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Book ; Online: Virusökologische Untersuchungen zur Bornaschen Krankheit in Bayern

Bourg, Manon

(Edition scientifique)

2018

Institution	VVB LAUFERSWEILER Verlag
Author's details	Manon Bourg
Series title	Edition scientifique
Keywords	Borna-Krankheit ; Karnivoren ; Bornavirus ; Infektion ; Kleinsäuger ; Bayern
Language	German
Size	1 Online-Ressource
Document type	Book ; Online
Note	In: Giessen : VVB Laufersweiler Verlag
ISBN	9783835967007 ; 3835967002
Database	Special collection on veterinary medicine and general parasitology

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Book ; Online ; Thesis: Virusökologische Untersuchungen zur Bornaschen Krankheit in Bayern

Bourg, Manon [Verfasser]

2018

Author's details	Manon Bourg
Keywords	Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
Subject code	sg630
Language	German
Publisher	Universitätsbibliothek
Publishing place	Gießen
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Usutu Virus Africa 3 Lineage, Luxembourg, 2020.

Snoeck, Chantal J / Sausy, Aurélie / Losch, Serge / Wildschutz, Félix / Bourg, Manon / Hübschen, Judith M

Emerging infectious diseases

2022 Volume 28, Issue 5, Page(s) 1076–1079

Abstract: We detected Usutu virus in a dead Eurasian blackbird (Turdus merula) in Luxembourg in September 2020. The strain clustered within the Africa 3.1 lineage identified in Western Europe since 2016. Our results suggest maintenance of the virus in Europe ... ...

Abstract	We detected Usutu virus in a dead Eurasian blackbird (Turdus merula) in Luxembourg in September 2020. The strain clustered within the Africa 3.1 lineage identified in Western Europe since 2016. Our results suggest maintenance of the virus in Europe despite little reporting during 2019-2020, rather than a new introduction.
MeSH term(s)	Animals ; Bird Diseases ; Flavivirus ; Flavivirus Infections ; Luxembourg/epidemiology ; Phylogeny
Language	English
Publishing date	2022-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2805.212012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Is in vitro maturation of oocytes retrieved ex vivo from ovarian tissue an effective fertility preservation technique in the presence of organic ovarian cysts?

Bourg, Mona / Moreau, Jessika / Carles, Manon / Cadoret, Florence / Lesourd, Florence / Tournier, Anna / Léandri, Roger D / Gatimel, Nicolas

European journal of obstetrics, gynecology, and reproductive biology

2022 Volume 281, Page(s) 87–91

Abstract: Objective(s): In vitro maturation (IVM) of oocytes retrieved ex vivo from ovarian tissue (OTO-IVM) could be an additional source of mature oocytes with the potential to optimise medical fertility preservation (FP) after oophorectomy. It is often ... ...

