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Article ; Online: Mesenchymal Stem Cells in the Pathogenesis and Therapy of Autoimmune and Autoinflammatory Diseases.

Zaripova, Lina N / Midgley, Angela / Christmas, Stephen E / Beresford, Michael W / Pain, Clare / Baildam, Eileen M / Oldershaw, Rachel A

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: Mesenchymal stem cells (MSCs) modulate immune responses and maintain self-tolerance. Their trophic activities and regenerative properties make them potential immunosuppressants for treating autoimmune and autoinflammatory diseases. MSCs are drawn to ... ...

Abstract	Mesenchymal stem cells (MSCs) modulate immune responses and maintain self-tolerance. Their trophic activities and regenerative properties make them potential immunosuppressants for treating autoimmune and autoinflammatory diseases. MSCs are drawn to sites of injury and inflammation where they can both reduce inflammation and contribute to tissue regeneration. An increased understanding of the role of MSCs in the development and progression of autoimmune disorders has revealed that MSCs are passive targets in the inflammatory process, becoming impaired by it and exhibiting loss of immunomodulatory activity. MSCs have been considered as potential novel cell therapies for severe autoimmune and autoinflammatory diseases, which at present have only disease modifying rather than curative treatment options. MSCs are emerging as potential therapies for severe autoimmune and autoinflammatory diseases. Clinical application of MSCs in rare cases of severe disease in which other existing treatment modalities have failed, have demonstrated potential use in treating multiple diseases, including rheumatoid arthritis, systemic lupus erythematosus, myocardial infarction, liver cirrhosis, spinal cord injury, multiple sclerosis, and COVID-19 pneumonia. This review explores the biological mechanisms behind the role of MSCs in autoimmune and autoinflammatory diseases. It also covers their immunomodulatory capabilities, potential therapeutic applications, and the challenges and risks associated with MSC therapy.
MeSH term(s)	Humans ; Mesenchymal Stem Cells/pathology ; Autoimmune Diseases/etiology ; Autoimmune Diseases/therapy ; Inflammation/therapy ; Inflammation/pathology ; Immune Tolerance ; Immunomodulation ; Hereditary Autoinflammatory Diseases ; Mesenchymal Stem Cell Transplantation
Language	English
Publishing date	2023-11-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216040
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Article ; Online: Mycorrhizal Association Better Predicts Tree Effects on Soil Than Leaf Habit

Meghan G. Midgley / Rachel S. Sims

Frontiers in Forests and Global Change, Vol

2020 Volume 3

Abstract: Predicting the ecological consequences of shifting forest composition requires an understanding of how tree species alter the soils beneath them. However, given the huge number of tree species on earth, it is critical to assess the extent to which easily ...

Abstract	Predicting the ecological consequences of shifting forest composition requires an understanding of how tree species alter the soils beneath them. However, given the huge number of tree species on earth, it is critical to assess the extent to which easily observable traits facilitate the prediction of soil biogeochemistry. Both aboveground and belowground traits are important drivers of forest function. The objective of this study was to assess the relative importance of leaf habit (evergreen or deciduous) and root mycorrhizal association (arbuscular [AM] or ectomycorrhizal ECM]) on biogeochemistry. The relative importance of these two traits for carbon (C) and nitrogen (N) dynamics have proven difficult to disentangle as most deciduous tree species associate with AM fungi and most evergreen tree species associate with ECM fungi. Using planted, single-species forestry plots at The Morton Arboretum (DuPage County, IL), we found that mycorrhizal association better predicted tree effects on soil than leaf habit. While both leaf habit and mycorrhizal association drove variation in soil C:N ratios, mycorrhizal association alone predicted differences in soil pH, available N pools, extracellular enzyme activities, and C and N cycling rates. Surprisingly, ammonium concentrations were higher and net nitrification rates were faster in ECM plots than in AM plots. Greater N-degrading enzyme activities in ECM plots and intrinsically high soil pH across the garden likely drove more rapid N cycling in ECM plots. Overall, this study supports the inclusion of mycorrhizal association in terrestrial biosphere models, but suggests that the effects of mycorrhizal association on N dynamics may be site-dependent.
Keywords	common garden ; functional groups ; nutrient economy ; plant-soil interactions ; soil ecology ; Forestry ; SD1-669.5 ; Environmental sciences ; GE1-350
Subject code	580
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Intraspecific trait variation influences physiological performance and fitness in the South Africa shrub genus Protea (Proteaceae).

