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Article ; Online: Trends in prescriptions for glaucoma and ocular hypertension in France between 2014 and 2019.

O'Shaughnessy, E / Fénolland, J R / Giraud, J-M / Renard, J-P

2022 Volume 45, Issue 3, Page(s) 331–337

Abstract: Purpose: To explore the national trend in prescriptions for glaucoma and ocular hypertension (OHT) in France between 2014 and 2019.: Methods: This is a retrospective descriptive study based on prescription data from the Primary Health Insurance Fund ... ...

Abstract	Purpose: To explore the national trend in prescriptions for glaucoma and ocular hypertension (OHT) in France between 2014 and 2019. Methods: This is a retrospective descriptive study based on prescription data from the Primary Health Insurance Fund databases. All patients with a social security number who received one or more glaucoma/OHT prescriptions between 2014 and 2019 were identified. Figures for 2020 are not yet available as of the date of submission of this article. Demographic characteristics from Common Classification of Medical Acts information and from National Institute of Statistics and Economic Studies were analyzed. The data analysis was carried out using the R version 3.6.2.software from the available databases of the Information Systems Medicalization Program. Results: Our results suggest an increase in the number of patients treated with glaucoma drugs, which cannot be explained simply by demographic growth. There is also a change in drug prescription habits, both in the class of medication used and in the use of fixed combinations. We also note the increasing use of SLT (Selective Laser Trabeculoplasty), a relatively newer tool in the therapeutic arsenal. Over the same time period, demographic characteristics remained stable; age and sex distribution for each year remained constant. In addition, the phenomenon of poor therapeutic compliance, which we attempted to explore, remained stable. Discussion: This study updates the French epidemiologic data available on prescriptions for glaucoma and ocular hypertension, a true public health concern. Conclusion: On the one hand, prescribing practices have evolved over the study period. On the other hand, the number of patients treated has increased faster than the growth of the French population over the same period. These findings are consistent with trends observed in previous studies.
MeSH term(s)	Antihypertensive Agents/therapeutic use ; Glaucoma/drug therapy ; Glaucoma/epidemiology ; Glaucoma/surgery ; Humans ; Intraocular Pressure ; Laser Therapy/methods ; Ocular Hypertension/drug therapy ; Ocular Hypertension/epidemiology ; Prescriptions ; Retrospective Studies ; Trabeculectomy/methods
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2022-01-19
Publishing country	France
Document type	Journal Article
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2021.05.012
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Article ; Online: Glaucoma progression analysis by Spectral-Domain Optical Coherence Tomography (SD-OCT).

Renard, J-P / Fénolland, J-R / Giraud, J-M

Journal francais d'ophtalmologie

2019 Volume 42, Issue 5, Page(s) 499–516

Abstract: Spectral domain optical coherence tomography (SD-OCT) provides an objective quantification of the lesions of various target tissue structures in glaucoma, with unprecedented resolution, which has now demonstrated its interest in controlling the ... ...

Abstract	Spectral domain optical coherence tomography (SD-OCT) provides an objective quantification of the lesions of various target tissue structures in glaucoma, with unprecedented resolution, which has now demonstrated its interest in controlling the progression of glaucomatous neuropathy, from early stages to late stages. A certain number of well-established proofs state that a progressive modification in OCT is a common predictor of functional loss, and that patients with rapid OCT changes have an increased risk of developing glaucomatous scotoma. Follow-up of the progression goes through three stages. It consists first of all in detecting the evolution of damage to the retinal nerve fiber layer (RNFL), then that of the macular ganglion cell complex (GCC), in order to better define this progression of the damage to the target structures and, thirdly, to complete its analysis by integrating it with the analysis of the functional impairment. We note today that there is a greater risk of developing a future functional deficit of the visual field in subjects with a RNFL loss slope greater than -1/year, for all clinical stages of glaucoma. The characteristics of GCC progression are much better specified. Often earlier than that of the progress of the thinning of the RNFL and much faster in the subjects considered as "progressors", its cartography is better defined, with a particular interest for the follow-up of diversion maps and "wide field" acquisitions offering better visibility of deficits and their progression. To date, a certain number of suspicious indicators of short-term progress can be retained, highlighting the essential precaution of having two or more basic measures and a confirmation of the change on at least one new OCT acquisition. Finally, if the interpretation of the progression must always be based on clinical examination data, and the macula in particular, it remains crucial to confront the progression of the RNFL with that of the GCC and with that of the visual field.
MeSH term(s)	Aging/pathology ; Aging/physiology ; Disease Progression ; Glaucoma/diagnosis ; Glaucoma/pathology ; Humans ; Macula Lutea/diagnostic imaging ; Macula Lutea/pathology ; Nerve Fibers/pathology ; Optic Disk/diagnostic imaging ; Optic Disk/pathology ; Retinal Ganglion Cells/pathology ; Time Factors ; Tomography, Optical Coherence/methods ; Visual Fields
Language	English
Publishing date	2019-04-05
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2019.03.001
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Article ; Online: Incidence, risk factors, and burden of incisional hernia repair after abdominal surgery in France: a nationwide study.

