LIVIVO - Search results -

Search results

Result 1 - 10 of total 32

Search options

Article ; Online: Evaluation of phytochemical composition, toxicity in

Luna, E M / Freitas, T S / Campina, F F / Costa, M S / Rocha, J E / Cruz, R P / Sena Júnior, D L / Silveira, Z S / Macedo, N S / Pinheiro, J C A / Pereira-Júnior, F N / Lisboa, M A N / Cruz, G V / Calixto Júnior, J T / Teixeira, A M R / Coutinho, H D M

Toxicology reports

2021 Volume 8, Page(s) 732–739

Abstract: Bacterial resistance is interfering with the action of antibiotics for clinical use in treating pathologies. The search for new substances capable of combating this resistance is necessary. An alternative to the search for these substances is in the ... ...

Abstract	Bacterial resistance is interfering with the action of antibiotics for clinical use in treating pathologies. The search for new substances capable of combating this resistance is necessary. An alternative to the search for these substances is in the extract of medicinal plants.
Language	English
Publishing date	2021-03-31
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2021.03.020
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: UPLC-QTOF-MS/MS analysis and antibacterial activity of the Manilkara zapota (L.) P. Royen against Escherichia coli and other MDR bacteria.

Freitas, Thiago S / Campina, Fábia F / Costa, Maria S / Rocha, Janaí Na E / Cruz, Rafael P / Pinheiro, Jacqueline C A / Pereira-Júnior, Francisco N / Lima, Micheline A / Pires de Sá, Maí Sa Freire Cartaxo / Teixeira, Alexandre M R / Coutinho, Henrique D M

Cellular and molecular biology (Noisy-le-Grand, France)

2021 Volume 67, Issue 1, Page(s) 116–124

Abstract: With the spread of bacterial resistance against clinically used antibiotics, natural plant-derived products are being studied as new sources of antibacterial molecules. Manilkara zapota is a common plant species in the American continent that is used as ... ...

Abstract	With the spread of bacterial resistance against clinically used antibiotics, natural plant-derived products are being studied as new sources of antibacterial molecules. Manilkara zapota is a common plant species in the American continent that is used as a food source. Studies show the M. zapota extract is rich in phenolic substances that can serve as basic molecules for the pharmaceutical industry. An extract from fresh M. zapota leaves was produced and tested to identify the compounds present, as well as its direct antibacterial and clinical antibiotic modulatory activities. To analyze the results, a new statistical methodology based on the Shannon-Wiener index was tested, capable of correcting distortions in heterogeneous environments. The Hydroethanolic Extract of Manilkara zapota leaves (HEMzL) presented a wide variety of phenolic products, as well as tannins, in the UPLC analysis. The extract showed direct antibacterial activity against the standard Staphylococcus aureus strain, however, it either acted antagonistically when associated with the tested antibiotics, or it did not present statistical significance when compared to the control. This demonstrates a need to be cautious when associating natural products with antibiotics for clinical use, as a hindrance to infectious treatments may occur. As for the statistical analysis mechanism tested, this proved to be effective, reducing false negatives at low antibiotic concentrations and false positives at high concentrations in the microdilution plate.
MeSH term(s)	Animals ; Anti-Bacterial Agents/analysis ; Anti-Bacterial Agents/pharmacology ; Bacteria/classification ; Bacteria/drug effects ; Bacteria/growth & development ; Chromatography, Liquid/methods ; Drug Resistance, Multiple, Bacterial/drug effects ; Escherichia coli/drug effects ; Escherichia coli/physiology ; Escherichia coli Infections/microbiology ; Escherichia coli Infections/prevention & control ; Humans ; Manilkara/chemistry ; Microbial Sensitivity Tests/methods ; Phenols/analysis ; Phenols/pharmacology ; Phytotherapy/methods ; Plant Extracts/analysis ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Tandem Mass Spectrometry/methods
Chemical Substances	Anti-Bacterial Agents ; Phenols ; Plant Extracts
Language	English
Publishing date	2021-01-31
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2021.67.1.18
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3812: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Beta-lactam hypersensitivity: from guidelines to daily practice.

