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Article: Minimal gauged U(1) B-L model with spontaneous R parity violation.

Barger, Vernon / Pérez, Pavel Fileviez / Spinner, Sogee

2009 Volume 102, Issue 18, Page(s) 181802

Abstract: ... theory for spontaneous R-parity violation. Both U(1) B-L and R parity are broken by the vacuum ... We study the minimal gauged U(1) B-L supersymmetric model and show that it provides an attractive ... linking the B-L and soft SUSY scales. In this context we find a consistent mechanism for generating ...

Abstract	We study the minimal gauged U(1) B-L supersymmetric model and show that it provides an attractive theory for spontaneous R-parity violation. Both U(1) B-L and R parity are broken by the vacuum expectation value of the right-handed sneutrino (proportional to the soft supersymmetry masses), thereby linking the B-L and soft SUSY scales. In this context we find a consistent mechanism for generating neutrino masses and a realistic mass spectrum, all without extending the Higgs sector of the minimal supersymmetry standard model. We discuss the most relevant collider signals and the connection between the Z' gauge boson and R-parity violation.
Language	English
Publishing date	2009-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.102.181802
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Article ; Online: Publisher Correction: Global monthly sectoral water use for 2010-2100 at 0.5° resolution across alternative futures.

Khan, Zarrar / Thompson, Isaac / Vernon, Chris R / Graham, Neal T / Wild, Thomas B / Chen, Min

Scientific data

2023 Volume 10, Issue 1, Page(s) 248

Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Published Erratum
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02168-1
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Article ; Online: Global monthly sectoral water use for 2010-2100 at 0.5° resolution across alternative futures.

Khan, Zarrar / Thompson, Isaac / Vernon, Chris R / Graham, Neal T / Wild, Thomas B / Chen, Min

Scientific data

2023 Volume 10, Issue 1, Page(s) 201

Abstract: Water usage is closely linked with societal goals that are both local and global in scale, such as sustainable development and economic growth. It is therefore of value, particularly for long-term planning, to understand how future sectoral water usage ... ...

Abstract	Water usage is closely linked with societal goals that are both local and global in scale, such as sustainable development and economic growth. It is therefore of value, particularly for long-term planning, to understand how future sectoral water usage could evolve on a global scale at fine resolution. Additionally, future water usage could be strongly shaped by global forces, such as socioeconomic and climate change, and the multi-sector dynamic interactions those forces create. We generate a novel global gridded monthly sectoral water withdrawal and consumption dataset at 0.5° resolution for 2010-2100 for a diverse range of 75 scenarios. The scenarios are harmonized with the five Shared Socioeconomic Pathways (SSPs) and four Representative Concentration Pathways (RCPs) scenarios to support its usage in studies evaluating the implications of uncertain human and earth system change for future global and regional dynamics. To generate the data, we couple the Global Change Analysis Model (GCAM) with a land use spatial downscaling model (Demeter), a global hydrologic framework (Xanthos), and a water withdrawal downscaling model (Tethys).
MeSH term(s)	Humans ; Water ; Socioeconomic Factors ; Forecasting ; Climate Change
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02086-2
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Article ; Online: Long-term Efficacy and Safety of Elamipretide in Patients with Barth Syndrome: 168-Week Open-label Extension Results of TAZPOWER.

Thompson, William R / Manuel, Ryan / Abbruscato, Anthony / Carr, Jim / Campbell, John / Hornby, Brittany / Vaz, Frédéric M / Vernon, Hilary J

Genetics in medicine : official journal of the American College of Medical Genetics

2024 , Page(s) 101138

Abstract: Purpose: Evaluate long-term efficacy and safety of elamipretide during the open-label extension (OLE) of the TAZPOWER trial in individuals with Barth syndrome (BTHS) .: Methods: TAZPOWER was a 28-week randomized, double-blind, placebo-controlled ... ...

