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Article ; Online: Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.

Sahu, Aresh / Karmakar, Susnata / Halder, Sudipta / Ghosh, Gaurab / Acharjee, Sayan / Dasgupta, Purbasa / Ghosh, Ritabrata / Deshpande, Girish / Prasad, Mohit

PLoS genetics

2021 Volume 17, Issue 8, Page(s) e1009685

Abstract: ... Somatically derived AFCs stretch and flatten when the adjacent germline cells start increasing in size. GJ ...

Abstract	Gap junction (GJ) proteins, the primary constituents of GJ channels, are conserved determinants of patterning. Canonically, a GJ channel, made up of two hemi-channels contributed by the neighboring cells, facilitates transport of metabolites/ions. Here we demonstrate the involvement of GJ proteins during cuboidal to squamous epithelial transition displayed by the anterior follicle cells (AFCs) from Drosophila ovaries. Somatically derived AFCs stretch and flatten when the adjacent germline cells start increasing in size. GJ proteins, Innexin2 (Inx2) and Innexin4 (Inx4), functioning in the AFCs and germline respectively, promote the shape transformation by modulating calcium levels in the AFCs. Our observations suggest that alterations in calcium flux potentiate STAT activity to influence actomyosin-based cytoskeleton, possibly resulting in disassembly of adherens junctions. Our data have uncovered sequential molecular events underlying the cuboidal to squamous shape transition and offer unique insight into how GJ proteins expressed in the neighboring cells contribute to morphogenetic processes.
MeSH term(s)	Actomyosin/metabolism ; Animals ; Body Patterning ; Calcium Signaling ; Connexins/genetics ; Connexins/metabolism ; Cytoskeleton/metabolism ; Drosophila/growth & development ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/physiology ; Female ; Morphogenesis ; Ovarian Follicle/metabolism ; Ovarian Follicle/physiology
Chemical Substances	Connexins ; Drosophila Proteins ; Zpg protein, Drosophila ; inx2 protein, Drosophila ; Actomyosin (9013-26-7)
Language	English
Publishing date	2021-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1009685
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Identification of genes associated with gall bladder cell carcinogenesis: Implications in targeted therapy of gall bladder cancer.

Ghosh, Ishita / Dey Ghosh, Ruma / Mukhopadhyay, Soma

World journal of gastrointestinal oncology

2024 Volume 15, Issue 12, Page(s) 2053–2063

Abstract: Gall bladder cancer (GBC) is becoming a very devastating form of hepatobiliary cancer in India. Every year new cases of GBC are quite high in India. Despite recent advanced multimodality treatment options, the survival of GBC patients is very low. If the ...

Abstract	Gall bladder cancer (GBC) is becoming a very devastating form of hepatobiliary cancer in India. Every year new cases of GBC are quite high in India. Despite recent advanced multimodality treatment options, the survival of GBC patients is very low. If the disease is diagnosed at the advanced stage (with local nodal metastasis or distant metastasis) or surgical resection is inoperable, the prognosis of those patients is very poor. So, perspectives of targeted therapy are being taken. Targeted therapy includes hormone therapy, proteasome inhibitors, signal transduction and apoptosis inhibitors, angiogenesis inhibitors, and immunotherapeutic agents. One such signal transduction inhibitor is the specific short interfering RNA (siRNA) or short hairpin RNA (shRNA). For developing siRNA-mediated therapy shRNA, although several preclinical studies to evaluate the efficacy of these key molecules have been performed using gall bladder cells, many more clinical trials are required. To date, many such genes have been identified. This review will discuss the recently identified genes associated with GBC and those that have implications in its treatment by siRNA or shRNA.
Language	English
Publishing date	2024-01-04
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v15.i12.2053
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Article ; Online: RP3MES: A Key to Minimize Infection Spreading.

Ghosh, Mahasweta / Barman Mandal, Soma

Transactions of the Indian National Academy of Engineering : an international journal of engineering and technology

2022 Volume 7, Issue 3, Page(s) 809–821

Abstract: Healthcare facilities, especially in highly populated countries like India where patient to doctor ratio is very high, are under a huge burden. Thus, Remote Patient Physiological Parameter Monitoring using Embedded System (RP3MES) becomes essential to ... ...

