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Article ; Online: [No title information]

van de Poel, Philip

Zorgvisie : vakopinieblad voor de zorgsector

2020 Volume 50, Issue 5, Page(s) 48–51

Title translation	José Geertsema.
Keywords	covid19
Language	Dutch
Publishing date	2020-07-17
Publishing country	Netherlands
Document type	Journal Article
ISSN	2468-1415
ISSN (online)	2468-1415
DOI	10.1007/s41187-020-0911-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: [No title information]

van de Poel, Philip

Zorgvisie : vakopinieblad voor de zorgsector

2020 Volume 50, Issue 3, Page(s) 18–21

Title translation	Besturen in crisistijd: zichtbaar maar ook inzetbaar blijven.
Keywords	covid19
Language	Dutch
Publishing date	2020-04-17
Publishing country	Netherlands
Document type	Journal Article
ISSN	2468-1415
ISSN (online)	2468-1415
DOI	10.1007/s41187-020-0355-1
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Article ; Online: Zoeken naar het nieuwe normaal

van de Poel, Philip

Skipr

Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1007/s12654-020-0709-8
Database	COVID19

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Article ; Online: [No title information]

Hinloopen, Hester / Houte de Lange, Sterre Ten / van de Poel, Philip

Zorgvisie : vakopinieblad voor de zorgsector

2020 Volume 50, Issue 8, Page(s) 52–55

Title translation	Gezonde voeding.
Keywords	covid19
Language	Dutch
Publishing date	2020-11-20
Publishing country	Netherlands
Document type	Journal Article
ISSN	2468-1415
ISSN (online)	2468-1415
DOI	10.1007/s41187-020-0958-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: First-in-patient study of OTL78 for intraoperative fluorescence imaging of prostate-specific membrane antigen-positive prostate cancer: a single-arm, phase 2a, feasibility trial.

Stibbe, Judith A / de Barros, Hilda A / Linders, Daan G J / Bhairosingh, Shadhvi S / Bekers, Elise M / van Leeuwen, Pim J / Low, Philip S / Kularatne, Sumith A / Vahrmeijer, Alexander L / Burggraaf, Jacobus / van der Poel, Henk G

The Lancet. Oncology

2023 Volume 24, Issue 5, Page(s) 457–467

Abstract: Background: Targeted real-time imaging during robot-assisted radical prostatectomy provides information on the localisation and extent of prostate cancer. We assessed the safety and feasibility of the prostate-specific membrane antigen (PSMA)-targeted ... ...

Abstract	Background: Targeted real-time imaging during robot-assisted radical prostatectomy provides information on the localisation and extent of prostate cancer. We assessed the safety and feasibility of the prostate-specific membrane antigen (PSMA)-targeted fluorescent tracer OTL78 in patients with prostate cancer. Methods: In this single-arm, phase 2a, feasibility trial with an adaptive design was carried out in The Netherlands Cancer Institute, Netherlands. Male patients aged 18 years or older, with PSMA PET-avid prostate cancer with an International Society of Urological Pathology (ISUP) grade group of 2 or more, who were scheduled to undergo robot-assisted radical prostatectomy with or without extended pelvic lymph node dissection were eligible. All patients had a robot-assisted radical prostatectomy using OTL78. Based on timing and dose, patients received a single intravenous infusion of OTL78 (0·06 mg/kg 1-2 h before surgery [dose cohort 1], 0·03 mg/kg 1-2 h before surgery [dose cohort 2], or 0·03 mg/kg 24 h before surgery [dose cohort 3]). The primary outcomes, assessed in all enrolled patients, were safety and pharmacokinetics of OTL78. This study is completed and is registered in the European Trial Database, 2019-002393-31, and the International Clinical Trials Registry Platform, NL8552, and is completed. Findings: Between June 29, 2020, and April 1, 2021, 19 patients were screened for eligibility, 18 of whom were enrolled. The median age was 69 years (IQR 64-70) and median prostate-specific antigen concentration was 15 ng/mL (IQR 9·3-22·0). In 16 (89%) of 18 patients, robot-assisted radical prostatectomy was accompanied by an extended pelvic lymph node dissection. Three serious adverse events occurred in one (6%) patient: an infected lymphocele, a urosepsis, and an intraperitoneal haemorrhage. These adverse events were considered unrelated to the administration of OTL78 or intraoperative fluorescence imaging. No patient died, required a dose reduction, or required discontinuation due to drug-related toxicity. The dose-normalised maximum serum concentration (C Interpretation: This first-in-patient study showed that OTL78 was well tolerated and had the potential to improve prostate cancer detection. Optimal dosing was 0·03 mg/kg, 24 h preoperatively. PSMA-directed fluorescence imaging allowed real-time identification of visually occult prostate cancer and might help to achieve complete oncological resections. Funding: On Target Laboratories.
MeSH term(s)	Humans ; Male ; Aged ; Prostate/pathology ; Feasibility Studies ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery ; Prostate-Specific Antigen ; Prostatectomy/adverse effects ; Optical Imaging ; Positron Emission Tomography Computed Tomography
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-04-14
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(23)00102-X
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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 460: Show issues

