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Article: Structural Safety of the Steel Hall under Dynamic Excitation Using the Relative Probabilistic Entropy Concept.

Bredow, Rafał / Kamiński, Marcin

2022 Volume 15, Issue 10

Abstract: This work aimed to analyze the reliability of a steel hall that was recently erected in central Poland subjected to dynamic wind excitation using the stochastic finite element method. Reliability analysis was completed using the relative entropy concept ... ...

Abstract	This work aimed to analyze the reliability of a steel hall that was recently erected in central Poland subjected to dynamic wind excitation using the stochastic finite element method. Reliability analysis was completed using the relative entropy concept delivered by Bhattacharyya and contrasted with the first-order reliability method recommended by the engineering design codes. Bhattacharyya probabilistic relative entropy was additionally rescaled in this study to fit the demands and recommended admissibility intervals given in Eurocode 0. The finite element method study was carried out thanks to a discrete model created in the system ABAQUS 2019, while all further statistical and probabilistic computations were programmed and completed in the symbolic environment of MAPLE 2019. Contrary to most engineering analyses in steel structure areas, this study included the important warping effect while designing the hall ridges and the purlins. Dynamic structural responses were determined via the Hilber-Hughes-Taylor algorithm and their series were numerically obtained for a series of input uncertainty parameters representing several mechanical and environmental quantities. The generalized 10th order iterative stochastic perturbation technique was contrasted in this context with statistical estimators from the Monte Carlo simulations and numerical integration resulting from the semi-analytical approach. The key research finding of this study was an extremely good coincidence between the FORM indices and the rescaled relative probabilistic entropies for the given stochastic excitations, which additionally did not depend on a choice of one of the three proposed numerical approaches.
Language	English
Publishing date	2022-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15103587
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Article: Effects of the COVID-19 Pandemic on the Interest of Google Queries in Cancer Screening and Cancers: A Retrospective Study.

Kamiński, Mikołaj / Skrzypczak, Piotr / Staszewski, Rafał / Roszak, Magdalena

Cancers

2023 Volume 15, Issue 3

Abstract: The COVID-19 pandemic disrupted cancer screening programs and care for individuals with malignancies. We aimed to analyze the effects of the COVID-19 pandemic on the interest of Google users in cancers and their screenings. We collected data from Google ... ...

Abstract	The COVID-19 pandemic disrupted cancer screening programs and care for individuals with malignancies. We aimed to analyze the effects of the COVID-19 pandemic on the interest of Google users in cancers and their screenings. We collected data from Google Trends (GT) from 1 January 2015 to 31 December 2021 worldwide for nine topics representing cancer screening and the HPV vaccine and for 33 topics representing malignancies. We performed a secular analysis comparing the prepandemic (2015-2019) and pandemic (2020-2021) period. We performed forecasting analysis on the prepandemic timeline to assess interest in the analyzed topics if the pandemic hadnot occurred.The actual interest in most of the analyzed topics was significantly lower than in the forecasted trend. Interest in 6 of the 9 topics representing cancer screening and 3 of the 33 topics representing cancer was higher during the pandemic than in the prepandemic period. The interest of Google users in cancer screenings increased in 2020-2021 compared to 2015-2019, but the growth was less dynamic than expected. The interest in many cancers during the pandemic was significantly lower than in the prepandemic period, especially during March and April 2020. The lower interest in cancers and their screenings may delay the diagnosis and worsen the long-term outcomes.
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15030617
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Article: Comparison of the Efficacy of Human Umbilical Cord-Derived and Bone Marrow Aspirate Concentrate Mesenchymal Stem Cells for Cartilage Repair Defects of the Knee via Arthroscopic Implementation on Scaffolds in a Retrospective Study.

Pałka, Karol / Sadlik, Bogusław / Kamiński, Paweł / Bułdak, Rafał J / Dobrakowski, Michał

Journal of personalized medicine

2024 Volume 14, Issue 3

Abstract: ... scales and radiologically with M-MOCART 2.0 score. The analysis demonstrated substantial overall ...