Nolting, Kristen M / Prunier, Rachel / Midgley, Guy F / Holsinger, Kent E

Annals of botany

2020 Volume 127, Issue 4, Page(s) 519–531

Abstract: Background and aims: Global plant trait datasets commonly identify trait relationships that are interpreted to reflect fundamental trade-offs associated with plant strategies, but often these trait relationships are not identified when evaluating them ... ...

Abstract	Background and aims: Global plant trait datasets commonly identify trait relationships that are interpreted to reflect fundamental trade-offs associated with plant strategies, but often these trait relationships are not identified when evaluating them at smaller taxonomic and spatial scales. In this study we evaluate trait relationships measured on individual plants for five widespread Protea species in South Africa to determine whether broad-scale patterns of structural trait (e.g. leaf area) and physiological trait (e.g. photosynthetic rates) relationships can be detected within natural populations, and if these traits are themselves related to plant fitness. Methods: We evaluated the variance structure (i.e. the proportional intraspecific trait variation relative to among-species variation) for nine structural traits and six physiological traits measured in wild populations. We used a multivariate path model to evaluate the relationships between structural traits and physiological traits, and the relationship between these traits and plant size and reproductive effort. Key results: While intraspecific trait variation is relatively low for structural traits, it accounts for between 50 and 100 % of the variation in physiological traits. Furthermore, we identified few trait associations between any one structural trait and physiological trait, but multivariate regressions revealed clear associations between combinations of structural traits and physiological performance (R2 = 0.37-0.64), and almost all traits had detectable associations with plant fitness. Conclusions: Intraspecific variation in structural traits leads to predictable differences in individual-level physiological performance in a multivariate framework, even though the relationship of any particular structural trait to physiological performance may be weak or undetectable. Furthermore, intraspecific variation in both structural and physiological traits leads to differences in plant size and fitness. These results demonstrate the importance of considering measurements of multivariate phenotypes on individual plants when evaluating trait relationships and how trait variation influences predictions of ecological and evolutionary outcomes.
MeSH term(s)	Biological Evolution ; Phenotype ; Plant Leaves ; Proteaceae/genetics ; South Africa
Language	English
Publishing date	2020-04-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1461328-1
ISSN	1095-8290 ; 0305-7364
ISSN (online)	1095-8290
ISSN	0305-7364
DOI	10.1093/aob/mcaa060
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Article ; Online: ACTivity as medicine In Oncology for Head and Neck (ACTIOHN): Protocol for a feasibility study investigating a patient-centred approach to exercise for people with head and neck cancer.

Midgley, Adrian W / Levy, Andrew R / Rogers, Simon N / Brooker, Rachel C / Bryant, Valerie / Cherry, Mary Gemma / Lane, Steven / Nugent, Michael M / Price, Ruth / Schache, Andrew G / Young, Bridget / Patterson, Joanne M

PloS one

2023 Volume 18, Issue 8, Page(s) e0289911

Abstract: Background and aim: Attempts at personalisation of exercise programmes in head and neck cancer (HaNC) have been limited. The main aim of the present study is to investigate the feasibility and acceptability of introducing a remotely delivered, fully ... ...