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Article ; Online: Development and Internal Validation of a Novel Nomogram Predicting the Outcome of Salvage Radiation Therapy for Biochemical Recurrence after Radical Prostatectomy in Patients without Metastases on Restaging Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography.

Meijer, Dennie / van Leeuwen, Pim J / Eppinga, Wietse S C / Vanneste, Ben G L / Meijnen, Philip / Daniels, Laurien A / van den Bergh, Roderick C N / Lont, Anne P / Bodar, Yves J L / Ettema, Rosemarijn H / de Bie, Katelijne C C / Oudshoorn, Frederik H K / Nieuwenhuijzen, Jakko A / van der Poel, Henk G / Donswijk, Maarten L / Heymans, Martijn W / Oprea-Lager, Daniela E / Schaake, Eva E / Vis, André N

European urology open science

2024 Volume 61, Page(s) 37–43

Abstract: Background and objective: Owing to the greater use of prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) in patients with biochemical recurrence (BCR) of prostate cancer (PCa) after robot-assisted radical ...

Abstract	Background and objective: Owing to the greater use of prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) in patients with biochemical recurrence (BCR) of prostate cancer (PCa) after robot-assisted radical prostatectomy (RARP), patient selection for local salvage radiation therapy (sRT) has changed. Our objective was to determine the short-term efficacy of sRT in patients with BCR after RARP, and to develop a novel nomogram predicting BCR-free survival after sRT in a nationwide contemporary cohort of patients who underwent PSMA PET/CT before sRT for BCR of PCa, without evidence of metastatic disease. Methods: All 302 eligible patients undergoing PCa sRT in four reference centers between September 2015 and August 2020 were included. We conducted multivariable logistic regression analysis using a backward elimination procedure to develop a nomogram for predicting biochemical progression of PCa, defined as prostate-specific antigen (PSA) ≥0.2 ng/ml above the post-sRT nadir within 1 yr after sRT. Key findings and limitations: Biochemical progression of disease within 1 yr after sRT was observed for 56/302 (19%) of the study patients. The final predictive model included PSA at sRT initiation, pathological grade group, surgical margin status, PSA doubling time, presence of local recurrence on PSMA PET/CT, and the presence of biochemical persistence (first PSA result ≥0.1 ng/ml) after RARP. The area under the receiver operating characteristic curve for this model was 0.72 (95% confidence interval 0.64-0.79). Using our nomogram, patients with a predicted risk of >20% had a 30.8% chance of developing biochemical progression within 1 yr after sRT. Conclusions: Our novel nomogram may facilitate better patient counseling regarding early oncological outcome after sRT. Patients with high risk of biochemical progression may be candidates for more extensive treatment. Patient summary: We developed a new tool for predicting cancer control outcomes of radiotherapy for patients with recurrence of prostate cancer after surgical removal of their prostate. This tool may help in better counseling of these patients with recurrent cancer regarding their early expected outcome after radiotherapy.
Language	English
Publishing date	2024-02-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3040546-4
ISSN	2666-1683 ; 2058-4881
ISSN (online)	2666-1683
ISSN	2058-4881
DOI	10.1016/j.euros.2024.01.009
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Article ; Online: Delphi consensus project on prostate-specific membrane antigen (PSMA)-targeted surgery-outcomes from an international multidisciplinary panel.

European journal of nuclear medicine and molecular imaging

2023

Abstract: Purpose: Prostate-specific membrane antigen (PSMA) is increasingly considered as a molecular target to achieve precision surgery for prostate cancer. A Delphi consensus was conducted to explore expert views in this emerging field and to identify ... ...

