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  1. Article ; Online: Christian Krumm, Johan Huizinga, Deutschland und die Deutschen. Begegnung und Auseinandersetzung mit dem Nachbarn

    Christoph Strupp

    BMGN : Low Countries Historical Review, Vol 127, Iss 1, Pp 9-

    2012  Volume 9

    Keywords Johan Huizinga ; cultural history ; History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 2012-03-01T00:00:00Z
    Publisher Utrecht University Library Open Access Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Christian Krumm, Johan Huizinga, Deutschland und die Deutschen. Begegnung und Auseinandersetzung mit dem Nachbarn

    Christoph Strupp

    BMGN : Low Countries Historical Review, Vol 127, Iss

    2012  Volume 1

    Keywords Johan Huizinga ; cultural history ; History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 2012-03-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Case report: Bitter vertigo.

    Goldschagg, Nicolina / Brem, Christian / Strupp, Michael

    Frontiers in neurology

    2022  Volume 13, Page(s) 1028597

    Abstract: Background: There are many causes of episodes of vertigo and very few causes of episodes of changes in taste, and the combination of the two is very rare. Here, we describe a patient with recurrent short episodes of vertigo in combination with ... ...

    Abstract Background: There are many causes of episodes of vertigo and very few causes of episodes of changes in taste, and the combination of the two is very rare. Here, we describe a patient with recurrent short episodes of vertigo in combination with simultaneous episodes of recurrent paroxysmal dysgeusia and altered feeling on the left side of face. The symptoms were caused by compression of the vestibulocochlear nerve and the facial nerve due to dolichoectasia of the basilar artery.
    Methods: The patient was diagnosed in our routine clinical practice and underwent a complete neurological and neuro-otological examination, including video head impulse test, caloric irrigation, ocular and cervical vestibular evoked myogenic potentials, acoustic-evoked potentials, neuro-orthoptic examination, cranial MRI, and MR angiography. The patient was seen twice for follow-up.
    Case: A 71-year-old patient primarily presented with a 2-year history of recurrent short episodes of spinning vertigo. Each of the episodes began with an altered feeling on the left side of the face, followed by a bitter taste on the left half of the tongue, and subsequently vertigo lasting for up to 15 s. The frequency of the attacks was high: up to 80 times per day. Laboratory tests revealed signs of a peripheral vestibular deficit on the left side. There were no signs of sensory or motor deficits or of altered taste between the episodes. An MRI of the brain showed an elongated basilar artery leading to an indentation of the facial and vestibulocochlear nerves on the left side.
    Conclusion: We propose a neurovascular compression in the proximal part of two cranial nerves because of pulsatile compression by the elongated basilar artery with ephatic discharges as the cause of the recurrent episodes. Consistent with the theory of ephatic discharges, treatment with the sodium channel blocker lacosamide for over six months with a final dosage of 200 mg per day p.o. led to a significant reduction of the attack frequency and intensity. This treatment option with a sodium channel blocker should therefore not only be considered in vestibular paroxysmia but also in cases of paroxysmal dysgeusia.
    Language English
    Publishing date 2022-10-06
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.1028597
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  4. Article: Treatment of vestibular paroxysmia with lacosamide.

    Strupp, Michael / Elger, Christian / Goldschagg, Nicolina

    Neurology. Clinical practice

    2020  Volume 9, Issue 6, Page(s) 539–541

    Language English
    Publishing date 2020-02-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000000610
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  5. Article ; Online: Can we determine burdensome transitions in the last year of life based on time of occurrence and frequency? An explanatory mixed-methods study.

    Schippel, Nicolas / Dust, Gloria / von Reeken, Christian / Voltz, Raymond / Strupp, Julia / Rietz, Christian

    Palliative & supportive care

    2022  Volume 20, Issue 5, Page(s) 637–645

    Abstract: Objective: Burdensome transitions are typically defined as having a transition in the last three days or multiple hospitalizations in the last three months of life, which is seldom verified with qualitative accounts from persons concerned. This study ... ...