Campina Costa, S / Neto, M / Trindade, M

Journal of investigational allergology & clinical immunology

2010 Volume 20, Issue 2, Page(s) 175–176

MeSH term(s)	Administration, Oral ; Algorithms ; Diagnosis, Differential ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/immunology ; Drug Hypersensitivity/physiopathology ; Exanthema ; Feasibility Studies ; Female ; Follow-Up Studies ; Humans ; Immunization ; Immunoassay ; Immunoglobulin E/blood ; Male ; Middle Aged ; Practice Guidelines as Topic ; Skin Tests ; Urticaria ; beta-Lactams/administration & dosage ; beta-Lactams/adverse effects ; beta-Lactams/immunology
Chemical Substances	beta-Lactams ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2010
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1128657-x
ISSN	1018-9068
ISSN	1018-9068
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3487: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Gas chromatography coupled to mass spectrometry (GC-MS) characterization and evaluation of antibacterial bioactivities of the essential oils from

da Silva, Ana Cristina A / Matias, Edinardo F F / Rocha, Janaína E / Araújo, Ana Carolina Justino de / de Freitas, Thiago S / Campina, Fábia F / Costa, Maria do S / Silva, Luiz E / Amaral, Wanderlei do / Maia, Beatriz Helena L N S / Ferriani, Aurea P / Bezerra, Camila F / Iriti, Marcello / Coutinho, Henrique D M

Zeitschrift fur Naturforschung. C, Journal of biosciences

2020 Volume 76, Issue 1-2, Page(s) 35–42

Abstract: The objective of this study was to determine the chemical profile and to evaluate the antibacterial activity of the essential oils ... ...

Abstract	The objective of this study was to determine the chemical profile and to evaluate the antibacterial activity of the essential oils of
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Escherichia coli/drug effects ; Oils, Volatile/chemistry ; Oils, Volatile/pharmacology ; Piper/chemistry ; Plant Oils/chemistry ; Plant Oils/pharmacology ; Sesquiterpenes/analysis ; Sesquiterpenes, Germacrane/analysis ; Staphylococcus aureus/drug effects
Chemical Substances	Anti-Bacterial Agents ; Oils, Volatile ; Plant Oils ; Sesquiterpenes ; Sesquiterpenes, Germacrane ; beta copaene ; spathulenol (7XV9L96SJJ)
Language	English
Publishing date	2020-07-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124636-7
ISSN	1865-7125 ; 0341-0382 ; 0341-0471 ; 0939-5075
ISSN (online)	1865-7125
ISSN	0341-0382 ; 0341-0471 ; 0939-5075
DOI	10.1515/znc-2020-0045
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 962: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The Galactose-Binding Lectin Isolated from Vatairea macrocarpa Seeds Enhances the Effect of Antibiotics Against Staphylococcus aureus-Resistant Strain.

Santos, Valdenice F / Costa, Maria S / Campina, Fábia F / Rodrigues, Renato R / Santos, Ana L E / Pereira, Felipe M / Batista, Karla L R / Silva, Rafael C / Pereira, Raquel O / Rocha, Bruno A M / Coutinho, Henrique D M / Teixeira, Claudener S

Probiotics and antimicrobial proteins

2019 Volume 12, Issue 1, Page(s) 82–90

Abstract: ... gentamicin, norfloxacin and penicillin, a significant increase in antibiotic activity was observed against S ... for the enhanced activity of gentamicin in S. aureus. Thus, our results suggest that the VML can be an effective ... modulating agent against S. aureus. This is the first study to report the effect of lectins as modulators ...

