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  1. Book: The treatment of myeloid malignancies with kinase inhibitors

    Mullally, Ann

    (Hematology/oncology clinics of North America ; volume 31, number 4 (August 2017))

    2017  

    Author's details editor Ann Mullally
    Series title Hematology/oncology clinics of North America ; volume 31, number 4 (August 2017)
    Hematology, oncology clinics of North America
    Collection Hematology, oncology clinics of North America
    Language English
    Size x Seiten, Seite 566-719, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019437191
    ISBN 978-0-323-53235-8 ; 0-323-53235-7
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Both sides now: losses and gains of mutant CALR.

    Mullally, Ann

    Blood

    2020  Volume 135, Issue 2, Page(s) 82–83

    MeSH term(s) Calreticulin ; Humans ; Megakaryocytes ; Myeloproliferative Disorders ; Neoplasms ; Receptors, Thrombopoietin
    Chemical Substances Calreticulin ; Receptors, Thrombopoietin
    Language English
    Publishing date 2020-01-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2019003820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antibody targeting of mutant calreticulin in myeloproliferative neoplasms.

    Kramer, Frederike / Mullally, Ann

    Journal of cellular and molecular medicine

    2023  Volume 28, Issue 5, Page(s) e17896

    Abstract: Mutations in calreticulin are one of the key disease-initiating mutations in myeloproliferative neoplasms (MPN). In MPN, mutant calreticulin translates with a novel C-terminus that leads to aberrant binding to the extracellular domain of the ... ...

    Abstract Mutations in calreticulin are one of the key disease-initiating mutations in myeloproliferative neoplasms (MPN). In MPN, mutant calreticulin translates with a novel C-terminus that leads to aberrant binding to the extracellular domain of the thrombopoietin receptor, MPL. This cell surface neoantigen has become an attractive target for immunological intervention. Here, we summarize recent advances in the development of mutant calreticulin targeting antibodies as a novel therapeutic approach in MPN.
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.17896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Two to tango! IL-13 and TGF-β drive myelofibrosis.

    Jutzi, Jonas S / Mullally, Ann

    Blood

    2022  Volume 140, Issue 26, Page(s) 2767–2768

    MeSH term(s) Humans ; Primary Myelofibrosis ; Transforming Growth Factor beta ; Interleukin-13 ; Interleukin-4 ; Neoplasms ; Myeloproliferative Disorders
    Chemical Substances Transforming Growth Factor beta ; Interleukin-13 ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2022-12-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022018859
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  5. Article ; Online: Molecular Pathogenesis of Myeloproliferative Neoplasms.

    Rolles, Benjamin / Mullally, Ann

    Current hematologic malignancy reports

    2022  Volume 17, Issue 6, Page(s) 319–329

    Abstract: Purpose of review: Myeloproliferative neoplasms (MPNs) are chronic hematological malignancies characterized by increased proliferation of MPN stem and myeloid progenitor cells with or without bone marrow fibrosis that typically lead to increased ... ...

    Abstract Purpose of review: Myeloproliferative neoplasms (MPNs) are chronic hematological malignancies characterized by increased proliferation of MPN stem and myeloid progenitor cells with or without bone marrow fibrosis that typically lead to increased peripheral blood cell counts. The genetic and cytogenetic alterations that initiate and drive the development of MPNs have largely been defined, and we summarize these here.
    Recent findings: In recent years, advances in understanding the pathogenesis of MPNs have defined a long-preclinical phase in JAK2-mutant MPN, identified genetic loci associated with MPN predisposition and uncovered mechanistic insights in CALR-mutant MPN. The integration of molecular genetics into prognostic risk models is well-established in myelofibrosis and ongoing studies are interrogating the prognostic implications of concomitant mutations in ET and PV. Despite all these advances, the field is deficient in clonally selective therapies to effectively target the MPN clone at any stage of disease, from pre-clinical to advanced. Although the biological understanding of the pathogenesis of MPNs has progressed quickly, substantial knowledge gaps remain, including in the molecular mechanisms underlying MPN progression and myelofibrotic transformation. An ongoing goal for the MPN field is to translate advances in biological understanding to improved treatments for patients.
    MeSH term(s) Humans ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/pathology ; Janus Kinase 2/genetics ; Primary Myelofibrosis/genetics ; Mutation ; Hematologic Neoplasms/genetics ; Prognosis
    Chemical Substances Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2229765-0
    ISSN 1558-822X ; 1558-8211
    ISSN (online) 1558-822X
    ISSN 1558-8211
    DOI 10.1007/s11899-022-00685-1
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  6. Article ; Online: Kinase Inhibitors in the Treatment of Myeloid Malignancies.