    Abstract Objective: Burdensome transitions are typically defined as having a transition in the last three days or multiple hospitalizations in the last three months of life, which is seldom verified with qualitative accounts from persons concerned. This study analyses types and frequencies of transitions in the last year of life and indicators of burdensome transitions from the perspective of bereaved relatives.
    Method: Cross-sectional explanatory mixed-methods study with 351 surveyed and 41 interviewed bereaved relatives in a German urban area. Frequencies,
    Results: Transitions rise sharply during the last year of life. 8.2% of patients experience a transition in the last three days and 7.8% three or more hospitalizations in the last three months of life. An empathetic way of telling patients about the prospect of death is associated with fewer transitions in the last month of life (
    Significance of results: Time of occurrence and frequency appear to be imperfect proxies for burdensome transitions. The subjective burden seems to be associated rather with insufficient information, preparation, and management of transitions.
    MeSH term(s) Cross-Sectional Studies ; Hospitalization ; Humans ; Terminal Care/methods
    Language English
    Publishing date 2022-09-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454009-2
    ISSN 1478-9523 ; 1478-9515
    ISSN (online) 1478-9523
    ISSN 1478-9515
    DOI 10.1017/S1478951521001395
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6697: Show issues Location:
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  6. Article ; Online: Dying in hospital is worse for non-cancer patients. A regional cross-sectional survey of bereaved relatives' views.

    Kasdorf, Alina / Dust, Gloria / Schippel, Nicolas / Pfaff, Holger / Rietz, Christian / Voltz, Raymond / Strupp, Julia

    European journal of cancer care

    2022  Volume 31, Issue 6, Page(s) e13683

    Abstract: Objective: The aim of the study is to examine differences in hospital care between patients with cancer and non-cancer conditions in their dying phase, perceived by bereaved relatives.: Methods: A retrospective cross-sectional post-bereavement survey, ...

    Abstract Objective: The aim of the study is to examine differences in hospital care between patients with cancer and non-cancer conditions in their dying phase, perceived by bereaved relatives.
    Methods: A retrospective cross-sectional post-bereavement survey, with the total population of 351 deceased, 91 cancer patients and 46 non-cancer patients, who spent their last 2 days of life in hospital. A validated German version of the VOICES-questionnaire ('VOICES-LYOL-Cologne') was used.
    Results: There were substantial differences between the two groups in the rating of sufficient practical care such as pain relief or support to eat or drink (p = 0.005) and sufficient emotional care needs (p = 0.006) and in the quality of communication with healthcare professionals (p < 0.001), with non-cancer patients scoring lowest in all these dimensions.
    Conclusion: In all surveyed dimensions on the quality of care in the dying phase, non-cancer patients' relatives rated the provided care worse than those of cancer patients. To compensate any differences in care in the dying phase between diagnosis groups, hospital care should be provided as needs-oriented and non-indication-specific.
    MeSH term(s) Humans ; Terminal Care/psychology ; Cross-Sectional Studies ; Family/psychology ; Retrospective Studies ; Bereavement ; Hospitals ; Surveys and Questionnaires ; Neoplasms/psychology ; Palliative Care/psychology
    Language English
    Publishing date 2022-08-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1303114-4
    ISSN 1365-2354 ; 0961-5423 ; 1360-5801
    ISSN (online) 1365-2354
    ISSN 0961-5423 ; 1360-5801
    DOI 10.1111/ecc.13683
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3347: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Unsolved problems and unwanted decision-making in the last year of life: A qualitative analysis of comments from bereaved caregivers.

    Knop, Jannis / Dust, Gloria / Kasdorf, Alina / Schippel, Nicolas / Rietz, Christian / Strupp, Julia / Voltz, Raymond

    Palliative & supportive care

    2022  , Page(s) 1–9

    Abstract: Objectives: Patients in their last year of life, as well as their relatives, often feel that existent care structures of the healthcare system do not adequately address their individual needs and challenges. This study analyzes unmet needs in terms of ... ...

