LIVIVO - Search results -

Search results

Result 1 - 10 of total 6634

Search options

Article ; Online: Rapid Detection of SARS-CoV-2 in Clinical and Environmental Samples via a Resonant Cavity SERS Platform within 20 min.

Huang, Jinglin / Wang, Conghui / Wang, Pingshi / Mo, Wenbo / Zhou, Minjie / Le, Wei / Qi, Daojian / Wei, Lai / Fan, Quanping / Yang, Yue / Ni, Shuang / Wu, Yan / Feng, Yuliang / Wang, Xiang / Zhao, Zongqing / He, Zhibing / Zhang, Haijun / Xue, Peili / Ren, Bin /

Ren, Lili / Pan, Ming / Du, Kai

ACS applied materials & interfaces

2023

Abstract: ... and rapid detection of SARS-CoV-2 antigen within 20 min by the combination of a highly consistent SERS ...

Abstract	The coronavirus disease 2019 (COVID-19) epidemic has given a warning that it is important to explore the rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical specimens or environmental samples for public health strategies and future variants. The surface-enhanced Raman spectroscopy (SERS) technique was demonstrated to achieve this goal. However, the consistency of signals originating from the poor compatibility of virions with SERS hotspots remains a key scientific challenge for the practical applications of SERS. Herein, we develop a SERS platform for the ultrasensitive and rapid detection of SARS-CoV-2 antigen within 20 min by the combination of a highly consistent SERS substrate and a supervised deep learning algorithm. A V-shaped resonant cavity array (VRC) substrate was fabricated to trap SARS-CoV-2 virions in the periodic V cavity array and stimulate the integral SERS signal of the virus via a resonance coupling effect. Benefiting from the unique architecture of the VRC substrate, we were able to directly detect the SARS-CoV-2 virus with high sensitivity and high consistency. These excellent performances enabled us to identify five different kinds of SARS-CoV-2 variants and detect SARS-CoV-2 from clinical and environmental samples with high accuracies.
Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c08819
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Exploration of the minimal clinically important difference value of the 3-min simulated pedal motion in patients with chronic obstructive pulmonary disease: A self-controlled prospective clinical trial.

Zhang, Xiaoting / Liu, Ni / Yang, Feng / Su, Guansheng / Hu, Jieying / Chen, Rongchang / Zheng, Zeguang

The clinical respiratory journal

2023 Volume 17, Issue 9, Page(s) 951–961

Abstract: ... can complete the 6-min walking distance (6MWD) and cardiopulmonary exercise testing (CPET).: Methods ... In this study, we discuss the definition of the standardized 3-min simulated pedal motion (3MSPM) test and ...

Abstract	Background: To help elderly patients with severe or very severe chronic obstructive pulmonary disease (COPD) with pulmonary rehabilitation, we have developed Zheng's supine rehabilitation exercise (ZSRE). Currently, none of the terminal or critically ill patients with severe exercise limitation can complete the 6-min walking distance (6MWD) and cardiopulmonary exercise testing (CPET). Methods: In this study, we discuss the definition of the standardized 3-min simulated pedal motion (3MSPM) test and its operational specifications. Also, we evaluate the minimal clinically important difference (MCID) value of the 3MSPM. Results: The results showed that the mMRC score of COPD patients with acute exacerbation of dyspnea was progressively reduced from the second day of respiratory rehabilitation, and the difference between the first and seventh days was statistically significant (p < 0.000, χ Conclusion: Based on the regression equation, 3MSPM can predict 6MWD, and it can be used as a simple exercise endurance method to evaluate patients with safety hazards in underground activities or who cannot complete the 6MWD test. The minimum clinically important difference value is increased by 23.
MeSH term(s)	Humans ; Aged ; Prospective Studies ; Minimal Clinically Important Difference ; Pulmonary Disease, Chronic Obstructive ; Exercise Test ; Exercise ; Exercise Tolerance
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13687
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Attribution Analysis of Runoff Change in Min-Tuo River Basin based on SWAT model simulations, China.