Abstract	Purpose: Prostate-specific membrane antigen (PSMA) is increasingly considered as a molecular target to achieve precision surgery for prostate cancer. A Delphi consensus was conducted to explore expert views in this emerging field and to identify knowledge and evidence gaps as well as unmet research needs that may help change practice and improve oncological outcomes for patients. Methods: One hundred and five statements (scored by a 9-point Likert scale) were distributed through SurveyMonkey®. Following evaluation, a consecutive second round was performed to evaluate consensus (16 statements; 89% response rate). Consensus was defined using the disagreement index, assessed by the research and development project/University of California, Los Angeles appropriateness method. Results: Eighty-six panel participants (72.1% clinician, 8.1% industry, 15.1% scientists, and 4.7% other) participated, most with a urological background (57.0%), followed by nuclear medicine (22.1%). Consensus was obtained on the following: (1) The diagnostic PSMA-ligand PET/CT should ideally be taken < 1 month before surgery, 1-3 months is acceptable; (2) a 16-20-h interval between injection of the tracer and surgery seems to be preferred; (3) PSMA targeting is most valuable for identification of nodal metastases; (4) gamma, fluorescence, and hybrid imaging are the preferred guidance technologies; and (5) randomized controlled clinical trials are required to define oncological value. Regarding surgical margin assessment, the view on the value of PSMA-targeted surgery was neutral or inconclusive. A high rate of "cannot answer" responses indicates further study is necessary to address knowledge gaps (e.g., Cerenkov or beta-emissions). Conclusions: This Delphi consensus provides guidance for clinicians and researchers that implement or develop PSMA-targeted surgery technologies. Ultimately, however, the consensus should be backed by randomized clinical trial data before it may be implemented within the guidelines.
Language	English
Publishing date	2023-11-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-023-06524-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1227: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.

Toledo-Sherman, Leticia / Breccia, Perla / Cachope, Roger / Bate, Jennifer R / Angulo-Herrera, Ivan / Wishart, Grant / Matthews, Kim L / Martin, Sarah L / Cox, Helen C / McAllister, George / Penrose, Stephen D / Vater, Huw / Esmieu, William / Van de Poël, Amanda / Van de Bospoort, Rhea / Strijbosch, Annelieke / Lamers, Marieke / Leonard, Philip / Jarvis, Rebecca E /

Blackaby, Wesley / Barnes, Karen / Eznarriaga, Maria / Dowler, Simon / Smith, Graham D / Fischer, David F / Lazari, Ovadia / Yates, Dawn / Rose, Mark / Jang, Sung-Wook / Muñoz-Sanjuan, Ignacio / Dominguez, Celia

Journal of medicinal chemistry

2019 Volume 62, Issue 6, Page(s) 2988–3008

Abstract: Genetic and pharmacological evidence indicates that the reduction of ataxia telangiectasia-mutated (ATM) kinase activity can ameliorate mutant huntingtin (mHTT) toxicity in cellular and animal models of Huntington's disease (HD), suggesting that ... ...

Abstract	Genetic and pharmacological evidence indicates that the reduction of ataxia telangiectasia-mutated (ATM) kinase activity can ameliorate mutant huntingtin (mHTT) toxicity in cellular and animal models of Huntington's disease (HD), suggesting that selective inhibition of ATM could provide a novel clinical intervention to treat HD. Here, we describe the development and characterization of ATM inhibitor molecules to enable in vivo proof-of-concept studies in HD animal models. Starting from previously reported ATM inhibitors, we aimed with few modifications to increase brain exposure by decreasing P-glycoprotein liability while maintaining potency and selectivity. Here, we report brain-penetrant ATM inhibitors that have robust pharmacodynamic (PD) effects consistent with ATM kinase inhibition in the mouse brain and an understandable pharmacokinetic/PD (PK/PD) relationship. Compound 17 engages ATM kinase and shows robust dose-dependent inhibition of X-ray irradiation-induced KAP1 phosphorylation in the mouse brain. Furthermore, compound 17 protects against mHTT (Q73)-induced cytotoxicity in a cortical-striatal cell model of HD.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Ataxia Telangiectasia Mutated Proteins/antagonists & inhibitors ; Disease Models, Animal ; Dogs ; Humans ; Huntington Disease/drug therapy ; Madin Darby Canine Kidney Cells ; Mice ; Neuroprotective Agents/metabolism ; Neuroprotective Agents/pharmacokinetics ; Neuroprotective Agents/therapeutic use ; Proof of Concept Study
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Neuroprotective Agents ; ATM protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
Language	English
Publishing date	2019-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.8b01819
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Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

