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Article ; Online: Traditional Chinese Medicine formula Bu-Shen-Huo-Xue-Fang (BSHXF) protects nucleus pulposus cells against the inflammatory and oxidative stress-induced degenerative changes.

Li, Linghui / Wei, Xu / Li, Kaiming / Gong, Hao / Zhu, Liguo / Yang, Shaofeng / Wang, Shangquan / Gu, Jinyu / Chen, Ming / Yin, Xunlu / Zhan, Jiawen / Feng, Minshan / Yu, Jie / Sun, Wu / Chen, Xin

Journal of pharmaceutical and biomedical analysis

2023 Volume 236, Page(s) 115656

Abstract: ... NPCs) and extracellular matrix (ECM) (IDD). Bu-Shen-Huo-Xue-Fang (BSHXF ...

Abstract	Degeneration of the intervertebral disc is primarily caused by the loss of nucleus pulposus cells (NPCs) and extracellular matrix (ECM) (IDD). Bu-Shen-Huo-Xue-Fang (BSHXF), a traditional Chinese medicine decoction, has been used to treat IDD in clinical; nevertheless, the active components and underlying molecular mechanisms remain unknown. BSHXF improved IL-1β and H
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2023.115656
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Article ; Online: Systematic Understanding of Mechanism of Yi-Qi-Huo-Xue Decoction Against Intracerebral Hemorrhagic Stroke Using a Network Pharmacology Approach.

Li, Jian / Ye, Ming / Gao, Jueming / Zhang, Yeqing / Zhu, Qiyong / Liang, Weibang

Medical science monitor : international medical journal of experimental and clinical research

2020 Volume 26, Page(s) e921849

Abstract: ... Yi-Qi-Huo-Xue decoction (YQHXD), a traditional Chinese medicine (TCM) prescription, is verified to be ...

Abstract	BACKGROUND Intracerebral hemorrhage (ICH), a fatal type of stroke, profoundly affects public health. Yi-Qi-Huo-Xue decoction (YQHXD), a traditional Chinese medicine (TCM) prescription, is verified to be an efficient method to treat ICH stroke among the Chinese population. Nevertheless, the pharmacological mechanisms of YQHXD have been unclear. MATERIAL AND METHODS We used a strategy based on network pharmacology to explore the possible multi-component, multi-target, and multi-pathway pattern of YQHXD in treating ICH. First, candidate targets for YQHXD were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Then, these candidate YQHXD targets were used in combination with the known targets for the treatment of ICH stroke to construct the core network (cPPI) using data on protein-protein interaction (PPI). We calculated 5 topological parameters for identification of the main hubs. Pathway enrichment and GO biological process enrichment analyses were performed after the incorporation of the main hubs into ClueGO. RESULTS In total, 55 candidate YQHXD targets for ICH were recognized to be the major hubs in accordance with their topological importance. As suggested by enrichment analysis, the YQHXD targets for ICH were roughly classified into several biological processes (related to redox equilibrium, cell-cell communication, adhesion and collagen biosynthesis, cytokine generation, lymphocyte differentiation and activation, neurocyte apoptosis and development, neuroendocrine system, and vascular development) and related pathways (VEGF, mTOR, NF-kappaB, RAS/MAPK, JAK/STAT and cytokine-cytokine receptors interaction), indicating those mechanisms underlying the therapeutic effect of YQHXD. CONCLUSIONS The present results may serve as a pharmacological framework for TCM studies in the future, helping to promote the use of YQHXD in clinical treatment of ICH.
MeSH term(s)	Gene Ontology ; Hemorrhagic Stroke/drug therapy ; Hemorrhagic Stroke/metabolism ; Humans ; Medicine, Chinese Traditional ; Protein Interaction Maps
Language	English
Publishing date	2020-08-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.921849
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Article: Corrigendum: The Therapeutic Effect of Huo Xue Tong Luo Capsules in Association Research Circulation Osseous (ARCO) Stage II Osteonecrosis of the Femoral Head: A Clinical Study With an Average Follow-up Period of 7.95 Years.