Hu, Jian / Ma, Jie / Nie, Chao / Xue, Lianqing / Zhang, Yang / Ni, Fuquan / Deng, Yu / Liu, Jinshan / Zhou, Dengke / Li, Linhuan / Wang, Zhigang

Scientific reports

2020 Volume 10, Issue 1, Page(s) 2900

Abstract: ... on runoff, we examined the changes and response mechanisms of runoff in the Min-Tuo River Basin, China ... to the runoff alteration in the Min-Tuo River Basin using the Budyko methods. The results suggested ... The aridity index and all the elasticities showed a spatial variations in the Min-Tuo River Basin ...

Abstract	To consummate watershed data and better quantify the impact of climate changes and human activities on runoff, we examined the changes and response mechanisms of runoff in the Min-Tuo River Basin, China. In the examination, the Soil and Water Assessment Tool (SWAT) model was used to simulate possible evapotranspiration, actual evapotranspiration, and runoff in 1980, 1990, 1995, 2000, 2005, 2010, and 2015 under different land-use conditions. SWAT weather generator was used to supplement the missing meteorological data. This study presents a quantitative analysis of the climatic and anthropogenic factors contributing to the runoff alteration in the Min-Tuo River Basin using the Budyko methods. The results suggested that the reduced precipitation was the main cause of runoff reduction. The contributions of precipitation, possible evapotranspiration, and underlying surface alterationsof runoff were 56.18%, 37.08%, and 6.74%, respectively. Sensitivity analysis indicated that the runoff alteration was most sensitive to changes of landscape parameters. The aridity index and all the elasticities showed a spatial variations in the Min-Tuo River Basin. The influence of the three factors on runoff reduction varied with seasons. During the high-flow period, changes of the precipitation and possible evapotranspiration and underlying surface had the greatest effect on runoff reduction, while changes of underlying surfaces had the least effect.
Language	English
Publishing date	2020-02-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-59659-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Mesenchymal stem cells combined with traditional Chinese medicine (qi-fang-bi-min-tang) alleviates rodent allergic rhinitis.

Fu, Yanxia / Kong, Yanhua / Li, Jun / Wang, Yi / Li, Mengdi / Wang, Ying / Wang, Yinyin / Ren, Fangli / Ni, Jian / Li, Youlin / Chang, Zhijie

Journal of cellular biochemistry

2019 Volume 121, Issue 2, Page(s) 1541–1551

Abstract: ... immune reactions. Traditional Chinese medicine (TCM), qi-fang-bi-min-tang, is effective for some patients ... of allergic rhinitis (AR). In this study, we reported an additional effect of TCM (qi-fang-bi-min-tang ... through regulating the secretion of Th1, Th2, and Th17 cytokines. This study suggested that TCM (qi-fang-bi-min-tang ...

Abstract	Mesenchymal stem cells (MSCs) have been proved to exert anti-inflammatory effects and regulate immune reactions. Traditional Chinese medicine (TCM), qi-fang-bi-min-tang, is effective for some patients with allergic diseases. However, it remains unclear whether MSCs combined with TCM could benefit the treatment of allergic rhinitis (AR). In this study, we reported an additional effect of TCM (qi-fang-bi-min-tang) on the therapy of AR under MSCs treatment. Intriguingly, we observed that TCM-treated MSCs significantly inhibited the symptoms of AR and reduced the pathological changes of nasal mucosa in ovalbumin (OVA)-induced rats. The expression levels of interferon γ (IFN-γ), interleukin-17 (IL-17), and IL-4 were significantly decreased in the plasma of AR rats after injection of TCM-treated MSCs. TCM-treated MSCs reduced the levels of histamine secreted by mast cells and immunoglobulin E (IgE) secreted by plasma cells. In addition, we found that MSCs combined with TCM had a better therapeutic effect than TCM alone on AR in an OVA-induced mouse model. After OVA induction, MSCs combined with TCM significantly reduced the ratio of T helper type 1 (Th1), Th2, and Th17, but increased the proportion of Treg in the spleen of mice. Consistently, the expression levels of IFN-γ, IL-4, and IL-17 were significantly decreased, but transforming growth factor-β1 was significantly increased in the plasma of AR mice after treated with TCM and MSCs. Our results from both rats and mice indicated that the effects of TCM combined with MSCs on the AR might be through regulating the secretion of Th1, Th2, and Th17 cytokines. This study suggested that TCM (qi-fang-bi-min-tang)-treated MSCs could be used in the clinical therapy of AR.
MeSH term(s)	Allografts ; Animals ; Cytokines/immunology ; Drugs, Chinese Herbal/pharmacology ; Male ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/immunology ; Mesenchymal Stem Cells/pathology ; Mice ; Mice, Inbred BALB C ; Rats ; Rats, Sprague-Dawley ; Rhinitis, Allergic/immunology ; Rhinitis, Allergic/pathology ; Rhinitis, Allergic/therapy ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/pathology
Chemical Substances	Cytokines ; Drugs, Chinese Herbal
Language	English
Publishing date	2019-09-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.29389
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1114: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Nitrous oxide concentration and flux in Min River Basin of southeast China: Effects of land use, stream order and water variables

