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  1. Article ; Online: Crystallization and In Situ Room Temperature Data Collection Using the Crystallization Facility at Harwell and Beamline VMXi, Diamond Light Source.

    Sandy, James / Mikolajek, Halina / Thompson, Amy J / Sanchez-Weatherby, Juan / Hough, Michael A

    Journal of visualized experiments : JoVE

    2024  , Issue 205

    Abstract: Protocols for robotic protein crystallization using the Crystallization Facility at Harwell and in situ room temperature data collection from crystallization plates at Diamond Light Source beamline VMXi are described. This approach enables high-quality ... ...

    Abstract Protocols for robotic protein crystallization using the Crystallization Facility at Harwell and in situ room temperature data collection from crystallization plates at Diamond Light Source beamline VMXi are described. This approach enables high-quality room-temperature crystal structures to be determined from multiple crystals in a straightforward manner and provides very rapid feedback on the results of crystallization trials as well as enabling serial crystallography. The value of room temperature structures in understanding protein structure, ligand binding, and dynamics is becoming increasingly recognized in the structural biology community. This pipeline is accessible to users from all over the world with several available modes of access. Crystallization experiments that are set up can be imaged and viewed remotely with crystals identified automatically using a machine learning tool. Data are measured in a queue-based system with up to 60° rotation datasets from user-selected crystals in a plate. Data from all the crystals within a particular well or sample group are automatically merged using xia2.multiplex with the outputs straightforwardly accessed via a web browser interface.
    MeSH term(s) Crystallization/methods ; Crystallography, X-Ray ; Temperature ; Synchrotrons ; Proteins/chemistry ; Data Collection
    Chemical Substances Proteins
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/65964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exaggerating contraceptive efficacy: the implications of the Advertising Standards Authority action against Natural Cycles.

    Hough, Amy / Bryce, Maggie

    BMJ sexual & reproductive health

    2019  Volume 45, Issue 1, Page(s) 71–72

    MeSH term(s) Advertising as Topic/legislation & jurisprudence ; Advertising as Topic/standards ; Advertising as Topic/trends ; Contraception/methods ; Contraception/standards ; Humans ; Social Media
    Language English
    Publishing date 2019-01-03
    Publishing country England
    Document type Journal Article
    ISSN 2515-2009
    ISSN (online) 2515-2009
    DOI 10.1136/bmjsrh-2018-200209
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  3. Article ; Online: Efficient in situ screening of and data collection from microcrystals in crystallization plates.

    Thompson, Amy J / Sanchez-Weatherby, Juan / Williams, Lewis J / Mikolajek, Halina / Sandy, James / Worrall, Jonathan A R / Hough, Michael A

    Acta crystallographica. Section D, Structural biology

    2024  Volume 80, Issue Pt 4, Page(s) 279–288

    Abstract: A considerable bottleneck in serial crystallography at XFEL and synchrotron sources is the efficient production of large quantities of homogenous, well diffracting microcrystals. Efficient high-throughput screening of batch-grown microcrystals and the ... ...

    Abstract A considerable bottleneck in serial crystallography at XFEL and synchrotron sources is the efficient production of large quantities of homogenous, well diffracting microcrystals. Efficient high-throughput screening of batch-grown microcrystals and the determination of ground-state structures from different conditions is thus of considerable value in the early stages of a project. Here, a highly sample-efficient methodology to measure serial crystallography data from microcrystals by raster scanning within standard in situ 96-well crystallization plates is described. Structures were determined from very small quantities of microcrystal suspension and the results were compared with those from other sample-delivery methods. The analysis of a two-dimensional batch crystallization screen using this method is also described as a useful guide for further optimization and the selection of appropriate conditions for scaling up microcrystallization.
    MeSH term(s) Crystallography, X-Ray ; Crystallization/methods ; Synchrotrons ; Data Collection
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2968623-4
    ISSN 2059-7983 ; 0907-4449
    ISSN (online) 2059-7983
    ISSN 0907-4449
    DOI 10.1107/S2059798324001955
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  4. Article ; Online: Early educational attainment in children with major congenital anomaly in the UK.

