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Article: Exploring Variability of Free Asparagine Content in the Grain of Bread Wheat (

Tafuri, Andrea / Zuccaro, Melania / Ravaglia, Stefano / Pirona, Raul / Masci, Stefania / Sestili, Francesco / Lafiandra, Domenico / Ceriotti, Aldo / Baldoni, Elena

Plants (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Acrylamide, a suspected human carcinogen, is generated during food processing at high temperatures in the Maillard reaction, which involves reducing sugars and free asparagine. In wheat derivatives, free asparagine represents a key factor in acrylamide ... ...

Abstract	Acrylamide, a suspected human carcinogen, is generated during food processing at high temperatures in the Maillard reaction, which involves reducing sugars and free asparagine. In wheat derivatives, free asparagine represents a key factor in acrylamide formation. Free asparagine levels in the grain of different wheat genotypes has been investigated in recent studies, but little is known about elite varieties that are cultivated in Italy. Here, we analysed the accumulation of free asparagine in a total of 54 bread wheat cultivars that are relevant for the Italian market. Six field trials in three Italian locations over two years were considered. Wholemeal flours obtained from harvested seeds were analysed using an enzymatic method. Free asparagine content ranged from 0.99 to 2.82 mmol/kg dry matter in the first year, and from 0.55 to 2.84 mmol/kg dry matter in the second year. Considering the 18 genotypes that were present in all the field trials, we evaluated possible environment and genetic influences for this trait. Some cultivars seemed to be highly affected by environment, whereas others showed a relative stability in free asparagine content across years and locations. Finally, we identified two varieties showing the highest free asparagine levels in our analysis, representing potential useful materials for genotype x environment interaction studies. Two other varieties, which were characterized by low amounts of free asparagine in the considered samples, may be useful for the food industry and for future breeding programs aimed to reduce acrylamide-forming potential in bread wheat.
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12061349
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Article ; Online: Daratumumab-based induction and autologous transplantation in concomitant multiple myeloma and chronic myeloid leukemia.

Liberatore, Carmine / Fioritoni, Francesca / Natale, Annalisa / Montanaro, Guido / La Barba, Gaetano / Passeri, Cecilia / Iuliani, Ornella / Fabi, Bianca / Baldoni, Stefano / Fantasia, Donatella / Calabrese, Giuseppe / Accorsi, Patrizia / Santarone, Stella / Pulini, Stefano / Di Ianni, Mauro

EJHaem

2023 Volume 4, Issue 4, Page(s) 1152–1156

Abstract: The coexistence of chronic myeloid leukemia (CML) and multiple myeloma (MM) is a rare clinical condition. By means of FISH and molecular analysis on both sorted CD138 plasma cells and cryopreserved CD34 stem cells, a distinct clonal origin of the ... ...

Abstract	The coexistence of chronic myeloid leukemia (CML) and multiple myeloma (MM) is a rare clinical condition. By means of FISH and molecular analysis on both sorted CD138 plasma cells and cryopreserved CD34 stem cells, a distinct clonal origin of the hematological malignancies was demonstrated in our case. We report on the first patient diagnosed with CML and MM treated with daratumumab, bortezomib, thalidomide, and dexamethasone (Dara-VTd) induction, stem-cell collection, and autologous stem cell transplantation (ASCT). The co-administration of Dara-VTd and imatinib proved feasible and highly effective in the management of both CML and MM. Despite concerns with stem cell mobilization and collection in patients exposed to daratumumab, in our experience the use of higher cyclophosphamide dose 4 g/m
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Case Reports
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.765
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Article ; Online: The identification of farnesoid X receptor modulators as treatment options for nonalcoholic fatty liver disease.

Fiorucci, Stefano / Biagioli, Michele / Baldoni, Monia / Ricci, Patrizia / Sepe, Valentina / Zampella, Angela / Distrutti, Eleonora

Expert opinion on drug discovery

2021 Volume 16, Issue 10, Page(s) 1193–1208

Abstract: Introduction: The farnesoid-x-receptor (FXR) is a ubiquitously expressed nuclear receptor selectively activated by primary bile acids.: Area covered: FXR is a validated pharmacological target. Herein, the authors review preclinical and clinical data ... ...

