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  1. Article ; Online: Using a "systems therapeutic for physiological renormalization" approach to vaccine development. Covid-19 as an example.

    Maguire, Greg

    Human vaccines & immunotherapeutics

    2022  Volume 18, Issue 5, Page(s) 2043105

    Abstract: Current vaccines for Covid-19 have failed to prevent the disease from spreading and have allowed more transmissible and virulent variants to form through mutations and recombinations as they replicate during the massive spread of the virions. Here I ... ...

    Abstract Current vaccines for Covid-19 have failed to prevent the disease from spreading and have allowed more transmissible and virulent variants to form through mutations and recombinations as they replicate during the massive spread of the virions. Here I suggest using a "systems therapeutic" vaccine and dosing strategy to induce "physiological renormalization" to induce mimicry in the innate and adaptive immune systems in the respiratory tracts and sera, similar to that when the body encounters the natural infectious agent.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Vaccine Development ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2022.2043105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6967: Show issues Location:
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  2. Article: Chronic inflammation induced by microneedling and the use of bone marrow stem cell cytokines.

    Maguire, Greg

    Journal of tissue viability

    2022  Volume 31, Issue 4, Page(s) 687–692

    Abstract: Physicians advocating the frequent use of microneedling for skin care are advocating for a potentially dangerous procedure, especially when coupled with the topical application of bone marrow stem cell derived cytokines. Not only are the physicians who ... ...

    Abstract Physicians advocating the frequent use of microneedling for skin care are advocating for a potentially dangerous procedure, especially when coupled with the topical application of bone marrow stem cell derived cytokines. Not only are the physicians who advocate for frequent microneedling as a skin care procedure not Board Certified in Dermatology (FAAD or FAOCD), they are not dermatologist; rather they are family practitioners. Further, they don't have M.D. or D.O. medical doctorate degrees, rather they have truncated bachelor in medicine degrees with limited education and training. Unlike board certified dermatologists, these physicians simply have neither a deep knowledge of dermatology, nor knowledge of the immunology of the skin. These physicians have developed and promulgated books, blogs, and training classes for these procedures that are offered to non-physicians, often to estheticians. Advocating the frequent use of microneedling for skin care, especially when coupled with the topical application of bone marrow stem cell derived cytokines induces a damaging chronic inflammatory state in the skin, and likely systemic inflammation too. Microneedling of the skin, even under sterile conditions, elicits a sterile inflammatory response, including early recruitment of neutrophils, throughout the layers of the skin, and even systemically. Given the non-sterile nature of the skin, a rich microbiome, including bacteria, viruses, and fungi, at the skin's surface, these procedures may allow microneedling to cause these microorganisms to gain entry into the epidermis and dermis, furthering an inflammatory response already induced by the wound and associated inflammatogenic self-molecules. The use of bone marrow stem cell cytokines can amplify the inflammatory response induced by injury, instead of resolving the inflammation such as that by the pro-resolving effects induced by adipose derived mesenchymal stem cells and fibroblasts acquired from skin tissue.
    Language English
    Publishing date 2022-09-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1282604-2
    ISSN 0965-206X
    ISSN 0965-206X
    DOI 10.1016/j.jtv.2022.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4357: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article: Stem cells part of the innate and adaptive immune systems as a therapeutic for Covid-19.

    Maguire, Greg

    Communicative & integrative biology

    2021  Volume 14, Issue 1, Page(s) 186–198

    Abstract: Some stem cell types not only release molecules that reduce viral replication, but also reduce the hypercytokinemia and inflammation induced by the immune system, and have been found to be part of the innate and adaptive immune systems. An important ... ...

    Abstract Some stem cell types not only release molecules that reduce viral replication, but also reduce the hypercytokinemia and inflammation induced by the immune system, and have been found to be part of the innate and adaptive immune systems. An important component of the stem cell's ability to ameliorate viral diseases, especially the complications post-clearance of the pathogen, is the ability of adult stem cells to reset the innate and adaptive immune systems from an inflammatory state to a repair state. Thus, the molecules released from certain stem cell types found to be safe and efficacious, may be an important new means for therapeutic development in Covid-19, especially for late-stage inflammation and tissue damage once the virus has cleared, particularly in the aged population.
    Language English
    Publishing date 2021-09-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2451097-X
    ISSN 1942-0889
    ISSN 1942-0889
    DOI 10.1080/19420889.2021.1965356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Stem cells part of the innate and adaptive immune systems as a therapeutic for Covid-19

    Greg Maguire

    Communicative & Integrative Biology, Vol 14, Iss 1, Pp 186-

    2021  Volume 198

    Abstract: Some stem cell types not only release molecules that reduce viral replication, but also reduce the hypercytokinemia and inflammation induced by the immune system, and have been found to be part of the innate and adaptive immune systems. An important ... ...