He, Xiao-Ming / He, Min-Cong / Yang, Peng / Zhang, Qing-Wen / Chen, Zhen-Qiu / He, Wei / Wei, Qiu-Shi

Frontiers in pharmacology

2022 Volume 13, Page(s) 896418

Abstract: This corrects the article DOI: 10.3389/fphar.2021.773758.]. ...

Abstract	[This corrects the article DOI: 10.3389/fphar.2021.773758.].
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.896418
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Article ; Online: A pilot randomized controlled trial of acupuncture at the Si Guan Xue for cancer pain.

Lam, To-Yi / Lu, Li-Ming / Ling, Wai-Man / Lin, Li-Zhu

BMC complementary and alternative medicine

2017 Volume 17, Issue 1, Page(s) 335

Abstract: ... for a wide range of clinical conditions, usually for its beneficial effects on pain control. Si guan xue ... Therefore, the aim of this study is to test the protocol and safety of acupuncture at the si guan xue ... sessions of treatment; that is, treatment arm 1 (the si guan xue arm, n = 14), treatment arm 2 (the si guan ...

Abstract	Background: Pain is a common symptom in cancer patients. Acupuncture is a suggested treatment for a wide range of clinical conditions, usually for its beneficial effects on pain control. Si guan xue (the four points) have been widely used in clinical practice, and has shown that it is highly effective, effective in obtaining qi, shows strong acupuncture stimulation, and is simple to manipulate and safe to use. Therefore, the aim of this study is to test the protocol and safety of acupuncture at the si guan xue in the management of cancer pain. Methods: This is a single-blind, randomized controlled pilot trial. 42 patients with moderate to severe cancer pain were randomly assigned to three different arms with seven sessions of treatment; that is, treatment arm 1 (the si guan xue arm, n = 14), treatment arm 2 (the si guan xue plus commonly used acupoints arm, n = 14) and the control arm (the commonly used acupoints arm n = 14). Primary outcomes included acupuncture relieving cancer pain, and patients' subjective improvement as measured by the Patient Global Impression of Change (PGIC). Secondary outcomes included the scores of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and Karnofsky's Performance Status (KPS). Results: The analysis showed that the cancer pain reduction in treatment arm 2 was most prominent on day 5 when compared with the control arm (P<0.05). There was no difference in the scores of PGIC, EORTC QLQ-C30 or KPS among the three groups (P>0.05). Furthermore, no serious adverse events were observed. Conclusions: These results indicate that acupuncture at the si guan xue plus commonly used acupoints tends to be effective in reducing cancer pain. However, the sample size was small, and a future multi-centre study with a larger sample size is warranted. Trial registration: ChiCTR-IOR-15007471 (Retroactively registered on 28 NOV 2015).
MeSH term(s)	Acupuncture Analgesia ; Acupuncture Points ; Acupuncture Therapy ; Adult ; Aged ; Aged, 80 and over ; Cancer Pain/therapy ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Single-Blind Method ; Treatment Outcome
Language	English
Publishing date	2017-06-26
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2050429-9
ISSN	1472-6882 ; 1472-6882
ISSN (online)	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-017-1838-5
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Article ; Online: Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1α and VEGF via inhibition of RBP2 and PKM2.

Tan, Shu-Qiu / Geng, Xue / Liu, Jorn-Hon / Pan, Wynn Hwai-Tzong / Wang, Li-Xiang / Liu, Hui-Kang / Hu, Lei / Chao, Hsiao-Ming

BMC complementary and alternative medicine

2017 Volume 17, Issue 1, Page(s) 365

Abstract: ... investigates the protective effects and mechanisms of Xue-Fu-Zhu-Yu decoction (XFZYD) with respect to retinal ...