Abstract	Objective(s): In vitro maturation (IVM) of oocytes retrieved ex vivo from ovarian tissue (OTO-IVM) could be an additional source of mature oocytes with the potential to optimise medical fertility preservation (FP) after oophorectomy. It is often undertaken at the same time as the ovarian tissue cryopreservation (OTC). In the presence of an organic ovarian cyst, OTO-IVM could prove to be the only technique available to permit FP since ovarian stimulation, transvaginal ovarian needle puncture or future ovarian tissue graft are contraindicated. However, the presence of an organic cyst could alter follicular growth and the number of retrievd oocytes. Our study aims to assess the efficiency of OTO-IVM in such situations. Study design: Retrospective, observational study involving 20 female patients with FP by OTO-IVM between May 2017 and November 2021 at the University Hospital of Toulouse. Oocytes retrieved "ex vivo" were transferred to an IVM medium with HP-hMG, LH and HSA and then vitrified after 24 to 48 h of IVM. Data analysis was performed on the total population and comparatively between patients who had or did not have an organic ovarian cyst. Results: The indications included 15 oncologic and 5 non-oncologic indications. Ten had an organic ovarian cyst on the retrieved ovary. The number of retrieved oocytes was 17.4+/-12.0 in the absence of cyst vs 4.1+/-6.3 in the presence (p = 0.003). The number of vitrified mature oocytes was 5.8+/-5.3 in the absence vs 1.1+/-2.2 (median = 0) in the presence of a cyst (p = 0.03). Ninety percent of the patients with an organic cyst had less than two vitrified mature oocytes. The mean maturation rate was 34%, not significantly different between the two groups. We found a correlation between serum AMH level and the number of mature oocytes: ρ:0.47 CI95 = [0.02; 0.76]; p = 0.04. Conclusion(s): OTO-IVM is an additional source of mature oocytes to optimise FP after oophorectomy. However, in the presence of an organic ovarian cyst on the retrieved ovary, the exocrine, paracrine and endocrine functions of the ovary are impaired. As such, the number of immature oocytes obtained is highly impacted and appears to be insufficient to be able to propose systematically this technique in such situations.
MeSH term(s)	Humans ; Female ; Fertility Preservation/methods ; In Vitro Oocyte Maturation Techniques/methods ; Retrospective Studies ; Oocytes/physiology ; Cryopreservation/methods ; Ovarian Cysts/surgery ; Cysts
Language	English
Publishing date	2022-12-27
Publishing country	Ireland
Document type	Observational Study ; Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2022.12.025
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Article: Dual Blockade of Misfolded Alpha-Sarcoglycan Degradation by Bortezomib and Givinostat Combination.

Hoch, Lucile / Bourg, Nathalie / Degrugillier, Fanny / Bruge, Céline / Benabides, Manon / Pellier, Emilie / Tournois, Johana / Mahé, Gurvan / Maignan, Nicolas / Dawe, Jack / Georges, Maxime / Papazian, David / Subramanian, Nik / Simon, Stéphanie / Fanen, Pascale / Delevoye, Cédric / Richard, Isabelle / Nissan, Xavier

Frontiers in pharmacology

2022 Volume 13, Page(s) 856804

Abstract: Limb-girdle muscular dystrophy type R3 (LGMD R3) is a rare genetic disorder characterized by a progressive proximal muscle weakness and caused by mutations in ... ...

Abstract	Limb-girdle muscular dystrophy type R3 (LGMD R3) is a rare genetic disorder characterized by a progressive proximal muscle weakness and caused by mutations in the
Language	English
Publishing date	2022-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.856804
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nearly Complete Genome Sequences of Two Bluetongue Viruses Isolated during the 2020 Outbreak in the Grand Duchy of Luxembourg.

Vandenbussche, Frank / Bourg, Manon / Mathijs, Elisabeth / Lefebvre, David J / De Leeuw, Ilse / Haegeman, Andy / Aerts, Laetitia / Van Borm, Steven / De Clercq, Kris

Microbiology resource announcements

2021 Volume 10, Issue 14

Abstract: Bluetongue is one of the major diseases of ruminants listed by the World Organisation for Animal Health. Bluetongue virus serotype 8 (BTV-8) has been considered enzootic in France since 2018. Here, we report the nearly complete genome sequences of two ... ...

Abstract	Bluetongue is one of the major diseases of ruminants listed by the World Organisation for Animal Health. Bluetongue virus serotype 8 (BTV-8) has been considered enzootic in France since 2018. Here, we report the nearly complete genome sequences of two BTV-8 isolates from the 2020 outbreak in the Grand Duchy of Luxembourg.
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/MRA.00210-21
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Molecular and virological characterization of the first poultry outbreaks of Genotype VII.2 velogenic avian orthoavulavirus type 1 (NDV) in North-West Europe, BeNeLux, 2018.

