quizzes, then presented 4 modules of the quality management system (personnel management, process control, sample management, and equipment) that are used to train quality in vertical programs by the World Health Organization.
    Results: Participants included 14 (34%) trainees, 14 (34%) pathologists, and 9 (22%) technologists from South Africa (11), Nigeria (6), Tanzania (4), and other countries (18). Thirty (73%) participants took the course because they had interest in the topic while 6 (15%) did it because it was recommended by a supervisor. Most participants thought that the quality of slides was medium to high in their institution and that clinicians trust results. The most frequent quality issues cited included problems from processing to staining, long turnaround times, and preanalytical issues (fixation, lack of clinical history). The average result of the knowledge quiz was 6.7 (range, 2-10) before (38 participants) the course and 8.3 (range, 5-10) after (30 participants) the course.
    Conclusions: This assessment suggests there is a need for quality management courses in pathology in Africa.
    MeSH term(s) Humans ; Pathologists ; Tanzania
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqad072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.91: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Validation of the Xpert Breast Cancer STRAT 4 Assay on the GeneXpert instrument to Assess Hormone Receptor, Ki67, and HER2 Gene Expression Status in Breast Cancer Tissue Samples.

    Sewanywa, Lina / Hale, Martin / Michelow, Pamela / Mayne, Elizabeth / Wiggill, Tracey

    Applied immunohistochemistry & molecular morphology : AIMM

    2023  Volume 31, Issue 9, Page(s) 613–620

    Abstract: Breast cancer is the commonest cause of cancer-related mortality in African females where patients often present later and with advanced disease. Causes for delayed diagnosis include restricted diagnostic access and international controversy on ... ...

    Abstract Breast cancer is the commonest cause of cancer-related mortality in African females where patients often present later and with advanced disease. Causes for delayed diagnosis include restricted diagnostic access and international controversy on interpretation of ancillary tests like immunohistochemistry (IHC). Fine needle aspirates (FNAC) are an attractive alternative although may have reduced sensitivity. The Xpert Breast Cancer STRAT4 (STRAT4) (CE-IVD*) assay (Cepheid, Sunnyvale) is a semi-quantitative reverse-transcription polymerase chain reaction assay which detects messenger RNA (mRNA) expression in breast samples for estrogen receptor ( ESR1 ), progesterone receptor ( PGR1 ), human epidermal growth factor receptor/Erb-B2 receptor tyrosine kinase 2 (HER2/ ERBB2 ) and the proliferation marker, MKi67 . We assessed the performance of this assay on both formalin-fixed paraffin-embedded (FFPE, n=31) and matched FNAC (n=20) samples from patients presenting with breast cancer to the Johannesburg academic hospitals. IHC and Fluorescent in situ hybridization analysis (performed on HER2-indeterminate samples) was compared with the mRNA expression of the corresponding target genes in FFPE samples, and mRNA expression on FNAC samples was compared with the FFPE results for both mRNA expression and IHC. Concordance between IHC/FISH and Xpert Breast Cancer STRAT4 in FFPE and FNAC samples using the Quick lysis (Q) method (a research-use-only modification of the validated FFPE-lysis method), showed an overall percentage agreement for ESR1 expression of 90.3% and 81.3%, and for PGR1 expression at 86.7% and 81.3% respectively in FFPE and FNAC samples. Concordance was lowest for Ki67 expression, using a binary IHC cutoff for Ki67 positivity at ≥20% staining) at 83.9% and 62.5%, for FFPE and FNAC samples, respectively. This suggests that the STRAT4 assay may be a useful ancillary test in determining HR and Ki67 status in FFPE samples and that use on FNAC samples may be feasible. Future studies should expand the sample numbers and establish locally relevant cutoffs.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Ki-67 Antigen/genetics ; In Situ Hybridization, Fluorescence ; South Africa ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; RNA, Messenger/genetics ; Gene Expression ; Hormones ; Biomarkers, Tumor/metabolism ; Paraffin Embedding
    Chemical Substances Ki-67 Antigen ; Receptor, ErbB-2 (EC 2.7.10.1) ; Receptors, Estrogen ; RNA, Messenger ; Hormones ; Biomarkers, Tumor
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473273-7
    ISSN 1533-4058 ; 1062-3345 ; 1541-2016
    ISSN (online) 1533-4058
    ISSN 1062-3345 ; 1541-2016
    DOI 10.1097/PAI.0000000000001149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3783: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Acute Compartment Syndrome in a Football Player With Quadriceps Contusion and Successful Return to Sport: A Case Report.