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Article ; Online: [No title information]

van der Poel, Philip

Zorgvisie : vakopinieblad voor de zorgsector

2020 Volume 50, Issue 3, Page(s) 40–43

Title translation	Ragfijn samen- spel: bestuurlijke organisatie crisisbestrijding.
Keywords	covid19
Language	Dutch
Publishing date	2020-04-17
Publishing country	Netherlands
Document type	Journal Article
ISSN	2468-1415
ISSN (online)	2468-1415
DOI	10.1007/s41187-020-0359-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Is Associated with Improved Oncological Outcome in Men Treated with Salvage Radiation Therapy for Biochemically Recurrent Prostate Cancer.

Meijer, Dennie / Eppinga, Wietse S C / Mohede, Roos M / Vanneste, Ben G L / Meijnen, Philip / Meijer, Otto W M / Daniels, Laurien A / van den Bergh, Roderick C N / Lont, Anne P / Ettema, Rosemarijn H / Oudshoorn, Frederik H K / van Leeuwen, Pim J / van der Poel, Henk G / Donswijk, Maarten L / Oprea-Lager, Daniela E / Schaake, Eva E / Vis, André N

European urology oncology

2022 Volume 5, Issue 2, Page(s) 146–152

Abstract: Background: Radiolabeled prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) has shown superior diagnostic accuracy to conventional imaging for the detection of prostate cancer deposits . Consequently, ... ...

Abstract	Background: Radiolabeled prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) has shown superior diagnostic accuracy to conventional imaging for the detection of prostate cancer deposits . Consequently, clinical management changes have been reported in patients with biochemical recurrence (BCR) of disease after robot-assisted radical prostatectomy (RARP). We hypothesized that, due to the exclusion of patients with metastatic disease on PSMA-PET/CT, those who underwent local salvage radiation therapy (SRT) after restaging PSMA-PET/CT for BCR may have better oncological outcomes than patients who underwent "blind" SRT. Objective: To compare the oncological outcome of a patient cohort that underwent PSMA-PET imaging prior to SRT with that of a patient cohort that did not have PSMA-PET imaging before SRT. Design, setting, and participants: We included 610 patients who underwent SRT, of whom 298 underwent PSMA-PET/CT prior to SRT and 312 did not. No additional hormonal therapy was prescribed. Outcome measurements and statistical analysis: To compare both cohorts, case-control matching was performed, using the prostate-specific antigen (PSA) value at the initiation of SRT, pathological grade group, pathological T stage, surgical margin status, and biochemical persistence after RARP as matching variables. The outcome variable was biochemical progression at 1 yr after SRT, defined as either a rise of PSA ≥0.2 ng/ml above the nadir after SRT or the start of additional treatment. Results and limitations: After case-control matching, 216 patients were matched in both cohorts (108 patients per cohort). In the patient cohort without PSMA-PET/CT prior to SRT, of 108 patients, 23 (21%) had biochemical progression of disease at 1 yr after SRT, compared with nine (8%) who underwent restaging PSMA-PET/CT prior to SRT (p = 0.007). Conclusions: PSMA-PET/CT is found to be associated with an improved oncological outcome in patients who undergo SRT for BCR after RARP. Patient summary: Performing prostate-specific membrane antigen positron emission tomography/computed tomography imaging in patients with biochemical recurrence of disease after robot-assisted radical prostatectomy, before initiating salvage radiation therapy, resulted in improved short-term oncological outcomes.
MeSH term(s)	Antigens, Surface ; Gallium Isotopes ; Gallium Radioisotopes ; Glutamate Carboxypeptidase II ; Humans ; Male ; Positron Emission Tomography Computed Tomography/methods ; Prostate/pathology ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy
Chemical Substances	Antigens, Surface ; Gallium Isotopes ; Gallium Radioisotopes ; FOLH1 protein, human (EC 3.4.17.21) ; Glutamate Carboxypeptidase II (EC 3.4.17.21) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2022-01-22
Publishing country	Netherlands
Document type	Journal Article
ISSN	2588-9311
ISSN (online)	2588-9311
DOI	10.1016/j.euo.2022.01.001
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