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  1. Book: Severe infections caused by Pseudomonas aeruginosa

    Hauser, Alan R.

    (Perspectives on critical care infectious diseases ; 7)

    2003  

    Author's details ed. by Alan R. Hauser
    Series title Perspectives on critical care infectious diseases ; 7
    Collection
    Keywords Pseudomonas Infections ; Pseudomonas aeruginosa / pathogenicity ; Cross Infection / prevention & control ; Infection Control / methods ; Pseudomonas aeruginosa ; Infektion
    Subject Ansteckung ; Erstinfektion ; Infektionen
    Language English
    Size X, 236 S. : graph. Darst.
    Publisher Kluwer
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013666978
    ISBN 1-4020-7421-2 ; 978-1-4020-7421-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 2014 order for loan Magazin

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  2. Article ; Online: Diversity of Contact-Dependent Growth Inhibition Systems of

    Allen, Jonathan P / Hauser, Alan R

    Journal of bacteriology

    2019  Volume 201, Issue 14

    Abstract: Contact-dependent growth inhibition (CDI) systems are used in bacterial competition to hinder the growth of neighboring microbes. These systems utilize a two-partner secretion mechanism to display the CdiA exoprotein at the bacterial cell surface. CdiA ... ...

    Abstract Contact-dependent growth inhibition (CDI) systems are used in bacterial competition to hinder the growth of neighboring microbes. These systems utilize a two-partner secretion mechanism to display the CdiA exoprotein at the bacterial cell surface. CdiA forms a long filamentous stalk that facilitates binding to a target cell and delivery of a C-terminal toxin (CT) domain. This CT domain is processed and delivered into the cytoplasm of a target cell upon contact. CDI systems also encode a cognate immunity protein (CdiI) that protects siblings and resistant targeted cells from intoxication by high-affinity binding to the CT. CdiA CT domains vary among strains within a species, and many alleles encode enzymatic functions that target nucleic acids. This variation is thought to help drive diversity and adaptation within a species. CdiA diversity is well studied in
    MeSH term(s) Alleles ; Bacterial Proteins/genetics ; Bacterial Proteins/physiology ; Bacterial Toxins/metabolism ; Escherichia coli ; Escherichia coli Proteins ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; Microbial Interactions ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/growth & development
    Chemical Substances Bacterial Proteins ; Bacterial Toxins ; CdiA protein, E coli ; Escherichia coli Proteins ; Membrane Proteins
    Language English
    Publishing date 2019-06-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00776-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Forest and Trees: Exploring Bacterial Virulence with Genome-wide Association Studies and Machine Learning.

    Allen, Jonathan P / Snitkin, Evan / Pincus, Nathan B / Hauser, Alan R

    Trends in microbiology

    2021  Volume 29, Issue 7, Page(s) 621–633

    Abstract: The advent of inexpensive and rapid sequencing technologies has allowed bacterial whole-genome sequences to be generated at an unprecedented pace. This wealth of information has revealed an unanticipated degree of strain-to-strain genetic diversity ... ...

    Abstract The advent of inexpensive and rapid sequencing technologies has allowed bacterial whole-genome sequences to be generated at an unprecedented pace. This wealth of information has revealed an unanticipated degree of strain-to-strain genetic diversity within many bacterial species. Awareness of this genetic heterogeneity has corresponded with a greater appreciation of intraspecies variation in virulence. A number of comparative genomic strategies have been developed to link these genotypic and pathogenic differences with the aim of discovering novel virulence factors. Here, we review recent advances in comparative genomic approaches to identify bacterial virulence determinants, with a focus on genome-wide association studies and machine learning.
    MeSH term(s) Bacteria/classification ; Bacteria/genetics ; Bacteria/pathogenicity ; Genetic Variation ; Genome, Bacterial ; Genome-Wide Association Study/methods ; Genomics ; Genotype ; Machine Learning ; Phylogeny ; Virulence/genetics ; Virulence Factors/genetics
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2021-01-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2020.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genome-wide screens reveal shared and strain-specific genes that facilitate enteric colonization by

    Cheung, Bettina H / Alisoltani, Arghavan / Kochan, Travis J / Lebrun-Corbin, Marine / Nozick, Sophia H / Axline, Christopher M R / Bachta, Kelly E R / Ozer, Egon A / Hauser, Alan R

    mBio

    2023  , Page(s) e0212823

    Abstract: Gastrointestinal (GI) colonization ... ...

    Abstract Gastrointestinal (GI) colonization by
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02128-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pseudomonas aeruginosa virulence and antimicrobial resistance: two sides of the same coin?

