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  1. Article ; Online: Infratentorial Multinodular and Vacuolating Neuronal Tumor or Multinodular and Vacuolating Posterior Fossa Lesions of Unknown Significance? Clinico-Radiologic Findings from 2 Cases.

    Morassi, Mauro / Bagatto, Daniele

    World neurosurgery

    2020  Volume 136, Page(s) 58–61

    Abstract: Background: Infratentorial multinodular lesions resembling multinodular and vacuolating neuronal tumor of the cerebrum (MVNT) have been indicated in literature with 2 different names reflecting alternative perspectives: multinodular and vacuolating ... ...

    Abstract Background: Infratentorial multinodular lesions resembling multinodular and vacuolating neuronal tumor of the cerebrum (MVNT) have been indicated in literature with 2 different names reflecting alternative perspectives: multinodular and vacuolating posterior fossa lesions of unknown significance (MV-PLUS), suggesting that these lesions may belong to a new entity, and MVNT of the brain, assuming that they actually correspond to infratentorial MVNT. Because of the limited number of cases reported and the absence of histopathologic data, it is unclear which denomination should be used.
    Cases description: Two patients, a 41-year-old man (case 1) suffering headache and a 44-year-old man (case 2) with vertigo, underwent magnetic resonance imaging (MRI) examination. MRI showed, in both cases, multinodular lesions involving the vermis, broadly extending to the superior part of the right cerebellar hemisphere in case 1, and involving the superior paravermian part of the left cerebellar hemisphere in case 2. The follow-up period was 3 years in case 1 and 14 years in case 2.
    Conclusions: Infratentorial lesions show nodules with cystic or cyst-like signal intensity on MRI, a feature infrequently reported in supratentorial MVNT, and may involve the cortex. No variations were noted during a prolonged follow-up supporting the benign behavior of these lesions.
    MeSH term(s) Adult ; Cerebellar Neoplasms/complications ; Cerebellar Neoplasms/diagnostic imaging ; Cerebellar Neoplasms/physiopathology ; Headache/etiology ; Humans ; Infratentorial Neoplasms/complications ; Infratentorial Neoplasms/diagnostic imaging ; Infratentorial Neoplasms/physiopathology ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Neoplasms, Neuroepithelial/complications ; Neoplasms, Neuroepithelial/diagnostic imaging ; Neoplasms, Neuroepithelial/physiopathology ; Perfusion Imaging ; Vertigo/etiology
    Language English
    Publishing date 2020-01-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2019.12.166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1159: Show issues Location:
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  2. Article ; Online: A multinodular and vacuolating neuronal tumor of the cerebrum (MVNT) with glioma-like appearance.

    Bagatto, Daniele / Ius, Tamara / Pegolo, Enrico / Morassi, Mauro

    Acta neurologica Belgica

    2020  Volume 121, Issue 6, Page(s) 1851–1854

    MeSH term(s) Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/pathology ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/pathology ; Female ; Glioma/diagnostic imaging ; Glioma/pathology ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Seizures/diagnostic imaging ; Seizures/etiology
    Language English
    Publishing date 2020-07-06
    Publishing country Italy
    Document type Case Reports ; Letter
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-020-01426-y
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  3. Article: Dural Metastases of Advanced Prostate Cancer Detected by

    Morassi, Mauro / Bonacina, Mattia / Bnà, Claudio / Zaniboni, Alberto / Savelli, Giordano

    Diagnostics (Basel, Switzerland)

    2020  Volume 10, Issue 6

    Abstract: Prostate cancer with extensive dural metastases is very rare, with only few cases described in the literature. We report one such case of a 74-year-old man with advanced prostate cancer, and in relatively good clinical condition. The patient returned ... ...

    Abstract Prostate cancer with extensive dural metastases is very rare, with only few cases described in the literature. We report one such case of a 74-year-old man with advanced prostate cancer, and in relatively good clinical condition. The patient returned with complaints of headache and diplopia. Fluorocholine (
    Language English
    Publishing date 2020-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics10060385
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  4. Article ; Online: Stroke in patients with COVID-19: Clinical and neuroimaging characteristics.

    Vogrig, Alberto / Gigli, Gian Luigi / Bnà, Claudio / Morassi, Mauro

    Neuroscience letters

    2020  Volume 743, Page(s) 135564

    Abstract: Acute cerebrovascular disease, particularly ischemic stroke, has emerged as a serious complication of infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of the Coronavirus disease-2019 (COVID-19). ... ...