    Abstract Some stem cell types not only release molecules that reduce viral replication, but also reduce the hypercytokinemia and inflammation induced by the immune system, and have been found to be part of the innate and adaptive immune systems. An important component of the stem cell’s ability to ameliorate viral diseases, especially the complications post-clearance of the pathogen, is the ability of adult stem cells to reset the innate and adaptive immune systems from an inflammatory state to a repair state. Thus, the molecules released from certain stem cell types found to be safe and efficacious, may be an important new means for therapeutic development in Covid-19, especially for late-stage inflammation and tissue damage once the virus has cleared, particularly in the aged population.
    Keywords adult stem cells ; immune system ; adipose derived mesenchymal stem cells ; covid-19 ; inflammation ; viral infection ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Better preventing and mitigating the effects of Covid-19.

    Maguire, Greg

    Future science OA

    2020  Volume 6, Issue 6, Page(s) FSO586

    Abstract: Currently, there are no proven medical treatments against SARS-CoV-2, the virus responsible for Covid-19. In addition to the all important public health measures needed to prevent the spread of this disease, a number of strategies related to our exposome ...

    Abstract Currently, there are no proven medical treatments against SARS-CoV-2, the virus responsible for Covid-19. In addition to the all important public health measures needed to prevent the spread of this disease, a number of strategies related to our exposome are recommended herein, to better prevent and mitigate the effects of a SARS-CoV-2 infection through enhancement of our immune system and reduction of inflammation.
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2056-5623
    ISSN 2056-5623
    DOI 10.2144/fsoa-2020-0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Physiological renormalization using systems therapeutics.

    Maguire, Greg

    Future science OA

    2019  Volume 6, Issue 1, Page(s) FSO428

    Language English
    Publishing date 2019-10-31
    Publishing country England
    Document type Editorial
    ISSN 2056-5623
    ISSN 2056-5623
    DOI 10.2144/fsoa-2019-0106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Transplanted stem cells survive a long time: do they make you sick?

    Maguire, Greg

    Journal of the Royal Society of Medicine

    2019  Volume 112, Issue 10, Page(s) 412–414

    MeSH term(s) Stem Cells
    Language English
    Publishing date 2019-09-17
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 6731-3
    ISSN 1758-1095 ; 0141-0768 ; 0035-9157
    ISSN (online) 1758-1095
    ISSN 0141-0768 ; 0035-9157
    DOI 10.1177/0141076819851657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.114: Show issues Location:
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  8. Article ; Online: Physiological renormalization using systems therapeutics

    Greg Maguire

    Future Science OA, Vol 6, Iss

    2020  Volume 1

    Keywords checkpoint inhibitors ; personalized medicine ; physiological renormalization ; systems therapeutics ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Future Science Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Better preventing and mitigating the effects of Covid-19

    Greg Maguire

    Future Science OA, Vol 6, Iss

    2020  Volume 6

    Abstract: Currently, there are no proven medical treatments against SARS-CoV-2, the virus responsible for Covid-19. In addition to the all important public health measures needed to prevent the spread of this disease, a number of strategies related to our exposome ...

    Abstract Currently, there are no proven medical treatments against SARS-CoV-2, the virus responsible for Covid-19. In addition to the all important public health measures needed to prevent the spread of this disease, a number of strategies related to our exposome are recommended herein, to better prevent and mitigate the effects of a SARS-CoV-2 infection through enhancement of our immune system and reduction of inflammation.
    Keywords Covid-19 ; diet ; exposome ; immunity ; inflammation ; SARS-CoV-2 ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Future Science Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: Neurodegenerative diseases are a function of matrix breakdown: how to rebuild extracellular matrix and intracellular matrix.

    Maguire, Greg

    Neural regeneration research

    2018  Volume 13, Issue 7, Page(s) 1185–1186

    Language English
    Publishing date 2018-07-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.235026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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