LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 21352

Search options

  1. Book ; Online: Geochemistry and age models of sediments from the Celtic margin, supplementary data to: Auffret, G?rard A; Zaragosi, Sebastien; Dennielou, Bernard; Cortijo, Elsa; Van Rooij, David; Grousset, Francis E; Pujol, Claude; Eynaud, Fr?d?rique; Siegert, Martin J (2002): Terrigenous fluxes at the Celtic Margin during the last glacial cycle. Marine Geology, 188(1-2), 79-108

    Auffret, G?rard A / Cortijo, Elsa / Dennielou, Bernard / Eynaud, Fr?d?rique / Grousset, Francis E / Pujol, Claude / Siegert, Martin J / Van Rooij, David / Zaragosi, Sebastien

    2002  

    Abstract: The sedimentary sections of three cores from the Celtic margin provide high-resolution records of the terrigenous fluxes during the last glacial cycle. A total of 21 14C AMS dates allow us to define age models with a resolution better than 100 yr during ... ...

    Abstract The sedimentary sections of three cores from the Celtic margin provide high-resolution records of the terrigenous fluxes during the last glacial cycle. A total of 21 14C AMS dates allow us to define age models with a resolution better than 100 yr during critical periods such as Heinrich events 1 and 2. Maximum sedimentary fluxes occurred at the Meriadzek Terrace site during the Last Glacial Maximum (LGM). Detailed X-ray imagery of core MD95-2002 from the Meriadzek Terrace shows no sedimentary structures suggestive of either deposition from high-density turbidity currents or significant erosion. Two paroxysmal terrigenous flux episodes have been identified. The first occurred after the deposition of Heinrich event 2 Canadian ice-rafted debris (IRD) and includes IRD from European sources. We suggest that the second represents an episode of deposition from turbid plumes, which precedes IRD deposition associated with Heinrich event 1. At the end of marine isotopic stage 2 (MIS 2) and the beginning of MIS 1 the highest fluxes are recorded on the Whittard Ridge where they correspond to deposition from turbidity current overflows. Canadian icebergs have rafted debris at the Celtic margin during Heinrich events 1, 2, 4 and 5. The high-resolution records of Heinrich events 1 and 2 show that in both cases the arrival of the Canadian icebergs was preceded by a European ice rafting precursor event, which took place about 1-1.5 kyr before. Two rafting episodes of European IRD also occurred immediately after Heinrich event 2 and just before Heinrich event 1. The terrigenous fluxes recorded in core MD95-2002 during the LGM are the highest reported at hemipelagic sites from the northwestern European margin. The magnitude of the Canadian IRD fluxes at Meriadzek Terrace is similar to those from oceanic sites.
    Language English
    Dates of publication 2002-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1016/S0025-3227(02)00276-1
    DOI 10.1594/PANGAEA.66871
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    More links

    Kategorien

  2. Book ; Online: Age control and stratigraphy of a sediment profile from the Lomonosov Ridge, Arctic Ocean, supplementary data to: Backman, Jan; Jakobsson, Martin; Frank, Martin; Sangiorgi, Francesca; Brinkhuis, Henk; Stickley, Catherine E; O'Regan, Matthew; Løvlie, Reidar; Pälike, Heiko; Spofforth, David JA; Gattacceca, Jérôme; Moran, Kathryn; King, John W; Heil, Chip (2008): Age model and core-seismic integration for the Cenozoic Arctic Coring Expedition sediments from the Lomonosov Ridge. Paleoceanography, 23, PA1S03

    Backman, Jan / Brinkhuis, Henk / Frank, Martin / Jakobsson, Martin / Løvlie, Reidar / O'Regan, Matthew / Pälike, Heiko / Sangiorgi, Francesca / Stickley, Catherine E / al., et

    2008  

    Abstract: The upper 200 m of the sediments recovered during IODP Leg 302, the Arctic Coring Expedition (ACEX), to the Lomonosov Ridge in the central Arctic Ocean consist almost exclusively of detrital material. The scarcity of biostratigraphic markers severely ... ...

    Abstract The upper 200 m of the sediments recovered during IODP Leg 302, the Arctic Coring Expedition (ACEX), to the Lomonosov Ridge in the central Arctic Ocean consist almost exclusively of detrital material. The scarcity of biostratigraphic markers severely complicates the establishment of a reliable chronostratigraphic framework for these sediments, which contain the first continuous record of the Neogene environmental and climatic evolution of the Arctic region. Here we present profiles of cosmogenic 10Be together with the seawater-derived fraction of stable 9Be obtained from the ACEX cores. The down-core decrease of 10Be/9Be provides an average sedimentation rate of 14.5 ± 1 m/Ma for the uppermost 151 m of the ACEX record and allows the establishment of a chronostratigraphy for the past 12.3 Ma. The age-corrected 10Be concentrations and 10Be/9Be ratios suggest the existence of an essentially continuous sea ice cover over the past 12.3 Ma.
    Language English
    Dates of publication 2008-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1029/2007PA001476
    DOI 10.1594/PANGAEA.706556
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    More links

    Kategorien

  3. Article ; Online: Screening Drugs for Broad-Spectrum, Host-Directed Antiviral Activity: Lessons from the Development of Probenecid for COVID-19.