    Abstract Acute cerebrovascular disease, particularly ischemic stroke, has emerged as a serious complication of infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of the Coronavirus disease-2019 (COVID-19). Accumulating data on patients with COVID-19-associated stroke have shed light on specificities concerning clinical presentation, neuroimaging findings, and outcome. Such specificities include a propensity towards large vessel occlusion, multi-territory stroke, and involvement of otherwise uncommonly affected vessels. Conversely, small-vessel brain disease, cerebral venous thrombosis, and intracerebral hemorrhage appear to be less frequent. Atypical neurovascular presentations were also described, ranging from bilateral carotid artery dissection to posterior reversible encephalopathy syndrome (PRES), and vasculitis. Cases presenting with encephalopathy or encephalitis with seizures heralding stroke were particularly challenging. The pathogenesis and optimal management of ischemic stroke associated with COVID-19 still remain uncertain, but emerging evidence suggest that cytokine storm-triggered coagulopathy and endotheliopathy represent possible targetable mechanisms. Some specific management issues in this population include the difficulty in identifying clinical signs of stroke in critically ill patients in the intensive care unit, as well as the need for a protected pathway for brain imaging, intravenous thrombolysis, and mechanical thrombectomy, keeping in mind that "time is brain" also for COVID-19 patients. In this review, we discuss the novel developments and challenges for the diagnosis and treatment of stroke in patients with COVID-19, and delineate the principles for a rational approach toward precision medicine in this emerging field.
    MeSH term(s) COVID-19/complications ; Humans ; SARS-CoV-2 ; Stroke/diagnostic imaging ; Stroke/pathology ; Stroke/virology
    Language English
    Publishing date 2020-12-19
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2020.135564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1166: Show issues Location:
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  5. Article ; Online: A hybrid machine learning/deep learning COVID-19 severity predictive model from CT images and clinical data.

    Chieregato, Matteo / Frangiamore, Fabio / Morassi, Mauro / Baresi, Claudia / Nici, Stefania / Bassetti, Chiara / Bnà, Claudio / Galelli, Marco

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 4329

    Abstract: COVID-19 clinical presentation and prognosis are highly variable, ranging from asymptomatic and paucisymptomatic cases to acute respiratory distress syndrome and multi-organ involvement. We developed a hybrid machine learning/deep learning model to ... ...

    Abstract COVID-19 clinical presentation and prognosis are highly variable, ranging from asymptomatic and paucisymptomatic cases to acute respiratory distress syndrome and multi-organ involvement. We developed a hybrid machine learning/deep learning model to classify patients in two outcome categories, non-ICU and ICU (intensive care admission or death), using 558 patients admitted in a northern Italy hospital in February/May of 2020. A fully 3D patient-level CNN classifier on baseline CT images is used as feature extractor. Features extracted, alongside with laboratory and clinical data, are fed for selection in a Boruta algorithm with SHAP game theoretical values. A classifier is built on the reduced feature space using CatBoost gradient boosting algorithm and reaching a probabilistic AUC of 0.949 on holdout test set. The model aims to provide clinical decision support to medical doctors, with the probability score of belonging to an outcome class and with case-based SHAP interpretation of features importance.
    MeSH term(s) Algorithms ; COVID-19/diagnostic imaging ; Deep Learning ; Humans ; Machine Learning ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-07890-1
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  6. Article ; Online: Bilateral carotid artery dissection in a SARS-CoV-2 infected patient: causality or coincidence?

    Morassi, Mauro / Bigni, Barbara / Cobelli, Milena / Giudice, Lodoviga / Bnà, Claudio / Vogrig, Alberto

    Journal of neurology

    2020  Volume 267, Issue 10, Page(s) 2812–2814

    MeSH term(s) Betacoronavirus ; Brain Neoplasms/complications ; COVID-19 ; Carotid Artery, Internal, Dissection/complications ; Coronavirus Infections/complications ; Humans ; Male ; Middle Aged ; Oligodendroglioma/complications ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-020-09984-0
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  7. Article ; Online: 18F-Fluorocholine Uptake by a Head and Neck Meningeal Inflammatory Pseudotumor.

    Savelli, Giordano / Morassi, Mauro / Cobelli, Milena / Stefanelli, Antonella / Zaniboni, Alberto

    Clinical nuclear medicine

    2019  Volume 44, Issue 8, Page(s) 657–659

    Abstract: F-Fluoro-ethyl-choline (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. However, F-FCH may be taken-up by other neoplastic diseases, infections, and non-infective inflammatory processes. While this behavior may be an ... ...

    Abstract F-Fluoro-ethyl-choline (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. However, F-FCH may be taken-up by other neoplastic diseases, infections, and non-infective inflammatory processes. While this behavior may be an opportunity to study different diseases, on the other hand, this condition brings with it the source of error in the evaluation of the images. Here we present the case of a meningeal inflammatory pseudotumor evidenced by F-FCH.
    MeSH term(s) Choline/analogs & derivatives ; Granuloma, Plasma Cell/diagnostic imaging ; Humans ; Male ; Meninges/diagnostic imaging ; Meninges/pathology ; Middle Aged ; Neck/diagnostic imaging ; Neck/pathology ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/diagnostic imaging ; Radiopharmaceuticals
    Chemical Substances Radiopharmaceuticals ; fluorocholine (6029HGL0QP) ; Choline (N91BDP6H0X)
    Language English
    Publishing date 2019-07-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000002635
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    Zs.A 1276: Show issues Location:
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  8. Article ; Online: New Indo-Pacific species of the genus Teretia Norman, 1888 (Gastropoda: Raphitomidae).