Abstract	Introduction: The farnesoid-x-receptor (FXR) is a ubiquitously expressed nuclear receptor selectively activated by primary bile acids. Area covered: FXR is a validated pharmacological target. Herein, the authors review preclinical and clinical data supporting the development of FXR agonists in the treatment of nonalcoholic fatty liver disease. Expert opinion: Development of systemic FXR agonists to treat the metabolic liver disease has been proven challenging because the side effects associated with these agents including increased levels of cholesterol and LDL-c and reduced HDL-c raising concerns over their long-term cardiovascular safety. Additionally, pruritus has emerged as a common, although poorly explained, dose-related side effect with all FXR ligands, but is especially common with OCA. FXR agonists that are currently undergoing phase 2/3 trials are cilofexor, tropifexor, nidufexor and MET409. Some of these agents are currently being developed as combination therapies with other agents including cenicriviroc, a CCR2/CCR5 inhibitor, or firsocostat an acetyl CoA carboxylase inhibitor. Additional investigations are needed to evaluate the beneficial effects of combination of these agents with statins. It is expected that in the coming years, FXR agonists will be developed as a combination therapy to minimize side effects and increase likelihood of success by targeting different metabolic pathways.
MeSH term(s)	Azetidines/therapeutic use ; Chenodeoxycholic Acid/pharmacology ; Chenodeoxycholic Acid/therapeutic use ; Humans ; Isonicotinic Acids/therapeutic use ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/drug therapy
Chemical Substances	Azetidines ; Isonicotinic Acids ; Chenodeoxycholic Acid (0GEI24LG0J) ; cilofexor (YUN2306954)
Language	English
Publishing date	2021-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2259618-5
ISSN	1746-045X ; 1746-0441
ISSN (online)	1746-045X
ISSN	1746-0441
DOI	10.1080/17460441.2021.1916465
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Article ; Online: Programming Agents by Their Social Relationships

Matteo Baldoni / Cristina Baroglio / Roberto Micalizio / Stefano Tedeschi

Algorithms, Vol 12, Iss 4, p

A Commitment-Based Approach

2019 Volume 76

Abstract: Multiagent systems can be seen as an approach to software engineering for the design and development of complex, distributed software. Generally speaking, multiagent systems provide two main abstractions for modularizing the software: the agents and the ... ...

Abstract	Multiagent systems can be seen as an approach to software engineering for the design and development of complex, distributed software. Generally speaking, multiagent systems provide two main abstractions for modularizing the software: the agents and the environment where agents operate. In this paper, we argue that also the social relationships among the agents should be expressed explicitly and become first-class objects both at design- and at development-time. In particular, we propose to represent social relationships as commitments that are reified as resources in the agents’ environment and can be directly manipulated by the agents via standard operations. We demonstrate that this view induces an agent programming schema that is substantially independent of the actual agent platform, provided that commitments are available as explained. The paper exemplifies the schema on two agent platforms, JADE and JaCaMo, where commitments are made available via the 2COMM library.
Keywords	social commitments ; agents and artifacts ; agent-oriented software engineering ; Industrial engineering. Management engineering ; T55.4-60.8 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	006
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Self-Aligning Finger Exoskeleton for the Mobilization of the Metacarpophalangeal Joint.

Peperoni, Emanuele / Capitani, Stefano Laszlo / Fiumalbi, Tommaso / Capotorti, Eugenio / Baldoni, Andrea / Dell'Agnello, Filippo / Creatini, Ilaria / Taglione, Elisa / Vitiello, Nicola / Trigili, Emilio / Crea, Simona

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

2023 Volume PP

Abstract: In the context of hand and finger rehabilitation, kinematic compatibility is key for the acceptability and clinical exploitation of robotic devices. Different kinematic chain solutions have been proposed in the state of the art, with different trade-offs ...