    Tripp, Ralph A / Martin, David E

    Viruses

    2023  Volume 15, Issue 11

    Abstract: In the early stages of drug discovery, researchers develop assays that are compatible with high throughput screening (HTS) and structure activity relationship (SAR) measurements. These assays are designed to evaluate the effectiveness of new and known ... ...

    Abstract In the early stages of drug discovery, researchers develop assays that are compatible with high throughput screening (HTS) and structure activity relationship (SAR) measurements. These assays are designed to evaluate the effectiveness of new and known molecular entities, typically targeting specific features within the virus. Drugs that inhibit virus replication by inhibiting a host gene or pathway are often missed because the goal is to identify active antiviral agents against known viral targets. Screening efforts should be sufficiently robust to identify all potential targets regardless of the antiviral mechanism to avoid misleading conclusions.
    MeSH term(s) Humans ; COVID-19 ; Probenecid/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Drug Discovery ; High-Throughput Screening Assays ; Virus Replication
    Chemical Substances Probenecid (PO572Z7917) ; Antiviral Agents
    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15112254
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Book: Schematherapie bei Depressionen

    Egli, Samy / Frieß, Elisabeth / Graf, Patricia / Höhn, David / Kopf-Beck, Johannes / Rein, Martin Ludwig / Ruderer, Amelie / Szesny-Mahlau, Nicole / Zimmermann, Petra / Keck, Martin Ekkehard

    ein Behandlungskonzept für das (teil)stationäre Setting

    (Therapeutische Praxis)

    2019  

    Author's details Samy Egli, Elisabeth Frieß, Patricia Graf, David Höhn, Johannes Kopf-Beck, Martin Ludwig Rein, Amelie Ruderer, Nicole Szesny-Mahlau, Petra Zimmermann, Martin Ekkehard Keck
    Series title Therapeutische Praxis
    Keywords Depression ; Schematherapie
    Subject Schemazentrierte emotiv-behaviorale Therapie ; SET ; Depressionen
    Language German
    Size 95 Seiten, Illustrationen, 29.7 cm x 21 cm
    Edition 1. Auflage
    Publisher Hogrefe
    Publishing place Göttingen
    Publishing country Germany
    Document type Book
    Note Literaturverzeichnis: Seite 91-95
    Accompanying material 1 CD-ROM
    HBZ-ID HT020236723
    ISBN 978-3-8017-2971-4 ; 3-8017-2971-0 ; 9783844429718 ; 9783840929717 ; 3844429719 ; 3840929717
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

  5. Article: [Besprechung von:] Income and welfare in the United States. By James N. Morgan, Martin H. David, Wilbur J. Cohen, and Harvey E. Brazer. A study by the Survey Research Center, Institute for Social Research, University of Michigan. New York 1962

    Rivlin, Alice M / Brazer, Harvey E / Cohen, Wilbur J / David, Martin H / Morgan, James N

    The American economic review Vol. 53, No. 5 , p. 1185-1187

    1963  Volume 53, Issue 5, Page(s) 1185–1187

    Author's details Alice M. Rivlin
    Publisher American Economic Assoc.
    Publishing place Nashville, Tenn.
    Document type Article
    ZDB-ID 203590x
    Database ECONomics Information System

    More links

    Kategorien

  6. Article: New-Onset Monosomy 7-Induced Pancytopenia in a 66-Year-Old Woman.

    Brock, Jordan M / Dillinger, Colten / Covey, David / Lim, Jayton A / Martin, David E

    Cureus

    2024  Volume 16, Issue 1, Page(s) e53159

    Abstract: Myelodysplastic syndrome (MDS) is characterized by failure to initiate hematopoiesis or impaired maturation of cells, often presenting with pancytopenias with or without associated fatigue, infections, or inappropriate bleeding and bruising. Karyotype ... ...