Abstract	Injuries to the articular cartilage of the human knee joint, commonly resulting from trauma, inflammation, or age- and activity-related wear and tear, have significant implications, primarily leading to osteoarthritis (OA). Conservative treatments for such injuries often yield suboptimal clinical outcomes. Surgical interventions using current methods may not consistently provide satisfactory results, largely due to the formation of low-quality scar tissue lacking the biomechanical properties of hyaline cartilage. In this retrospective study, we compared the results of two promising methods for regenerating cartilage defects in the knee joints using scaffolds soaked with stem cells of different origins: bone marrow aspirate concentrate mesenchymal stem cells (BMAC-MSCs) and human umbilical cord-derived mesenchymal stem cells (hUCB-MSCs). We evaluated 39 patients (39 knees, hUCB-MSCs: 20 knees, BMAC: 19 knees) at the 12-month follow-up using VAS, KOOS, Lysholm scales and radiologically with M-MOCART 2.0 score. The analysis demonstrated substantial overall improvement in both groups, notably reflected in enhanced quality of life for the patients. Interestingly, the final scores in the hUCB-MSCs group were comparable to those in the BMAC-MSCs group, with no statistically significant differences observed, despite variations in preoperative age and lesion size. Notably, the hUCB-MSCs group consisted of significantly older individuals with larger lesion sizes. Both procedures were found to be safe, and improvement was observed in both groups, which holds promise for future clinical investigations.
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14030220
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Article ; Online: A systems-level framework for anti-epilepsy drug discovery.

Johnson, Michael R / Kaminski, Rafal M

Neuropharmacology

2019 Volume 170, Page(s) 107868

Abstract: Modern anti-seizure drug development yielded benefits in terms of improved pharmacokinetics, safety and tolerability profiles, but offered no advances in efficacy compared to previous older generations of anti-seizure drugs. Despite significant advances ... ...

Abstract	Modern anti-seizure drug development yielded benefits in terms of improved pharmacokinetics, safety and tolerability profiles, but offered no advances in efficacy compared to previous older generations of anti-seizure drugs. Despite significant advances in our understanding of the genetic bases to epilepsy, and a welcome renewed interest on the severe monogenic epilepsies, modern genetics has yet to directly inform more effective or disease-modifying anti-seizure drugs. Here, we describe a new approach to the identification of novel disease modifying anti-epilepsy drugs. The systems genetics approach aims to first identify pathophysiological mechanisms by integrating polygenic risk with cellular gene expression profiles and then to relate these molecular mechanisms to druggable targets using a gene regulatory (regulome) framework. The approach offers an exciting and flexible framework for future drug discovery in epilepsy, and is applicable to any disease for which appropriate cell-type and disease-context specific data exist. This article is part of the special issue entitled 'New Epilepsy Therapies for the 21st Century - From Antiseizure Drugs to Prevention, Modification and Cure of Epilepsy'.
MeSH term(s)	Animals ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Drug Discovery/methods ; Drug Discovery/trends ; Epilepsy/diagnosis ; Epilepsy/drug therapy ; Epilepsy/genetics ; Gene Regulatory Networks/drug effects ; Gene Regulatory Networks/genetics ; Humans ; Sequence Analysis, DNA/methods ; Sequence Analysis, RNA/methods ; Systems Analysis
Chemical Substances	Anticonvulsants
Language	English
Publishing date	2019-11-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2019.107868
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Article: Sex Differentiation of Trabecular Bone Structure Based on Textural Analysis of Pelvic Radiographs.

Kamiński, Paweł / Nurzynska, Karolina / Kwiecień, Joanna / Obuchowicz, Rafał / Piórkowski, Adam / Pociask, Elżbieta / Stępień, Aleksandra / Kociołek, Marcin / Strzelecki, Michał / Augustyniak, Piotr

Journal of clinical medicine

2024 Volume 13, Issue 7

Abstract: Objectives: ...

Abstract	Objectives:
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13071904
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Article: State of the Art in Temporomandibular Joint Arthrocentesis-A Systematic Review.

Siewert-Gutowska, Marta / Pokrowiecki, Rafał / Kamiński, Artur / Zawadzki, Paweł / Stopa, Zygmunt

Journal of clinical medicine

2023 Volume 12, Issue 13

Abstract: Temporomandibular joint disorders are a heterogenic group of clinical conditions, which impair physiological functioning of the masticatory system. Arthrocentesis of the temporomandibular joint has become a widely approved method for non-invasive ... ...

