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Article ; Online: Cognitive Performance Does not Limit Physical Activity Participation in the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P).

Reid, K F / Walkup, M P / Katula, J A / Sink, K M / Anton, S / Axtell, R / Kerwin, D R / King, A C / Kramer, F / Miller, M E / Myers, V / Rosano, C / Studenski, S A / Lopez, O L / Verghese, J / Fielding, R A / Williamson, J

The journal of prevention of Alzheimer's disease

2017 Volume 4, Issue 1, Page(s) 44–50

Abstract: ... Pilot study (LIFE-P).: Design, setting, participants: The LIFE-P study was a single-blind, multicenter ... of LIFE-P. Compared to participants with high cognitive performance, participants with low performance had ... similar PA adherence rates (all P ≥ 0.34). Furthermore, weak and non-significant univariate relationships ...

Abstract	Objectives: We examined whether multiple domains of baseline cognitive performance were associated with prospective physical activity (PA) adherence in the Lifestyle Interventions and Independence for Elders Pilot study (LIFE-P). Design, setting, participants: The LIFE-P study was a single-blind, multicenter, randomized controlled trial of a PA intervention compared to a successful aging educational intervention in sedentary, mobility-limited older adults. Intervention: A 12-month structured, moderate-intensity, multi-modal PA program that included walking, resistance training, and flexibility exercises. For the first 2 months (adoption), 3 center-based exercise sessions (40-60 min) / week were conducted. During the next 4 months (transition), center-based sessions were conducted 2 times / week. The subsequent maintenance phase consisted of optional once-to-twice-per-week center-based sessions and home-based PA. Measurements: Tests of executive and global cognitive functioning, working memory and psychomotor speed were administered at baseline. Median test scores were used to dichotomize participants into low or high cognitive performance groups. Results: 52 mobility-limited older adults (age: 76.9 ±5 yrs) were randomized to the PA arm of LIFE-P. Compared to participants with high cognitive performance, participants with low performance had similar PA adherence rates (all P ≥ 0.34). Furthermore, weak and non-significant univariate relationships were elicited between all measures of cognition and overall PA adherence levels (r values ranged: -0.20 to 0.12, P ≥ 0.12). Conclusion: These data suggest that cognitive performance does not limit long-term PA adherence in mobility-limited older adults. Additional studies in larger cohorts are warranted to verify these findings.
MeSH term(s)	Aged ; Aged, 80 and over ; Cognition ; Cognitive Dysfunction ; Exercise ; Exercise Therapy/psychology ; Female ; Health Education ; Humans ; Male ; Memory, Short-Term ; Mobility Limitation ; Neuropsychological Tests ; Patient Compliance/psychology ; Pilot Projects ; Sedentary Lifestyle ; Single-Blind Method
Language	English
Publishing date	2017-11-30
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2782183-3
ISSN	2426-0266 ; 2274-5807
ISSN (online)	2426-0266
ISSN	2274-5807
DOI	10.14283/jpad.2016.107
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Article ; Online: The impact of sarcopenia on a physical activity intervention: the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P).

Liu, C K / Leng, X / Hsu, F-C / Kritchevsky, S B / Ding, J / Earnest, C P / Ferrucci, L / Goodpaster, B H / Guralnik, J M / Lenchik, L / Pahor, M / Fielding, R A

The journal of nutrition, health & aging

2012 Volume 18, Issue 1, Page(s) 59–64

Abstract: ... to sarcopenic and non-sarcopenic subjects in SA (8.3±0.5 and 8.4±0.2 points, p = 0.24 and 0.10 ... 0.91±0.03 meters/second in sarcopenic and non-sarcopenic SA subjects (p = 0.98 and 0.26 ...