    O'Toole, Riley / Hale, Martina / Scarcella, Michael J

    JBJS case connector

    2024  Volume 14, Issue 2

    Abstract: Case: This report describes the case of quadriceps contusion progressing to acute compartment syndrome (ACS) of the thigh. A 17-year-old football player presented the morning after a direct impact injury to the anterior thigh in intractable pain and ... ...

    Abstract Case: This report describes the case of quadriceps contusion progressing to acute compartment syndrome (ACS) of the thigh. A 17-year-old football player presented the morning after a direct impact injury to the anterior thigh in intractable pain and pain with short arc motion. He was diagnosed with ACS and underwent successful fasciotomy, ultimately returning to play at 4 months.
    Conclusion: ACS is rare but potential catastrophic progression of quadriceps contusion. Accurate and timely diagnosis followed by appropriate rehabilitation is necessary for optimal outcomes.
    MeSH term(s) Humans ; Male ; Adolescent ; Compartment Syndromes/surgery ; Compartment Syndromes/etiology ; Return to Sport ; Contusions ; Quadriceps Muscle/injuries ; Football/injuries ; Soccer/injuries
    Language English
    Publishing date 2024-05-17
    Publishing country United States
    Document type Journal Article ; Case Reports
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e23.00688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Benefit-Risk Analysis of Buprenorphine for Pain Management.

    Hale, Martin / Garofoli, Mark / Raffa, Robert B

    Journal of pain research

    2021  Volume 14, Page(s) 1359–1369

    Abstract: Health care providers in the United States are facing challenges in selecting appropriate medication for patients with acute and chronic pain in the midst of the current opioid crisis and COVID-19 pandemic. When compared with conventional opioids, the ... ...

    Abstract Health care providers in the United States are facing challenges in selecting appropriate medication for patients with acute and chronic pain in the midst of the current opioid crisis and COVID-19 pandemic. When compared with conventional opioids, the partial µ-opioid receptor agonist buprenorphine has unique pharmacologic properties that may be more desirable for pain management. The formulations of buprenorphine approved by the US Food and Drug Administration for pain management include intravenous injection, transdermal patch, and buccal film. A comparison of efficacy and safety data from studies of buprenorphine and conventional opioids suggests that buprenorphine may be a better-tolerated treatment option for many patients that provides similar or superior analgesia. Our benefit-risk assessment in this narrative review suggests that health care providers should consider that buprenorphine may be an appropriate alternative for pain management over other opioids.
    Language English
    Publishing date 2021-05-24
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S305146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Changes in the properties of membrane tethers in response to HP1α depletion in MCF7 cells.

    Pradhan, Susav / Williams, Martin A K / Hale, Tracy K

    Biochemical and biophysical research communications

    2021  Volume 587, Page(s) 126–130

    Abstract: Plasma membrane tension is known to regulate many cell functions, such as motility and membrane trafficking. Membrane tether pulling is an effective method for measuring the apparent membrane tension of cells and exploring membrane-cytoskeleton ... ...

    Abstract Plasma membrane tension is known to regulate many cell functions, such as motility and membrane trafficking. Membrane tether pulling is an effective method for measuring the apparent membrane tension of cells and exploring membrane-cytoskeleton interactions. In this article, the mechanical properties of HP1α-depleted MCF7 breast cancer cells are explored in comparison to controls, by pulling membrane tethers using optical tweezers. These studies were inspired by previous findings that a loss of HP1α correlates with an increase in the invasive potential of malignant cancer cells. Specifically, the membrane tension and force relaxation curves for tethers pulled from MCF7 breast cancer cells with HP1α knockdown and their matched controls were measured, and shown to be significantly different.
    MeSH term(s) Actins/genetics ; Actins/metabolism ; Biomechanical Phenomena ; Cell Membrane/chemistry ; Cell Movement/genetics ; Chromobox Protein Homolog 5/deficiency ; Chromobox Protein Homolog 5/genetics ; Cytoskeleton/chemistry ; Gene Knockout Techniques ; Humans ; MCF-7 Cells ; Optical Tweezers ; Surface Tension
    Chemical Substances Actins ; CBX5 protein, human ; Chromobox Protein Homolog 5 (107283-02-3)
    Language English
    Publishing date 2021-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2021.11.081
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 116: Show issues Location:
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