Abstract	In the context of hand and finger rehabilitation, kinematic compatibility is key for the acceptability and clinical exploitation of robotic devices. Different kinematic chain solutions have been proposed in the state of the art, with different trade-offs between characteristics of kinematic compatibility, adaptability to different anthropometries, and the ability to compute relevant clinical information. This study presents the design of a novel kinematic chain for the mobilization of the metacarpophalangeal (MCP) joint of the long fingers and a mathematical model for the real-time computation of the joint angle and transferred torque. The proposed mechanism can self-align with the human joint without hindering force transfer or inducing parasitic torque. The chain has been designed for integration into an exoskeletal device aimed at rehabilitating traumatic-hand patients. The exoskeleton actuation unit has a series-elastic architecture for compliant human-robot interaction and has been assembled and preliminarily tested in experiments with eight human subjects. Performance has been investigated in terms of (i) accuracy of the MCP joint angle estimation through comparison with a video-based motion tracking system, (ii) residual MCP torque when the exoskeleton is controlled to provide null output impedance and (iii) torque-tracking performance. Results showed a root-mean-square error (RMSE) below 5 degrees in the estimated MCP angle. The estimated residual MCP torque resulted below 7 mNm. Torque tracking performance shows an RMSE lower than 8 mNm in following sinusoidal reference profiles. The results encourage further investigations of the device in a clinical scenario.
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1166307-8
ISSN	1558-0210 ; 1063-6528 ; 1534-4320
ISSN (online)	1558-0210
ISSN	1063-6528 ; 1534-4320
DOI	10.1109/TNSRE.2023.3236070
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Article ; Online: Case Report: Invasive fungal infection after anti-CD19 CAR-T cell therapy. Implication for antifungal prophylaxis.

Pennese, Elsa / Salutari, Prassede / Carriero, Luigi / Restuccia, Francesco / De Filippis, Antonio Fabio / De Luca, Giulia / Giancola, Raffaella / Guardalupi, Francesco / Corradi, Giulia / Fabi, Bianca / Baldoni, Stefano / Di Ianni, Mauro

Frontiers in immunology

2023 Volume 14, Page(s) 1272798

Abstract: CAR-T therapy has revolutionized the treatment of relapsed/refractory B-cell malignancies. Patients who are receiving such therapy are susceptible to an increased incidence of infections due to post-treatment immunosuppression. The need for antifungal ... ...

Abstract	CAR-T therapy has revolutionized the treatment of relapsed/refractory B-cell malignancies. Patients who are receiving such therapy are susceptible to an increased incidence of infections due to post-treatment immunosuppression. The need for antifungal prophylaxis during the period of neutropenia remains to be determined. The clinical outcome of a 55-year-old patient with relapsed/refractory DLBCL who received axicabtagene ciloleucel is described here. The patient developed CRS grade II and ICANS grade IV requiring tocilizumab, prolonged use of steroids and anakinra. An invasive pulmonary aspergillosis arose after 1 month from CAR-T reinfusion, resolved with tracheal sleeve pneumonectomy. The patient is now in Complete Remission. This case suggests that antifungal prophylaxis should be considered. We have now included micafungin as a standard prophylaxis in our institution.
MeSH term(s)	Humans ; Middle Aged ; Receptors, Chimeric Antigen ; Antifungal Agents/therapeutic use ; Neoplasm Recurrence, Local/drug therapy ; Antigens, CD19/therapeutic use ; Invasive Fungal Infections/drug therapy ; Invasive Fungal Infections/etiology ; Invasive Fungal Infections/prevention & control ; Cell- and Tissue-Based Therapy
Chemical Substances	Receptors, Chimeric Antigen ; Antifungal Agents ; Antigens, CD19
Language	English
Publishing date	2023-09-28
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1272798
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Article ; Online: Bile acid-activated receptors and the regulation of macrophages function in metabolic disorders.

Fiorucci, Stefano / Baldoni, Monia / Ricci, Patrizia / Zampella, Angela / Distrutti, Eleonora / Biagioli, Michele

Current opinion in pharmacology

2020 Volume 53, Page(s) 45–54

Abstract: Bile acids are produced in the liver by the cholesterol breakdown and further metabolized by the intestinal microbiota to generate a group of chemically heterogeneous steroids that bind and activate a family of cells surface and nuclear receptors, ... ...