Abstract	Objective: To determine if sarcopenia modulates the response to a physical activity intervention in functionally limited older adults. Design: Secondary analysis of a randomized controlled trial. Setting: Three academic centers. Participants: Elders aged 70 to 89 years at risk for mobility disability who underwent dual-energy x-ray absorptiometry (DXA) for body composition at enrollment and follow-up at twelve months (N = 177). Intervention: Subjects participated in a physical activity program (PA) featuring aerobic, strength, balance, and flexibility training, or a successful aging (SA) educational program about healthy aging. Measurements: Sarcopenia as determined by measuring appendicular lean mass and adjusting for height and total body fat mass (residuals method), Short Physical Performance Battery score (SPPB), and gait speed determined on 400 meter course. Results: At twelve months, sarcopenic and non-sarcopenic subjects in PA tended to have higher mean SPPB scores (8.7±0.5 and 8.7±0.2 points) compared to sarcopenic and non-sarcopenic subjects in SA (8.3±0.5 and 8.4±0.2 points, p = 0.24 and 0.10), although the differences were not statistically significant. At twelve months, faster mean gait speeds were observed in PA: 0.93±0.4 and 0.95±0.03 meters/second in sarcopenic and non-sarcopenic PA subjects, and 0.89±0.4 and 0.91±0.03 meters/second in sarcopenic and non-sarcopenic SA subjects (p = 0.98 and 0.26), although not statistically significant. There was no difference between the sarcopenic and non-sarcopenic groups in intervention adherence or number of adverse events. Conclusion: These data suggest that older adults with sarcopenia, who represent a vulnerable segment of the elder population, are capable of improvements in physical performance after a physical activity intervention.
MeSH term(s)	Absorptiometry, Photon ; Aged ; Aged, 80 and over ; Aging/physiology ; Body Composition ; Exercise/physiology ; Female ; Gait ; Geriatric Assessment ; Humans ; Independent Living ; Life Style ; Male ; Mobility Limitation ; Physical Fitness/physiology ; Pilot Projects ; Sarcopenia/complications ; Sarcopenia/physiopathology ; Sarcopenia/therapy
Language	English
Publishing date	2012-07-13
Publishing country	France
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1007/s12603-013-0369-0
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Article ; Online: Muscle strength and BMI as predictors of major mobility disability in the Lifestyle Interventions and Independence for Elders pilot (LIFE-P).

Marsh, Anthony P / Rejeski, W Jack / Espeland, Mark A / Miller, Michael E / Church, Timothy S / Fielding, Roger A / Gill, Thomas M / Guralnik, Jack M / Newman, Anne B / Pahor, Marco

The journals of gerontology. Series A, Biological sciences and medical sciences

2011 Volume 66, Issue 12, Page(s) 1376–1383

Abstract: ... disability, with and without covariate adjustment (p < .01): The hazard ratio (95% confidence interval ... 30 kg/m(2) or more (p = .04 in fully adjusted analyses).: Conclusions: Our data highlight ...

Abstract	Background: Muscle weakness and obesity are two significant threats to mobility facing the increasing number of older adults. To date, there are no studies that have examined the association of strength and body mass index (BMI) on event rates on a widely used performance measure of major mobility disability. Methods: This study was a secondary analysis of a randomized controlled trial in which sedentary functionally limited participants (70-89 years, Short Physical Performance Battery ≤ 9) who were able to complete a 400-m walk test at baseline were randomized to a physical activity or health education intervention and reassessed for major mobility disability every 6 months for up to 18 months. We evaluated whether baseline grip strength and BMI predicted failure to complete the 400-m walk test in 15 minutes or less (major mobility disability). Results: Among N = 406 participants with baseline measures, lower grip strength was associated with an increased risk for developing major mobility disability, with and without covariate adjustment (p < .01): The hazard ratio (95% confidence interval) for the lowest versus high sex-specific quartile of grip strength was 6.11 (2.24-16.66). We observed a U-shaped relationship between baseline BMI and the risk of developing major mobility disability, such that the risk for participants with a BMI of 25-29 kg/m(2) was approximately half that of participants with BMI less than 25 or 30 kg/m(2) or more (p = .04 in fully adjusted analyses). Conclusions: Our data highlight the importance of muscle weakness, low BMI, and obesity as risk factors for major mobility disability in older adults. Being overweight may be protective for major mobility disability.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging/pathology ; Aging/physiology ; Body Mass Index ; Female ; Hand Strength/physiology ; Humans ; Life Style ; Male ; Motor Activity ; Muscle Strength/physiology ; Obesity/physiopathology ; Pilot Projects ; Risk Factors ; Single-Blind Method ; Walking/physiology
Language	English
Publishing date	2011-10-05
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glr158
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Article ; Online: A delay in entering invoice charges is associated with a decrease in total invoice amount in equine practice.