Steensels, Mieke / Van Borm, Steven / Mertens, Ingeborg / Houdart, Philippe / Rauw, Fabienne / Roupie, Virginie / Snoeck, Chantal J / Bourg, Manon / Losch, Serge / Beerens, Nancy / van den Berg, Thierry / Lambrecht, Bénédicte

Transboundary and emerging diseases

2020 Volume 68, Issue 4, Page(s) 2147–2160

Abstract: After two decades free of Newcastle disease, Belgium encountered a velogenic avian orthoavulavirus type 1 epizootic in 2018. In Belgium, 20 cases were diagnosed, of which 15 occurred in hobby flocks, 2 in professional poultry flocks and 3 in poultry ... ...

Abstract	After two decades free of Newcastle disease, Belgium encountered a velogenic avian orthoavulavirus type 1 epizootic in 2018. In Belgium, 20 cases were diagnosed, of which 15 occurred in hobby flocks, 2 in professional poultry flocks and 3 in poultry retailers. The disease also disseminated from Belgium towards the Grand Duchy of Luxembourg by trade. Independently, the virus was detected once in the Netherlands, almost simultaneously to the first Belgian detection. As such Newcastle disease emerged in the entire BeNeLux region. Both the polybasic sequence of the fusion gene cleavage site and the intracerebral pathotyping assay demonstrated the high pathogenicity of the strain. This paper represents the first notification of this specific VII.2 subgenotype in the North-West of Europe. Time-calibrated full genome phylogenetic analysis indicated the silent or unreported circulation of the virus prior to the emergence of three genetic clusters in the BeNeLux region without clear geographical or other epidemiological correlation. The Dutch strain appeared as an outgroup to the Belgian and Luxembourgian strains in the time-correlated genetic analysis and no epidemiological link could be identified between the Belgian and Dutch outbreaks. In contrast, both genetic and epidemiological outbreak investigation data linked the G.D. Luxembourg case to the Belgian outbreak. The genetic links between Belgian viruses from retailers and hobby flocks only partially correlated with epidemiological data. Two independent introductions into the professional poultry sector were identified, although their origin could not be determined. Animal experiments using 6-week- old specific pathogen-free chickens indicated a systemic infection and efficient transmission of the virus. The implementation of re-vaccination in the professional sector, affected hobby and retailers, as well as the restriction on assembly and increased biosecurity measures, possibly limited the epizootic and resulted in the disappearance of the virus. These findings emphasize the constant need for awareness and monitoring of notifiable viruses in the field.
MeSH term(s)	Animals ; Chickens ; Disease Outbreaks/veterinary ; Europe/epidemiology ; Genotype ; Newcastle Disease/epidemiology ; Newcastle disease virus/genetics ; Phylogeny ; Poultry ; Poultry Diseases/epidemiology
Language	English
Publishing date	2020-10-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.13863
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: High pathogenic avian influenza A(H5) viruses of clade 2.3.4.4b in Europe-Why trends of virus evolution are more difficult to predict.

Fusaro, Alice / Zecchin, Bianca / Giussani, Edoardo / Palumbo, Elisa / Agüero-García, Montserrat / Bachofen, Claudia / Bálint, Ádám / Banihashem, Fereshteh / Banyard, Ashley C / Beerens, Nancy / Bourg, Manon / Briand, Francois-Xavier / Bröjer, Caroline / Brown, Ian H / Brugger, Brigitte / Byrne, Alexander M P / Cana, Armend / Christodoulou, Vasiliki / Dirbakova, Zuzana /

Fagulha, Teresa / Fouchier, Ron A M / Garza-Cuartero, Laura / Georgiades, George / Gjerset, Britt / Grasland, Beatrice / Groza, Oxana / Harder, Timm / Henriques, Ana Margarida / Hjulsager, Charlotte Kristiane / Ivanova, Emiliya / Janeliunas, Zygimantas / Krivko, Laura / Lemon, Ken / Liang, Yuan / Lika, Aldin / Malik, Péter / McMenamy, Michael J / Nagy, Alexander / Nurmoja, Imbi / Onita, Iuliana / Pohlmann, Anne / Revilla-Fernández, Sandra / Sánchez-Sánchez, Azucena / Savic, Vladimir / Slavec, Brigita / Smietanka, Krzysztof / Snoeck, Chantal J / Steensels, Mieke / Svansson, Vilhjálmur / Swieton, Edyta / Tammiranta, Niina / Tinak, Martin / Van Borm, Steven / Zohari, Siamak / Adlhoch, Cornelia / Baldinelli, Francesca / Terregino, Calogero / Monne, Isabella