Abstract	Background and aim: Attempts at personalisation of exercise programmes in head and neck cancer (HaNC) have been limited. The main aim of the present study is to investigate the feasibility and acceptability of introducing a remotely delivered, fully personalised, collaborative, and flexible approach to prescribing and delivering exercise programmes into the HaNC usual care pathway. Methods: This is a single arm, feasibility study. Seventy patients diagnosed with HaNC will be recruited from two regional HaNC centres in the United Kingdom. Patients will undertake an 8-week exercise programme designed and delivered by cancer exercise specialists. The exercise programme will start any time between the time of diagnosis and up to 8 weeks after completing treatment, depending on patient preference. The content of the exercise programme will be primarily based on patient needs, preferences, and goals, but guided by current physical activity guidelines for people with cancer. The primary outcome measure is retention to the study. Secondary quantitative outcomes are uptake to the exercise programme, different measures of exercise adherence, pre- and post-intervention assessments of fatigue (Multidimensional Fatigue Symptom Inventory-Short Form), quality of life (SF-36), physical activity levels (International Physical Activity Questionnaire-Short Form), and various components of physical fitness. The outcomes of the nested qualitative study are acceptability and feasibility of the intervention evaluated via interviews with patients, health care professionals, and the cancer exercise specialists. Intervention and participant fidelity will be determined using checklists and scrutiny of each patient's logbook and the cancer exercise specialists' meeting notes. Analysis of quantitative data will be via standard summary statistics. Qualitative data will be analysed using thematic analysis. Expected results: This feasibility study will inform the design and conduct of a future randomised controlled trial. Success will be defined according to a traffic light system for identifying the appropriateness of progression to a randomised controlled trial. Trial registration: International Standard Randomised Controlled Trial Number registry (ISRCTN82505455).
MeSH term(s)	Humans ; Feasibility Studies ; Quality of Life ; Head and Neck Neoplasms/therapy ; Exercise ; Fatigue ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0289911
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Article ; Online: Adjuvant chemotherapy for stage II colon cancer: less complicated than we thought.

Midgley, Rachel S / Kerr, David J

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2013 Volume 31, Issue 12, Page(s) 1611

MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Colonic Neoplasms/drug therapy ; Female ; Humans ; Male
Language	English
Publishing date	2013-04-20
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2012.47.2852
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches.

Zaripova, Lina N / Midgley, Angela / Christmas, Stephen E / Beresford, Michael W / Baildam, Eileen M / Oldershaw, Rachel A

Pediatric rheumatology online journal

2021 Volume 19, Issue 1, Page(s) 135

Abstract: Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatological disorder and is classified by subtype according to International League of Associations for Rheumatology criteria. Depending on the number of joints affected, presence of ... ...

Abstract	Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatological disorder and is classified by subtype according to International League of Associations for Rheumatology criteria. Depending on the number of joints affected, presence of extra-articular manifestations, systemic symptoms, serology and genetic factors, JIA is divided into oligoarticular, polyarticular, systemic, psoriatic, enthesitis-related and undifferentiated arthritis. This review provides an overview of advances in understanding of JIA pathogenesis focusing on aetiology, histopathology, immunological changes associated with disease activity, and best treatment options. Greater understanding of JIA as a collective of complex inflammatory diseases is discussed within the context of therapeutic interventions, including traditional non-biologic and up-to-date biologic disease-modifying anti-rheumatic drugs. Whilst the advent of advanced therapeutics has improved clinical outcomes, a considerable number of patients remain unresponsive to treatment, emphasising the need for further understanding of disease progression and remission to support stratification of patients to treatment pathways.
MeSH term(s)	Antirheumatic Agents/classification ; Antirheumatic Agents/pharmacology ; Arthritis, Juvenile/drug therapy ; Arthritis, Juvenile/etiology ; Arthritis, Juvenile/immunology ; Arthritis, Juvenile/physiopathology ; Child ; Disease Progression ; Humans ; Medication Therapy Management/trends ; Risk Assessment
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2021-08-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2279468-2
ISSN	1546-0096 ; 1546-0096
ISSN (online)	1546-0096
ISSN	1546-0096
DOI	10.1186/s12969-021-00629-8
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Article ; Online: Defective mismatch repair in colon cancer: a prognostic or predictive biomarker?

Kerr, David J / Midgley, Rachel

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2010 Volume 28, Issue 20, Page(s) 3210–3212

MeSH term(s)	Antimetabolites, Antineoplastic/administration & dosage ; Biomarkers/analysis ; Chemotherapy, Adjuvant ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/genetics ; DNA Mismatch Repair ; Fluorouracil/administration & dosage ; Humans ; Prognosis
Chemical Substances	Antimetabolites, Antineoplastic ; Biomarkers ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2010-07-10
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2010.28.9322
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Can we treat cancer for a dollar a day? Guidelines for low-income countries.