    Mullally, Ann

    Hematology/oncology clinics of North America

    2017  Volume 31, Issue 4, Page(s) ix–x

    MeSH term(s) Humans ; Myeloproliferative Disorders/drug therapy ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/pathology ; Protein Kinase Inhibitors/therapeutic use ; Signal Transduction/drug effects ; Signal Transduction/genetics
    Chemical Substances Protein Kinase Inhibitors
    Language English
    Publishing date 2017-07-01
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2017.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Busy signal: platelet-derived growth factor activation in myelofibrosis.

    Marneth, Anna E / Mullally, Ann

    Haematologica

    2020  Volume 105, Issue 8, Page(s) 1988–1990

    MeSH term(s) Animals ; Blood Platelets ; Humans ; Mice ; Platelet-Derived Growth Factor ; Primary Myelofibrosis ; Receptor, Platelet-Derived Growth Factor beta
    Chemical Substances Platelet-Derived Growth Factor ; Receptor, Platelet-Derived Growth Factor beta (EC 2.7.10.1)
    Language English
    Publishing date 2020-08-01
    Publishing country Italy
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2020.253708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Biology and therapeutic targeting of molecular mechanisms in MPNs.

    How, Joan / Garcia, Jacqueline S / Mullally, Ann

    Blood

    2022  Volume 141, Issue 16, Page(s) 1922–1933

    Abstract: Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by activated Janus kinase (JAK)-signal transducer and activator of transcription signaling. As a result, JAK inhibitors have been the standard therapy for ... ...

    Abstract Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by activated Janus kinase (JAK)-signal transducer and activator of transcription signaling. As a result, JAK inhibitors have been the standard therapy for treatment of patients with myelofibrosis (MF). Although currently approved JAK inhibitors successfully ameliorate MPN-related symptoms, they are not known to substantially alter the MF disease course. Similarly, in essential thrombocythemia and polycythemia vera, treatments are primarily aimed at reducing the risk of cardiovascular and thromboembolic complications, with a watchful waiting approach often used in patients who are considered to be at a lower risk for thrombosis. However, better understanding of MPN biology has led to the development of rationally designed therapies, with the goal of not only addressing disease complications but also potentially modifying disease course. We review the most recent data elucidating mechanisms of disease pathogenesis and highlight emerging therapies that target MPN on several biologic levels, including JAK2-mutant MPN stem cells, JAK and non-JAK signaling pathways, mutant calreticulin, and the inflammatory bone marrow microenvironment.
    MeSH term(s) Humans ; Janus Kinase Inhibitors/therapeutic use ; Myeloproliferative Disorders/drug therapy ; Polycythemia Vera/drug therapy ; Primary Myelofibrosis/drug therapy ; Janus Kinase 2/genetics ; Janus Kinases ; Disease Progression ; Biology ; Mutation ; Tumor Microenvironment
    Chemical Substances Janus Kinase Inhibitors ; Janus Kinase 2 (EC 2.7.10.2) ; Janus Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2022-12-14
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022017416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: COVID-19 and myeloproliferative neoplasms: some considerations.

    Kamaz, Baransel / Mullally, Ann

    Leukemia

    2020  Volume 35, Issue 1, Page(s) 279–281

    MeSH term(s) COVID-19/drug therapy ; COVID-19/epidemiology ; Humans ; Interferon-alpha/therapeutic use ; Myeloproliferative Disorders/complications ; Myeloproliferative Disorders/drug therapy ; Nitriles ; Pyrazoles/therapeutic use ; Pyrimidines ; SARS-CoV-2
    Chemical Substances Interferon-alpha ; Nitriles ; Pyrazoles ; Pyrimidines ; ruxolitinib (82S8X8XX8H)
    Keywords covid19
    Language English
    Publishing date 2020-10-26
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-020-01070-8
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  10. Article ; Online: The Molecular Genetics of Myeloproliferative Neoplasms.

    Marneth, Anna E / Mullally, Ann

    Cold Spring Harbor perspectives in medicine

    2020  Volume 10, Issue 2

    Abstract: Activated JAK-STAT signaling is central to the pathogenesis ... ...

    Abstract Activated JAK-STAT signaling is central to the pathogenesis of
    MeSH term(s) Animals ; Calreticulin/genetics ; DNA Mutational Analysis/methods ; Disease Models, Animal ; High-Throughput Nucleotide Sequencing ; Humans ; Janus Kinase 2/genetics ; Mice ; Mutation ; Myeloproliferative Disorders/genetics ; Receptors, Thrombopoietin/genetics ; Signal Transduction
    Chemical Substances CALR protein, human ; Calreticulin ; Receptors, Thrombopoietin ; MPL protein, human (143641-95-6) ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2020-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a034876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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