Abstract	Purpose: Evaluate long-term efficacy and safety of elamipretide during the open-label extension (OLE) of the TAZPOWER trial in individuals with Barth syndrome (BTHS) . Methods: TAZPOWER was a 28-week randomized, double-blind, placebo-controlled trial followed by a 168-week OLE. Patients entering the OLE continued elamipretide 40mg subcutaneous daily. OLE primary endpoints were safety and tolerability; secondary endpoints included change from baseline in the 6-minute walk test (6MWT) and BarTH Syndrome Symptom Assessment (BTHS-SA) Total Fatigue. Muscle strength, physician- and patient-assessed outcomes, echocardiographic parameters, and biomarkers, including cardiolipin (CL) and monolysocardiolipin (MLCL), were assessed. Results: Ten patients entered the OLE; 8 reached the Week 168 visit. Elamipretide was well tolerated, with injection site reactions being the most common adverse events. Significant improvements from OLE baseline on 6MWT occurred at all OLE timepoints (cumulative 96.1 meters of improvement [Week 168, p=0.003]). Mean BTHS-SA Total Fatigue scores were below baseline (improved) at all OLE timepoints. 3-D left ventricular stroke, end-diastolic, and end-systolic volumes improved, showing significant trends for improvement from baseline to Week 168. MLCL/CL values showed improvement, correlating to important clinical outcomes. Conclusion: Elamipretide was associated with sustained long-term tolerability and efficacy, with improvements in functional assessments and cardiac function in BTHS.
Language	English
Publishing date	2024-04-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1455352-1
ISSN	1530-0366 ; 1098-3600
ISSN (online)	1530-0366
ISSN	1098-3600
DOI	10.1016/j.gim.2024.101138
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Article ; Online: Suppressed immune and metabolic responses to intestinal damage-associated microbial translocation in myalgic encephalomyelitis/chronic fatigue syndrome.

Uhde, Melanie / Indart, Alyssa C / Green, Peter H R / Yolken, Robert H / Cook, Dane B / Shukla, Sanjay K / Vernon, Suzanne D / Alaedini, Armin

Brain, behavior, & immunity - health

2023 Volume 30, Page(s) 100627

Abstract: The etiology and mechanism of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are poorly understood and no biomarkers have been established. Specifically, the relationship between the immunologic, metabolic, and gastrointestinal abnormalities ...

Abstract	The etiology and mechanism of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are poorly understood and no biomarkers have been established. Specifically, the relationship between the immunologic, metabolic, and gastrointestinal abnormalities associated with ME/CFS and their relevance to established symptoms of the condition remain unclear. Relying on data from two independent pairs of ME/CFS and control cohorts, one at rest and one undergoing an exercise challenge, we identify a state of suppressed acute-phase innate immune response to microbial translocation in conjunction with a compromised gut epithelium in ME/CFS. This immunosuppression, along with observed enhancement of compensatory antibody responses to counter the microbial translocation, was associated with and may be mediated by alterations in glucose and citrate metabolism and an IL-10 immunoregulatory response. Our findings provide novel insights into mechanistic pathways, biomarkers, and potential therapeutic targets in ME/CFS, including in the context of exertion, with relevance to both intestinal and extra-intestinal symptoms.
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Journal Article
ISSN	2666-3546
ISSN (online)	2666-3546
DOI	10.1016/j.bbih.2023.100627
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Article ; Online: The Emergence of Tuning to Global Shape Properties of Radial Frequency Patterns in the Ventral Visual Pathway.

Lawrence, Samuel J D / Zamboni, Elisa / Vernon, Richard J W / Gouws, André D / Wade, Alex R / Morland, Antony B

The Journal of neuroscience : the official journal of the Society for Neuroscience

2023 Volume 43, Issue 29, Page(s) 5378–5390

Abstract: Radial frequency (RF) patterns, created by sinusoidal modulations of a circle's radius, are processed globally when RF is low. These closed shapes therefore offer a useful way to interrogate the human visual system for global processing of curvature. RF ... ...

Abstract	Radial frequency (RF) patterns, created by sinusoidal modulations of a circle's radius, are processed globally when RF is low. These closed shapes therefore offer a useful way to interrogate the human visual system for global processing of curvature. RF patterns elicit greater responses than those to radial gratings in V4 and more anterior face-selective regions of the ventral visual pathway. This is largely consistent with work on nonhuman primates showing curvature processing emerges in V4, but is evident also higher up the ventral visual stream. Rather than contrasting RF patterns with other stimuli, we presented them at varied frequencies in a regimen that allowed tunings to RF to be derived from 8 human participants (3 female). We found tuning to low RF in lateral occipital areas and to some extent in V4. In a control experiment, we added a high-frequency ripple to the stimuli disrupting the local contour. Low-frequency tuning to these stimuli remained in the ventral visual stream, underscoring its role in global processing of shape curvature. We then used representational similarity analysis to show that, in lateral occipital areas, the neural representation was related to stimulus similarity, when it was computed with a model that captured how stimuli are perceived. We therefore show that global processing of shape curvature emerges in the ventral visual stream as early as V4, but is found more strongly in lateral occipital regions, which exhibit responses and representations that relate well to perception.
MeSH term(s)	Animals ; Humans ; Female ; Visual Pathways/physiology ; Radius ; Pattern Recognition, Visual/physiology ; Occipital Lobe ; Form Perception/physiology ; Photic Stimulation
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.2237-22.2023
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Article ; Online: Transitional care of adolescents with inflammatory bowel disease to adult services varies widely across Australia and New Zealand.