Ortega-Deballon, P / Renard, Y / de Launay, J / Lafon, T / Roset, Q / Passot, G

Hernia : the journal of hernias and abdominal wall surgery

2023 Volume 27, Issue 4, Page(s) 861–871

Abstract: Purpose: Incisional hernias are common after laparotomies. The aims of this study were to assess the rate of incisional hernia repair after abdominal surgery, recurrence rate, hospital costs, and risk factors, in France.: Methods: This national, ... ...

Abstract	Purpose: Incisional hernias are common after laparotomies. The aims of this study were to assess the rate of incisional hernia repair after abdominal surgery, recurrence rate, hospital costs, and risk factors, in France. Methods: This national, retrospective, longitudinal, observational study was based on the exhaustive hospital discharge database (PMSI). All adult patients (≥ 18 years old) hospitalised for an abdominal surgical procedure between 01-01-2013 and 31-12-2014 and hospitalised for incisional hernia repair within five years were included. Descriptive analyses and cost analyses from the National Health Insurance (NHI) viewpoint (hospital care for the hernia repair) were performed. To identify risk factors for hernia repair a multivariable Cox model and a machine learning analysis were performed. Results: In 2013-2014, 710074 patients underwent abdominal surgery, of which 32633 (4.6%) and 5117 (0.7%) had ≥ 1 and ≥ 2 incisional hernia repair(s) within five years, respectively. Mean hospital costs amounted to €4153/hernia repair, representing nearly €67.7 million/year. Some surgical sites exposed patients at high risk of incisional hernia repair: colon and rectum (hazard ratio [HR] 1.2), and other sites on the small bowel and the peritoneum (HR 1.4). Laparotomy procedure and being ≥ 40 years old put patients at high risk of incisional hernia repair even when operated on low-risk sites such as stomach, duodenum, and hepatobiliary. Conclusion: The burden of incisional hernia repair is high and most patients are at risk either due to age ≥ 40 or the surgery site. New approaches to prevent the onset of incisional hernia are warranted.
MeSH term(s)	Adult ; Humans ; Adolescent ; Incisional Hernia/epidemiology ; Incisional Hernia/etiology ; Incisional Hernia/surgery ; Retrospective Studies ; Incidence ; Herniorrhaphy/adverse effects ; Herniorrhaphy/methods ; Hernia, Ventral/surgery ; Peritoneum/surgery ; Risk Factors ; Surgical Mesh/adverse effects
Language	English
Publishing date	2023-06-27
Publishing country	France
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-023-02825-9
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Zs.A 5390: Show issues

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Article ; Online: Communication "Grand Public" et glaucome.

Renard, J-P

Journal francais d'ophtalmologie

2009 Volume 32, Issue 3, Page(s) 197–202

Abstract: Glaucoma is particularly frequent and increase with age. Its silent evolution and worsening lead to a delayed diagnosis, until non reversible visual field impairment occurs. Early diagnosis and management, would permit to prevent glaucoma progression and, ...

Title translation	Communication towards "lay people" and glaucoma.
Abstract	Glaucoma is particularly frequent and increase with age. Its silent evolution and worsening lead to a delayed diagnosis, until non reversible visual field impairment occurs. Early diagnosis and management, would permit to prevent glaucoma progression and, likely, to reduce the high direct cost of the disease and to preserve patient's quality of life. Furthermore, society changes as well as the weight given to patients' associations, result in an increasing demand for information on the disease, its treatment and on therapeutic education. Physician's specialized scientific Association should play a crucial role in communication towards patients and general population, as already implemented, through several actions since 2004, by the French scientific Societies: Comité de Lutte contre le Glaucome (CLG) and Société Française d'Ophtalmologie (SFO).
MeSH term(s)	Glaucoma/prevention & control ; Health Education ; Health Promotion/methods ; Humans
Language	French
Publishing date	2009-03
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2009.03.013
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Article: The PRAMOS Study: PRostaglandin Analogues Monotherapy-Awareness Survey on Ocular Surface Involvement.