    Wands, Zoë E / Cave, Daniel G W / Cromie, Kirsten / Hough, Amy / Johnson, Kathryn / Mon-Williams, Mark / Feltbower, Richard G / Glaser, Adam W

    Archives of disease in childhood

    2024  Volume 109, Issue 4, Page(s) 326–333

    Abstract: Objective: To describe early educational attainment and special educational needs (SEN) provision in children with major congenital anomaly (CA) compared with peers.: Design: Analysis of educational data linked to the ongoing Born in Bradford cohort ... ...

    Abstract Objective: To describe early educational attainment and special educational needs (SEN) provision in children with major congenital anomaly (CA) compared with peers.
    Design: Analysis of educational data linked to the ongoing Born in Bradford cohort study. Confounders were identified via causal inference methods and multivariable logistic regression performed.
    Setting: Children born in Bradford Royal Infirmary (BRI), West Yorkshire.
    Patients: All women planning to give birth at BRI and attending antenatal clinic from March 2007 to December 2010 were eligible. 12 453 women with 13 776 pregnancies (>80% of those attending) were recruited. Records of 555 children with major CA and 11 188 without were linked to primary education records.
    Outcomes: Key Stage 1 (KS1) attainment at age 6-7 years in Maths, Reading, Writing and Science. SEN provision from age 4 to 7 years.
    Results: 41% of children with major CA received SEN provision (compared with 14% without), and 48% performed below expected standards in at least one KS1 domain (compared with 29% without). The adjusted odds of children with CA receiving SEN provision and failing to achieve the expected standard at KS1 were, respectively, 4.30 (95% CI 3.49 to 5.31) and 3.06 (95% CI 2.47 to 3.79) times greater than their peers. Those with genetic, heart, neurological, urinary, gastrointestinal and limb anomalies had significantly poorer academic achievement.
    Conclusions: These novel results demonstrate that poor educational attainment extends to children with urinary, limb and gastrointestinal CAs. We demonstrate the need for collaboration between health and education services to assess and support children with major CA, so every CA survivor can maximise their potential.
    MeSH term(s) Child ; Humans ; Female ; Pregnancy ; Child, Preschool ; Academic Success ; Cohort Studies ; Educational Status ; Longitudinal Studies ; United Kingdom/epidemiology
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2023-326471
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  5. Article ; Online: Health care utilisation and education outcomes of children with rare diseases: a born in Bradford cohort study.

    Lodh, Rajib / Hou, Bo / Hough, Amy / Oddie, Sam / Mason, Dan / Wright, John

    European journal of pediatrics

    2023  Volume 182, Issue 12, Page(s) 5511–5517

    Abstract: The purpose of this study is to describe the burden of health care utilisation and early education outcomes of children with and without rare diseases. Using the Born in Bradford birth cohort and its linked routine health care and education data, we ... ...

    Abstract The purpose of this study is to describe the burden of health care utilisation and early education outcomes of children with and without rare diseases. Using the Born in Bradford birth cohort and its linked routine health care and education data, we looked at cumulative primary care episodes, hospital admissions and medication prescriptions. We assessed education outcomes using Early Years Foundation Stage Profile and the National Curriculum Tests-Key Stage 1 results. Among analytical sample of 13,858, 1711 or 12.3% children were identified with a rare disease by an average age of 14 years. Children with rare diseases were twice more likely to be admitted to hospital compared to children without. Average length of stay was around 5 days in those with rare diseases group compared to less than 1 day in those without. The average number of primary care episodes was 45.4 in children with rare diseases and 28.2 visits in those without. These children were over three times more likely to be on multiple medications. Children with rare diseases had 30% higher risk of being below academic expectations at Foundation Year and, depending on subject, between 50 and 60% higher risks at KS1 tests.  Conclusions: Children with rare diseases are significantly more likely to have increased primary care episodes and to have more regular medications. They are likely to have more hospital admissions with a longer stay also. Educationally, they are at higher risk of failing to achieve expected standards in early-year settings. What is Known: • Existing studies of rare diseases have used cross sectional data to describe secondary care data. Previous research has not explored the impact of rare diseases on academic outcomes in children. What is New: • Using Born in Bradford birth cohort and its linked primary and secondary care data, this study provides the most comprehensive estimate of prevalence of rare diseases in any study to date. Children with rare diseases were not only significantly more likely to have contact with primary care and to be admitted to hospitals; they were also more like to be on more regular medications and had higher risk of not achieving expected standards in early-year education outcomes. • Our study is unusual in being able to access linked health and education data and reinforces the importance of adopting a whole system approach to children's health and wellbeing that recognises the close links between health and education.
    MeSH term(s) Child ; Humans ; Adolescent ; Cohort Studies ; Rare Diseases/epidemiology ; Rare Diseases/therapy ; Cross-Sectional Studies ; Hospitalization ; Patient Acceptance of Health Care
    Language English
    Publishing date 2023-10-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-023-05225-4
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  6. Article ; Online: Digital Navigator Training to Increase Access to Mental Health Care in Community-Based Organizations.