Fielding, C Langdon

Journal of the American Veterinary Medical Association

2024 , Page(s) 1–6

Abstract: ... 271) and those entered > 1 day after the work was performed (193 ± $196; P < .0001).: Clinical ...

Abstract	Objective: To evaluate the relationship in equine practice between the time delay for charge entry (time between when work was performed and when the invoice charges were entered) and the total amount of the invoice. Sample: A total of 67,597 invoices from 3 hospitals were included for analysis. Methods: Analysis of 67,597 invoices from 49 doctors working out of 3 hospitals was performed. Variables collected included invoice total, date of work, date of invoice entry, month of work, invoice category (A = ambulatory daytime, E = after-hours, I = hospital), and veterinarian. Time delay to invoice entry was the difference between the day of work and the day of charge entry. A generalized additive model was used to describe the relationship between the time delay for invoice entry and the invoice type, month of work, and invoice category. The best model was selected using the Akaike information criterion. Results: In the selected model, total invoice amount was associated with time delay for charge entry and invoice category. Invoices entered on the same day of work were 299 ± $345, as compared to those entered the next day (255 ± $271) and those entered > 1 day after the work was performed (193 ± $196; P < .0001). Clinical relevance: If the observed relationship between time delay (time between work performed and invoice entry) and total invoice amount is causal, equine practitioners may have significant opportunity to improve revenues by simply entering charges on the same day the work is performed.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.23.12.0672
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Article: The impact of sarcopenia on a physical activity intervention: The lifestyle interventions and independence for elders pilot study (LIFE-P)

Liu, Christine K / Leng, X / Hsu, F. -C / Kritchevsky, S. B / Ding, J / Earnest, C. P / Ferrucci, L / Goodpaster, B. H / Guralnik, J. M / Lenchik, L / Pahor, M / Fielding, R. A

journal of nutrition, health & aging. 2014 Jan., v. 18, no. 1

2014

Abstract: ... and non-sarcopenic subjects in SA (8.3±0.5 and 8.4±0.2 points, p = 0.24 and 0.10 ... 0.91±0.03 meters/second in sarcopenic and non-sarcopenic SA subjects (p = 0.98 and 0.26 ...

Abstract	OBJECTIVE: To determine if sarcopenia modulates the response to a physical activity intervention in functionally limited older adults. DESIGN: Secondary analysis of a randomized controlled trial. SETTING: Three academic centers. PARTICIPANTS: Elders aged 70 to 89 years at risk for mobility disability who underwent dualenergy x-ray absorptiometry (DXA) for body composition at enrollment and follow-up at twelve months (N = 177). INTERVENTION: Subjects participated in a physical activity program (PA) featuring aerobic, strength, balance, and flexibility training, or a successful aging (SA) educational program about healthy aging. MEASUREMENTS: Sarcopenia as determined by measuring appendicular lean mass and adjusting for height and total body fat mass (residuals method), Short Physical Performance Battery score (SPPB), and gait speed determined on 400 meter course. RESULTS: At twelve months, sarcopenic and non-sarcopenic subjects in PA tended to have higher mean SPPB scores (8.7±0.5 and 8.7±0.2 points) compared to sarcopenic and non-sarcopenic subjects in SA (8.3±0.5 and 8.4±0.2 points, p = 0.24 and 0.10), although the differences were not statistically significant. At twelve months, faster mean gait speeds were observed in PA: 0.93±0.4 and 0.95±0.03 meters/second in sarcopenic and non-sarcopenic PA subjects, and 0.89±0.4 and 0.91±0.03 meters/second in sarcopenic and non-sarcopenic SA subjects (p = 0.98 and 0.26), although not statistically significant. There was no difference between the sarcopenic and non-sarcopenic groups in intervention adherence or number of adverse events. CONCLUSION: These data suggest that older adults with sarcopenia, who represent a vulnerable segment of the elder population, are capable of improvements in physical performance after a physical activity intervention.
Keywords	X-radiation ; body fat ; dual-energy X-ray absorptiometry ; elderly ; exercise test ; gait ; lifestyle ; physical activity ; randomized clinical trials ; risk ; sarcopenia
Language	English
Dates of publication	2014-01
Size	p. 59-64.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1007/s12603-013-0369-0
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Article: Predictors of adherence to physical activity in the Lifestyle Interventions and Independence for Elders pilot study (LIFE-P).