Virus evolution

2024 Volume 10, Issue 1, Page(s) veae027

Abstract: Since 2016, A(H5Nx) high pathogenic avian influenza (HPAI) virus of clade 2.3.4.4b has become one of the most serious global threats not only to wild and domestic birds, but also to public health. In recent years, important changes in the ecology, ... ...

Abstract	Since 2016, A(H5Nx) high pathogenic avian influenza (HPAI) virus of clade 2.3.4.4b has become one of the most serious global threats not only to wild and domestic birds, but also to public health. In recent years, important changes in the ecology, epidemiology, and evolution of this virus have been reported, with an unprecedented global diffusion and variety of affected birds and mammalian species. After the two consecutive and devastating epidemic waves in Europe in 2020-2021 and 2021-2022, with the second one recognized as one of the largest epidemics recorded so far, this clade has begun to circulate endemically in European wild bird populations. This study used the complete genomes of 1,956 European HPAI A(H5Nx) viruses to investigate the virus evolution during this varying epidemiological outline. We investigated the spatiotemporal patterns of A(H5Nx) virus diffusion to/from and within Europe during the 2020-2021 and 2021-2022 epidemic waves, providing evidence of ongoing changes in transmission dynamics and disease epidemiology. We demonstrated the high genetic diversity of the circulating viruses, which have undergone frequent reassortment events, providing for the first time a complete overview and a proposed nomenclature of the multiple genotypes circulating in Europe in 2020-2022. We described the emergence of a new genotype with gull adapted genes, which offered the virus the opportunity to occupy new ecological niches, driving the disease endemicity in the European wild bird population. The high propensity of the virus for reassortment, its jumps to a progressively wider number of host species, including mammals, and the rapid acquisition of adaptive mutations make the trend of virus evolution and spread difficult to predict in this unfailing evolving scenario.
Language	English
Publishing date	2024-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2818949-8
ISSN	2057-1577
ISSN	2057-1577
DOI	10.1093/ve/veae027
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Article: Molecular and virological characterization of the first poultry outbreaks of Genotype VII.2 velogenic avian orthoavulavirus type 1 (NDV) in North‐West Europe, BeNeLux, 2018

Steensels, Mieke / Van Borm, Steven / Mertens, Ingeborg / Houdart, Philippe / Rauw, Fabienne / Roupie, Virginie / Snoeck, Chantal J. / Bourg, Manon / Losch, Serge / Beerens, Nancy / van den Berg, Thierry / Lambrecht, Bénédicte