Abstract	Healthcare facilities, especially in highly populated countries like India where patient to doctor ratio is very high, are under a huge burden. Thus, Remote Patient Physiological Parameter Monitoring using Embedded System (RP3MES) becomes essential to monitor a large number of people admitted in hospitals and also patients afflicted with infectious diseases. The design for RP3MES addresses the key issues of portability, cost-effectiveness, low power consumption, user-friendliness, high accuracy and remote communication to facilitate vital parameter(s), like heart rate and body temperature, measurements and emergency notification, keeping in mind, the health of the caregiver(s). ARM Cortex M3 embedded processor and low-cost sensors are used to achieve the cost-effectiveness and low power consumption. Alarming unit intimidates a remote caregiver regarding their patient's health condition. The accuracy of the system measured data is 99.4% compared with the gold standard, which has been verified using Lin's Concordance Correlation Coefficient and Bland-Altman analysis. A comparison of our system with other commercially available ones is also presented here. The proposed system has wireless connectivity which minimizes infection transmission among family members and caregivers of the patients. It may also reduce the burden on healthcare staffs in hospitals.
Language	English
Publishing date	2022-04-12
Publishing country	Singapore
Document type	Journal Article
ISSN	2662-5423
ISSN (online)	2662-5423
DOI	10.1007/s41403-022-00328-0
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Article ; Online: High-grade serous ovarian carcinoma, the "Achiles' hill" for clinicians and molecular biologists: a molecular insight.

Bhattacharya, Rittwika / Ghosh, Arijit / Mukhopadhyay, Soma

Molecular biology reports

2023 Volume 50, Issue 11, Page(s) 9511–9519

Abstract: High-grade serous ovarian carcinoma (HGSOC), the deadliest ovarian cancer, alone accounts for 90% of all its subtypes. Characterized by hallmark mutation of TP53, HGSOC show diverse molecular etiology. HGSOC can arise from both ovarian epithelium as well ...

Abstract	High-grade serous ovarian carcinoma (HGSOC), the deadliest ovarian cancer, alone accounts for 90% of all its subtypes. Characterized by hallmark mutation of TP53, HGSOC show diverse molecular etiology. HGSOC can arise from both ovarian epithelium as well as the fimbrial epithelium of the fallopian tube. Ovulation induced reactive oxygen species, follicular fluid associated growth factor induced stemness, deregulation of hormone receptors like ER, FSHR, AR and hormones like FSH, LH, prolonged ovulation cycle, use of oral contraceptives are agonists of HGSOC while parity, breastfeeding provide protective effect from HGSOC development. Apart from a generic TP53 mutation, mutation of BRCA1/2, RAD51, BRIP1, PALB2, CHEK2, RAD50 etc., were reportedly associated with development of HGSOC. Epigenetic events like methylation of RASSF1A of RAS signaling pathway,OR51L1, OR51I1, OR51F1 etc. has been reported in HGSOC. Micro-RNAs like miR-1290, miR 27-a-3p miR23a, miR205 were reportedly upregulated in HGSOC. Amongst its cognate subtypes viz. differentiated, immunoreactive, mesenchymal, and proliferative, mesenchymal, and proliferative show worst prognosis. A system biology approach showed five major altered pathways in HGSOC, namely, RB, PI3K/RAS, NOTCH, HRR and FOXM1 signaling. For chemonaive patients, drugs that helps in efflux of reduced glutathione or prevent the redox coupling of GSH-GSSG, like Cisplatin, could be considered as the best therapeutic choice for HGSOC. For patients with BRCA1/2 mutations, PARP inhibitors alone or with Bevacizumab can be effective. Immune checkpoint inhibitors could be effective against immunoreactive subtypes. Identification of genes deregulated in chemoresistance could provide better insights in dealing with the disease.
MeSH term(s)	Pregnancy ; Female ; Humans ; BRCA1 Protein ; BRCA2 Protein ; Ovarian Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/therapeutic use
Chemical Substances	BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein ; MicroRNAs
Language	English
Publishing date	2023-09-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-08760-3
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Article: Picosecond Bessel Beam Fabricated Pure, Gold-Coated Silver Nanostructures for Trace-Level Sensing of Multiple Explosives and Hazardous Molecules.

Banerjee, Dipanjan / Akkanaboina, Mangababu / Ghosh, Subhasree / Soma, Venugopal Rao

Materials (Basel, Switzerland)

2022 Volume 15, Issue 12

Abstract: A zeroth-order, non-diffracting Bessel beam, generated by picosecond laser pulses (1064 nm, 10 Hz, 30 ps) through an axicon, was utilized to perform pulse energy-dependent (12 mJ, 16 mJ, 20 mJ, 24 mJ) laser ablation of silver (Ag) substrates in air. The ... ...

