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  1. Conference proceedings: Gen-Therapie für die altersbedingte Makuladegeneration

    Grisanti, Salvatore

    2023  , Page(s) 23vnda39

    Event/congress 72. Tagung der Vereinigung Norddeutscher Augenärzte (VNDA); Osnabrück; Vereinigung Norddeutscher Augenärzte; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-06-01
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23vnda39
    Database German Medical Science

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  2. Conference proceedings: Detection of circulating tumor cells in small choroidal melanocytic lesions

    Grisanti, Salvatore

    2023  , Page(s) 23vnda12

    Event/congress 72. Tagung der Vereinigung Norddeutscher Augenärzte (VNDA); Osnabrück; Vereinigung Norddeutscher Augenärzte; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-06-01
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23vnda12
    Database German Medical Science

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  3. Article ; Online: Die proliferative Vitreoretinopathie: das ungelöste Problem.

    Grisanti, Salvatore

    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft

    2021  Volume 118, Issue 1, Page(s) 2

    Title translation Proliferative vitreoretinopathy: the unsolved problem.
    MeSH term(s) Humans ; Retinal Detachment/diagnosis ; Retinal Detachment/surgery ; Vitrectomy ; Vitreoretinopathy, Proliferative/diagnosis ; Vitreoretinopathy, Proliferative/surgery ; Vitreous Body
    Language German
    Publishing date 2021-01-14
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1105167-x
    ISSN 1433-0423 ; 0941-293X
    ISSN (online) 1433-0423
    ISSN 0941-293X
    DOI 10.1007/s00347-020-01295-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Conference proceedings: Wie verändert die Biopsie unsere Therapie?

    Grisanti, Salvatore

    2021  , Page(s) 21rg26

    Event/congress 33. Jahrestagung der Retinologischen Gesellschaft; München (digital); Retinologische Gesellschaft; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2021-06-24
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21rg26
    Database German Medical Science

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  5. Book ; Thesis: The implication of retinal pigment epithelium transdifferentiation in proliferative vitreoretinopathy

    Grisanti, Salvatore

    2000  

    Author's details vorgelegt von Salvatore Grisanti
    Language German
    Size 150 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Habil.-Schr., 2000
    HBZ-ID HT012923942
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 E 246 order for loan Magazin

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  6. Article: Letter to the Editor Regarding "LIGHTSITE II Randomized Multicenter Trial: Evaluation of Multiwavelength Photobiomodulation in Non-exudative Age-Related Macular Degeneration".

    Grisanti, Salvatore / Bartz-Schmidt, Karl-Ulrich / Heimann, Heinrich / Lommatzsch, Albrecht / Walter, Peter / Ach, Thomas

    Ophthalmology and therapy

    2024  Volume 13, Issue 4, Page(s) 1051–1053

    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Letter ; Comment
    ISSN 2193-8245
    ISSN 2193-8245
    DOI 10.1007/s40123-024-00894-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Could a comprehensive urinary endogenous steroidal profile improve the accuracy of prostate-specific antigen screening?

    Berruti, Alfredo / Grisanti, Salvatore

    Minerva urology and nephrology

    2021  Volume 73, Issue 1, Page(s) 130–131

    MeSH term(s) Carcinoma ; Humans ; Male ; Prospective Studies ; Prostate ; Prostate-Specific Antigen ; Steroids
    Chemical Substances Steroids ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2021-04-07
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 3062840-4
    ISSN 2724-6442
    ISSN (online) 2724-6442
    DOI 10.23736/S2724-6051.21.04342-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of Nintedanib and Anti-Angiogenic Agents on Uveal Melanoma Cell Behavior.

    Pawlik, Vera E / Sonntag, Svenja R / Grisanti, Salvatore / Tura, Aysegül / Kakkassery, Vinodh / Ranjbar, Mahdy

    Investigative ophthalmology & visual science

    2024  Volume 65, Issue 2, Page(s) 30

    Abstract: Purpose: The purpose of this study was to investigate the direct impact of the combined angiokinase inhibitor nintedanib as well as the anti-angiogenic agents ranibizumab, bevacizumab, and aflibercept on the primary uveal melanoma (UM) cell line Mel270 ... ...

    Abstract Purpose: The purpose of this study was to investigate the direct impact of the combined angiokinase inhibitor nintedanib as well as the anti-angiogenic agents ranibizumab, bevacizumab, and aflibercept on the primary uveal melanoma (UM) cell line Mel270 and liver metastasis UM cell line OMM2.5.
    Methods: The metabolic activity, viability, and oxidative stress levels were analyzed by the Thiazolyl Blue Tetrazolium Bromide (MTT), LIVE/DEAD, and reactive oxygen species (ROS) assays. Expression of intracellular VEGF-A165 and VEGF receptor-2 was detected by immunofluorescent staining. The secretion of VEGF-A165 into the cell culture supernatants was evaluated by VEGF-A165 ELISA.
    Results: Nintedanib, at a concentration of 1 µg/mL, resulted in a median reduction of metabolic activity (for Mel270 of approximately 38% and for OMM2.5 of 46% compared to the untreated control) without exerting toxicity in either cell line, whereas the other 3 substances did not result in any changes (which also means that none of the 4 substances led to an increased cell death). Moreover, nintedanib (1 µg/mL) induced oxidative stress in the Mel270 by approximately 1.2 to 1.5-fold compared to the untreated control, but not the OMM2.5 cells.
    Conclusions: Nintedanib could suppress the growth of UM cells in a concentration-dependent manner. The metastatic UM cell line OMM2.5 was not sensitive to the pro-oxidant activity of nintedanib. This study was the first to investigate nintedanib in the context of UM. We propose further investigation of this substance to elucidate its effects on this tumor entity with the hope of identifying advantageous therapeutic options for future adjuvant tumor therapies.
    MeSH term(s) Humans ; Vascular Endothelial Growth Factor A ; Uveal Neoplasms/drug therapy ; Angiogenesis Inhibitors/pharmacology ; Indoles ; Melanoma
    Chemical Substances nintedanib (G6HRD2P839) ; Vascular Endothelial Growth Factor A ; Angiogenesis Inhibitors ; Indoles
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.65.2.30
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Detection sensitivity of fluorescence lifetime imaging ophthalmoscopy for laser-induced selective damage of retinal pigment epithelium.