Transboundary and emerging diseases. 2021 July, v. 68, no. 4

2021

Abstract	After two decades free of Newcastle disease, Belgium encountered a velogenic avian orthoavulavirus type 1 epizootic in 2018. In Belgium, 20 cases were diagnosed, of which 15 occurred in hobby flocks, 2 in professional poultry flocks and 3 in poultry retailers. The disease also disseminated from Belgium towards the Grand Duchy of Luxembourg by trade. Independently, the virus was detected once in the Netherlands, almost simultaneously to the first Belgian detection. As such Newcastle disease emerged in the entire BeNeLux region. Both the polybasic sequence of the fusion gene cleavage site and the intracerebral pathotyping assay demonstrated the high pathogenicity of the strain. This paper represents the first notification of this specific VII.2 subgenotype in the North‐West of Europe. Time‐calibrated full genome phylogenetic analysis indicated the silent or unreported circulation of the virus prior to the emergence of three genetic clusters in the BeNeLux region without clear geographical or other epidemiological correlation. The Dutch strain appeared as an outgroup to the Belgian and Luxembourgian strains in the time‐correlated genetic analysis and no epidemiological link could be identified between the Belgian and Dutch outbreaks. In contrast, both genetic and epidemiological outbreak investigation data linked the G.D. Luxembourg case to the Belgian outbreak. The genetic links between Belgian viruses from retailers and hobby flocks only partially correlated with epidemiological data. Two independent introductions into the professional poultry sector were identified, although their origin could not be determined. Animal experiments using 6‐week‐ old specific pathogen‐free chickens indicated a systemic infection and efficient transmission of the virus. The implementation of re‐vaccination in the professional sector, affected hobby and retailers, as well as the restriction on assembly and increased biosecurity measures, possibly limited the epizootic and resulted in the disappearance of the virus. These findings emphasize the constant need for awareness and monitoring of notifiable viruses in the field.
Keywords	Newcastle disease ; biosecurity ; epizootic diseases ; genes ; genetic analysis ; outbreak investigation ; pathogenicity ; phylogeny ; specific pathogen-free animals ; subgenotype ; trade ; viruses ; Belgium ; Luxembourg ; Netherlands ; Northern European region
Language	English
Dates of publication	2021-07
Size	p. 2147-2160.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.13863
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification of thiostrepton as a pharmacological approach to rescue misfolded alpha-sarcoglycan mutant proteins from degradation.

Hoch, Lucile / Henriques, Sara F / Bruge, Celine / Marsolier, Justine / Benabides, Manon / Bourg, Nathalie / Tournois, Johana / Mahé, Gurvan / Morizur, Lise / Jarrige, Margot / Bigot, Anne / Richard, Isabelle / Nissan, Xavier

Scientific reports

2019 Volume 9, Issue 1, Page(s) 6915

Abstract: Limb-girdle muscular dystrophy type 2D (LGMD2D) is characterized by a progressive proximal muscle weakness. LGMD2D is caused by mutations in the gene encoding α-sarcoglycan (α-SG), a dystrophin-associated glycoprotein that plays a key role in the ... ...

Abstract	Limb-girdle muscular dystrophy type 2D (LGMD2D) is characterized by a progressive proximal muscle weakness. LGMD2D is caused by mutations in the gene encoding α-sarcoglycan (α-SG), a dystrophin-associated glycoprotein that plays a key role in the maintenance of sarcolemma integrity in striated muscles. We report here on the development of a new in vitro high-throughput screening assay that allows the monitoring of the proper localization of the most prevalent mutant form of α-SG (R77C substitution). Using this assay, we screened a library of 2560 FDA-approved drugs and bioactive compounds and identified thiostrepton, a cyclic antibiotic, as a potential drug to repurpose for LGMD2D treatment. Characterization of the thiostrepton effect revealed a positive impact on R77C-α-SG and other missense mutant protein localization (R34H, I124T, V247M) in fibroblasts overexpressing these proteins. Finally, further investigations of the molecular mechanisms of action of the compound revealed an inhibition of the chymotrypsin-like activity of the proteasome 24 h after thiostrepton treatment and a synergistic effect with bortezomib, an FDA-approved proteasome inhibitor. This study reports on the first in vitro model for LGMD2D that is compatible with high-throughput screening and proposes a new therapeutic option for LGMD2D caused by missense mutations of α-SG.
MeSH term(s)	Cell Line ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Drug Evaluation, Preclinical ; Humans ; Induced Pluripotent Stem Cells/cytology ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Myoblasts/cytology ; Myoblasts/drug effects ; Protein Folding/drug effects ; Proteolysis/drug effects ; Sarcoglycans/chemistry ; Sarcoglycans/genetics ; Sarcoglycans/metabolism ; Thiostrepton/pharmacology
Chemical Substances	Mutant Proteins ; Sarcoglycans ; Thiostrepton (HR4S203Y18)
Language	English
Publishing date	2019-05-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-43399-w
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