Rejeski, W Jack / Miller, Michael E / King, Abby C / Studenski, Stephanie A / Katula, Jeffrey A / Fielding, Roger A / Glynn, Nancy W / Walkup, Michael P / Ashmore, Jamile A

Clinical interventions in aging

2007 Volume 2, Issue 3, Page(s) 485–494

Abstract: Objectives: A prospective design was used to examine predictors of adherence to a physical activity intervention in older adults with compromised function.: Methods: The sample included 213 men (31.1%) and women (68.9%) with an average age of 76.53 ... ...

Abstract	Objectives: A prospective design was used to examine predictors of adherence to a physical activity intervention in older adults with compromised function. Methods: The sample included 213 men (31.1%) and women (68.9%) with an average age of 76.53 years. Results: The predictor variables accounted for 10% of the variance in percent attendance during adoption and transition, respectively. Adding percent attendance during adoption to the prediction of percent attendance during transition increased the explained variance in this phase to 21%. During maintenance, the predictors accounted for 13% of the variance in frequency of physical activity; this estimate increased to 46% when adding in percent attendance from the transition phase. Discussion: These results are encouraging in that the physical activity intervention appears to have been well tolerated by diverse subgroups of older adults. The role of prior behavior in predicting downstream adherence underscores the importance of developing proactive interventions for treating nonadherence in older adult populations.
MeSH term(s)	Activities of Daily Living ; Aged ; Aged, 80 and over ; Aging ; Disability Evaluation ; Female ; Health Behavior ; Humans ; Life Style ; Male ; Motor Activity ; Patient Compliance ; Pilot Projects ; Prospective Studies ; United States
Language	English
Publishing date	2007-11-28
Publishing country	New Zealand
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2364924-0
ISSN	1176-9092
ISSN	1176-9092
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Article ; Online: Relation of pulse pressure to long-distance gait speed in community-dwelling older adults: findings from the LIFE-P study.

Heffernan, Kevin S / Manini, Todd M / Hsu, Fang-Chi / Blair, Steven N / Nicklas, Barbara J / Kritchevsky, Stephen B / Newman, Anne B / Sutton-Tyrrell, Kim / Church, Timothy S / Haskell, William L / Fielding, Roger A

PloS one

2012 Volume 7, Issue 11, Page(s) e49544

Abstract: ... in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study.: Methods: Brachial ... speed than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was ... significantly and inversely associated with 400-meter gait speed (p<0.05). Other significant predictors of gait ...