Abstract	The use of natural products together with standard antimicrobial drugs has recently received more attention as a strategy to combat infectious diseases caused by multidrug-resistant (MDR) microorganisms. This study aimed to evaluate the capacity of a galactose-binding lectin from Vatairea macrocarpa seeds (VML) to modulate antibiotic activity against standard and MDR Staphylococcus aureus and Escherichia coli bacterial strains. The minimum inhibitory concentration (MIC) obtained for VML against all strains was not clinically relevant (MIC ≥ 1024 μg/mL). However, when VML was combined with the antibacterial drugs gentamicin, norfloxacin and penicillin, a significant increase in antibiotic activity was observed against S. aureus, whereas the combination of VML and norfloxacin presented decreased and, hence, antagonistic antibiotic activity against E. coli. By its inhibition of hemagglutinating activity, gentamicin (MIC = 50 mM) revealed its interaction with the carbohydrate-binding site (CBS) of VML. Using molecular docking, it was found that gentamicin interacts with residues that constitute the CBS of VML with a score of - 120.79 MDS. It is this interaction between the antibiotic and the lectin's CBS that may be responsible for the enhanced activity of gentamicin in S. aureus. Thus, our results suggest that the VML can be an effective modulating agent against S. aureus. This is the first study to report the effect of lectins as modulators of bacterial sensitivity, and as such, the outcome of this study could lay the groundwork for future research involving the use of lectins and conventional antibiotics against such infectious diseases such as community-acquired methicillin-resistant S. aureus (MRSA).
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Drug Interactions ; Escherichia coli/drug effects ; Fabaceae/chemistry ; Galectins/pharmacology ; Plant Proteins/pharmacology ; Seeds/chemistry ; Staphylococcus aureus/drug effects
Chemical Substances	Anti-Bacterial Agents ; Galectins ; Plant Proteins
Language	English
Publishing date	2019-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-019-9526-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Evaluation of chelating and cytoprotective activity of vanillin against the toxic action of mercuric chloride as an alternative for phytoremediation.

da Silva, Joelma P / do S Costa, Maria / Campina, Fabia F / Bezerra, Camila F / de Freitas, Thiago S / Sousa, Amanda K / Sobral Souza, Celestina E / de Matos, Yedda M L S / Pereira-Junior, Francisco N / Menezes, Irwim R A / Coutinho, Henrique D M / Rocha, Janaína E

Environmental geochemistry and health

2020 Volume 43, Issue 4, Page(s) 1609–1616

Abstract: Mercury is widely found in nature, however, in low concentrations, but anthropological activities have increased its concentration considerably. This causes various environmental hazards and human health. Many substances are capable of reversing the ... ...

Abstract	Mercury is widely found in nature, however, in low concentrations, but anthropological activities have increased its concentration considerably. This causes various environmental hazards and human health. Many substances are capable of reversing the toxicity of mercuric chloride in the environment. The aim of the present study was to determine the chelating effect of vanillin, as well as to evaluate its capacity for cytoprotection in prokaryotic and eukaryotic plant models. Chelating activity was determined from vanillin's ability to reduce iron III ions. To evaluate cytoprotection in a unicellular prokaryotic and eukaryotic model, Escherichia coli and Candida albicans, respectively, were used. And to evaluate the cytoprotective activity in vegetables, lettuce seeds were submitted to different concentrations of mercuric chloride and its association with the sub-allelopathic concentration of vanillin (32 µg/mL). Vanillin has been found to have antioxidant activity as it can reduce iron III ions. The use of vanillin also allows for better growth and development of Lactuca sativa seed root and stem, also allowing better preservation of its biochemical structures. These results are quite important, as environmental contamination by heavy metals has increased dramatically and finding a viable alternative to grow vegetables in contaminated areas is very valid.
MeSH term(s)	Antioxidants/chemistry ; Benzaldehydes/chemistry ; Biodegradation, Environmental ; Chelating Agents/chemistry ; Ferric Compounds/chemistry ; Humans ; Lactuca ; Mercuric Chloride/toxicity ; Mercury ; Metals, Heavy/analysis ; Seeds/chemistry ; Vegetables
Chemical Substances	Antioxidants ; Benzaldehydes ; Chelating Agents ; Ferric Compounds ; Metals, Heavy ; Mercuric Chloride (53GH7MZT1R) ; vanillin (CHI530446X) ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2020-03-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-020-00538-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4723: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Antibacterial and modulatory activities of β-cyclodextrin complexed with (+)-β-citronellol against multidrug-resistant strains.