Abstract	Bile acids are produced in the liver by the cholesterol breakdown and further metabolized by the intestinal microbiota to generate a group of chemically heterogeneous steroids that bind and activate a family of cells surface and nuclear receptors, collectively known as the bile acid-activated receptors (BARs). The two best characterized members of this family are the farnesoid-x-receptor (FXR) and G protein Bile Acid Receptor (GPBAR1). Both receptors are expressed by cells of innate immunity including liver-resident and intestinal-resident macrophages and monocytes-derived macrophages. Because FXR and GPBAR1 knockout mice are biased toward a pro-inflammatory phenotype, it appears the both receptors might have a role in the development and maintenance of a tolerogenic phenotype. FXR and GPBAR1 ligands have been proven effective in the treatment in inflammatory and metabolic disorders and ligands for these receptors are currently under development for the treatment of non-alcoholic steato-hepatitis and diabetes.
MeSH term(s)	Animals ; Bile Acids and Salts/metabolism ; Gastrointestinal Microbiome ; Humans ; Macrophages/metabolism ; Metabolic Diseases/metabolism ; Receptors, Cytoplasmic and Nuclear/agonists ; Receptors, Cytoplasmic and Nuclear/metabolism ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	Bile Acids and Salts ; GPBAR1 protein, human ; Receptors, Cytoplasmic and Nuclear ; Receptors, G-Protein-Coupled ; farnesoid X-activated receptor (0C5V0MRU6P)
Language	English
Publishing date	2020-05-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2037057-X
ISSN	1471-4973 ; 1471-4892
ISSN (online)	1471-4973
ISSN	1471-4892
DOI	10.1016/j.coph.2020.04.008
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Article ; Online: Richter's transformation in the heart.

Marra, Andrea / Adamo, Francesco / Baldoni, Stefano / Laurenti, Maria Elena / Giansanti, Michele / Pasquino, Stefano / Bigerna, Barbara / Sorcini, Daniele / Stella, Arianna / Guarente, Valerio / Limongello, Roberto / Perriello, Vincenzo / Martino, Giovanni / Ascani, Stefano / Falini, Brunangelo / Sportoletti, Paolo

The Lancet. Oncology

2021 Volume 22, Issue 7, Page(s) e341

MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/genetics ; Cardiac Surgical Procedures ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/immunology ; Cell Transformation, Neoplastic/pathology ; Diagnosis, Differential ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Lymphoma, Large B-Cell, Diffuse/therapy ; Myocardium/immunology ; Myocardium/pathology ; Predictive Value of Tests ; Treatment Outcome
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2021-06-29
Publishing country	England
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(21)00153-4
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Article: NOTCH1

Silva Barcelos, Estevão Carlos / Rompietti, Chiara / Adamo, Francesco Maria / Dorillo, Erica / De Falco, Filomena / Del Papa, Beatrice / Baldoni, Stefano / Nogarotto, Manuel / Esposito, Angela / Capoccia, Silvia / Geraci, Clelia / Sorcini, Daniele / Stella, Arianna / Arcaleni, Roberta / Tini, Valentina / Imbroisi Valle Errera, Flávia / Rosati, Emanuela / Sportoletti, Paolo

Frontiers in oncology

2023 Volume 13, Page(s) 1218989

Abstract: Introduction: Constitutive activation of : Methods: We performed a bioinformatics analysis of : Results and discussion: Bioinformatics analysis revealed gene enrichment of the components of the ER stress/UPR pathway in NT1-M compared to those in ... ...

Abstract	Introduction: Constitutive activation of Methods: We performed a bioinformatics analysis of Results and discussion: Bioinformatics analysis revealed gene enrichment of the components of the ER stress/UPR pathway in NT1-M compared to those in NT1-WT CLL. Ectopic expression of
Language	English
Publishing date	2023-09-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1218989
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Article ; Online: A pro-inflammatory environment in bone marrow of Treg transplanted patients matches with graft-versus-leukemia effect.

Guardalupi, Francesco / Sorrentino, Carlo / Corradi, Giulia / Giancola, Raffaella / Baldoni, Stefano / Ulbar, Francesca / Fabi, Bianca / Andres Ejarque, Rosa / Timms, Jessica / Restuccia, Francesco / Santarone, Stella / Accorsi, Patrizia / Sportoletti, Paolo / De Falco, Filomena / Rosati, Emanuela / Carotti, Alessandra / Falzetti, Franca / Velardi, Andrea / Martelli, Massimo Fabrizio /

Kordasti, Shahram / Pierini, Antonio / Ruggeri, Loredana / Di Ianni, Mauro

Leukemia

2023 Volume 37, Issue 7, Page(s) 1572–1575

MeSH term(s)	Humans ; Bone Marrow ; T-Lymphocytes, Regulatory ; Bone Marrow Transplantation ; Transplantation, Homologous ; Leukemia ; Graft vs Host Disease/etiology
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Research Support, Non-U.S. Gov't ; Letter
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/s41375-023-01932-x
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