Abstract	Temporomandibular joint disorders are a heterogenic group of clinical conditions, which impair physiological functioning of the masticatory system. Arthrocentesis of the temporomandibular joint has become a widely approved method for non-invasive treatment, bridging the gap between conservative and surgical approaches. Regardless of technique, treatment is based upon joint lavage and lysis of the inflammatory fibrous tissue adhesions, which, in turn, improves joint mobility and reduces pain and closed lock. Recently, approaches for intra-articular injections have been proposed as adjuvant or replacement therapy. The aim of this study was to assess the most efficient technique of arthrocentesis. A systematic search based on PRISMA guidelines, including a computer search with specific keywords, a reference list search and a manual search, was performed. Relevant articles were selected after three search rounds for final review. The studies pulled for the analysis presented information about the relevant predictors, including the technique of arthrocentesis (single- or two-needle method), fluid used for lavage (Ringer lactate or saline), volume of the fluid, application of the injectable, number of interventions, pain (VAS) and mouth opening scores (MMO) and follow-up. All cohorts showed improvement in mouth opening, but significant pain reduction was observed only in cohorts treated either by arthrocentesis alone or arthrocentesis followed by intra-articular injectables. Intra-articular injectables used alone failed to reduce pain post-operatively when compared to other cohorts. We concluded that both double-needle and single-puncture arthrocentesis techniques are equally efficient. Application of the adjuvant injectable did not improve the outcomes of arthrocentesis performed alone. The volume of the fluid used for joint lavage and its chemical composition were not significant in clinical outcomes. However, due to the lack of homogeneity in the study settings, a meta-analysis could not be applied and a systematic review was conducted. We still, however, state that there is a knowledge gap in the current literature regarding the use of injectables alone, as well as a longitudinal follow-up, which provides information about treatment efficiency. More high-quality and randomized controlled trials are required to shed light on this subject.
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12134439
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Article: Connectivity Mapping Using a Novel

Zhang, Yifan / Heylen, Lise / Partoens, Michèle / Mills, James D / Kaminski, Rafal M / Godard, Patrice / Gillard, Michel / de Witte, Peter A M / Siekierska, Aleksandra

Frontiers in molecular neuroscience

2022 Volume 15, Page(s) 881933

Abstract: Synaptic vesicle glycoprotein 2A (SV2A) regulates action potential-dependent neurotransmitter release and is commonly known as the primary binding site of an approved anti-epileptic drug, levetiracetam. Although several rodent knockout models have ... ...

Abstract	Synaptic vesicle glycoprotein 2A (SV2A) regulates action potential-dependent neurotransmitter release and is commonly known as the primary binding site of an approved anti-epileptic drug, levetiracetam. Although several rodent knockout models have demonstrated the importance of SV2A for functional neurotransmission, its precise physiological function and role in epilepsy pathophysiology remains to be elucidated. Here, we present a novel
Language	English
Publishing date	2022-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2022.881933
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Article ; Online: Translocator protein PET imaging in temporal lobe epilepsy: A reliable test-retest study using asymmetry index.

Mahmud, Mohammad / Wade, Charles / Jawad, Sarah / Hadi, Zaeem / Otoul, Christian / Kaminski, Rafal M / Muglia, Pierandrea / Kadiu, Irena / Rabiner, Eugenii / Maguire, Paul / Owen, David R / Johnson, Michael R

Frontiers in neuroimaging

2023 Volume 2, Page(s) 1142463

Abstract: Objective: Translocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous studies in ... ...

Abstract	Objective: Translocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous studies in healthy volunteers have indicated limited test-retest reliability of TSPO ligands. Here, we examine test-retest measures using TSPO PET imaging in subjects with epilepsy and healthy controls, to explore whether this biomarker can be used as an endpoint in clinical trials for epilepsy. Methods: Five subjects with epilepsy and confirmed mesial temporal lobe sclerosis (mean age 36 years, 3 men) were scanned twice-on average 8 weeks apart-using a second generation TSPO targeting radioligand, [ Results: The mean (± SD) of the volume of distribution ( Conclusion: When using TSPO PET in patients with epilepsy with hippocampal sclerosis (HS), an inter-hemispheric asymmetry index in the hippocampus is a measure with good test-retest reliability. We provide estimates of test-retest variability that may be useful for estimating power where group change in
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	3123824-5
ISSN	2813-1193 ; 2813-1193
ISSN (online)	2813-1193
ISSN	2813-1193
DOI	10.3389/fnimg.2023.1142463
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Article ; Online: AlphaFold2 captures the conformational landscape of the HAMP signaling domain.