    Morassi, Mauro / Bonfitto, Antonio

    Zootaxa

    2015  Volume 3911, Issue 4, Page(s) 560–570

    Abstract: Four new species are assigned to the genus Teretia Norman, 1888 in the family Raphitomidae Bellardi, 1875 and herein described: Teretia neocaledonica sp. nov., T. sysoevi sp. nov., T. tongaensis sp. nov. from the southeastern Pacific and Teretia tavianii ...

    Abstract Four new species are assigned to the genus Teretia Norman, 1888 in the family Raphitomidae Bellardi, 1875 and herein described: Teretia neocaledonica sp. nov., T. sysoevi sp. nov., T. tongaensis sp. nov. from the southeastern Pacific and Teretia tavianii sp. nov. from the Gulf of Aden. The new species represent the first Indo-Pacific record of a genus previously known in the recent molluscan fauna by only two species from the Atlantic Ocean-Mediterranean Sea and Southern Africa. A possible Tethyan origin for the genus Teretia is suggested.
    MeSH term(s) Animal Distribution ; Animal Structures/anatomy & histology ; Animal Structures/growth & development ; Animals ; Atlantic Ocean ; Body Size ; Gastropoda/anatomy & histology ; Gastropoda/classification ; Gastropoda/growth & development ; Indian Ocean ; Organ Size
    Language English
    Publishing date 2015-01-21
    Publishing country New Zealand
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.3911.4.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Four new African turriform gastropods (Mollusca: Conoidea).

    Morassi, Mauro / Bonfitto, Antonio

    Zootaxa

    2015  Volume 3710, Page(s) 271–280

    Abstract: Four new species, belonging to four distinct conoidean families, are described from east Africa and Mozambique Channel. Iredalea adenensis sp. nov. (Drilliidae Olsson, 1964), from Gulf of Aden, and Buchema shearmani sp. nov. (Horaiclavidae Bouchet et al., ...

    Abstract Four new species, belonging to four distinct conoidean families, are described from east Africa and Mozambique Channel. Iredalea adenensis sp. nov. (Drilliidae Olsson, 1964), from Gulf of Aden, and Buchema shearmani sp. nov. (Horaiclavidae Bouchet et al., 2011), from off Mogadishu (Somalia), both trawled by local fishermen, represent the first record of their respective genera in eastern Africa. Crassispira somalica sp. nov. (Pseudomelatomidae Morrison, 1965), also collected offshore from Modagishu (Somalia), represents the first eastern Africa species bearing "typical" Crassispira features. Tropidoturris vizcondei sp. nov. (Borsoniidae Bellardi, 1875), from the Mozambique Channel, increases the knowledge of a genus considered endemic to southeastern Africa.
    MeSH term(s) Africa, Eastern ; Animals ; Biodiversity ; Gastropoda/anatomy & histology ; Gastropoda/classification
    Language English
    Publishing date 2015-06-02
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5326
    ISSN 1175-5326
    DOI 10.11646/zootaxa.3710.3.5
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  10. Article ; Online: Late intracranial metastasis from adenoid-cystic carcinoma of the parotid gland: Imaging, histologic and molecular features.

    Morassi, Mauro / Scavuzzo, Alessandro / Cobelli, Milena / Liserre, Barbara / Arias, Jahard Aliaga / Biasi, Brunella Di

    Current problems in cancer

    2020  Volume 44, Issue 5, Page(s) 100564

    Abstract: We describe the neuroradiologic, histologic, and genetic features of a very unusual intracranial dural metastasis from adenoid cystic carcinoma of the parotid gland detected 27 years after the initial diagnosis. ...

    Abstract We describe the neuroradiologic, histologic, and genetic features of a very unusual intracranial dural metastasis from adenoid cystic carcinoma of the parotid gland detected 27 years after the initial diagnosis.
    MeSH term(s) Brain Neoplasms/secondary ; Brain Neoplasms/surgery ; Carcinoma, Adenoid Cystic/pathology ; Carcinoma, Adenoid Cystic/surgery ; Humans ; Male ; Middle Aged ; Parotid Neoplasms/pathology ; Parotid Neoplasms/surgery ; Prognosis
    Language English
    Publishing date 2020-03-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 441816-5
    ISSN 1535-6345 ; 0147-0272
    ISSN (online) 1535-6345
    ISSN 0147-0272
    DOI 10.1016/j.currproblcancer.2020.100564
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