Abstract	Background: Retinal ischemia-related eye diseases result in visual dysfunction. This study investigates the protective effects and mechanisms of Xue-Fu-Zhu-Yu decoction (XFZYD) with respect to retinal ischemia. Methods: Retinal ischemia (I) was induced in Wistar rats by a high intraocular pressure (HIOP) of 120 mmHg for 1 h, which was followed by reperfusion of the ischemic eye; the fellow untreated eye acted as a control. Electroretinogram (ERG), biochemistry and histopathology investigations were performed. Results: Significant ischemic changes occurred after ischemia including decreased ERG b-wave ratios, less numerous retinal ganglion cells (RGCs), reduced inner retinal thickness, fewer choline acetyltransferase (ChAT) labeled amacrine cell bodies, increased glial fibrillary acidic protein (GFAP) immunoreactivity and increased vimentin Müller immunolabeling. These were accompanied by significant increases in the mRNA/protein concentrations of vascular endothelium growth factor, hypoxia-inducible factor-1α, pyruvate kinase M2 and retinoblastoma-binding protein 2. The ischemic changes were concentration-dependently and significantly altered when XFZYD was given for seven consecutive days before or after retina ischemia, compared to vehicle. These alterations included enhanced ERG b-wave amplitudes, more numerous RGCs, enhanced inner retinal thickness, a greater number of ChAT immunolabeled amacrine cell bodies and decreased GFAP/vimentin immunoreactivity. Furthermore, decreased mRNA levels of VEGF, HIF-1α, PKM2, and RBP2 were also found. Reduced protein concentrations of VEGF, HIF-1α, PKM2, and RBP2 were also demonstrated. Furthermore, there was an inhibition of the ischemia-associated increased ratios (target protein/β-actin) in the protein levels of VEGF, HIF-1α, PKM2, and RBP2, which were induced by Shikonin, JIB-04 or Avastin. Conclusion: XFZYD would seem to protect against well-known retinal ischemic changes via a synergistic inhibition of RBP2 and PKM2, as well as down-regulation of HIF-1α and a reduction in VEGF secretion.
MeSH term(s)	Animals ; Down-Regulation ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Electroretinography ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Ischemia/drug therapy ; Ischemia/metabolism ; Male ; Phytotherapy ; Pyruvate Kinase/metabolism ; Rats, Wistar ; Retina/drug effects ; Retina/metabolism ; Retina/pathology ; Retinal Diseases/drug therapy ; Retinal Diseases/metabolism ; Retinoblastoma-Binding Protein 2/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Hypoxia-Inducible Factor 1, alpha Subunit ; Vascular Endothelial Growth Factor A ; Xue-Fu-Zhu-Yu decoction ; Retinoblastoma-Binding Protein 2 (EC 1.14.11.27) ; Pyruvate Kinase (EC 2.7.1.40)
Language	English
Publishing date	2017-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2050429-9
ISSN	1472-6882 ; 1472-6882
ISSN (online)	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-017-1857-2
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Book: Tui na zhi liao xue

Lü, Ming

2013

Author's details	zhu bian Lü Ming
MeSH term(s)	Massage
Language	Chinese
Size	6, 245 pages :, illustrations
Edition	Di 1 ban.
Document type	Book
ISBN	9787506760560 ; 7506760568
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Effect of Sheng Xue Ning Tablets on Renal Anemia in Patients Subject to Maintenance Hemodialysis and Safety Evaluation: A Multi-setting Prospective Randomized Study.

Tang, Xiao-Jing / Rong, Shu / Mei, Chang-Lin / Ni, Zhao-Hui / Jiang, Geng-Ru / Yuan, Wei-Jie / Wang, Nian-Song / Guo, Zhi-Yong / Ma, Jun / Yan, Hai-Dong / ZHang, Li-Ming

Current medical science

2020 Volume 40, Issue 2, Page(s) 327–331

Abstract: This study compared Sheng Xue Ning (SXN) tablets with ferrous succinate (FS) tablets in terms ...