Abstract	Background: Reduced gait speed is associated with falls, late-life disability, hospitalization/institutionalization and cardiovascular morbidity and mortality. Aging is also accompanied by a widening of pulse pressure (PP) that contributes to ventricular-vascular uncoupling. The purpose of this study was to test the hypothesis that PP is associated with long-distance gait speed in community-dwelling older adults in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Methods: Brachial blood pressure and 400-meter gait speed (average speed maintained over a 400-meter walk at "usual" pace) were assessed in 424 older adults between the ages of 70-89 yrs at risk for mobility disability (mean age=77 yrs; 31% male). PP was calculated as systolic blood pressure (BP) - diastolic BP. Results: Patients with a history of heart failure and stroke (n=42) were excluded leaving 382 participants for final analysis. When categorized into tertiles of PP, participants within the highest PP tertile had significantly slower gait speed than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was significantly and inversely associated with 400-meter gait speed (p<0.05). Other significant predictors of gait speed included: handgrip strength, body weight, age and history of diabetes mellitus (p<0.05). Mean arterial pressure, systolic BP and diastolic BP were not predictors of gait speed. Conclusions: Pulse pressure is associated long-distance gait speed in community-dwelling older adults. Vascular senescence and altered ventricular-vascular coupling may be associated with the deterioration of mobility and physical function in older adults.
MeSH term(s)	Accidental Falls/prevention & control ; Aged ; Aged, 80 and over ; Blood Pressure/physiology ; Exercise ; Female ; Gait/physiology ; Heart Rate ; Humans ; Life Style ; Male ; ROC Curve ; Regression Analysis ; Walking
Language	English
Publishing date	2012-11-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0049544
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Article ; Online: Evaluation of the late life disability instrument in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study.

Hsu, Fang-Chi / Rejeski, W Jack / Ip, Edward H / Katula, Jeff A / Fielding, Roger / Jette, Alan M / Studenski, Stephanie A / Blair, Steven N / Miller, Michael E

Health and quality of life outcomes

2010 Volume 8, Page(s) 115

Abstract: ... properties of the LLDI using data from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P ... study.: Methods: LIFE-P participants, aged 70-89 years, were at elevated risk of disability. The 424 ... within the LLDI in the LIFE-P study did not corroborate previous findings. However, the factor structure using ...

Abstract	Background: The late life disability instrument (LLDI) was developed to assess limitations in instrumental and management roles using a small and restricted sample. In this paper we examine the measurement properties of the LLDI using data from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Methods: LIFE-P participants, aged 70-89 years, were at elevated risk of disability. The 424 participants were enrolled at the Cooper Institute, Stanford University, University of Pittsburgh, and Wake Forest University. Physical activity and successful aging health education interventions were compared after 12-months of follow-up. Using factor analysis, we determined whether the LLDI's factor structure was comparable with that reported previously. We further examined how each item related to measured disability using item response theory (IRT). Results: The factor structure for the limitation domain within the LLDI in the LIFE-P study did not corroborate previous findings. However, the factor structure using the abbreviated version was supported. Social and personal role factors were identified. IRT analysis revealed that each item in the social role factor provided a similar level of information, whereas the items in the personal role factor tended to provide different levels of information. Conclusions: Within the context of community-based clinical intervention research in aged populations, an abbreviated version of the LLDI performed better than the full 16-item version. In addition, the personal subscale would benefit from additional research using IRT. Trial registration: The protocol of LIFE-P is consistent with the principles of the Declaration of Helsinki and is registered at http://www.ClinicalTrials.gov (registration # NCT00116194).
MeSH term(s)	Aged ; Aged, 80 and over ; Disability Evaluation ; Factor Analysis, Statistical ; Female ; Follow-Up Studies ; Geriatric Assessment ; Humans ; Life Style ; Male ; Middle Aged ; Pennsylvania ; Pilot Projects ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2010-10-06
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1477-7525
ISSN (online)	1477-7525
DOI	10.1186/1477-7525-8-115
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Article: Designing clinical trials of interventions for mobility disability: results from the lifestyle interventions and independence for elders pilot (LIFE-P) trial.

Espeland, Mark A / Gill, Thomas M / Guralnik, Jack / Miller, Michael E / Fielding, Roger / Newman, Anne B / Pahor, Marco

The journals of gerontology. Series A, Biological sciences and medical sciences

2007 Volume 62, Issue 11, Page(s) 1237–1243

Abstract: Background: Clinical trials to assess interventions for mobility disability are critically needed; however, data for efficiently designing such trials are lacking.: Methods: Results are described from a pilot clinical trial in which 424 volunteers ... ...