Li, Xiaofei / Sardans, Jordi / Qi, Mengting / Ni, Xiangyin / Zhang, Mingfeng / Peñuelas, Josep / Yue, Kai / Wu, Fuzhong

Journal of Hydrology. 2022 Nov., v. 614 p.128507-

2022

Abstract: ... concentration and water–air interface N₂O flux across the land uses and stream orders in Min River Basin ...

Abstract	Estimates of riverine nitrous oxide (N₂O) emissions have great uncertainty partly due to the fact that the data is still sparse for stream sizes and land uses. Here we determined water dissolved N₂O concentration and water–air interface N₂O flux across the land uses and stream orders in Min River Basin of southeast China. N₂O concentrations ranged from 11.1 to 27.4 nmol/L, increasing from first- to eighth-order rivers. The first- and second-order streams showed negative N₂O flux (−0.33 and −0.05 µg m⁻²h⁻¹, respectively) compared to third- to eighth-order rivers (from 0.29 to 2.85 µg m⁻²h⁻¹). Average N₂O flux was significantly higher in urban (1.60 µg m⁻²h⁻¹) and cropland rivers (0.89 µg m⁻²h⁻¹) than in forest rivers (−0.47 µg m⁻²h⁻¹), which could be due to the main effect of land use was on the nitrogen load. Indirect N₂O emission factor varied between 0.035 and 0.14 % across the rivers, which decreased from the urban to forest rivers and were lower than the IPCC default value (0.26 %). N₂O concentration and flux were positively correlated with NO₃⁻, NH₄⁺, depth, velocity and temperature, suggesting the importance of stream surface hydromoprhology to N₂O emissions. Land use indirectly affected N₂O flux by affecting water NO₃⁻, NH₄⁺, DO, DOC, pH and temperature, which could further explain the land use dependence of N₂O emissions on water variables. High DOC:NO₃⁻ ratio (>6) was the main factor of N₂O sink in the small streams, which may be due to the enhanced N₂O consumption and low N₂O production. Therefore, riverine N₂O emissions are highly variable across stream sizes and land uses, which are not only increased by inorganic nitrogen load and are also dependent on stream hydraulics and morphology.
Keywords	cropland ; emissions factor ; fluid mechanics ; forests ; hydrology ; land use ; liquid-air interface ; nitrogen ; nitrous oxide ; pH ; riparian areas ; streams ; temperature ; uncertainty ; watersheds ; China ; Stream order ; Emission factor ; Min River Basin
Language	English
Dates of publication	2022-11
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2022.128507
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Transformational Leadership in Human Resources Development to Improve Education Quality in Min 9 Blitar and Mi Wakhid Hasyim Blitar

Ibadul Mutho'i / Akhyak Akhyak / Syamsun Ni'am / Ngainun Naim / Asrop Safi'i / Maftukhin Maftukhin

Technium Social Sciences Journal, Vol 17, Iss

2021 Volume 1

Abstract: Transformational leadership is an effort to improve the quality of educational institutions. Transformational leadership is an effort to move educational organizations / institutions to achieve educational goals with all transformational attributes. ... ...