Silva Pereira, Raimundo Luiz / Campina, Fábia Ferreira / Costa, Maria do Socorro / Pereira da Cruz, Rafael / Sampaio de Freitas, Thiago / Lucas Dos Santos, Antonia Thassya / Cruz, Beatriz Gonçalves / Maciel de Sena Júnior, Diniz / Campos Lima, Igor Kleber / Xavier, Maria Regivânia / Rodrigues Teixeira, Alexandre Magno / Alencar de Menezes, Irwin Rose / Quintans-Júnior, Lucindo José / Araújo, Adriano A de S / Melo Coutinho, Henrique Douglas

Microbial pathogenesis

2021 Volume 156, Page(s) 104928

Abstract: The present study aimed to investigate the antibacterial and modulatory activities of (+)-β-citronellol (βCT), β-cyclodextrin (β-CD), and their complex βCT/β-CD and characterize them using infrared spectroscopy. Infrared spectra were recorded in the 750- ... ...

Abstract	The present study aimed to investigate the antibacterial and modulatory activities of (+)-β-citronellol (βCT), β-cyclodextrin (β-CD), and their complex βCT/β-CD and characterize them using infrared spectroscopy. Infrared spectra were recorded in the 750-4000 cm
MeSH term(s)	Acyclic Monoterpenes ; Anti-Bacterial Agents/pharmacology ; Escherichia coli ; Microbial Sensitivity Tests ; Staphylococcus aureus ; beta-Cyclodextrins/pharmacology
Chemical Substances	Acyclic Monoterpenes ; Anti-Bacterial Agents ; beta-Cyclodextrins ; citronellol (P01OUT964K)
Language	English
Publishing date	2021-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2021.104928
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2136: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: FTIR analysis of pyrogallol and phytotoxicity-reductive effect against mercury chloride.

Rocha, Janaina E / Guedes, Tássia T A M / Bezerra, Camila F / Costa, Maria do S / Campina, Fabia F / de Freitas, Thiago S / Sousa, Amanda K / Sobral Souza, Celestina E / Silva, Maria K N / Lobo, Yedda M / Pereira-Junior, Francisco N / da Silva, João H / Menezes, Irwin R A / Teixeira, Raimundo N P / Colares, Aracélio V / Coutinho, Henrique D M

Environmental geochemistry and health

2020 Volume 43, Issue 6, Page(s) 2433–2442

Abstract: Human activities, especially in industry, have contributed to soil contamination with heavy or toxic metals. The objective of this study was to determine the chelating effect and antioxidant activity of pyrogallol, as well as to evaluate its ... ...

Abstract	Human activities, especially in industry, have contributed to soil contamination with heavy or toxic metals. The objective of this study was to determine the chelating effect and antioxidant activity of pyrogallol, as well as to evaluate its cytoprotective activity in prokaryotic and eukaryotic models, animal and plant, respectively, against toxic mercury chloride action. Antioxidant activity was determined by DPPH where pyrogallol showed considerable action, chelating even iron ions. For the microbiologic activity assays, microdilution was performed to obtain the minimal inhibitory concentration, minimum bactericidal and minimum fungicide concentration, from which the sub-inhibitory concentrations were determined. The product did not conferred cytoprotection to the tested bacteria and fungi. To evaluate plant cytoprotection, Lactuta sativa seeds were used together with the product at a sub-allelopathic concentration with different HgCl
MeSH term(s)	Allelopathy ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Chelating Agents/chemistry ; Chelating Agents/pharmacology ; Germination/drug effects ; Iron Chelating Agents/chemistry ; Iron Chelating Agents/pharmacology ; Lactuca/drug effects ; Mercuric Chloride/chemistry ; Mercuric Chloride/toxicity ; Microbial Sensitivity Tests ; Pyrogallol/chemistry ; Pyrogallol/pharmacology ; Seeds/drug effects ; Soil Pollutants/toxicity ; Spectroscopy, Fourier Transform Infrared/methods
Chemical Substances	Antioxidants ; Chelating Agents ; Iron Chelating Agents ; Soil Pollutants ; Pyrogallol (01Y4A2QXY0) ; Mercuric Chloride (53GH7MZT1R)
Language	English
Publishing date	2020-06-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-020-00607-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4723: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Comparative analysis of the antibacterial and drug-modulatory effect of d-limonene alone and complexed with β-cyclodextrin.