    Abstract Objectives: Patients in their last year of life, as well as their relatives, often feel that existent care structures of the healthcare system do not adequately address their individual needs and challenges. This study analyzes unmet needs in terms of unsolved problems and unwanted decision-making in the health and social care of patients in their last year of life from the perspective of bereaved caregivers.
    Methods: This qualitative study is based on free-text comments from informal caregivers of deceased patients collected as part of the Last-Year-of-Life-Study-Cologne (LYOL-C) using a postal survey. With qualitative content analysis, a category system with main and subcategories was developed in a multi-step process.
    Results: Free-text commentaries and demographic data were collected from 240 bereaved caregivers. Particularly outside of hospice and palliative care services, study participants addressed the following unsolved problems: poor communication with medical and nursing staff, insufficient professional support for informal caregivers, inadequate psycho-social support for patients, and poor management of pain and other symptoms. Respondents often stated that their relative had to be cared for and die outside their own home, which the relative did not want.
    Significance of results: Our findings suggest the necessity for greater awareness of patients' and their relatives' needs in the last year of life. Addressing individual needs, integrating palliative and hospice care in acute hospitals and other healthcare structures, and identifying patients in their last year of life and their caregivers could help to achieve more targeted interventions and optimization of care.
    Language English
    Publishing date 2022-03-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2454009-2
    ISSN 1478-9523 ; 1478-9515
    ISSN (online) 1478-9523
    ISSN 1478-9515
    DOI 10.1017/S1478951522000165
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6697: Show issues Location:
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  8. Article ; Online: The last year of life for patients dying from cancer vs. non-cancer causes: a retrospective cross-sectional survey of bereaved relatives.

    Kasdorf, Alina / Dust, Gloria / Hamacher, Stefanie / Schippel, Nicolas / Rietz, Christian / Voltz, Raymond / Strupp, Julia

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2022  Volume 30, Issue 6, Page(s) 4971–4979

    Abstract: Purpose: To compare health care experiences of patients with cancer or non-cancer diseases in their last year of life.: Methods: A cross-sectional post-bereavement survey was conducted using an adapted German version of the VOICES questionnaire ( ... ...

    Abstract Purpose: To compare health care experiences of patients with cancer or non-cancer diseases in their last year of life.
    Methods: A cross-sectional post-bereavement survey was conducted using an adapted German version of the VOICES questionnaire (VOICES-LYOL-Cologne). Differences in the reported experiences were assessed using a two-sided Pearson's chi-square test and Mann-Whitney U test.
    Results: We collected data from 351 bereaved relatives. More than half of non-cancer patients were not informed that their disease could lead to death (p < 0.001). When this was communicated, in 46.7% of non-cancer and 64.5% of cancer patients, it was reported by the hospital doctor (p = 0.050). In all, 66.9% of non-cancer and 41.6% of cancer patients were not informed about death being imminent (p < 0.001). On average, non-cancer patients had significantly fewer transitions and hospital stays in their last year of life (p = 0.014; p = 0.008, respectively). Non-cancer patients were treated more often by general practitioners, and cancer patients were treated more often by specialists (p = 0.002; p = 0.002, respectively). A substantially lower proportion of non-cancer patients were treated by at least one member of or in the setting of general or specialized palliative care (p < 0.001).
    Conclusions: Non-cancer patients experience disadvantages in communication regarding their care and in access to specialized palliative care in their last year of life compared to cancer patients. Regarding the assessment of palliative care needs and the lack of communication of an incurable disease, non-cancer patients are underserved. An early identification of patients requiring palliative care is a major public health concern and should be addressed irrespective of diagnosis.
    Trial registration: Prospectively registered by the German Clinical Trials Register (DRKS00011925, data of registration: 13.06.2017).
    MeSH term(s) Bereavement ; Cross-Sectional Studies ; Family ; Humans ; Neoplasms/therapy ; Palliative Care ; Retrospective Studies ; Surveys and Questionnaires ; Terminal Care
    Language English
    Publishing date 2022-02-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-022-06908-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3697: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Quality of care in the last year of life: adaptation and validation of the German "Views of Informal Carers' Evaluation of Services - Last Year of Life - Cologne".

    Dust, Gloria / Schippel, Nicolas / Stock, Stephanie / Strupp, Julia / Voltz, Raymond / Rietz, Christian

    BMC health services research

    2022  Volume 22, Issue 1, Page(s) 1433

    Abstract: Background: To inform quality improvement and strengthen services provided in the last year of life, measuring quality of care is essential. For Germany, data on care experiences in the last year of life that go beyond diagnoses and care settings are ... ...