Bastelica, Paul / Renard, Jean Paul / Aptel, Florent / Labbé, Antoine / Schweitzer, Cédric / Poli, Muriel / Rousseau, Antoine / Lamirel, Cédric / Baudouin, Christophe

Ophthalmology and therapy

2024

Abstract: ... conjunctival hyperemia as consistently associated with preservative use (odds ratio = 7.654; p = 0.003 ...

Abstract	Introduction: Even though the local tolerance of prostaglandin (PG) analogues has improved drastically since the introduction of preservative-free (PF) eye drops, prescription patterns still vary widely among practitioners and between countries and could have an impact on the ocular surface of treated patients and, in consequence, their adherence. The aim of this study is to explore the prescribing patterns of PG analogues monotherapy in France and to evaluate their impact on ocular surface status. Methods: This was a national multicenter cross-sectional observational study that was conducted by 18 glaucoma experts in France. Patients over 18 years of age and receiving monotherapy with topical PG analogues for the treatment of ocular hypertension and/or glaucoma, with no history of prior glaucoma surgery, were consecutively selected from the glaucoma outpatient clinics of participating physicians and underwent an ocular surface examination. Results: A total of 344 eyes of 344 patients were enrolled between November 2022 and November 2023. Prescribed PG monotherapy was PF in 271 (78.7%) patients. Clinical history and ocular surface evaluation indicated that 79.4% of the study population (n = 273) presented with at least one symptom or clinical sign of dry eye and that three patients out of four had an unstable tear film. Subgroup analysis comparing preserved and PF PG analogues showed a higher prevalence of conjunctival hyperemia and corneal staining in the preserved group. Multivariate analysis identified conjunctival hyperemia as consistently associated with preservative use (odds ratio = 7.654; p = 0.003 for moderate conjunctival hyperemia). Conclusions: This study highlights the growing trend toward PF PG analogue prescriptions by specialists in France. However, ocular surface issues remain prevalent, impacting patient adherence and treatment efficacy. Comprehensive ocular surface examinations are crucial in glaucoma management to enhance long-term tolerance, compliance, and overall treatment success.
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ISSN	2193-8245
ISSN	2193-8245
DOI	10.1007/s40123-024-00936-9
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Article ; Online: The use of an automated insulin delivery system is associated with a reduction in diabetes distress and improvement in quality of life in people with type 1 diabetes.

Reznik, Yves / Bonnemaison, Elisabeth / Fagherazzi, Guy / Renard, Eric / Hanaire, Hélène / Schaepelynck, Pauline / Mihaileanu, Mihaela / Riveline, Jean-Pierre

Diabetes, obesity & metabolism

2024 Volume 26, Issue 5, Page(s) 1962–1966

MeSH term(s)	Humans ; Diabetes Mellitus, Type 1/drug therapy ; Quality of Life ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Insulin Infusion Systems ; Blood Glucose ; Blood Glucose Self-Monitoring
Chemical Substances	Hypoglycemic Agents ; Insulin ; Blood Glucose
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Letter
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15462
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Zs.A 5442: Show issues

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Article ; Online: Hypertension artérielle-hypertonie oculaire, les parallèles. Les facteurs de risque vasculaire dans le glaucome.

Renard, J-P

Journal francais d'ophtalmologie

2007 Volume 30, Issue 5 Pt 2, Page(s) 3S18–21

Abstract: Within risk factors of glaucoma, vascular risk factors are actually well demonstrated. Blood pressure and ocular perfusion pressure variations, in relation to vascular dysregulation, play a major role in the pathogenesis of glaucomatous neuropathy. In ... ...

Title translation	High blood pressure-low ocular pressure: the parallels. Vascular risk factors in glaucoma.
Abstract	Within risk factors of glaucoma, vascular risk factors are actually well demonstrated. Blood pressure and ocular perfusion pressure variations, in relation to vascular dysregulation, play a major role in the pathogenesis of glaucomatous neuropathy. In clinical practice, treated and non controlled hypertension, cardiovascular disease and low ocular diastolic perfusion pressure, are vascular risk factors that should be constantly detected in the management of glaucoma.
MeSH term(s)	Blood Pressure/physiology ; Cardiovascular Diseases/physiopathology ; Eye/blood supply ; Glaucoma/physiopathology ; Humans ; Hypertension/physiopathology ; Risk Factors
Language	French
Publishing date	2007-06-07
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
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Article ; Online: Interstitial brachytherapy for lip carcinomas: Comparison between Ir-192 low-dose-rate and high-dose-rate treatment.