Abstract	Background: Clinical trials to assess interventions for mobility disability are critically needed; however, data for efficiently designing such trials are lacking. Methods: Results are described from a pilot clinical trial in which 424 volunteers aged 70-89 years were randomly assigned to one of two interventions-physical activity or a healthy aging education program-and followed for a planned minimum of 12 months. We evaluated the longitudinal distributions of four standardized outcomes to contrast how they may serve as primary outcomes of future clinical trials: ability to walk 400 meters, ability to walk 4 meters in < or =10 seconds, a physical performance battery, and a questionnaire focused on physical function. Results: Changes in all four outcomes were interrelated over time. The ability to walk 400 meters as a dichotomous outcome provided the smallest sample size projections (i.e., appeared to be the most efficient outcome). It loaded most heavily on the underlying latent variable in structural equation modeling with a weight of 80%. A 4-year trial based on the outcome of the 400-meter walk is projected to require N = 962-2234 to detect an intervention effect of 30%-20% with 90% power. Conclusions: Future clinical trials of interventions designed to influence mobility disability may have greater efficiency if they adopt the ability to complete a 400-meter walk as their primary outcome.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging/pathology ; Aging/physiology ; Disability Evaluation ; Disabled Persons/rehabilitation ; Exercise ; Female ; Health Education ; Humans ; Life Style ; Linear Models ; Male ; Pilot Projects ; Randomized Controlled Trials as Topic ; Research Design
Language	English
Publishing date	2007-11-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/62.11.1237
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Article: Relation of Pulse Pressure to Long-Distance Gait Speed in Community-Dwelling Older Adults: Findings from the LIFE-P Study

Heffernan, Kevin S / Blair, Steven N / Church, Timothy S / Fielding, Roger A / Haskell, William L / Hsu, Fang-Chi / Kritchevsky, Stephen B / Manini, Todd M / Newman, Anne B / Nicklas, Barbara J / Scuteri, Angelo / Sutton-Tyrrell, Kim

PloS one. , v. 7, no. 11

2012

Abstract: ... in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Brachial blood pressure and 400 ... than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was significantly and inversely ... associated with 400-meter gait speed (p<0.05). Other significant predictors of gait speed included: handgrip ...

Title variant	Aging, Pulse Pressure and Gait Speed
Abstract	Reduced gait speed is associated with falls, late-life disability, hospitalization/institutionalization and cardiovascular morbidity and mortality. Aging is also accompanied by a widening of pulse pressure (PP) that contributes to ventricular-vascular uncoupling. The purpose of this study was to test the hypothesis that PP is associated with long-distance gait speed in community-dwelling older adults in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Brachial blood pressure and 400-meter gait speed (average speed maintained over a 400-meter walk at “usual” pace) were assessed in 424 older adults between the ages of 70–89 yrs at risk for mobility disability (mean age = 77 yrs; 31% male). PP was calculated as systolic blood pressure (BP) – diastolic BP. Patients with a history of heart failure and stroke (n = 42) were excluded leaving 382 participants for final analysis. When categorized into tertiles of PP, participants within the highest PP tertile had significantly slower gait speed than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was significantly and inversely associated with 400-meter gait speed (p<0.05). Other significant predictors of gait speed included: handgrip strength, body weight, age and history of diabetes mellitus (p<0.05). Mean arterial pressure, systolic BP and diastolic BP were not predictors of gait speed. Pulse pressure is associated long-distance gait speed in community-dwelling older adults. Vascular senescence and altered ventricular-vascular coupling may be associated with the deterioration of mobility and physical function in older adults.
Keywords	body weight ; diabetes mellitus ; elderly ; gait ; heart failure ; lifestyle ; males ; morbidity ; mortality ; patients ; risk ; stroke ; systolic blood pressure
Language	English
Dates of publication	2012-1121
Publishing place	Public Library of Science
Document type	Article
ISSN	1932-6203
DOI	10.1371/journal.pone.0049544
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In stock of ZB MED Cologne/Königswinter

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More links

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Order via subito

Inter-library loan at ZB MED