    Abstract Myelodysplastic syndrome (MDS) is characterized by failure to initiate hematopoiesis or impaired maturation of cells, often presenting with pancytopenias with or without associated fatigue, infections, or inappropriate bleeding and bruising. Karyotype analyses of MDS patients commonly show deletion of the q arm of chromosome 7, suggesting loss of this region is likely implicated in the insufficient hematopoiesis seen in MDS. The predisposition to deletion of 7q is commonly inherited, with clinical presentation in early childhood associated with pancytopenia or hematological malignancy. In this case, we present a 66-year-old female who was incidentally found to be pancytopenic in the emergency department while being evaluated for dyspnea, with a bone marrow biopsy later confirming a diagnosis of MDS with monosomy 7. Sporadic loss of 7q can occur at any stage in life without any family history of hematological disease. Our patient has no known personal or family history of MDS, with normal blood counts during hospitalization three years prior, suggesting de novo loss of 7q occurring at greater than 60 years of age.
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53159
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Intracerebral Hemorrhage in a Patient With Newly Diagnosed Immune Thrombocytopenic Purpura Precipitated by a Viral Illness.

    Pongsakul, Ann / Daniel, Amy / Lochala, Roddy / Martin, David E

    Cureus

    2024  Volume 16, Issue 3, Page(s) e57284

    Abstract: Intracerebral hemorrhage (ICH) is a rare and severe complication of immune thrombocytopenic purpura (ITP) that can be spontaneous. Viral illnesses, other infections, autoimmune disorders, and medications can cause ITP. ITP causes a significant decrease ... ...

    Abstract Intracerebral hemorrhage (ICH) is a rare and severe complication of immune thrombocytopenic purpura (ITP) that can be spontaneous. Viral illnesses, other infections, autoimmune disorders, and medications can cause ITP. ITP causes a significant decrease in platelet levels, increasing bleeding risk. ITP can be treated by steroids, intravenous immunoglobulin, plasmapheresis, platelet transfusion, biological agents, and splenectomy. ICH treatment involves the treatment of underlying ITP, as well as any neuro-interventional procedures needed. In this case report, we look at the presenting symptoms and treatment course of an interesting case of ICH in a patient who developed ITP after a viral upper respiratory infection.
    Language English
    Publishing date 2024-03-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57284
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Repurposing Probenecid to Inhibit SARS-CoV-2, Influenza Virus, and Respiratory Syncytial Virus (RSV) Replication.

    Tripp, Ralph A / Martin, David E

    Viruses

    2022  Volume 14, Issue 3

    Abstract: Viral replication and transmissibility are the principal causes of endemic and pandemic disease threats. There remains a need for broad-spectrum antiviral agents. The most common respiratory viruses are endemic agents such as coronaviruses, respiratory ... ...

    Abstract Viral replication and transmissibility are the principal causes of endemic and pandemic disease threats. There remains a need for broad-spectrum antiviral agents. The most common respiratory viruses are endemic agents such as coronaviruses, respiratory syncytial viruses, and influenza viruses. Although vaccines are available for SARS-CoV-2 and some influenza viruses, there is a paucity of effective antiviral drugs, while for RSV there is no vaccine available, and therapeutic treatments are very limited. We have previously shown that probenecid is safe and effective in limiting influenza A virus replication and SARS-CoV-2 replication, along with strong evidence showing inhibition of RSV replication in vitro and in vivo. This review article will describe the antiviral activity profile of probenecid against these three viruses.
    MeSH term(s) COVID-19/drug therapy ; Drug Repositioning ; Humans ; Orthomyxoviridae ; Probenecid/pharmacology ; Respiratory Syncytial Virus, Human ; SARS-CoV-2
    Chemical Substances Probenecid (PO572Z7917)
    Language English
    Publishing date 2022-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14030612
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: In Reply: Middle Meningeal Artery Embolization for Primary Treatment of a Chronic Subdural Hematoma in a Pediatric Patient: A Systematic Review of the Literature and Case Report.

    Hersh, David S / Martin, Jonathan E / Bulsara, Ketan R / Ollenschleger, Martin D

    Operative neurosurgery (Hagerstown, Md.)

    2023  Volume 24, Issue 5, Page(s) e387–e388

    MeSH term(s) Humans ; Child ; Hematoma, Subdural, Chronic/diagnostic imaging ; Hematoma, Subdural, Chronic/therapy ; Meningeal Arteries/diagnostic imaging ; Embolization, Therapeutic ; Head
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Systematic Review ; Case Reports ; Journal Article ; Comment
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/ons.0000000000000660
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Letter to the Editor. Tracking neurosurgery resident performance on simulation-based training tasks.

    Hersh, David S / Martin, Jonathan E / Kureshi, Inam U / Bulsara, Ketan R

    Journal of neurosurgery

    2023  Volume 139, Issue 4, Page(s) 1204–1206

    MeSH term(s) Humans ; Neurosurgery/education ; Neurosurgical Procedures ; Internship and Residency ; Simulation Training
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2023.3.JNS23610
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top