Kerr, David J / Midgley, Rachel

The New England journal of medicine

2010 Volume 363, Issue 9, Page(s) 801–803

MeSH term(s)	Cost-Benefit Analysis ; Developing Countries ; Evidence-Based Medicine ; Health Care Costs ; Humans ; Income ; Neoplasms/economics ; Neoplasms/therapy ; Practice Guidelines as Topic ; Therapeutics/economics ; World Health Organization
Language	English
Publishing date	2010-08-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMp1002812
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Article ; Online: Medical oncology: A novel low-toxicity regimen for advanced colorectal cancer?

Yanagisawa, Yoko / Midgley, Rachel S

Nature reviews. Clinical oncology

2010 Volume 7, Issue 10, Page(s) 556–557

MeSH term(s)	Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bevacizumab ; Capecitabine ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Deoxycytidine/administration & dosage ; Deoxycytidine/adverse effects ; Deoxycytidine/analogs & derivatives ; Disease-Free Survival ; Fluorouracil/administration & dosage ; Fluorouracil/adverse effects ; Fluorouracil/analogs & derivatives ; Humans ; Randomized Controlled Trials as Topic ; Survival Rate
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Deoxycytidine (0W860991D6) ; Bevacizumab (2S9ZZM9Q9V) ; Capecitabine (6804DJ8Z9U) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2010-09-29
Publishing country	England
Document type	News
ZDB-ID	2491410-1
ISSN	1759-4782 ; 1759-4774
ISSN (online)	1759-4782
ISSN	1759-4774
DOI	10.1038/nrclinonc.2010.140
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Zs.A 6029: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 103: Show issues

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Article ; Online: Symptom Profiles and Progression in Hospitalized and Nonhospitalized Patients with Coronavirus Disease, Colorado, USA, 2020.

Vahey, Grace M / Marshall, Kristen E / McDonald, Emily / Martin, Stacey W / Tate, Jacqueline E / Midgley, Claire M / Killerby, Marie E / Kawasaki, Breanna / Herlihy, Rachel K / Alden, Nisha B / Staples, J Erin

Emerging infectious diseases

2021 Volume 27, Issue 2, Page(s) 385–395

Abstract: To improve recognition of coronavirus disease (COVID-19) and inform clinical and public health guidance, we randomly selected 600 COVID-19 case-patients in Colorado. A telephone questionnaire captured symptoms experienced, when symptoms occurred, and how ...

Abstract	To improve recognition of coronavirus disease (COVID-19) and inform clinical and public health guidance, we randomly selected 600 COVID-19 case-patients in Colorado. A telephone questionnaire captured symptoms experienced, when symptoms occurred, and how long each lasted. Among 128 hospitalized patients, commonly reported symptoms included fever (84%), fatigue (83%), cough (73%), and dyspnea (72%). Among 236 nonhospitalized patients, commonly reported symptoms included fatigue (90%), fever (83%), cough (83%), and myalgia (74%). The most commonly reported initial symptoms were cough (21%-25%) and fever (20%-25%). In multivariable analysis, vomiting, dyspnea, altered mental status, dehydration, and wheezing were significantly associated with hospitalization, whereas rhinorrhea, headache, sore throat, and anosmia or ageusia were significantly associated with nonhospitalization. General symptoms and upper respiratory symptoms occurred earlier in disease, and anosmia, ageusia, lower respiratory symptoms, and gastrointestinal symptoms occurred later. Symptoms should be considered alongside other epidemiologic factors in clinical and public health decisions regarding potential COVID-19 cases.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/virology ; Child ; Child, Preschool ; Colorado/epidemiology ; Cough/epidemiology ; Cough/virology ; Disease Progression ; Dyspnea/epidemiology ; Dyspnea/virology ; Fatigue/epidemiology ; Fatigue/virology ; Female ; Fever/epidemiology ; Fever/virology ; Humans ; Infant ; Inpatients/statistics & numerical data ; Male ; Middle Aged ; Myalgia/epidemiology ; Myalgia/virology ; Outpatients/statistics & numerical data ; SARS-CoV-2 ; Symptom Assessment ; Young Adult
Language	English
Publishing date	2021-01-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2702.203729
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