    Alon, Noy / Perret, Sarah / Cohen, Amy / Partiquin, Michelle / LeMelle, Stephanie / Boyd, Chasee / Aguilera, Jacqueline / Reat, Cristen / Hough, Elise / Walsh, Jessica / Dwyer, Bridget / Hogan, Julianna / Smith, Ashley Helm / Torous, John

    Psychiatric services (Washington, D.C.)

    2024  , Page(s) appips20230391

    Abstract: Providing human support for users of behavioral health technology can help facilitate the necessary engagement and clinical integration of digital tools in mental health care. A team conducted digital navigator training that taught participants how to ... ...

    Abstract Providing human support for users of behavioral health technology can help facilitate the necessary engagement and clinical integration of digital tools in mental health care. A team conducted digital navigator training that taught participants how to promote patrons' digital literacy, evaluate and recommend health apps, and interpret smartphone data. The authors trained 80 participants from 21 organizations, demonstrating this training's feasibility, acceptability, and need. Case studies explore the implementation of this training curriculum. As technology's potential in mental health care expands, training can empower digital navigators to ensure that the use of digital tools is informed, equitable, and clinically relevant.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.20230391
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    Zs.A 416: Show issues Location:
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  7. Article ; Online: Social media and advertising natural contraception to young women: the case for clarity and transparency with reference to the example of 'Natural Cycles'.

    Hough, Amy / Bryce, Maggie / Forrest, Simon

    BMJ sexual & reproductive health

    2018  

    Language English
    Publishing date 2018-07-21
    Publishing country England
    Document type Journal Article
    ISSN 2515-2009
    ISSN (online) 2515-2009
    DOI 10.1136/bmjsrh-2018-200110
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  8. Article ; Online: Educational attainment of children with congenital Heart disease in the United Kingdom.

    Cave, Daniel G W / Wands, Zoë E / Cromie, Kirsten / Hough, Amy / Johnson, Kathryn / Mon-Williams, Mark / Bentham, James R / Feltbower, Richard G / Glaser, Adam W

    European heart journal. Quality of care & clinical outcomes

    2023  

    Abstract: Background: Educational attainment in children with congenital heart disease (CHD) within the UK has not been reported, despite the possibility of school absences and disease-specific factors creating educational barriers.: Methods: Children were ... ...

    Abstract Background: Educational attainment in children with congenital heart disease (CHD) within the UK has not been reported, despite the possibility of school absences and disease-specific factors creating educational barriers.
    Methods: Children were prospectively recruited to the Born in Bradford birth cohort between March 2007 and December 2010. Diagnoses of CHD were identified through linkage to the congenital anomaly register and independently verified by clinicians. Multivariable regression accounted for relevant confounders. Our primary outcome was the odds of 'below expected' attainment in Maths, Reading and Writing at ages 4-11 years.
    Results: Educational records of 139 children with non-genetic CHD were compared to 11 188 age-matched children with no major congenital anomaly. Children with CHD had significantly higher odds of 'below expected' attainment in Maths at age 4-5 years (Odds Ratio 1.64, 95% CI 1.07-2.52), age 6-7 (OR 2.03, 95% CI 1.32-3.12), and age 10-11 (OR 2.28, 95% CI 1.01-5.14). Odds worsened with age, with similar results for Reading and Writing. The odds of receiving special educational needs support reduced with age for children with CHD relative to controls (age 4-5: OR 4.84 (2.06-11.40); age 6-7: OR 3.65 (2.41-5.53); age 10-11: OR 2.73 (1.84-4.06)). Attainment was similar for children with and without exposure to cardio-pulmonary bypass. Lower attainment was strongly associated with the number of pre-school hospital admissions.
    Conclusions: Children with CHD have lower educational attainment compared to their peers. Deficits are evident from school entry and increase throughout primary school.
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2823451-0
    ISSN 2058-1742 ; 2058-5225
    ISSN (online) 2058-1742
    ISSN 2058-5225
    DOI 10.1093/ehjqcco/qcad068
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  9. Article ; Online: Beyond the mask: a multidisciplinary reflection on palliating patients with COVID-19 receiving continuous positive airway pressure ventilation.