Abstract	Transformational leadership is an effort to improve the quality of educational institutions. Transformational leadership is an effort to move educational organizations / institutions to achieve educational goals with all transformational attributes. These attributes are packaged in the form; efforts to establish a vision-mission or set the direction of the school, efforts to develop human resources (HR), and transformational leadership efforts in redesigning the organization. This phenomenon raises an idea in the form of transformational leadership in improving the quality of education with all its attributes. This research uses a qualitative approach, a type of case study with a multi-case design. The results showed that transformational leadership in developing human resources was carried out by increasing the level of higher education, workshop activities, training and competency improvement training, religious motivation, performance appraisal, fingerprinting, good examples, external tutors, adding authority and position.
Keywords	Transformational Leadership ; Human Resource Development ; Education Quality ; Social sciences (General) ; H1-99
Subject code	370
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Technium Science
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: A novel approach to assess the spontaneous gastrointestinal bleeding risk of antithrombotic agents using Apc(min/+) mice.

Wei, Huijun / Shang, Jin / Keohane, CarolAnn / Wang, Min / Li, Qiu / Ni, Weihua / O'Neill, Kim / Chintala, Madhu

Thrombosis and haemostasis

2014 Volume 111, Issue 6, Page(s) 1121–1132

Abstract: ... pathologies such as GI ulcerations and polyps. Apc(min/+) mice are reported to develop multiple adenomas ... of Apc(min/+) mice as a model for assessing spontaneous GI bleeding with antithrombotic agents. Apc(min ... in bleeding, Apc(min/+) mice were in a hypercoagulable state and displayed an age-dependent increase ...

Abstract	Assessment of the bleeding risk of antithrombotic agents is usually performed in healthy animals with some form of vascular injury to peripheral organs to induce bleeding. However, bleeding observed in patients with currently marketed antithrombotic drugs is typically spontaneous in nature such as intracranial haemorrhage (ICH) and gastrointestinal (GI) bleeding, which happens most frequently on top of preexisting pathologies such as GI ulcerations and polyps. Apc(min/+) mice are reported to develop multiple adenomas through the entire intestinal tract and display progressive anaemia.In this study, we evaluated the potential utility of Apc(min/+) mice as a model for assessing spontaneous GI bleeding with antithrombotic agents. Apc(min/+) mice exhibited progressive blood loss starting at the age of nine weeks. Despite the increase in bleeding, Apc(min/+) mice were in a hypercoagulable state and displayed an age-dependent increase in thrombin generation and circulating fibrinogen as well as a significant decrease in clotting times. We evaluated the effect of warfarin, dabigatran etexilate, apixaban and clopidogrel in this model by administering them in diet or in the drinking water to mice for 1-4 weeks. All of these marketed drugs significantly increased GI bleeding in Apc(min/+) mice, but not in wild-type mice. Although different exposure profiles of these antithrombotic agents make it challenging to compare the bleeding risk of compounds, our results indicate that the Apc(min/+) mouse may be a sensitive preclinical model for assessing the spontaneous GI bleeding risk of novel antithrombotic agents.
MeSH term(s)	Age Factors ; Animals ; Benzimidazoles/adverse effects ; Dabigatran ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Fibrinolytic Agents/adverse effects ; Gastrointestinal Hemorrhage/chemically induced ; Gastrointestinal Hemorrhage/genetics ; Genes, APC ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Pyrazoles/adverse effects ; Pyridines/adverse effects ; Pyridones/adverse effects ; Risk Factors ; Ticlopidine/adverse effects ; Ticlopidine/analogs & derivatives ; Warfarin/adverse effects
Chemical Substances	Benzimidazoles ; Fibrinolytic Agents ; Pyrazoles ; Pyridines ; Pyridones ; apixaban (3Z9Y7UWC1J) ; Warfarin (5Q7ZVV76EI) ; clopidogrel (A74586SNO7) ; Dabigatran (I0VM4M70GC) ; Ticlopidine (OM90ZUW7M1)
Language	English
Publishing date	2014-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	518294-3
ISSN	0340-6245
ISSN	0340-6245
DOI	10.1160/TH13-11-0926
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 433: Show issues

Order via subito

Details ▾

Article ; Online: YYFZBJS ameliorates colorectal cancer progression in Apc Min/+ mice by remodeling gut microbiota and inhibiting regulatory T-cell generation

