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  1. Article ; Online: Metastases go with the flow.

    Goetz, Jacky G

    Science (New York, N.Y.)

    2018  Volume 362, Issue 6418, Page(s) 999–1000

    MeSH term(s) Animals ; Biomechanical Phenomena ; Blood Circulation ; Humans ; Mice ; Microvessels/physiopathology ; Neoplasm Metastasis/physiopathology ; Neoplastic Cells, Circulating/pathology
    Language English
    Publishing date 2018-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aat9100
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  2. Article: Exploiting Anatomical Landmarks for Efficient In Vivo CLEM.

    Goetz, Jacky G

    Trends in biochemical sciences

    2018  Volume 43, Issue 10, Page(s) 744–747

    Abstract: Established protocols for correlating intravital microscopy with electron microscopy remain cumbersome and mostly rely on a combination of artificial fiducials with anatomical landmarks. A recent study describes a new workflow, achieving label-free 3D ... ...

    Abstract Established protocols for correlating intravital microscopy with electron microscopy remain cumbersome and mostly rely on a combination of artificial fiducials with anatomical landmarks. A recent study describes a new workflow, achieving label-free 3D correlative light and electron microscopy in the mouse brain.
    Language English
    Publishing date 2018-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2018.08.003
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  3. Article ; Online: Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases.

    Mittelheisser, Vincent / Gensbittel, Valentin / Bonati, Lucia / Li, Weilin / Tang, Li / Goetz, Jacky G

    Nature nanotechnology

    2024  Volume 19, Issue 3, Page(s) 281–297

    Abstract: Disease progression is usually accompanied by changes in the biochemical composition of cells and tissues and their biophysical properties. For instance, hallmarks of cancer include the stiffening of tissues caused by extracellular matrix remodelling and ...

    Abstract Disease progression is usually accompanied by changes in the biochemical composition of cells and tissues and their biophysical properties. For instance, hallmarks of cancer include the stiffening of tissues caused by extracellular matrix remodelling and the softening of individual cancer cells. In this context, accumulating evidence has shown that immune cells sense and respond to mechanical signals from the environment. However, the mechanisms regulating these mechanical aspects of immune surveillance remain partially understood. The growing appreciation for the 'mechano-immunology' field has urged researchers to investigate how immune cells sense and respond to mechanical cues in various disease settings, paving the way for the development of novel engineering strategies that aim at mechanically modulating and potentiating immune cells for enhanced immunotherapies. Recent pioneer developments in this direction have laid the foundations for leveraging 'mechanical immunoengineering' strategies to treat various diseases. This Review first outlines the mechanical changes occurring during pathological progression in several diseases, including cancer, fibrosis and infection. We next highlight the mechanosensitive nature of immune cells and how mechanical forces govern the immune responses in different diseases. Finally, we discuss how targeting the biomechanical features of the disease milieu and immune cells is a promising strategy for manipulating therapeutic outcomes.
    MeSH term(s) Humans ; Monitoring, Immunologic ; Neoplasms/therapy ; Neoplasms/pathology ; Immunotherapy ; Immunity
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2254964-X
    ISSN 1748-3395 ; 1748-3387
    ISSN (online) 1748-3395
    ISSN 1748-3387
    DOI 10.1038/s41565-023-01535-8
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  4. Article ; Online: Organelle morphology and positioning orchestrate physiological and disease-associated processes.

    Jerabkova-Roda, Katerina / Marwaha, Rituraj / Das, Tamal / Goetz, Jacky G

    Current opinion in cell biology

    2023  Volume 86, Page(s) 102293

    Abstract: In cells, organelles are distributed nonrandomly to regulate cells' physiological and disease-associated processes. Based on their morphology, position within the cell, and contacts with other organelles, they exert different biological functions. Endo- ... ...

    Abstract In cells, organelles are distributed nonrandomly to regulate cells' physiological and disease-associated processes. Based on their morphology, position within the cell, and contacts with other organelles, they exert different biological functions. Endo-lysosomes are critical cell metabolism and nutrient-sensing regulators modulating cell growth and cellular adaptation in response to nutrient availability. Their spatial distribution is intimately linked to their function. In this review, we will discuss the role of endolysosomes under physiological conditions and in the context of cancer progression, with a special focus on their morphology, the molecular mechanisms determining their subcellular position, and the contacts they form with other organelles. We aim to highlight the relationship between cell architecture and cell function and its impact on maintaining organismal homeostasis.
    MeSH term(s) Organelles/metabolism ; Lysosomes/metabolism ; Homeostasis
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2023.102293
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  5. Article ; Online: Circulating tumor cells: Towards mechanical phenotyping of metastasis.

    Peralta, Marina / Osmani, Naël / Goetz, Jacky G

    iScience

    2022  Volume 25, Issue 3, Page(s) 103969

    Abstract: During cancer progression, metastatic dissemination accounts for ∼90% of death in patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through body fluids, in particular the bloodstream, and several key steps remain elusive. ... ...

    Abstract During cancer progression, metastatic dissemination accounts for ∼90% of death in patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through body fluids, in particular the bloodstream, and several key steps remain elusive. Although the majority of CTCs travel as single cells, they can form clusters either with themselves (homoclusters) or with other circulating cells (heteroclusters) and thereby increase their metastatic potential. In addition, cancer cell mechanics and mechanical cues from the microenvironment are important factors during metastatic progression. Recent progress in intravital imaging technologies, biophysical methods, and microfluidic-based isolation of CTCs allow now to probe mechanics at single cell resolution while shedding light on key steps of the hematogenous metastatic cascade. In this review, we discuss the importance of CTC mechanics and their correlation with metastatic success and how such development could lead to the identification of therapeutically relevant targets.
    Language English
    Publishing date 2022-02-22
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.103969
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  6. Article ; Online: Circulating tumor cells

    Marina Peralta / Naël Osmani / Jacky G. Goetz

    iScience, Vol 25, Iss 3, Pp 103969- (2022)

    Towards mechanical phenotyping of metastasis

    2022  

    Abstract: Summary: During cancer progression, metastatic dissemination accounts for ∼90% of death in patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through body fluids, in particular the bloodstream, and several key steps remain ... ...

    Abstract Summary: During cancer progression, metastatic dissemination accounts for ∼90% of death in patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through body fluids, in particular the bloodstream, and several key steps remain elusive. Although the majority of CTCs travel as single cells, they can form clusters either with themselves (homoclusters) or with other circulating cells (heteroclusters) and thereby increase their metastatic potential. In addition, cancer cell mechanics and mechanical cues from the microenvironment are important factors during metastatic progression. Recent progress in intravital imaging technologies, biophysical methods, and microfluidic-based isolation of CTCs allow now to probe mechanics at single cell resolution while shedding light on key steps of the hematogenous metastatic cascade. In this review, we discuss the importance of CTC mechanics and their correlation with metastatic success and how such development could lead to the identification of therapeutically relevant targets.
    Keywords Mechanobiology ; Biological sciences ; Cancer ; Biological sciences research methodologies ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Liquid Biopsies: Flowing Biomarkers.

    Hyenne, Vincent / Goetz, Jacky G / Osmani, Naël

    Advances in experimental medicine and biology

    2022  Volume 1379, Page(s) 341–368

    Abstract: Metastatic dissemination accounts for most of the death in patients during cancer progression. There is thus an urge to identify specific biomarkers as proxies for cancer progression and assessment of treatment efficiency. Cancer is a systemic disease ... ...

    Abstract Metastatic dissemination accounts for most of the death in patients during cancer progression. There is thus an urge to identify specific biomarkers as proxies for cancer progression and assessment of treatment efficiency. Cancer is a systemic disease involving the shuttling of tumor cells and tumor secreted factors to distant organs, mostly via biofluids. During this transfer, these factors are accessible for easy sampling and therefore constitute a unique source of information witnessing the presence and the evolution of the disease. Hence, liquid biopsies offer multiple advantages, including simple and low-invasive sampling procedures, low cost, and higher compliance. Importantly, liquid biopsies are adapted to personalized medicine allowing a longitudinal follow-up to monitor treatment efficiency or resistance, and risk of relapse.The evolution of methodologies to isolate circulating tumor cells (CTCs) and extracellular vesicles (EVs) from blood samples associated with the characterization of their membrane surface repertoire and content have been instrumental in the emergence of liquid biopsies as an easy and non-invasive alternative as opposed to classical surgery-mediated tumor biopsies.In this chapter, we comment on CTCs and EVs carrying features with great potential as cancer biomarkers. More specifically, we focus on the adhesive and mechanical properties of CTCs as metastatic markers. We also consider the recent development of EVs isolation methods and the identification of new biomarkers. Finally, we discuss their relevance as cancer prognosis tools.
    MeSH term(s) Biomarkers, Tumor ; Extracellular Vesicles/chemistry ; Humans ; Liquid Biopsy ; Neoplasm Recurrence, Local ; Neoplastic Cells, Circulating/pathology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-031-04039-9_14
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  8. Article ; Online: Tracking Mechanisms of Viral Dissemination In Vivo.

    Gaudin, Raphael / Goetz, Jacky G

    Trends in cell biology

    2020  Volume 31, Issue 1, Page(s) 17–23

    Abstract: Dissemination and replication of viruses into hosts is a multistep process where viral particles infect, navigate, and indoctrinate various cell types. Viruses can reach tissues that are distant from their infection site by subverting subcellular ... ...

    Abstract Dissemination and replication of viruses into hosts is a multistep process where viral particles infect, navigate, and indoctrinate various cell types. Viruses can reach tissues that are distant from their infection site by subverting subcellular mechanisms in ways that are, sometimes, disruptive. Modeling these steps, at appropriate resolution and within animal models, is cumbersome. Yet, mimicking these strategies in vitro fails to recapitulate the complexity of the cellular ecosystem. Here, we will discuss relevant in vivo platforms to dissect the cellular and molecular programs governing viral dissemination and briefly discuss organoid and ex vivo alternatives. We will focus on the zebrafish model and will describe how it provides a transparent window to unravel new cellular mechanisms of viral dissemination in vivo.
    MeSH term(s) Animals ; Embryo, Nonmammalian/virology ; Humans ; Mice ; Models, Animal ; Viruses/metabolism ; Zebrafish/embryology ; Zebrafish/virology
    Keywords covid19
    Language English
    Publishing date 2020-10-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2020.09.005
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  9. Article ; Online: CD44 Orchestrates Metastatic Teamwork.

    Chaffer, Christine L / Goetz, Jacky G

    Developmental cell

    2019  Volume 47, Issue 6, Page(s) 691–693

    Abstract: Inhibition of metastatic cancer cell colonization and outgrowth is arguably one of the greatest therapeutic challenges. Reporting in Cancer Discovery, Liu et al. (2018) describe how homophilic interactions of CD44, a classical breast cancer stem cell ... ...

    Abstract Inhibition of metastatic cancer cell colonization and outgrowth is arguably one of the greatest therapeutic challenges. Reporting in Cancer Discovery, Liu et al. (2018) describe how homophilic interactions of CD44, a classical breast cancer stem cell marker, drive tumor cell aggregation outside the primary tumor to augment their metastatic potential.
    MeSH term(s) Breast Neoplasms ; Cell Aggregation ; Humans ; Hyaluronan Receptors ; Neoplastic Stem Cells
    Chemical Substances CD44 protein, human ; Hyaluronan Receptors
    Language English
    Publishing date 2019-01-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2018.11.038
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  10. Article ; Online: Biomechanics: a driving force behind metastatic progression.

    Colin, Florent / Gensbittel, Valentin / Goetz, Jacky G

    Comptes rendus biologies

    2021  Volume 344, Issue 3, Page(s) 249–262

    Abstract: Metastatic progression, which begins with the invasion and migration of tumor cells from a primary tumor, marks a major turning point in the evolution of cancer. Indeed, it eventually leads to the formation of secondary tumors, the metastases, which are ... ...

    Abstract Metastatic progression, which begins with the invasion and migration of tumor cells from a primary tumor, marks a major turning point in the evolution of cancer. Indeed, it eventually leads to the formation of secondary tumors, the metastases, which are very often responsible for the patient's death. Understanding the mechanisms controlling the different steps of this process, as well as those explaining the fundamental phenomenon of organotropism (i.e. the distribution of metastases in distant organs by a non-random and tumor-specific process), is essential to define new innovative therapeutic solutions. In this review paper, we will present how biomechanics is an essential element to this understanding, and will emphasize the importance of this orthogonal and promising angle of study as well as our laboratory's focus on the late stages of dissemination, arrest and extravasation of circulating cancer cells and factors secreted by the primary tumor such as extracellular vesicles.
    MeSH term(s) Biomechanical Phenomena ; Humans ; Neoplasms
    Language English
    Publishing date 2021-11-15
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 2072863-3
    ISSN 1768-3238 ; 1631-0691
    ISSN (online) 1768-3238
    ISSN 1631-0691
    DOI 10.5802/crbiol.62
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