Winski, Aleksander / Ludwiczak, Jan / Orlowska, Malgorzata / Madaj, Rafal / Kaminski, Kamil / Dunin-Horkawicz, Stanislaw

Protein science : a publication of the Protein Society

2024 Volume 33, Issue 1, Page(s) e4846

Abstract: In this study, we present a conformational landscape of 5000 AlphaFold2 models of the Histidine kinases, Adenyl cyclases, Methyl-accepting proteins and Phosphatases (HAMP) domain, a short helical bundle that transduces signals from sensors to effectors ... ...

Abstract	In this study, we present a conformational landscape of 5000 AlphaFold2 models of the Histidine kinases, Adenyl cyclases, Methyl-accepting proteins and Phosphatases (HAMP) domain, a short helical bundle that transduces signals from sensors to effectors in two-component signaling proteins such as sensory histidine kinases and chemoreceptors. The landscape reveals the conformational variability of the HAMP domain, including rotations, shifts, displacements, and tilts of helices, many combinations of which have not been observed in experimental structures. HAMP domains belonging to a single family tend to occupy a defined region of the landscape, even when their sequence similarity is low, suggesting that individual HAMP families have evolved to operate in a specific conformational range. The functional importance of this structural conservation is illustrated by poly-HAMP arrays, in which HAMP domains from families with opposite conformational preferences alternate, consistent with the rotational model of signal transduction. The only poly-HAMP arrays that violate this rule are predicted to be of recent evolutionary origin and structurally unstable. Finally, we identify a family of HAMP domains that are likely to be dynamic due to the presence of a conserved pi-helical bulge. All code associated with this work, including a tool for rapid sequence-based prediction of the rotational state in HAMP domains, is deposited at https://github.com/labstructbioinf/HAMPpred.
MeSH term(s)	Bacterial Proteins/chemistry ; Histidine ; Molecular Conformation ; Signal Transduction ; Histidine Kinase/genetics ; Histidine Kinase/metabolism
Chemical Substances	Bacterial Proteins ; Histidine (4QD397987E) ; Histidine Kinase (EC 2.7.13.1)
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1106283-6
ISSN	1469-896X ; 0961-8368
ISSN (online)	1469-896X
ISSN	0961-8368
DOI	10.1002/pro.4846
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Article ; Online: Analysis of the Polymorphisms and Expression Levels of the BCL2, BAX and c-MYC Genes in Patients with Ovarian Cancer.

Olbromski, Piotr Józef / Bogacz, Anna / Bukowska, Marta / Kamiński, Adam / Moszyński, Rafał / Pawlik, Piotr / Szeliga, Anna / Kotrych, Katarzyna / Czerny, Bogusław

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: Ovarian cancer (OC) is one of the biggest problems in gynecological oncology and is one of the most lethal cancers in women worldwide. Most patients with OC are diagnosed at an advanced stage; therefore, there is an urgent need to find new biomarkers for ...

Abstract	Ovarian cancer (OC) is one of the biggest problems in gynecological oncology and is one of the most lethal cancers in women worldwide. Most patients with OC are diagnosed at an advanced stage; therefore, there is an urgent need to find new biomarkers for this disease. Gene expression profiling is proving to be a very effective tool for exploring new molecular markers for OC patients, although the relationship between such markers and patient survival and clinical outcomes is still elusive. Moreover, polymorphisms in genes encoding both apoptosis-associated proteins and oncoproteins may serve as key markers of cancer susceptibility. The aim of our study was to analyze the polymorphisms and expressions of the
MeSH term(s)	Humans ; Female ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Genes, myc ; Polymorphism, Single Nucleotide ; Genotype ; Apoptosis Regulatory Proteins/genetics ; Ovarian Neoplasms/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	bcl-2-Associated X Protein ; Proto-Oncogene Proteins c-bcl-2 ; Apoptosis Regulatory Proteins ; RNA, Messenger ; BCL2 protein, human
Language	English
Publishing date	2023-11-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216309
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