Hua Sui / Lu Zhang / Kaijuan Gu / Ni Chai / Qing Ji / Lihong Zhou / Yan Wang / Junze Ren / Limei Yang / Bimeng Zhang / Jing Hu / Qi Li

Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-

2020 Volume 17

Abstract: ... Apc Min/+ mice, an animal model of human intestinal tumorigenesis, to investigate the gut bacterial ... in Apc Min/+ mice with less change of body weight and increased immune function. Moreover, diversity ... CD25+ Foxp3 positive Treg cells were reduced by YYFZBJS treatment in Apc Min/+ mice. Although YYFZBJS ...

Abstract	Abstract Background Progression of Colorectal cancer (CRC) is influenced by single or compounded environmental factors. Accumulating evidence shows that microbiota can influence the outcome of cancer immunotherapy. T cell, one of the main populations of effector immune cells in antitumor immunity, has been considered as a double-edged sword during the progression of CRC. Our previous studies indicate that traditional Chinese herbs (TCM) have potential anticancer effects in improving quality of life and therapeutic effect. However, little is known about the mechanism of TCM formula in cancer prevention. Methods Here, we used C57BL/6 J Apc Min/+ mice, an animal model of human intestinal tumorigenesis, to investigate the gut bacterial diversity and their mechanisms of action in gastrointestinal adenomas, and to evaluate the effects of Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS) on of colon carcinogenesis in vivo and in vitro. Through human-into-mice fecal microbiota transplantation (FMT) experiments from YYFZBJS volunteers or control donors, we were able to differentially modulate the tumor microbiome and affect tumor growth as well as tumor immune infiltration. Results We report herein, YYFZBJS treatment blocked tumor initiation and progression in Apc Min/+ mice with less change of body weight and increased immune function. Moreover, diversity analysis of fecal samples demonstrated that YYFZBJS regulated animal’s natural gut flora, including Bacteroides fragilis, Lachnospiraceae and so on. Intestinal tumors from conventional and germ-free mice fed with stool from YYFZBJS volunteers had been decreased. Some inflammation’ expression also have been regulated by the gut microbiota mediated immune cells. Intestinal lymphatic, and mesenteric lymph nodes (MLN), accumulated CD4+ CD25+ Foxp3 positive Treg cells were reduced by YYFZBJS treatment in Apc Min/+ mice. Although YYFZBJS had no inhibition on CRC cell proliferation by itself, the altered Tregs mediated by YYFZBJS repressed CRC cancer cell growth, along with reduction of ...
Keywords	Colorectal Cancer ; Apc Min/+ mice ; Gut microbiota ; Fecal microbiota transplantation ; Regulatory T cell ; Immune ; Medicine ; R ; Cytology ; QH573-671
Subject code	570
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Comparative Analyses between Skeletal Muscle miRNAomes from Large White and Min Pigs Revealed MicroRNAs Associated with Postnatal Muscle Hypertrophy.

Sheng, Xihui / Wang, Ligang / Ni, Hemin / Wang, Lixian / Qi, Xiaolong / Xing, Shuhan / Guo, Yong

PloS one

2016 Volume 11, Issue 6, Page(s) e0156780

Abstract: ... postnatal stages (60, 120, 150, 180, and 210 days after birth) from Large White (commercial breed) and Min ... miR-204 was significantly more highly expressed in Min pig skeletal muscle at all postnatal stages ...