Abstract	This study compared Sheng Xue Ning (SXN) tablets with ferrous succinate (FS) tablets in terms of their efficacy for the treatment of iron-deficient renal anemia and safety in patients subject to maintenance hemodialysis (MHD). A total of 94 patients undergoing MHD were randomly assigned to an experiment group (receiving oral SXN tablets, SXN group) and a control group (orally given FS tablets, FS group) and followed up for 12 weeks. Erythropoietin (EPO) was used in both groups. The efficacy was assessed by detecting the subsequent changes in hemoglobin (Hb), serum iron (SI), SF and transferrin saturation (TSAT). At the 12th week, Hb and TSAT levels in both groups were significantly increased compared to those in the screening period (P<0.05). However, no significant difference in Hb and TSAT was found between the two groups. The average weekly EPO dosage used was lower in SXN group than in FS group (P<0.05) at the 10th week and the 12th week. Our study showed that SXN tablets can effectively ameliorate renal anemia and keep iron metabolism stable in MHD patients, and its efficacy is virtually close to that of FS tablets. Meanwhile, SXN tablets can reduce the dosage of EPO and have a good safety profile.
MeSH term(s)	Administration, Oral ; Adult ; Aged ; Anemia/drug therapy ; Anemia/etiology ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/therapeutic use ; Female ; Ferrous Compounds/administration & dosage ; Ferrous Compounds/therapeutic use ; Hemoglobins/analysis ; Humans ; Iron/blood ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Prospective Studies ; Renal Dialysis/adverse effects ; Tablets ; Treatment Outcome ; Young Adult
Chemical Substances	Drugs, Chinese Herbal ; Ferrous Compounds ; Hemoglobins ; Tablets ; shengxuening ; ferrous succinate (818ZYK7N91) ; Iron (E1UOL152H7)
Language	English
Publishing date	2020-04-26
Publishing country	China
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-020-2179-z
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Article: The Therapeutic Effect of Huo Xue Tong Luo Capsules in Association Research Circulation Osseous (ARCO) Stage II Osteonecrosis of the Femoral Head: A Clinical Study With an Average Follow-up Period of 7.95 Years.

He, Xiao-Ming / He, Min-Cong / Yang, Peng / Zhang, Qing-Wen / Chen, Zhen-Qiu / He, Wei / Wei, Qiu-Shi

Frontiers in pharmacology

2021 Volume 12, Page(s) 773758

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.773758
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Book: Tui na gong fa xue

Lü, Ming

2012

Author's details	zhu bian Lü Ming, Jin Hongzhu
MeSH term(s)	Massage/methods ; Medicine, Chinese Traditional
Language	Chinese
Size	12, 205 pages :, illustrtions.
Edition	Di 1 ban.
Document type	Book
ISBN	9787117157872 ; 7117157879
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Qing Re Liang Xue Decoction Alleviates Hypercoagulability in Kawasaki Disease.

Chen, Jiao-Yang / Yin, Ji-Ming / Du, Zhong-Dong / Hao, Jing / Yan, Hui-Min

Evidence-based complementary and alternative medicine : eCAM

2015 Volume 2015, Page(s) 864597

Abstract: ... were treated with Qing Re Liang Xue decoction and Western medicine (integrative medicine treatment ... Conclusion. Qing Re Liang Xue decoction improved the hypercoagulable state of KD patients. Potential ...

Abstract	Objective. Kawasaki disease (KD) is a multisystemic autoimmune vasculitis. Intravenous immunoglobulin (IVIG) is the first-line treatment for KD. It is unclear whether traditional Chinese medicine (TCM) has an effect on KD. We aimed to observe the clinical efficacy of TCM on acute KD via serum interleukin-33 (IL-33) and tumor necrosis factor alpha (TNF-α) measurements. Methods. Thirty-one KD patients were treated with Qing Re Liang Xue decoction and Western medicine (integrative medicine treatment group), while 28 KD patients were treated with Western medicine only (Western medicine treatment group). Thirty patients were included in a febrile group and 28 healthy children were included in the control group. Clinical characteristics and laboratory findings were gathered and compared. Serum IL-33 and TNF-α levels were measured by multiplex Luminex assay. Results. The platelet count in the integrative medicine treatment group was significantly lower than that in the Western medicine treatment group. The integrative medicine group had a shorter fever duration and lower IL-33 and TNF-α levels than those in the Western medicine group, but there were no significant differences between the two KD groups after treatment. Conclusion. Qing Re Liang Xue decoction improved the hypercoagulable state of KD patients. Potential myocardial protective effects require further research.
Language	English
Publishing date	2015-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2015/864597
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