    Hauser, Alan R

    Critical care medicine

    2013  Volume 42, Issue 1, Page(s) 201–202

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Cross Infection/etiology ; Female ; Fluoroquinolones/therapeutic use ; Humans ; Male ; Pneumonia, Bacterial/etiology ; Pseudomonas Infections/etiology ; Pseudomonas aeruginosa/pathogenicity
    Chemical Substances Anti-Bacterial Agents ; Fluoroquinolones
    Language English
    Publishing date 2013-12-18
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0b013e3182a120cd
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Phenotypes of a

    Nozick, Sophia H / Ozer, Egon A / Medernach, Rachel / Kochan, Travis J / Kumar, Rebecca / Mills, Jori O / Wunderlink, Richard G / Qi, Chao / Hauser, Alan R

    mSystems

    2023  Volume 9, Issue 1, Page(s) e0048423

    Abstract: Hypermutator lineages ... ...

    Abstract Hypermutator lineages of
    MeSH term(s) Humans ; Cystic Fibrosis/complications ; Pseudomonas aeruginosa/genetics ; Respiration, Artificial/adverse effects ; Persistent Infection ; Pandemics ; Pseudomonas Infections/complications ; Phenotype ; COVID-19/complications
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5077
    ISSN (online) 2379-5077
    DOI 10.1128/msystems.00484-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa: cap your needles!

    Hauser, Alan R

    Critical care medicine

    2012  Volume 40, Issue 8, Page(s) 2503–2504

    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Female ; Humans ; Male ; Pneumonia, Ventilator-Associated/prevention & control ; Pseudomonas Infections/drug therapy
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2012-07-18
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0b013e318258e5bb
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Genome-wide screens reveal shared and strain-specific genes that facilitate enteric colonization by

    Cheung, Bettina H / Alisoltani, Arghavan / Kochan, Travis J / Lebrun-Corbin, Marine / Nozick, Sophia H / Axline, Christopher Mr / Bachta, Kelly Er / Ozer, Egon A / Hauser, Alan R

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Gastrointestinal (GI) colonization by : Importance: Klebsiella ... ...

    Abstract Gastrointestinal (GI) colonization by
    Importance: Klebsiella pneumoniae
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.30.555643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genomics of Aminoglycoside Resistance in Pseudomonas aeruginosa Bloodstream Infections at a United States Academic Hospital.

    Atassi, Giancarlo / Medernach, Rachel / Scheetz, Marc / Nozick, Sophia / Rhodes, Nathaniel J / Murphy-Belcaster, Megan / Murphy, Katherine R / Alisoltani, Arghavan / Ozer, Egon A / Hauser, Alan R

    Microbiology spectrum

    2023  Volume 11, Issue 3, Page(s) e0508722

    Abstract: Pseudomonas aeruginosa frequently becomes resistant to aminoglycosides by the acquisition of aminoglycoside modifying enzyme (AME) genes and the occurrence of mutations in ... ...

    Abstract Pseudomonas aeruginosa frequently becomes resistant to aminoglycosides by the acquisition of aminoglycoside modifying enzyme (AME) genes and the occurrence of mutations in the
    MeSH term(s) Humans ; United States/epidemiology ; Pseudomonas aeruginosa ; Aminoglycosides/pharmacology ; Colistin/pharmacology ; Drug Resistance, Bacterial/genetics ; Anti-Bacterial Agents/pharmacology ; Tobramycin/pharmacology ; Gentamicins/pharmacology ; Pseudomonas Infections/epidemiology ; Ciprofloxacin/pharmacology ; Genomics ; Sepsis ; Microbial Sensitivity Tests
    Chemical Substances Aminoglycosides ; Colistin (Z67X93HJG1) ; Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK) ; Gentamicins ; Ciprofloxacin (5E8K9I0O4U)
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.05087-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Taxonomic characterization of

    Turner, Timothy L / Mitra, Sumitra D / Kochan, Travis J / Pincus, Nathan B / Lebrun-Corbin, Marine / Cheung, Bettina H / Gatesy, Samuel W / Afzal, Tania / Nozick, Sophie H / Ozer, Egon A / Hauser, Alan R

    Microbiology spectrum

    2023  , Page(s) e0183821

    Abstract: In an attempt to identify novel bacterial species, microbiologists have examined a wide range of environmental niches. We describe the serendipitous discovery of a novel gram-negative bacterial species from a different type of extreme niche: a purchased ... ...

    Abstract In an attempt to identify novel bacterial species, microbiologists have examined a wide range of environmental niches. We describe the serendipitous discovery of a novel gram-negative bacterial species from a different type of extreme niche: a purchased vial of antibiotic. The vial of antibiotic hygromycin B was found to be factory contaminated with a bacterial species, which we designate
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01838-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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