Cuenin, M / Salleron, J / Peiffert, D / Meknaci, É / Gallet, P / Abushama, Y / Py, J-F / Renard, S

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2023 Volume 28, Issue 2, Page(s) 145–151

Abstract: ... the local control rates were 96.3% for LDR/PDR group and 100% for HDR (P=0.180). The regional control rates ... were 85.9% and 92% without any difference according to the two groups (P=0.179). The specific overall ... in the HDR group than in LDR/PDR group (40% versus 16.7%, P=0.042). One case of grade 3 mucositis was ...

Abstract	Purpose: Low-dose-rate (LDR) and high-dose-rate (HDR) interstitial brachytherapy are known to be effective in the treatment of lip carcinomas. The aim of this study was to retrospectively compare oncologic and toxicity outcomes between the two techniques. Patients and methods: From 2007 to 2018, patients at the Institut de cancérologie de Lorraine (France) who received exclusive or adjuvant interstitial brachytherapy for lip squamous carcinomas were studied. Two groups were defined: the LDR/PDR group, including patients treated with iridium-192 wires, or pulsed-dose rate technique, and the high-dose-rate group, with patients treated by high-dose-rate technique. The dose ranged between 50Gy and 65Gy (depending on previous surgery) for low-dose-/pulsed-dose rate treatments, and 39Gy for high-dose-rate (twice a day). Early, late toxicity events and oncologic control were reported. Results: Among the 61 patients whose data were analyzed retrospectively, 36 received the low-dose-/pulsed-dose rate treatment (59%) and 25 the high-dose-rate brachytherapy (41%). The median follow-up time was 44 months. At 36 months, the local control rates were 96.3% for LDR/PDR group and 100% for HDR (P=0.180). The regional control rates were 85.9% and 92% without any difference according to the two groups (P=0.179). The specific overall survival rate was 95.5% with no difference between groups. There were more grade 2 or higher mucositis in the HDR group than in LDR/PDR group (40% versus 16.7%, P=0.042). One case of grade 3 mucositis was recorded in each group. No grade 3 late complications were recorded. High-dose-rate brachytherapy reduced the length of hospitalization by 2 days (P<0.001). Conclusion: High-dose- or low-dose-/pulsed-dose rate brachytherapy seemed to be as effective and well tolerated in our experience of 61 patients.
MeSH term(s)	Humans ; Radiotherapy Dosage ; Iridium Radioisotopes/therapeutic use ; Retrospective Studies ; Brachytherapy/adverse effects ; Brachytherapy/methods ; Lip ; Mucositis/etiology ; Carcinoma, Squamous Cell/radiotherapy ; Head and Neck Neoplasms
Chemical Substances	Iridium-192 ; Iridium Radioisotopes
Language	English
Publishing date	2023-12-09
Publishing country	France
Document type	Journal Article
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2023.06.031
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Zs.A 4832: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 96: Show issues

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Article ; Online: In vivo validation of

Renard, Isaline / Domarkas, Juozas / Poty, Sophie / Burke, Benjamin P / Roberts, David P / Goze, Christine / Denat, Franck / Cawthorne, Christopher J / Archibald, Stephen J

Nuclear medicine and biology

2023 Volume 120-121, Page(s) 108335

Abstract: Introduction: The chemokine receptor CXCR4 has been shown to be over-expressed in multiple types of cancer and is usually associated with aggressive phenotypes and poor prognosis. Successfully targeting and imaging the expression level of this receptor ... ...

