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  1. Article ; Online: Heart Failure in Menopause: Treatment and New Approaches.

    da Silva, Jaqueline S / Montagnoli, Tadeu Lima / de Sá, Mauro Paes Leme / Zapata-Sudo, Gisele

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: Aging is an important risk factor for the development of heart failure (HF) and half of patients with HF have preserved ejection fraction (HFpEF) which is more common in elderly women. In general, sex differences that lead to discrepancies in risk ... ...

    Abstract Aging is an important risk factor for the development of heart failure (HF) and half of patients with HF have preserved ejection fraction (HFpEF) which is more common in elderly women. In general, sex differences that lead to discrepancies in risk factors and to the development of cardiovascular disease (CVD) have been attributed to the reduced level of circulating estrogen during menopause. Estrogen receptors adaptively modulate fibrotic, apoptotic, inflammatory processes and calcium homeostasis, factors that are directly involved in the HFpEF. Therefore, during menopause, estrogen depletion reduces the cardioprotection. Preclinical menopause models demonstrated that several signaling pathways and organ systems are closely involved in the development of HFpEF, including dysregulation of the renin-angiotensin system (RAS), chronic inflammatory process and alteration in the sympathetic nervous system. Thus, this review explores thealterations observed in the condition of HFpEF induced by menopause and the therapeutic targets with potential to interfere with the disease progress.
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232315140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Heart Failure in Menopause

    Jaqueline S. da Silva / Tadeu Lima Montagnoli / Mauro Paes Leme de Sá / Gisele Zapata-Sudo

    International Journal of Molecular Sciences, Vol 23, Iss 15140, p

    Treatment and New Approaches

    2022  Volume 15140

    Abstract: Aging is an important risk factor for the development of heart failure (HF) and half of patients with HF have preserved ejection fraction (HFpEF) which is more common in elderly women. In general, sex differences that lead to discrepancies in risk ... ...

    Abstract Aging is an important risk factor for the development of heart failure (HF) and half of patients with HF have preserved ejection fraction (HFpEF) which is more common in elderly women. In general, sex differences that lead to discrepancies in risk factors and to the development of cardiovascular disease (CVD) have been attributed to the reduced level of circulating estrogen during menopause. Estrogen receptors adaptively modulate fibrotic, apoptotic, inflammatory processes and calcium homeostasis, factors that are directly involved in the HFpEF. Therefore, during menopause, estrogen depletion reduces the cardioprotection. Preclinical menopause models demonstrated that several signaling pathways and organ systems are closely involved in the development of HFpEF, including dysregulation of the renin-angiotensin system (RAS), chronic inflammatory process and alteration in the sympathetic nervous system. Thus, this review explores thealterations observed in the condition of HFpEF induced by menopause and the therapeutic targets with potential to interfere with the disease progress.
    Keywords heartfailure ; diastolic dysfunction ; menopausal ; estrogen ; therapeutic targets ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article: The aorta, the elastic tissue and cystic medial necrosis.

    Sá, Mauro Paes Leme de

    Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular

    2011  Volume 26, Issue 1, Page(s) III–V

    MeSH term(s) Aorta ; Aortic Aneurysm, Thoracic ; Cysts ; Elastic Tissue ; Elastin/genetics ; Elastin/physiology ; Fibrillins ; Humans ; Microfilament Proteins/physiology
    Chemical Substances Fibrillins ; Microfilament Proteins ; Elastin (9007-58-3)
    Language English
    Publishing date 2011-11-01
    Publishing country Brazil
    Document type Editorial
    DOI 10.1590/s0102-76382011000100002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A aorta, o tecido elástico e a necrose cística da média The aorta, the elastic tissue and cystic medial necrosis

    Mauro Paes Leme de Sá

    Revista Brasileira de Cirurgia Cardiovascular, Vol 26, Iss 1, Pp III-V (2011)

    2011  

    Keywords Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2011-03-01T00:00:00Z
    Publisher Sociedade Brasileira de Cirurgia Cardiovascular
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Mesenchymal Stem Cells Therapies on Fibrotic Heart Diseases.

    Gubert, Fernanda / da Silva, Jaqueline Soares / Vasques, Juliana F / de Jesus Gonçalves, Renata Guedes / Martins, Robertta Silva / de Sá, Mauro Paes Leme / Mendez-Otero, Rosalia / Zapata-Sudo, Gisele

    International journal of molecular sciences

    2021  Volume 22, Issue 14

    Abstract: Stem cell therapy is a promising alternative approach to heart diseases. The most prevalent source of multipotent stem cells, usually called somatic or adult stem cells (mesenchymal stromal/stem cells, MSCs) used in clinical trials is bone marrow (BM- ... ...

    Abstract Stem cell therapy is a promising alternative approach to heart diseases. The most prevalent source of multipotent stem cells, usually called somatic or adult stem cells (mesenchymal stromal/stem cells, MSCs) used in clinical trials is bone marrow (BM-MSCs), adipose tissue (AT-MSCs), umbilical cord (UC-MSCs) and placenta. Therapeutic use of MSCs in cardiovascular diseases is based on the benefits in reducing cardiac fibrosis and inflammation that compose the cardiac remodeling responsible for the maintenance of normal function, something which may end up causing progressive and irreversible dysfunction. Many factors lead to cardiac fibrosis and failure, and an effective therapy is lacking to reverse or attenuate this condition. Different approaches have been shown to be promising in surpassing the poor survival of transplanted cells in cardiac tissue to provide cardioprotection and prevent cardiac remodeling. This review includes the description of pre-clinical and clinical investigation of the therapeutic potential of MSCs in improving ventricular dysfunction consequent to diverse cardiac diseases.
    MeSH term(s) Animals ; Fibrosis/therapy ; Heart Diseases/therapy ; Humans ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/cytology
    Language English
    Publishing date 2021-07-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22147447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mesenchymal Stem Cells Therapies on Fibrotic Heart Diseases

    Fernanda Gubert / Jaqueline Soares da Silva / Juliana F. Vasques / Renata Guedes de Jesus Gonçalves / Robertta Silva Martins / Mauro Paes Leme de Sá / Rosalia Mendez-Otero / Gisele Zapata-Sudo

    International Journal of Molecular Sciences, Vol 22, Iss 7447, p

    2021  Volume 7447

    Abstract: Stem cell therapy is a promising alternative approach to heart diseases. The most prevalent source of multipotent stem cells, usually called somatic or adult stem cells (mesenchymal stromal/stem cells, MSCs) used in clinical trials is bone marrow (BM- ... ...

    Abstract Stem cell therapy is a promising alternative approach to heart diseases. The most prevalent source of multipotent stem cells, usually called somatic or adult stem cells (mesenchymal stromal/stem cells, MSCs) used in clinical trials is bone marrow (BM-MSCs), adipose tissue (AT-MSCs), umbilical cord (UC-MSCs) and placenta. Therapeutic use of MSCs in cardiovascular diseases is based on the benefits in reducing cardiac fibrosis and inflammation that compose the cardiac remodeling responsible for the maintenance of normal function, something which may end up causing progressive and irreversible dysfunction. Many factors lead to cardiac fibrosis and failure, and an effective therapy is lacking to reverse or attenuate this condition. Different approaches have been shown to be promising in surpassing the poor survival of transplanted cells in cardiac tissue to provide cardioprotection and prevent cardiac remodeling. This review includes the description of pre-clinical and clinical investigation of the therapeutic potential of MSCs in improving ventricular dysfunction consequent to diverse cardiac diseases.
    Keywords mesenchymal stem cells ; cardiac fibrosis ; cardiovascular diseases ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Bicuspid aortic valve: theoretical and clinical aspects of concomitant ascending aorta replacement.

    De Sá, Mauro Paes Leme / Bastos, Eduardo Sergio / Murad, Henrique

    Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular

    2010  Volume 24, Issue 2, Page(s) 218–224

    Abstract: Bicuspid aortic valve (BAV) is associated with annuloaortic ectasia, dissection and ascending aortic aneurysm. The high incidence of this congenital malformation and aortic disease suggests a close correlation between the two phenomena. Abnormalities in ... ...

    Abstract Bicuspid aortic valve (BAV) is associated with annuloaortic ectasia, dissection and ascending aortic aneurysm. The high incidence of this congenital malformation and aortic disease suggests a close correlation between the two phenomena. Abnormalities in different phases of cell migration of the neural crest might be responsible for the occurrence of abnormalities in the aortic valve, media layer of the ascending aorta and vessels of the aortic arch. Previous studies have shown that patients with normal BAV or slight dysfunction may present with dilation of the aortic root. The hemodynamic changes caused by BAV without stenosis or insufficiency seem to be an insufficient explanation for these findings. Several mechanisms have been proposed to explain the molecular and hystological aspects of this disease. We found a reduced fibrillin-1 content in both ascending aorta and pulmonary trunk as a possible cause. Histologically, the ascending aorta can present cystic medial necrosis and elastic fragmentation, similar to Marfan's disease. Some authors concluded that many patients, mainly those with aortic regurgitation, should have the aortic valve and the ascending aorta replaced at the same procedure, even if a mild dilatation (45 mm) is present in patients with BAV if life expectancy is anticipated to be greater than 10 years to prevent further aneurysms or ruptures.
    MeSH term(s) Aorta/pathology ; Aorta/surgery ; Aortic Aneurysm/prevention & control ; Aortic Valve/abnormalities ; Aortic Valve/embryology ; Aortic Valve/surgery ; Aortic Valve Insufficiency/congenital ; Aortic Valve Insufficiency/embryology ; Aortic Valve Insufficiency/surgery ; Humans
    Language English
    Publishing date 2010-03-01
    Publishing country Brazil
    Document type Journal Article ; Review
    DOI 10.1590/s0102-76382009000200019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Technical option for temporary coronary clamping in off pump coronary surgery.

    Segalote, Rodrigo Coelho / Noronha, André Prado / Sá, Mauro Paes Leme de / Murad, Henrique

    Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular

    2010  Volume 25, Issue 1, Page(s) 124–125

    MeSH term(s) Constriction ; Coronary Artery Bypass, Off-Pump/instrumentation ; Coronary Artery Bypass, Off-Pump/methods ; Coronary Disease/surgery ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2010-06-01
    Publishing country Brazil
    Document type Case Reports ; Journal Article ; Webcasts
    DOI 10.1590/s0102-76382010000100026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Opção técnica para pinçamento coronariano temporário em cirurgia de revascularização do miocárdio sem circulação extracorpórea Technical option for temporary coronary clamping in off pump coronary surgery

    Rodrigo Coelho Segalote / André Prado Noronha / Mauro Paes Leme de Sá / Henrique Murad

    Revista Brasileira de Cirurgia Cardiovascular, Vol 25, Iss 1, Pp 124-

    2010  Volume 125

    Keywords Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2010-03-01T00:00:00Z
    Publisher Sociedade Brasileira de Cirurgia Cardiovascular
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  10. Article ; Online: Valva aórtica bicúspide

    Mauro Paes Leme De Sá / Eduardo Sergio Bastos / Henrique Murad

    Revista Brasileira de Cirurgia Cardiovascular, Vol 24, Iss 2, Pp 218-

    fundamentos teóricos e clínicos para substituição simultânea da aorta ascendente Bicuspid aortic valve: theoretical and clinical aspects of concomitant ascending aorta replacement

    2009  Volume 224

    Abstract: ... complicações vasculares observadas nos portadores de VAB. Vários mecanismos têm sido propostos para explicar os ... cística da média e fragmentação elástica, semelhante àquela encontrada em portadores de síndrome de Marfan ... insuficiência aórtica, mesmo na presença de uma discreta dilatação (45 mm) deve-se substituir a valva aórtica e ...

    Abstract A valva aórtica bicúspide (VAB) está associada à ectasia ânulo-aórtica, aneurisma e dissecção da aorta ascendente. A alta incidência desta malformação congênita e doença da aorta sugere íntima relação entre os fenômenos. Anormalidades ocorrendo em diferentes fases da migração das células da crista neural podem ser responsáveis pela ocorrência em anormalidades na valva aórtica, na camada média da aorta ascendente e nos vasos do arco aórtico. Estudos prévios revelam que mesmo indivíduos com VAB normal ou com disfunção leve podem apresentar dilatação da raiz aórtica. Os autores acreditam que somente as alterações hemodinâmicas produzidas por uma VAB sem estenose ou insuficiência parecem ser insuficientes para as graves complicações vasculares observadas nos portadores de VAB. Vários mecanismos têm sido propostos para explicar os achados moleculares e histológicos desta doença. Encontramos a redução da fibrilina-1 na aorta ascendente e artéria pulmonar como possível causa. Histologicamente, a aorta ascendente pode apresentar necrose cística da média e fragmentação elástica, semelhante àquela encontrada em portadores de síndrome de Marfan. Vários autores atualmente recomendam que em se operando um paciente com VAB, especialmente aqueles com insuficiência aórtica, mesmo na presença de uma discreta dilatação (45 mm) deve-se substituir a valva aórtica e a aorta ascendente concomitantemente quando a expectativa de vida exceder 10 anos, para se prevenir futuros aneurismas ou rupturas. Bicuspid aortic valve (BAV) is associated with annuloaortic ectasia, dissection and ascending aortic aneurysm. The high incidence of this congenital malformation and aortic disease suggests a close correlation between the two phenomena. Abnormalities in different phases of cell migration of the neural crest might be responsible for the occurrence of abnormalities in the aortic valve, media layer of the ascending aorta and vessels of the aortic arch. Previous studies have shown that patients with normal BAV or slight dysfunction may present with dilation of the aortic root. The hemodynamic changes caused by BAV without stenosis or insufficiency seem to be an insufficient explanation for these findings. Several mechanisms have been proposed to explain the molecular and hystological aspects of this disease. We found a reduced fibrillin-1 content in both ascending aorta and pulmonary trunk as a possible cause. Histologically, the ascending aorta can present cystic medial necrosis and elastic fragmentation, similar to Marfan's disease. Some authors concluded that many patients, mainly those with aortic regurgitation, should have the aortic valve and the ascending aorta replaced at the same procedure, even if a mild dilatation (45 mm) is present in patients with BAV if life expectancy is anticipated to be greater than 10 years to prevent further aneurysms or ruptures.
    Keywords Valva aórtica ; Aneurisma da aorta torácica ; Insuficiência da valva aórtica ; Aorta ; Aortic valve ; Aortic aneurysm ; thoracic ; Aortic valve insufficiency ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2009-06-01T00:00:00Z
    Publisher Sociedade Brasileira de Cirurgia Cardiovascular
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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