Vernon-Roberts, Angharad / Chan, Patrick / Christensen, Britt / Day, Andrew S / Havrlant, Rachael / Giles, Edward / Williams, Astrid-Jane

JGH open : an open access journal of gastroenterology and hepatology

2024 Volume 8, Issue 1, Page(s) e13032

Abstract: Background and aim: Children and adolescents account for approximately 14% of inflammatory bowel disease (IBD) diagnoses. At an appropriate age and level of development adolescents with IBD have their care transferred from the pediatric to adult ... ...

Abstract	Background and aim: Children and adolescents account for approximately 14% of inflammatory bowel disease (IBD) diagnoses. At an appropriate age and level of development adolescents with IBD have their care transferred from the pediatric to adult clinical team during a process termed "transition". The study aim was to survey pediatric gastroenterologists throughout Australasia to identify commonality in the transition process to contribute to standardized guideline development. Methods: A descriptive survey captured key variables: transition clinic format, process and infrastructure, transition assessments, and guidelines. The survey was distributed electronically to 59 Pediatric Gastroenterologists throughout Australasia in January 2023. Results: Seventeen (29%) clinicians completed the survey: Australia 13 (76%). New Zealand 4 (24%). Thirteen (76%) respondents had access to a dedicated IBD transition clinic. Adolescents attended transition clinics 1-7 times, and the main processes transferred were: prescription provision, biologic appointments, and adult team contacts. Transition was first discussed age 13-15 years (53%), or 16-18 years (47%), with the main discussion topics including: continuing adherence (88%), smoking (59%), alcohol use (59%), recreational drug use (59%). Transition readiness assessments were done infrequently (24%). The minority (24%) used formal guidelines to inform the transition process, but 15 (88%) considered the development of a standardized Australasian guideline as beneficial/extremely beneficial. Conclusions: This survey highlighted that transition care for adolescents with IBD is variable across Australasia. Australasian guideline development may optimize the transition process for adolescents with IBD and improve their longitudinal outcomes.
Language	English
Publishing date	2024-01-17
Publishing country	Australia
Document type	Journal Article
ISSN	2397-9070
ISSN (online)	2397-9070
DOI	10.1002/jgh3.13032
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Article ; Online: Modelling the impact of hybrid immunity on future COVID-19 epidemic waves.

Le, Thao P / Abell, Isobel / Conway, Eamon / Campbell, Patricia T / Hogan, Alexandra B / Lydeamore, Michael J / McVernon, Jodie / Mueller, Ivo / Walker, Camelia R / Baker, Christopher M

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 407

Abstract: Background: Since the emergence of SARS-CoV-2 (COVID-19), there have been multiple waves of infection and multiple rounds of vaccination rollouts. Both prior infection and vaccination can prevent future infection and reduce severity of outcomes, ... ...

Abstract	Background: Since the emergence of SARS-CoV-2 (COVID-19), there have been multiple waves of infection and multiple rounds of vaccination rollouts. Both prior infection and vaccination can prevent future infection and reduce severity of outcomes, combining to form hybrid immunity against COVID-19 at the individual and population level. Here, we explore how different combinations of hybrid immunity affect the size and severity of near-future Omicron waves. Methods: To investigate the role of hybrid immunity, we use an agent-based model of COVID-19 transmission with waning immunity to simulate outbreaks in populations with varied past attack rates and past vaccine coverages, basing the demographics and past histories on the World Health Organization Western Pacific Region. Results: We find that if the past infection immunity is high but vaccination levels are low, then the secondary outbreak with the same variant can occur within a few months after the first outbreak; meanwhile, high vaccination levels can suppress near-term outbreaks and delay the second wave. Additionally, hybrid immunity has limited impact on future COVID-19 waves with immune-escape variants. Conclusions: Enhanced understanding of the interplay between infection and vaccine exposure can aid anticipation of future epidemic activity due to current and emergent variants, including the likely impact of responsive vaccine interventions.
MeSH term(s)	Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Epidemics ; Vaccination ; Vaccines ; Adaptive Immunity
Chemical Substances	Vaccines
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-024-09282-4
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Article ; Online: Increased Handpiece Speeds without Air Coolant: Aerosols and Thermal Impact.