Abstract	The molecular mechanism regulated by microRNAs (miRNAs) that underlies postnatal hypertrophy of skeletal muscle is complex and remains unclear. Here, the miRNAomes of longissimus dorsi muscle collected at five postnatal stages (60, 120, 150, 180, and 210 days after birth) from Large White (commercial breed) and Min pigs (indigenous breed of China) were analyzed by Illumina sequencing. We identified 734 miRNAs comprising 308 annotated miRNAs and 426 novel miRNAs, of which 307 could be considered pig-specific. Comparative analysis between two breeds suggested that 60 and 120 days after birth were important stages for skeletal muscle hypertrophy and intramuscular fat accumulation. A total of 263 miRNAs were significantly differentially expressed between two breeds at one or more developmental stages. In addition, the differentially expressed miRNAs between every two adjacent developmental stages in each breed were determined. Notably, ssc-miR-204 was significantly more highly expressed in Min pig skeletal muscle at all postnatal stages compared with its expression in Large White pig skeletal muscle. Based on gene ontology and KEGG pathway analyses of its predicted target genes, we concluded that ssc-miR-204 may exert an impact on postnatal hypertrophy of skeletal muscle by regulating myoblast proliferation. The results of this study will help in elucidating the mechanism underlying postnatal hypertrophy of skeletal muscle modulated by miRNAs, which could provide valuable information for improvement of pork quality and human myopathy.
MeSH term(s)	Animals ; Animals, Newborn ; Base Sequence ; Cluster Analysis ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Gene Library ; Gene Ontology ; Hypertrophy ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Sequence Analysis, RNA ; Sus scrofa/genetics ; Swine ; Swine, Miniature/genetics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2016-06-02
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0156780
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Serum Bilirubin and 6-min Walk Distance as Prognostic Predictors for Inoperable Chronic Thromboembolic Pulmonary Hypertension: A Prospective Cohort Study.

Gong, Juan-Ni / Zhai, Zhen-Guo / Yang, Yuan-Hua / Liu, Yan / Gu, Song / Kuang, Tu-Guang / Xie, Wan-Mu / Miao, Ran / Wang, Chen

Chinese medical journal

2015 Volume 128, Issue 23, Page(s) 3125–3131

Abstract: ... of transaminase, bilirubin, and gamma-glutamyl transpeptidase [GGT]) combined with 6-min walk test ... for this prospective cohort study. Baseline clinical characteristics and 6-min walk distance (6MWD) results were ...

Abstract	Background: Inoperable chronic thromboembolic pulmonary hypertension (CTEPH) is a severe clinical syndrome characterized by right cardiac failure and possibly subsequent liver dysfunction. However, whether serum markers of liver dysfunction can predict prognosis in inoperable CTEPH patients has not been determined. Our study aimed to evaluate the potential role of liver function markers (such as serum levels of transaminase, bilirubin, and gamma-glutamyl transpeptidase [GGT]) combined with 6-min walk test in the prediction of prognosis in patients with inoperable CTEPH. Methods: From June 2005 to May 2013, 77 consecutive patients with inoperable CTEPH without confounding co-morbidities were recruited for this prospective cohort study. Baseline clinical characteristics and 6-min walk distance (6MWD) results were collected. Serum biomarkers of liver function, including levels of aspartate aminotransferase, alanine aminotransferase, GGT, uric acid, and serum bilirubin, were also determined at enrollment. All-cause mortality was recorded during the follow-up period. Results: During the follow-up, 22 patients (29%) died. Cox regression analyses demonstrated that increased serum concentration of total bilirubin (hazard ratio [HR] = 7.755, P < 0.001), elevated N-terminal of the prohormone brain natriuretic peptide (HR = 1.001, P = 0.001), decreased 6MWD (HR = 0.990, P < 0.001), increased central venous pressure (HR = 1.074, P = 0.040), and higher pulmonary vascular resistance (HR = 1.001, P = 0.018) were associated with an increased risk of mortality. Serum concentrations of total bilirubin (HR = 4.755, P = 0.007) and 6MWD (HR = 0.994, P = 0.017) were independent prognostic predictors for CTEPH patients. Patients with hyperbilirubinemia (≥23.7 μmol/L) had markedly worse survival than those with normobilirubinemia. Conclusion: Elevated serum bilirubin and decreased 6MWD are potential predictors for poor prognosis in inoperable CTEPH.
MeSH term(s)	Aged ; Antihypertensive Agents/therapeutic use ; Bilirubin/blood ; Exercise Test ; Female ; Humans ; Hypertension, Pulmonary/blood ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/pathology ; Male ; Middle Aged ; Prognosis ; Prospective Studies
Chemical Substances	Antihypertensive Agents ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2015-12-05
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127089-8
ISSN	0366-6999 ; 1002-0187
ISSN	0366-6999 ; 1002-0187
DOI	10.4103/0366-6999.170267
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 1207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.425: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito