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  1. Article: Late prosthetic knee joint infection with

    Brand, Yves E / Rufer, Benjamin

    IDCases

    2021  Volume 24, Page(s) e01160

    Abstract: Prosthethic Joint Infection (PJI) is a severe complication following joint replacement. Late PJI can occur years after implantation by hematogenous seeding of a microbial agent. ...

    Abstract Prosthethic Joint Infection (PJI) is a severe complication following joint replacement. Late PJI can occur years after implantation by hematogenous seeding of a microbial agent.
    Language English
    Publishing date 2021-05-12
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2021.e01160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bilateral Hip Dislocation: An Indicator for Emergent Full-Body Computed Tomography Scan in Polytraumatized Patients? A Case Report and Review of the Literature.

    Rufer, Benjamin / Keel, Marius Johann Baptist / Schnüriger, Beat / Deml, Moritz Caspar

    Journal of emergencies, trauma, and shock

    2016  Volume 11, Issue 1, Page(s) 53–56

    Abstract: We present a rare case of traumatic bilateral asymmetric hip dislocation with pelvic fractures and a traumatic diaphragmatic hernia. A 53-year-old machinist was transferred to our emergency department with the suspicion of a bilateral hip dislocation ... ...

    Abstract We present a rare case of traumatic bilateral asymmetric hip dislocation with pelvic fractures and a traumatic diaphragmatic hernia. A 53-year-old machinist was transferred to our emergency department with the suspicion of a bilateral hip dislocation after he was trapped between an elevator and the roof. Immediate closed reduction of the hips was not performed because of the expected risk of increasing hemodynamic instability with muscular relaxation. An emergent full-body computed tomography (CT) scan was made to assess injuries with need for further operative treatment. Thus, closed reduction of both hips was finally performed in the OR directly before the laparotomy for the diaphragmatic repair and the osteosynthesis of the anterior pelvic ring. A 12-month follow-up showed good general health condition with asymptomatic situation of the hip joints and the abdomen. The diagnostic work-up of patients with severe trauma is still debated, a randomized controlled trial showed no reduction of the in-hospital mortality with immediate full-body CT scan compared to a conventional radiological work-up. Traumatic hip dislocations (THDs) are always due to high-energy trauma and additional injuries are frequent. To attempt a closed reduction of THD, under general anesthesia can be life-threatening with unrecognized associated injuries. Therefore, THD can serve as selection criteria for immediate full-body CT scan to facilitate diagnosis and treatment of associated injuries sustained by the patient.
    Language English
    Publishing date 2016-10-28
    Publishing country India
    Document type Case Reports
    ZDB-ID 2461111-6
    ISSN 0974-519X ; 0974-2700
    ISSN (online) 0974-519X
    ISSN 0974-2700
    DOI 10.4103/JETS.JETS_12_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe.

    Gazzi, Thais / Brennecke, Benjamin / Atz, Kenneth / Korn, Claudia / Sykes, David / Forn-Cuni, Gabriel / Pfaff, Patrick / Sarott, Roman C / Westphal, Matthias V / Mostinski, Yelena / Mach, Leonard / Wasinska-Kalwa, Malgorzata / Weise, Marie / Hoare, Bradley L / Miljuš, Tamara / Mexi, Maira / Roth, Nicolas / Koers, Eline J / Guba, Wolfgang /
    Alker, André / Rufer, Arne C / Kusznir, Eric A / Huber, Sylwia / Raposo, Catarina / Zirwes, Elisabeth A / Osterwald, Anja / Pavlovic, Anto / Moes, Svenja / Beck, Jennifer / Nettekoven, Matthias / Benito-Cuesta, Irene / Grande, Teresa / Drawnel, Faye / Widmer, Gabriella / Holzer, Daniela / van der Wel, Tom / Mandhair, Harpreet / Honer, Michael / Fingerle, Jürgen / Scheffel, Jörg / Broichhagen, Johannes / Gawrisch, Klaus / Romero, Julián / Hillard, Cecilia J / Varga, Zoltan V / van der Stelt, Mario / Pacher, Pal / Gertsch, Jürg / Ullmer, Christoph / McCormick, Peter J / Oddi, Sergio / Spaink, Herman P / Maccarrone, Mauro / Veprintsev, Dmitry B / Carreira, Erick M / Grether, Uwe / Nazaré, Marc

    Chemical science

    2022  Volume 13, Issue 19, Page(s) 5539–5545

    Abstract: Despite its essential role in the (patho)physiology of several diseases, ... ...

    Abstract Despite its essential role in the (patho)physiology of several diseases, CB
    Language English
    Publishing date 2022-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d1sc06659e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Taurolidine in the prevention and therapy of lung metastases.

    Hoksch, Beatrix / Rufer, Benjamin / Gazdhar, Amiq / Bilici, Murat / Beshay, Morris / Gugger, Matthias / Schmid, Ralph Alexander

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2009  Volume 36, Issue 6, Page(s) 1058–1063

    Abstract: Objective: During surgery for colon carcinoma, tumour cells may spread into the blood and may lead to the development of distant metastases. The most frequent sites of metastases are the liver and lungs. A new therapeutic approach is required to prevent ...

    Abstract Objective: During surgery for colon carcinoma, tumour cells may spread into the blood and may lead to the development of distant metastases. The most frequent sites of metastases are the liver and lungs. A new therapeutic approach is required to prevent tumour implantation of freely circulating tumour cells during and after surgery and to treat established metastases. The aim of this prospective study was to observe the influence of long-term intravenous taurolidine on the development of lung metastases after intravenous injection of colon adenocarcinoma cells.
    Methods: Tumour cells (DHD/K12/TRb colon adenocarcinoma cell line, 1 x 10(6) cells) were injected into the right vena jugularis interna of BDIX rats. The animals (n=13) were randomised into three groups: group 1: tumour cell implantation without taurolidine application (control group); group 2: tumour cell implantation and simultaneous start of the taurolidine injection through osmotic pump, removal of the osmotic pump on day 7; group 3: tumour cell implantation on day 0 and start of the taurolidine injection through osmotic pump on day 14.
    Results: In the taurolidine groups, the number and size of lung metastases were significantly lower compared to the control group (p=0.018; p=0.018 and p=0.036; p=0.018). Although the results of the intravenous long-term therapy with taurolidine in group 2 did not reach statistical significance in comparison with the results of group 3, a positive trend was revealed: The mean number of metastases in group 2 was 18.2 versus 28.2 in group 3.
    Conclusions: The application of taurolidine tends to prevent the development of lung metastases. Furthermore, taurolidine seems to reduce established lung metastases in this in vivo model. Taurolidine may offer additional therapeutic options in patients with colon adenocarcinoma.
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/prevention & control ; Adenocarcinoma/secondary ; Animals ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Colonic Neoplasms/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/prevention & control ; Lung Neoplasms/secondary ; Random Allocation ; Rats ; Taurine/analogs & derivatives ; Taurine/therapeutic use ; Thiadiazines/therapeutic use ; Xenograft Model Antitumor Assays
    Chemical Substances Antineoplastic Agents ; Thiadiazines ; Taurine (1EQV5MLY3D) ; taurolidine (8OBZ1M4V3V)
    Language English
    Publishing date 2009-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1016/j.ejcts.2009.04.065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells.

    Sarott, Roman C / Westphal, Matthias V / Pfaff, Patrick / Korn, Claudia / Sykes, David A / Gazzi, Thais / Brennecke, Benjamin / Atz, Kenneth / Weise, Marie / Mostinski, Yelena / Hompluem, Pattarin / Koers, Eline / Miljuš, Tamara / Roth, Nicolas J / Asmelash, Hermon / Vong, Man C / Piovesan, Jacopo / Guba, Wolfgang / Rufer, Arne C /
    Kusznir, Eric A / Huber, Sylwia / Raposo, Catarina / Zirwes, Elisabeth A / Osterwald, Anja / Pavlovic, Anto / Moes, Svenja / Beck, Jennifer / Benito-Cuesta, Irene / Grande, Teresa / Ruiz de Martı N Esteban, Samuel / Yeliseev, Alexei / Drawnel, Faye / Widmer, Gabriella / Holzer, Daniela / van der Wel, Tom / Mandhair, Harpreet / Yuan, Cheng-Yin / Drobyski, William R / Saroz, Yurii / Grimsey, Natasha / Honer, Michael / Fingerle, Jürgen / Gawrisch, Klaus / Romero, Julian / Hillard, Cecilia J / Varga, Zoltan V / van der Stelt, Mario / Pacher, Pal / Gertsch, Jürg / McCormick, Peter J / Ullmer, Christoph / Oddi, Sergio / Maccarrone, Mauro / Veprintsev, Dmitry B / Nazaré, Marc / Grether, Uwe / Carreira, Erick M

    Journal of the American Chemical Society

    2020  Volume 142, Issue 40, Page(s) 16953–16964

    Abstract: Pharmacological modulation of cannabinoid type 2 receptor ( ... ...

    Abstract Pharmacological modulation of cannabinoid type 2 receptor (CB
    MeSH term(s) Alzheimer Disease/metabolism ; Animals ; CHO Cells ; Cricetulus ; Disease Models, Animal ; Flow Cytometry ; Fluorescence Resonance Energy Transfer ; Fluorescent Dyes/chemistry ; Humans ; Ligands ; Mice ; Microglia/metabolism ; Molecular Docking Simulation ; Molecular Probes/chemistry ; Optical Imaging ; Receptor, Cannabinoid, CB2/analysis ; Sensitivity and Specificity ; Signal Transduction
    Chemical Substances Fluorescent Dyes ; Ligands ; Molecular Probes ; Receptor, Cannabinoid, CB2
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.0c05587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  6. Article: Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells

    Sarott, Roman C / Westphal, Matthias V / Pfaff, Patrick / Korn, Claudia / Sykes, David A / Gazzi, Thais / Brennecke, Benjamin / Atz, Kenneth / Weise, Marie / Mostinski, Yelena / Hompluem, Pattarin / Koers, Eline / Miljuš, Tamara / Roth, Nicolas J / Asmelash, Hermon / Vong, Man C / Piovesan, Jacopo / Guba, Wolfgang / Rufer, Arne C /
    Kusznir, Eric A / Huber, Sylwia / Raposo, Catarina / Zirwes, Elisabeth A / Osterwald, Anja / Pavlovic, Anto / Moes, Svenja / Beck, Jennifer / Benito-Cuesta, Irene / Grande, Teresa / Ruiz de Martı́n Esteban, Samuel / Yeliseev, Alexei / Drawnel, Faye / Widmer, Gabriella / Holzer, Daniela / van der Wel, Tom / Mandhair, Harpreet / Yuan, Cheng-Yin / Drobyski, William R / Saroz, Yurii / Grimsey, Natasha / Honer, Michael / Fingerle, Jürgen / Gawrisch, Klaus / Romero, Julian / Hillard, Cecilia J / Varga, Zoltan V / van der Stelt, Mario / Pacher, Pal / Gertsch, Jürg / McCormick, Peter J / Ullmer, Christoph / Oddi, Sergio / Maccarrone, Mauro / Veprintsev, Dmitry B / Nazaré, Marc / Grether, Uwe / Carreira, Erick M

    Journal of the American Chemical Society. 2020 Sept. 09, v. 142, no. 40

    2020  

    Abstract: Pharmacological modulation of cannabinoid type 2 receptor (CB₂R) holds promise for the treatment of numerous conditions, including inflammatory diseases, autoimmune disorders, pain, and cancer. Despite the significance of this receptor, researchers lack ... ...

    Abstract Pharmacological modulation of cannabinoid type 2 receptor (CB₂R) holds promise for the treatment of numerous conditions, including inflammatory diseases, autoimmune disorders, pain, and cancer. Despite the significance of this receptor, researchers lack reliable tools to address questions concerning the expression and complex mechanism of CB₂R signaling, especially in cell-type and tissue-dependent contexts. Herein, we report for the first time a versatile ligand platform for the modular design of a collection of highly specific CB₂R fluorescent probes, used successfully across applications, species, and cell types. These include flow cytometry of endogenously expressing cells, real-time confocal microscopy of mouse splenocytes and human macrophages, as well as FRET-based kinetic and equilibrium binding assays. High CB₂R specificity was demonstrated by competition experiments in living cells expressing CB₂R at native levels. The probes were effectively applied to FACS analysis of microglial cells derived from a mouse model relevant to Alzheimer’s disease.
    Keywords cannabinoids ; confocal microscopy ; flow cytometry ; fluorescence ; humans ; ligands ; macrophages ; mice ; pain ; splenocytes
    Language English
    Dates of publication 2020-0909
    Size p. 16953-16964.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.0c05587
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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