Abstract	Introduction: The chemokine receptor CXCR4 has been shown to be over-expressed in multiple types of cancer and is usually associated with aggressive phenotypes and poor prognosis. Successfully targeting and imaging the expression level of this receptor in tumours could inform treatment selection and facilitate patient stratification. Methods: Known conjugates of AMD3100 that are specific to CXCR4 have been radiolabelled with gallium-68 and evaluated in naïve and tumour-bearing mice. Tumour uptake of the radiotracers was compared to the known CXCR4-specific PET imaging agent, [ Results: Ex vivo biodistribution in naïve animals showed CXCR4-mediated uptake in the liver with both radiotracers, confirmed by blocking experiments with the high affinity CXCR4 antagonist Cu Conclusion and advances in knowledge: This initial study offers some interesting insights on the impact of some structural features on the pharmacokinetics and metabolic stability of the radiotracer. Additionally, as Pentixafor only binds to human CXCR4, the development of CXCR4-targeted imaging agents that bind to the receptor across different species could significantly help with preclinical evaluation of new CXCR4-specific therapeutics.
MeSH term(s)	Humans ; Animals ; Mice ; Positron Emission Tomography Computed Tomography ; Cyclams ; Gallium Radioisotopes ; Tissue Distribution ; Positron-Emission Tomography/methods ; Peptides, Cyclic/pharmacokinetics ; Receptors, CXCR4/metabolism ; Coordination Complexes ; Neoplasms
Chemical Substances	plerixafor (S915P5499N) ; Cyclams ; Gallium Radioisotopes ; Peptides, Cyclic ; Receptors, CXCR4 ; Coordination Complexes ; CXCR4 protein, human
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1138098-6
ISSN	1872-9614 ; 0883-2897 ; 0969-8051
ISSN (online)	1872-9614
ISSN	0883-2897 ; 0969-8051
DOI	10.1016/j.nucmedbio.2023.108335
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Zs.A 1090: Show issues

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Article ; Online: Analyse des fibres nerveuses rétiniennes péripapillaires ajustée selon l'angle papillo-maculaire en tomographie par cohérence optique en domaine spectral. Étude préliminaire.

El Chehab, H / Dot, C / Renard, J-P

Journal francais d'ophtalmologie

2016 Volume 39, Issue 2, Page(s) 149–155

Abstract: ... for controls vs. -6.6 ± 1.2° for POAG, P=0.70). There is a significant variance of this angle in both groups ... statistically significant (0.910 ± 0.056 vs. 0.936 ± 0.045, P=0.06).: Conclusions: There is a significant ...

Title translation	Disc-fovea angle adjustment for peripallary retinal nerve fiber layer analysis by a spectral domain optical coherence tomography. Preliminary study.
Abstract	Introduction: Circumpapillary retinal nerve fiber layer (cpRNFL) analysis by spectral domain optical coherence tomography (SD-OCT) has become essential for the assessment of glaucoma patients. The foveal projection is conventionally below the disc plane, creating an angle with the horizontal meridian, the disc-fovea angle. The purpose of this study is to evaluate the role of adjustment of cpRNFL analysis based on this angle. Materials and methods: This study concerns 40 control eyes and 55 eyes affected with and followed for primary open angle glaucoma (POAG). After precise localization of the optic disc center and the axis connecting it to the center of the fovea, a circular peripapillary scan is performed with Spectralis OCT (Heidelberg Engineering, Germany). The mean thickness in each of six papillary sectors and the global mean thickness of the cpRNFL were evaluated. The ROC (receiver operating characteristic) analysis evaluated the diagnostic capabilities of the various sectors before and after adjustment of the analysis for the disc-fovea angle. Results: The disc-fovea angle was not different between the two groups (-7.0 ± 1.2° for controls vs. -6.6 ± 1.2° for POAG, P=0.70). There is a significant variance of this angle in both groups (the angle varies in the control group between -22.5° to +1.8° and in the POAG group between -18° to +2.4°). The global mean and inferior temporal (IT) thickness of the cpRNFL show the best diagnostic performance. Adjustment for disc-fovea angle does not increase the diagnostic accuracy of the various sectors analyzed. Although there is an increase in the area under the curve for the IT sector after adjustment, it is not statistically significant (0.910 ± 0.056 vs. 0.936 ± 0.045, P=0.06). Conclusions: There is a significant variation in disc-fovea angle. In this study, accounting for it does not significantly improve the diagnostic capabilities of cpRNFL in patients with POAG.
MeSH term(s)	Aged ; Aged, 80 and over ; Calibration ; Case-Control Studies ; Female ; Fovea Centralis/diagnostic imaging ; Fovea Centralis/pathology ; Glaucoma, Open-Angle/diagnostic imaging ; Glaucoma, Open-Angle/pathology ; Humans ; Male ; Middle Aged ; Nerve Fibers/pathology ; Optic Disk/diagnostic imaging ; Optic Disk/pathology ; Pilot Projects ; Retina/cytology ; Retina/diagnostic imaging ; Retina/pathology ; Retinal Neurons/cytology ; Retinal Neurons/pathology ; Tomography, Optical Coherence/methods ; Tomography, Optical Coherence/standards ; Visual Fields
Language	French
Publishing date	2016-02-05
Publishing country	France
Document type	Evaluation Studies ; Journal Article
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2015.06.011
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