    Sonntag, Svenja Rebecca / Hamann, Maximilian / Seifert, Eric / Grisanti, Salvatore / Brinkmann, Ralf / Miura, Yoko

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2024  

    Abstract: Purpose: To investigate the sensitivity of fluorescence lifetime imaging ophthalmoscopy (FLIO) to detect retinal laser spots by comparative analysis with other imaging modalities.: Methods: A diode laser with a wavelength of 514 nm was applied with ... ...

    Abstract Purpose: To investigate the sensitivity of fluorescence lifetime imaging ophthalmoscopy (FLIO) to detect retinal laser spots by comparative analysis with other imaging modalities.
    Methods: A diode laser with a wavelength of 514 nm was applied with pulse durations of 5.2, 12, 20, and 50 µs. The laser pulse energy was increased so that the visibility of the laser spot by slit-lamp fundus examination (SL) under the irradiator's observation covers from the subvisible to visible range immediately after irradiation. The irradiated areas were then examined by fundus color photography (FC), optical coherence tomography (OCT), fundus autofluorescence (AF), FLIO, and fluorescein angiography (FA). The visibility of a total of over 2200 laser spots was evaluated by two independent researchers, and effective dose (ED) 50 laser pulse energy values were calculated for each imaging modality and compared.
    Results: Among examined modalities, FA showed the lowest mean of ED50 energy value and SL the highest, that is, they had the highest and lowest sensitivity to detect retinal pigment epithalium (RPE)-selective laser spots, respectively. FLIO also detected spots significantly more sensitively than SL at most laser pulse durations and was not significantly inferior to FA. AF was also often more sensitive than SL, but the difference was slightly less significant than FLIO.
    Conclusion: Considering its high sensitivity in detecting laser spots and previously reported potential of indicating local wound healing and metabolic changes around laser spots, FLIO may be useful as a non-invasive monitoring tool during and after minimally invasive retinal laser treatment.
    Language English
    Publishing date 2024-04-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-024-06449-2
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    Ul I Zs.15: Show issues Location:
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  10. Article ; Online: Fluorescence Lifetime Imaging Ophthalmoscopy of Mouse Models of Age-related Macular Degeneration.

    Sonntag, Svenja Rebecca / Klein, Britta / Brinkmann, Ralf / Grisanti, Salvatore / Miura, Yoko

    Translational vision science & technology

    2024  Volume 13, Issue 1, Page(s) 24

    Abstract: Purpose: To investigate fluorescence lifetime of mouse models of age-related macular degeneration (AMD) by fluorescence lifetime imaging ophthalmoscopy (FLIO).: Methods: Two AMD mouse models, apolipoprotein E knockout (ApoE-/-) mice and NF-E2-related ...

    Abstract Purpose: To investigate fluorescence lifetime of mouse models of age-related macular degeneration (AMD) by fluorescence lifetime imaging ophthalmoscopy (FLIO).
    Methods: Two AMD mouse models, apolipoprotein E knockout (ApoE-/-) mice and NF-E2-related factor-2 knockout (Nrf2-/-) mice, and their wild-type mice underwent monthly ophthalmic examinations including FLIO from 3 months of age. After euthanasia at the age of 6 or 11 months, blood plasma was collected to determine total antioxidant capacity and eyes were enucleated for Oil red O (ORO) lipid staining of chorioretinal tissue.
    Results: In FLIO, the mean fluorescence lifetime (τm) of wild type shortened with age in both spectral channels. In short spectral channel, τm shortening was observed in both AMD models as well, but its rate was more pronounced in ApoE-/- mice and significantly different from the other strains as months of age progressed. In contrast, in long spectral channel, both model strains showed completely opposite trends, with τm becoming shorter in ApoE-/- and longer in Nrf2-/- mice than the others. Oil red O staining at Bruch's membrane was significantly stronger in ApoE-/- mice at 11 months than the other strains. Plasma total antioxidant capacity was highest in ApoE-/- mice at both 6 and 11 months.
    Conclusions: The two AMD mouse models exhibited largely different fundus fluorescence lifetime, which might be related to the different systemic metabolic state. FLIO might be able to indicate different metabolic states of eyes at risk for AMD.
    Translational relevance: This animal study may provide new insights into the relationship between early AMD-associated metabolic changes and FLIO findings.
    MeSH term(s) Mice ; Animals ; Antioxidants ; NF-E2-Related Factor 2 ; Mice, Knockout, ApoE ; Ophthalmoscopy ; Macular Degeneration/genetics ; Disease Models, Animal ; Fundus Oculi ; Apolipoproteins E ; Azo Compounds
    Chemical Substances oil red O (G7S71FND9B) ; Antioxidants ; NF-E2-Related Factor 2 ; Apolipoproteins E ; Azo Compounds
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2674602-5
    ISSN 2164-2591 ; 2164-2591
    ISSN (online) 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.13.1.24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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