Abstract	A zeroth-order, non-diffracting Bessel beam, generated by picosecond laser pulses (1064 nm, 10 Hz, 30 ps) through an axicon, was utilized to perform pulse energy-dependent (12 mJ, 16 mJ, 20 mJ, 24 mJ) laser ablation of silver (Ag) substrates in air. The fabrication resulted in finger-like Ag nanostructures (NSs) in the sub-200 nm domain and obtained structures were characterized using the FESEM and AFM techniques. Subsequently, we employed those Ag NSs in surface-enhanced Raman spectroscopy (SERS) studies achieving promising sensing results towards trace-level detection of six different hazardous materials (explosive molecules of picric acid (PA) and ammonium nitrate (AN), a pesticide thiram (TH) and the dye molecules of Methylene Blue (MB), Malachite Green (MG), and Nile Blue (NB)) along with a biomolecule (hen egg white lysozyme (HEWL)). The remarkably superior plasmonic behaviour exhibited by the AgNS corresponding to 16 mJ pulse ablation energy was further explored. To accomplish a real-time application-oriented understanding, time-dependent studies were performed utilizing the AgNS prepared with 16 mJ and TH molecule by collecting the SERS data periodically for up to 120 days. The coated AgNSs were prepared with optimized gold (Au) deposition, accomplishing a much lower trace detection in the case of thiram (~50 pM compared to ~50 nM achieved prior to the coating) as well as superior EF up to ~10
Language	English
Publishing date	2022-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15124155
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Article ; Online: Structural diversity, functional aspects and future therapeutic applications of human gut microbiome.

Ghosh, Soma / Pramanik, Sreemanta

Archives of microbiology

2021 Volume 203, Issue 9, Page(s) 5281–5308

Abstract: The research on human gut microbiome, regarded as the black box of the human body, is still at the stage of infancy as the functional properties of the complex gut microbiome have not yet been understood. Ongoing metagenomic studies have deciphered that ... ...

Abstract	The research on human gut microbiome, regarded as the black box of the human body, is still at the stage of infancy as the functional properties of the complex gut microbiome have not yet been understood. Ongoing metagenomic studies have deciphered that the predominant microbial communities belong to eubacterial phyla Firmicutes, Bacteroidetes, Proteobacteria, Fusobacteria, Cyanobacteria, Verrucomicrobia and archaebacterial phylum Euryarchaeota. The indigenous commensal microbial flora prevents opportunistic pathogenic infection and play undeniable roles in digestion, metabolite and signaling molecule production and controlling host's cellular health, immunity and neuropsychiatric behavior. Besides maintaining intestinal health via short-chain fatty acid (SCFA) production, gut microbes also aid in neuro-immuno-endocrine modulatory molecule production, immune cell differentiation and glucose and lipid metabolism. Interdependence of diet and intestinal microbial diversity suggests the effectiveness of pre- and pro-biotics in maintenance of gut and systemic health. Several companies worldwide have started potentially exploiting the microbial contribution to human health and have translated their use in disease management and therapeutic applications. The present review discusses the vast diversity of microorganisms playing intricate roles in human metabolism. The contribution of the intestinal microbiota to regulate systemic activities including gut-brain-immunity crosstalk has been focused. To the best of our knowledge, this review is the first of its kind to collate and discuss the companies worldwide translating the multi-therapeutic potential of human intestinal microbiota, based on the multi-omics studies, i.e. metagenomics and metabolomics, as ready solutions for several metabolic and systemic disorders.
MeSH term(s)	Cyanobacteria ; Gastrointestinal Microbiome ; Humans ; Metagenomics ; Microbiota ; RNA, Ribosomal, 16S
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2021-08-17
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-021-02516-y
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Zs.A 805: Show issues

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Article: Calcium imaging: a technique to monitor calcium dynamics in biological systems.

Ghosh, Soma / Dahiya, Monika / Kumar, Amit / Bheri, Malathi / Pandey, Girdhar K

Physiology and molecular biology of plants : an international journal of functional plant biology

2023 Volume 29, Issue 12, Page(s) 1777–1811

Language	English
Publishing date	2023-12-30
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2487126-6
ISSN	0974-0430 ; 0971-5894
ISSN (online)	0974-0430
ISSN	0971-5894
DOI	10.1007/s12298-023-01405-6
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Article: Delineating Calcium Signaling Machinery in Plants: Tapping the Potential through Functional Genomics.

Ghosh, Soma / Bheri, Malathi / Pandey, Girdhar K

Current genomics

2021 Volume 22, Issue 6, Page(s) 404–439

Abstract: Plants have developed calcium ( ... ...

