Article ; Online: Benign COVID-19 in an immunocompromised cancer patient - the case of a married couple.
2020 Volume 150, Page(s) w20246
Abstract: Respiratory failure in COVID-19 is a common feature in fatal cases and has been considered as a failure of the immune system to control the virus. Here we report the case of COVID-19 affecting an immunocompromised women and her presumably immunocompetent ...
| Abstract | Respiratory failure in COVID-19 is a common feature in fatal cases and has been considered as a failure of the immune system to control the virus. Here we report the case of COVID-19 affecting an immunocompromised women and her presumably immunocompetent spouse. A married couple (age 60 years) was simultaneously admitted to the emergency department on 10 March 2020 because of dyspnoea and fever, consistent with COVID-19. The wife (patient 1) was partially immunocompromised as a consequence of a recently started chemotherapy with fulvestrant and abemaciclid for recurring breast cancer, her husband (patient 2) had been healthy except for a history of controlled arterial hypertension. Both patients were treated with darunavir/cobicistat and hydroxychloroquine. The clinical course of the immunocompromised partner was benign, without need of intensive care. She was able to leave the hospital on day 6 after admission. In contrast, her husband needed intensive care and his recovery was slow, although eventually successful too. These findings suggest that the course of COVID-19 is not necessarily ominous in the presence of a compromised immune response and tend to reinforce the emerging therapeutic concepts of a controlled mitigation of the immune cascade following SARS CoV-2 infection. |
|---|---|
| MeSH term(s) | Anti-Bacterial Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus ; Breast Neoplasms/complications ; Cobicistat/therapeutic use ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Critical Care ; Darunavir/therapeutic use ; Dyspnea/etiology ; Emergency Service, Hospital ; Female ; Fever/etiology ; Humans ; Hydroxychloroquine/therapeutic use ; Immunocompetence ; Immunocompromised Host ; Male ; Middle Aged ; Neoplasm Recurrence, Local/drug therapy ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Spouses ; Treatment Outcome |
| Chemical Substances | Anti-Bacterial Agents ; Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Cobicistat (LW2E03M5PG) ; Darunavir (YO603Y8113) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-04-11 |
| Publishing country | Switzerland |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 2036179-8 |
| ISSN | 1424-3997 ; 1424-7860 |
| ISSN (online) | 1424-3997 |
| ISSN | 1424-7860 |
| DOI | 10.4414/smw.2020.20246 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Ua VI Zs.152: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.