    Abstract Background: To inform quality improvement and strengthen services provided in the last year of life, measuring quality of care is essential. For Germany, data on care experiences in the last year of life that go beyond diagnoses and care settings are still rare. The aim of this study was to develop and validate a German version of the 'Views of Informal Carers' Evaluation of Services - Short Form (VOICES-SF)' suitable to assess the quality of care and services received across settings and healthcare providers in the German setting in the last year of life (VOICES-LYOL-Cologne).
    Methods: VOICES-SF was adapted and translated following the 'TRAPD' team approach. Data collected in a retrospective cross-sectional survey with bereaved relatives in the region of Cologne, Germany were used to assess validity and reliability.
    Results: Data from 351 bereaved relatives of adult decedents were analysed. The VOICES-LYOL-Cologne demonstrated construct validity in performing according to expected patterns, i.e. correlation of scores to care experiences and significant variability based on care settings. It further correlated with the PACIC-S9 Proxy, indicating good criterion validity. The newly added scale "subjective experiences of process and outcome of care in the last year of life" showed good internal consistency for each given care setting, except for the homecare setting. Test-retest analyses revealed no significant differences in satisfaction ratings according to the length of time since the patient's death. Overall, our data demonstrated the feasibility of collecting patient care experiences reported by proxy-respondents across multiple care settings.
    Conclusion: VOICES-LYOL-Cologne is the first German instrument to analyse care experiences in the last year of life in a comprehensive manner and encourages further research in German-speaking countries. This instrument enables the comparison of quality of care between settings and may be used to inform local and national quality improvement activities.
    Trial registration: This study was registered in the German Clinical Trials Register (DRKS00011925; Date of registration: 13/06/2017).
    MeSH term(s) Adult ; Humans ; Caregivers ; Cross-Sectional Studies ; Reproducibility of Results ; Retrospective Studies ; Quality Improvement
    Language English
    Publishing date 2022-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-022-08700-0
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  10. Article ; Online: Increased Cell Proliferation as a Key Event in Chemical Carcinogenesis: Application in an Integrated Approach for the Testing and Assessment of Non-Genotoxic Carcinogenesis.

    Strupp, Christian / Corvaro, Marco / Cohen, Samuel M / Corton, J Christopher / Ogawa, Kumiko / Richert, Lysiane / Jacobs, Miriam N

    International journal of molecular sciences

    2023  Volume 24, Issue 17

    Abstract: In contrast to genotoxic carcinogens, there are currently no internationally agreed upon regulatory tools for identifying non-genotoxic carcinogens of human relevance. The rodent cancer bioassay is only used in certain regulatory sectors and is ... ...

    Abstract In contrast to genotoxic carcinogens, there are currently no internationally agreed upon regulatory tools for identifying non-genotoxic carcinogens of human relevance. The rodent cancer bioassay is only used in certain regulatory sectors and is criticized for its limited predictive power for human cancer risk. Cancer is due to genetic errors occurring in single cells. The risk of cancer is higher when there is an increase in the number of errors per replication (genotoxic agents) or in the number of replications (cell proliferation-inducing agents). The default regulatory approach for genotoxic agents whereby no threshold is set is reasonably conservative. However, non-genotoxic carcinogens cannot be regulated in the same way since increased cell proliferation has a clear threshold. An integrated approach for the testing and assessment (IATA) of non-genotoxic carcinogens is under development at the OECD, considering learnings from the regulatory assessment of data-rich substances such as agrochemicals. The aim is to achieve an endorsed IATA that predicts human cancer better than the rodent cancer bioassay, using methodologies that equally or better protect human health and are superior from the view of animal welfare/efficiency. This paper describes the technical opportunities available to assess cell proliferation as the central gateway of an IATA for non-genotoxic carcinogenicity.
    MeSH term(s) Animals ; Humans ; Carcinogenesis ; Carcinogens/toxicity ; Agrochemicals ; Biological Assay ; Cell Proliferation
    Chemical Substances Carcinogens ; Agrochemicals
    Language English
    Publishing date 2023-08-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241713246
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