Abstract	Plants have developed calcium (Ca
Language	English
Publishing date	2021-06-15
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2033677-9
ISSN	1875-5488 ; 1389-2029
ISSN (online)	1875-5488
ISSN	1389-2029
DOI	10.2174/1389202922666211130143328
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Zs.A 5571: Show issues

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Article ; Online: Structural diversity, functional aspects and future therapeutic applications of human gut microbiome

Ghosh, Soma / Pramanik, Sreemanta

Arch Microbiol. 2021 Nov., v. 203, no. 9 p.5281-5308

2021

Abstract	The research on human gut microbiome, regarded as the black box of the human body, is still at the stage of infancy as the functional properties of the complex gut microbiome have not yet been understood. Ongoing metagenomic studies have deciphered that the predominant microbial communities belong to eubacterial phyla Firmicutes, Bacteroidetes, Proteobacteria, Fusobacteria, Cyanobacteria, Verrucomicrobia and archaebacterial phylum Euryarchaeota. The indigenous commensal microbial flora prevents opportunistic pathogenic infection and play undeniable roles in digestion, metabolite and signaling molecule production and controlling host’s cellular health, immunity and neuropsychiatric behavior. Besides maintaining intestinal health via short-chain fatty acid (SCFA) production, gut microbes also aid in neuro-immuno-endocrine modulatory molecule production, immune cell differentiation and glucose and lipid metabolism. Interdependence of diet and intestinal microbial diversity suggests the effectiveness of pre- and pro-biotics in maintenance of gut and systemic health. Several companies worldwide have started potentially exploiting the microbial contribution to human health and have translated their use in disease management and therapeutic applications. The present review discusses the vast diversity of microorganisms playing intricate roles in human metabolism. The contribution of the intestinal microbiota to regulate systemic activities including gut–brain–immunity crosstalk has been focused. To the best of our knowledge, this review is the first of its kind to collate and discuss the companies worldwide translating the multi-therapeutic potential of human intestinal microbiota, based on the multi-omics studies, i.e. metagenomics and metabolomics, as ready solutions for several metabolic and systemic disorders.
Keywords	Bacteroidetes ; Cyanobacteria ; Euryarchaeota ; Firmicutes ; Fusobacteria ; Proteobacteria ; Verrucomicrobia ; cell differentiation ; diet ; digestion ; disease control ; glucose ; human health ; humans ; immunity ; infancy ; intestinal microorganisms ; intestines ; lipid metabolism ; metabolites ; metabolomics ; metagenomics ; multiomics ; short chain fatty acids ; therapeutics
Language	English
Dates of publication	2021-11
Size	p. 5281-5308.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
Note	Review
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-021-02516-y
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Novel Systemic Treatment Modalities Including Immunotherapy and Molecular Targeted Therapy for Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma.

Ghosh, Soma / Shah, Pooja A / Johnson, Faye M

International journal of molecular sciences

2022 Volume 23, Issue 14

Abstract: Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers worldwide. More than half of patients with HNSCC eventually experience disease recurrence and/or metastasis, which can threaten their long-term survival. HNSCCs located in ... ...

Abstract	Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers worldwide. More than half of patients with HNSCC eventually experience disease recurrence and/or metastasis, which can threaten their long-term survival. HNSCCs located in the oral cavity and larynx are usually associated with tobacco and/or alcohol use, whereas human papillomavirus (HPV) infection, particularly HPV16 infection, is increasingly recognized as a cause of oropharyngeal HNSCC. Despite clinical, histologic, and molecular differences between HPV-positive and HPV-negative HNSCCs, current treatment approaches are the same. For recurrent disease, these strategies include chemotherapy, immunotherapy with PD-1-inhibitors, or a monoclonal antibody, cetuximab, that targets epidermal growth factor; these therapies can be administered either as single agents or in combination. However, these treatment strategies carry a high risk of toxic side effects; therefore, more effective and less toxic treatments are needed. The landscape of HNSCC therapy is changing significantly; numerous clinical trials are underway to test novel therapeutic options like adaptive cellular therapy, antibody-drug conjugates, new targeted therapy agents, novel immunotherapy combinations, and therapeutic vaccines. This review helps in understanding the various developments in HNSCC therapy and sheds light on the path ahead in terms of further research in this field.
MeSH term(s)	Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/drug therapy ; Humans ; Immunotherapy ; Molecular Targeted Therapy ; Neoplasm Recurrence, Local/therapy ; Papillomavirus Infections ; Squamous Cell Carcinoma of Head and Neck/complications ; Squamous Cell Carcinoma of Head and Neck/therapy
Language	English
Publishing date	2022-07-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23147889
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