Costa, Maria Do S / Rocha, Janaína E / Campina, Fábia F / Silva, Ana R P / Da Cruz, Rafael P / Pereira, Raimundo L S / Quintans-Júnior, Lucindo J / De Menezes, Irwin R A / De S Araújo, Adriano A / De Freitas, Thiago S / Teixeira, Alexandre M R / Coutinho, Henrique D M

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2018 Volume 128, Page(s) 158–161

Abstract: ... a MIC equal to 256 μg/mL against standard S. aureus and 512 μg/mL against resistant P. aeruginosa ... In the gentamicin modulatory activity, the isolated d-limonene presented synergism against S. aureus and E ...

Abstract	With the increase in bacterial resistance to antibiotics, many studies have been directed towards finding new agents with antibacterial activity, such as studies with natural products. These products can have antibacterial activity such as d-limonene as described in the literature. The aim of this study was to evaluate the antibacterial activity of d-limonene, isolated and complexed with β-cyclodextrin, and to evaluate its potentiating activity of different antibiotic classes. Antibacterial activity was determined by the broth microdilution method, obtaining in this way the Minimal Inhibitory Concentration (MIC), with the antibiotic modulatory activity being obtained using a sub-inhibitory concentration (MIC/8). d-Limonene showed a MIC equal to 256 μg/mL against standard S. aureus and 512 μg/mL against resistant P. aeruginosa. In the gentamicin modulatory activity, the isolated d-limonene presented synergism against S. aureus and E. coli bacteria. Thus, d-limonene showed relevant clinical antibacterial activity, for both Gram-positive and Gram-negative bacteria as well as a synergistic effect when associated with gentamicin. These results are promising in the combat against bacterial resistance, however further studies are needed to better elucidate the mechanisms of action.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Limonene/chemistry ; Limonene/pharmacology ; beta-Cyclodextrins/chemistry
Chemical Substances	Anti-Bacterial Agents ; beta-Cyclodextrins ; Limonene (9MC3I34447) ; betadex (JV039JZZ3A)
Language	English
Publishing date	2018-11-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2018.11.036
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3705: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cholesterol and ergosterol affect the activity of Staphylococcus aureus antibiotic efflux pumps.

Tintino, S R / Oliveira-Tintino, C D M / Campina, F F / Costa, M S / Cruz, R P / Pereira, R L S / Andrade, J C / Sousa, E O / Siqueira-Junior, J P / Coutinho, H D M / Leal-Balbino, T C / Balbino, V Q

Microbial pathogenesis

2017 Volume 104, Page(s) 133–136

Abstract: ... pumps in multidrug resistant strains of S. aureus. Were used RN4220 harboring plasmid pUL5054 ...

Abstract	The aim of this study is to evaluate the effect of ergosterol on steroids and cholesterol efflux pumps in multidrug resistant strains of S. aureus. Were used RN4220 harboring plasmid pUL5054, which carries the gene encoding the MsrA macrolide efflux protein; and IS-58, which possesses the TetK tetracycline efflux protein; 1199B resists hydrophilic fluoroquinolones via a NorA-mediated mechanism and wild strain 1199B. The Minimal Inhibitory Concentration (MIC) was determined and the evaluation of possible inhibition of efflux pumps by reduction of MIC. Some of the detrimental effects on bacterial cells can be attributed to the detergent properties of cholesterol and ergosterol on account of their amphipathic structure. Besides the cholesterol did not affect directly the pump structure, a synergism was observed, maybe due the interaction with the cell membrane and interference in the lipid bilayer.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Cholesterol/chemistry ; Cholesterol/pharmacology ; Drug Antagonism ; Ergosterol/chemistry ; Ergosterol/pharmacology ; Microbial Sensitivity Tests ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/physiology
Chemical Substances	Anti-Bacterial Agents ; Cholesterol (97C5T2UQ7J) ; Ergosterol (Z30RAY509F)
Language	English
Publishing date	2017-03
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2017.01.019
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2136: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito