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  1. Article ; Online: Which therapeutic strategy will achieve a cure for HIV-1?

    Cillo, Anthony R / Mellors, John W

    Current opinion in virology

    2016  Volume 18, Page(s) 14–19

    Abstract: Strategies to achieve a cure for HIV-1 infection can be broadly classified into three categories: eradication cure (elimination of all viral reservoirs), functional cure (immune control without reservoir eradication), or a hybrid cure (reservoir ... ...

    Abstract Strategies to achieve a cure for HIV-1 infection can be broadly classified into three categories: eradication cure (elimination of all viral reservoirs), functional cure (immune control without reservoir eradication), or a hybrid cure (reservoir reduction with improved immune control). The many HIV-1 cure strategies being investigated include modification of host cells to resist HIV-1, engineered T cells to eliminate HIV-infected cells, broadly HIV-1 neutralizing monoclonal antibodies, and therapeutic vaccination, but the 'kick and kill' strategy to expose latent HIV-1 with latency reversing agents (LRAs) and kill the exposed cells through immune effector functions is currently the most actively pursued. It is unknown, however, whether LRAs can deplete viral reservoirs in vivo or whether current LRAs are sufficiently safe for clinical use.
    MeSH term(s) Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; CD4-Positive T-Lymphocytes/immunology ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/therapy ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/immunology ; Humans ; Virus Activation/drug effects ; Virus Latency/drug effects
    Chemical Substances Anti-HIV Agents ; Antibodies, Monoclonal
    Language English
    Publishing date 2016-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2016.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Conference proceedings: FACS- und Einzelzell-RNA-Sequenzierung zeigen ein Spektrum an dysfunktionalen Zuständen von CD8+zytotoxischen T Zellen bei Kopf-Hals-Plattenepithelkarzinomen

    Kürten, Cornelius H.L. / Kulkarni, Aditi / Vujanovic, Lazar / Cillo, Anthony R. / Lang, Stephan / Ferris, Robert L.

    Laryngo-Rhino-Otologie

    (Abstract- und Posterband)

    2022  Volume 101, Issue S 02

    Event/congress Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten Medizin, Deutsche Messe Hannover, 2022-05-25
    Series title Abstract- und Posterband
    Language German
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0042-1747307
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  3. Article ; Conference proceedings: 17-chanel FACS analysis and single cell RNA Sequencing identifies a dysfunctional spectrum of CD8+ cytotoxic T cell states in head and neck cancer

    Kürten, Cornelius H.L. / Kulkarni, Aditi / Vujanovic, Lazar / Cillo, Anthony R. / Lang, Stephan / Ferris, Robert L.

    Laryngo-Rhino-Otologie

    (Abstract- und Posterband)

    2022  Volume 101, Issue S 02

    Event/congress Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten Medizin, Deutsche Messe Hannover, 2022-05-25
    Series title Abstract- und Posterband
    Language English
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0042-1746687
    Database Thieme publisher's database

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  4. Article ; Online: Molecular Pathways and Mechanisms of LAG3 in Cancer Therapy.

    Andrews, Lawrence P / Cillo, Anthony R / Karapetyan, Lilit / Kirkwood, John M / Workman, Creg J / Vignali, Dario A A

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2022  Volume 28, Issue 23, Page(s) 5030–5039

    Abstract: Immunotherapy targeting coinhibitory receptors has been highly successful in treating a wide variety of malignancies; however, only a subset of patients exhibits durable responses. The first FDA-approved immunotherapeutics targeting coinhibitory ... ...

    Abstract Immunotherapy targeting coinhibitory receptors has been highly successful in treating a wide variety of malignancies; however, only a subset of patients exhibits durable responses. The first FDA-approved immunotherapeutics targeting coinhibitory receptors PD1 and CTLA4, alone or in combination, significantly improved survival but were also accompanied by substantial toxicity in combination. The third FDA-approved immune checkpoint inhibitor targets LAG3, a coinhibitory receptor expressed on activated CD4+ and CD8+ T cells, especially in settings of long-term antigenic stimulation, such as chronic viral infection or cancer. Mechanistically, LAG3 expression limits both the expansion of activated T cells and the size of the memory pool, suggesting that LAG3 may be a promising target for immunotherapy. Importantly, the mechanism(s) by which LAG3 contributes to CD8+ T-cell exhaustion may be distinct from those governed by PD1, indicating that the combination of anti-LAG3 and anti-PD1 may synergistically enhance antitumor immunity. Clinical studies evaluating the role of anti-LAG3 in combination with anti-PD1 are underway, and recent phase III trial results in metastatic melanoma demonstrate both the efficacy and safety of this combination. Further ongoing clinical trials are evaluating this combination across multiple tumor types and the adjuvant setting, with accompanying translational and biomarker-focused studies designed to elucidate the molecular pathways that lead to improved antitumor T-cell responses following dual blockade of PD1 and LAG3. Overall, LAG3 plays an important role in limiting T-cell activation and has now become part of the repertoire of combinatorial immunotherapeutics available for the treatment of metastatic melanoma.
    MeSH term(s) Humans ; Antigens, CD/metabolism ; CD8-Positive T-Lymphocytes ; Immunotherapy/methods ; Melanoma/drug therapy ; Melanoma/genetics ; Programmed Cell Death 1 Receptor ; Clinical Trials, Phase III as Topic
    Chemical Substances Antigens, CD ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-21-2390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells.

    Shan, Feng / Cillo, Anthony R / Cardello, Carly / Yuan, Daniel Y / Kunning, Sheryl R / Cui, Jian / Lampenfeld, Caleb / Williams, Asia M / McDonough, Alexandra P / Pennathur, Arjun / Luketich, James D / Kirkwood, John M / Ferris, Robert L / Bruno, Tullia C / Workman, Creg J / Benos, Panayiotis V / Vignali, Dario A A

    Science immunology

    2023  Volume 8, Issue 87, Page(s) eadf6717

    Abstract: Human regulatory T cells ( ... ...

    Abstract Human regulatory T cells (T
    MeSH term(s) Humans ; Autoimmune Diseases ; Basic-Leucine Zipper Transcription Factors/genetics ; Gene Regulatory Networks ; Head and Neck Neoplasms/genetics ; Squamous Cell Carcinoma of Head and Neck/genetics ; T-Lymphocytes, Regulatory
    Chemical Substances Basic-Leucine Zipper Transcription Factors ; BATF protein, human
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adf6717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Publisher Correction: Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment.

    Onkar, Sayali / Cui, Jian / Zou, Jian / Cardello, Carly / Cillo, Anthony R / Uddin, Mostofa Rafid / Sagan, April / Joy, Marion / Osmanbeyoglu, Hatice U / Pogue-Geile, Katherine L / McAuliffe, Priscilla F / Lucas, Peter C / Tseng, George C / Lee, Adrian V / Bruno, Tullia C / Oesterreich, Steffi / Vignali, Dario A A

    Nature cancer

    2023  Volume 4, Issue 4, Page(s) 582

    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Published Erratum
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-023-00549-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: NKG7 Is Required for Optimal Antitumor T-cell Immunity.

    Li, Xian-Yang / Corvino, Dillon / Nowlan, Bianca / Aguilera, Amelia Roman / Ng, Susanna S / Braun, Matthias / Cillo, Anthony R / Bald, Tobias / Smyth, Mark J / Engwerda, Christian R

    Cancer immunology research

    2022  Volume 10, Issue 2, Page(s) 154–161

    Abstract: Tumor antigen-specific ... ...

    Abstract Tumor antigen-specific CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes ; Humans ; Immune Checkpoint Inhibitors ; Immunotherapy ; Killer Cells, Natural ; Melanoma/immunology ; Membrane Proteins/metabolism ; Mice ; Tumor Microenvironment
    Chemical Substances Immune Checkpoint Inhibitors ; Membrane Proteins ; Nkg7 protein, mouse
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-20-0649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment.

    Onkar, Sayali / Cui, Jian / Zou, Jian / Cardello, Carly / Cillo, Anthony R / Uddin, Mostofa Rafid / Sagan, April / Joy, Marion / Osmanbeyoglu, Hatice U / Pogue-Geile, Katherine L / McAuliffe, Priscilla F / Lucas, Peter C / Tseng, George C / Lee, Adrian V / Bruno, Tullia C / Oesterreich, Steffi / Vignali, Dario A A

    Nature cancer

    2023  Volume 4, Issue 4, Page(s) 516–534

    Abstract: T cell-centric immunotherapies have shown modest clinical benefit thus far for estrogen receptor-positive ( ... ...

    Abstract T cell-centric immunotherapies have shown modest clinical benefit thus far for estrogen receptor-positive (ER
    MeSH term(s) Female ; Humans ; Carcinoma, Lobular/drug therapy ; Breast Neoplasms/drug therapy ; Carcinoma, Ductal, Breast/drug therapy ; Treatment Outcome ; Disease-Free Survival ; Tumor Microenvironment
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-023-00527-w
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  9. Article ; Online: Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy.

    Wang, Weihong / Wu, Shaoxian / Cen, Zhanpeng / Zhang, Yixin / Chen, Yuang / Huang, Yixian / Cillo, Anthony R / Prokopec, Joshua S / Quarato, Giovanni / Vignali, Dario A A / Stewart-Ornstein, Jacob / Li, Song / Lu, Binfeng / Gong, Yi-Nan

    Cell reports

    2022  Volume 41, Issue 5, Page(s) 111582

    Abstract: In "healthy" tumor cells, phosphatidylserine (PS) is predominately localized in the inner plasma membrane leaflet. During apoptosis, PS relocates to the outer leaflet. Herein, we established ... ...

    Abstract In "healthy" tumor cells, phosphatidylserine (PS) is predominately localized in the inner plasma membrane leaflet. During apoptosis, PS relocates to the outer leaflet. Herein, we established PS
    MeSH term(s) Humans ; Phosphatidylserines/metabolism ; Phospholipids/metabolism ; Cell Membrane/metabolism ; Apoptosis/physiology ; Neoplasms/therapy ; Neoplasms/metabolism ; Immunotherapy
    Chemical Substances Phosphatidylserines ; Phospholipids
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.111582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Autoreactive CD8

    Grebinoski, Stephanie / Zhang, Qianxia / Cillo, Anthony R / Manne, Sasikanth / Xiao, Hanxi / Brunazzi, Erin A / Tabib, Tracy / Cardello, Carly / Lian, Christine G / Murphy, George F / Lafyatis, Robert / Wherry, E John / Das, Jishnu / Workman, Creg J / Vignali, Dario A A

    Nature immunology

    2022  Volume 23, Issue 6, Page(s) 868–877

    Abstract: Impaired chronic viral and tumor clearance has been attributed to ... ...

    Abstract Impaired chronic viral and tumor clearance has been attributed to CD8
    MeSH term(s) Autoimmunity ; CD8-Positive T-Lymphocytes ; Humans ; Neoplasms/pathology ; Phenotype
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01210-5
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    Zs.MG 42: Show issues

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