Vernon, J J / Lancaster, P E / Black, E V I / Devine, D A / Fletcher, L / Wood, D J / Nattress, B R

Journal of dental research

2022 Volume 102, Issue 1, Page(s) 53–60

Abstract: ... Contra-Angle 1:5 Nova Micro Series (HSCAH-B) at speeds of 60,000, 100,000, and 200,000 revolutions ... preparation was assessed with an infrared camera with HSCAH-A and HSCAH-B at 200,000 rpm (water flows ≈15 mL ...

Abstract	This study assessed the impact of increased speed of high-speed contra-angle handpieces (HSCAHs) on the aerosolization of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surrogate virus and any concomitant thermal impact on dental pulp. A bacteriophage phantom-head model was used for bioaerosol detection. Crown preparations were performed with an NSK Z95L Contra-Angle 1:5 (HSCAH-A) and a Bien Air Contra-Angle 1:5 Nova Micro Series (HSCAH-B) at speeds of 60,000, 100,000, and 200,000 revolutions per minute (rpm), with no air coolant. Bioaerosol dispersal was measured with Φ6-bacteriophage settle plates, air sampling, and particle counters. Heating of the internal walls of the pulp chambers during crown preparation was assessed with an infrared camera with HSCAH-A and HSCAH-B at 200,000 rpm (water flows ≈15 mL min
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Respiratory Aerosols and Droplets ; Temperature ; Water ; Dental High-Speed Equipment
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2022-10-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/00220345221123253
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Ul III Zs.75: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Evaluating APSIM-and-DSSAT-CERES-Maize Models under Rainfed Conditions Using Zambian Rainfed Maize Cultivars

Charles B. Chisanga / Elijah Phiri / Vernon R. N. Chinene

Nitrogen, Vol 2, Iss 27, Pp 392-

2021 Volume 414

Abstract: Crop model calibration and validation is vital for establishing their credibility and ability in simulating crop growth and yield. A split–split plot design field experiment was carried out with sowing dates (SD1, SD2 and SD3); maize cultivars (ZMS606, ... ...

Abstract	Crop model calibration and validation is vital for establishing their credibility and ability in simulating crop growth and yield. A split–split plot design field experiment was carried out with sowing dates (SD1, SD2 and SD3); maize cultivars (ZMS606, PHB30G19 and PHB30B50) and nitrogen fertilizer rates (N1, N2 and N3) as the main plot, subplot and sub-subplot with three replicates, respectively. The experiment was carried out at Mount Makulu Central Research Station, Chilanga, Zambia in the 2016/2017 season. The study objective was to calibrate and validate APSIM-Maize and DSSAT-CERES-Maize models in simulating phenology, mLAI, soil water content, aboveground biomass and grain yield under rainfed and irrigated conditions. Days after planting to anthesis (APSIM-Maize, anthesis (DAP) RMSE = 1.91 days; DSSAT-CERES-Maize, anthesis (DAP) RMSE = 2.89 days) and maturity (APSIM-Maize, maturity (DAP) RMSE = 3.35 days; DSSAT-CERES-Maize, maturity (DAP) RMSE = 3.13 days) were adequately simulated, with RMSEn being <5%. The grain yield RMSE was 1.38 t ha −1 (APSIM-Maize) and 0.84 t ha −1 (DSSAT-CERES-Maize). The APSIM- and-DSSAT-CERES-Maize models accurately simulated the grain yield, grain number m −2 , soil water content (soil layers 1–8, RMSEn ≤ 20%), biomass and grain yield, with RMSEn ≤ 30% under rainfed condition. Model validation showed acceptable performances under the irrigated condition. The models can be used in identifying management options provided climate and soil physiochemical properties are available.
Keywords	APSIM-Maize ; calibration ; CERES-Maize model ; grain yield ; RMSE ; maize ; Ecology ; QH540-549.5
Subject code	630 ; 333
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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