    Hough, Amy / Dell, Georgia Daisy / Blaber, Michael / Kavanagh, Diana / Lock, Anna

    International journal of palliative nursing

    2020  Volume 26, Issue 7, Page(s) 336–340

    Abstract: This narrative describes the experiences of an inner city respiratory unit that was transformed to treat COVID-19 patients with continuous positive airway pressure (CPAP) ventilation who were not scheduled for any further escalation in treatment. The ... ...

    Abstract This narrative describes the experiences of an inner city respiratory unit that was transformed to treat COVID-19 patients with continuous positive airway pressure (CPAP) ventilation who were not scheduled for any further escalation in treatment. The high mortality rate and unconventional way of dying led to the creation of local guidance for removing assisted ventilation when the treatment ceased to be effective. We reflect on the specific challenges that caring for these patients holistically has presented and how we have learnt to deliver good palliative care in a unique set of circumstances. We also consider the impact of the pandemic on our team and how the development of a multidisciplinary support system has improved team dynamics and ultimately patient care.
    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Continuous Positive Airway Pressure ; Coronavirus Infections/epidemiology ; Coronavirus Infections/nursing ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Female ; Humans ; Male ; Masks ; Palliative Care ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/nursing ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2115109-X
    ISSN 2052-286X ; 1357-6321
    ISSN (online) 2052-286X
    ISSN 1357-6321
    DOI 10.12968/ijpn.2020.26.7.336
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    Zs.A 5870: Show issues Location:
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  10. Article ; Online: Stillbirths and neonatal deaths among 18 942 women with postpartum hemorrhage: Analysis of perinatal outcomes in the WOMAN trial.

    Hough, Amy / Shakur-Still, Haleema / Roberts, Ian / Koukounari, Artemis / Lawn, Joy E

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2020  Volume 153, Issue 1, Page(s) 146–153

    Abstract: Objective: To describe the rates and risk factors for stillbirth and pre-discharge neonatal mortality (PDNM), and impact on quality of life (QoL) among women with postpartum hemorrhage (PPH).: Methods: A secondary analysis was conducted of the WOMAN ... ...

    Abstract Objective: To describe the rates and risk factors for stillbirth and pre-discharge neonatal mortality (PDNM), and impact on quality of life (QoL) among women with postpartum hemorrhage (PPH).
    Methods: A secondary analysis was conducted of the WOMAN trial, which evaluated the use of tranexamic acid for PPH and collected infant outcome data to assess drug safety. The analysis was restricted to singletons (n=18 942). Overall and country-level rates of stillbirth and PDNM were calculated. Multilevel logistic regression models examined the association of stillbirth and PDNM with selected risks, and the association of mother's QoL at discharge after stillbirth or PDNM.
    Results: For women with PPH, the rate of stillbirths was 104.42 per 1000 births (n=1978) and the rate of PDNM was 15.56 per 1000 live births (n=264). Cesarean delivery, increasing blood loss, maternal complications, and maternal death were strongly associated with these adverse outcomes. Women with stillbirth and PDNM were significantly more likely to report poorer QoL.
    Conclusion: Women with PPH experience an extremely high rate of stillbirth and slightly elevated PDNM, which is associated with markers of the severity of their condition and impacts on their QoL.
    MeSH term(s) Adult ; Cesarean Section/adverse effects ; Female ; Humans ; Infant ; Infant Mortality ; Infant, Newborn ; Maternal Death ; Perinatal Death/etiology ; Postpartum Hemorrhage/epidemiology ; Pregnancy ; Quality of Life ; Risk Factors ; Stillbirth/epidemiology ; Young Adult
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.13413
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