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Article ; Online: A Retrospective Cohort Analysis of Mental Health-Related Emergency Department Visits Among Veterans and Non-Veterans Residing in Ontario, Canada: Une analyse de cohorte rétrospective des visites au service d'urgence liées à la santé mentale parmi les vétérans et non-vétérans résidant en Ontario, Canada.

St Cyr, Kate / Smith, Peter / Kurdyak, Paul / Cramm, Heidi / Aiken, Alice B / Mahar, Alyson

Canadian journal of psychiatry. Revue canadienne de psychiatrie

2024 Volume 69, Issue 5, Page(s) 347–357

Abstract: Objectives: Emergency departments (EDs) are a vital part of healthcare systems, at times acting as a gateway to community-based mental health (MH) services. This may be particularly true for veterans of the Royal Canadian Mounted Police who were ... ...

Abstract	Objectives: Emergency departments (EDs) are a vital part of healthcare systems, at times acting as a gateway to community-based mental health (MH) services. This may be particularly true for veterans of the Royal Canadian Mounted Police who were released prior to 2013 and the Canadian Armed Forces, as these individuals transition from federal to provincial healthcare coverage on release and may use EDs because of delays in obtaining a primary care provider. We aimed to estimate the hazard ratio (HR) of MH-related ED visits between veterans and non-veterans residing in Ontario, Canada: (1) overall; and by (2) sex; and (3) length of service. Methods: This retrospective cohort study used administrative healthcare data from 18,837 veterans and 75,348 age-, sex-, geography-, and income-matched non-veterans residing in Ontario, Canada between April 1, 2002, and March 31, 2020. Anderson-Gill regression models were used to estimate the HR of recurrent MH-related ED visits during the period of follow-up. Sex and length of service were used as stratification variables in the models. Results: Veterans had a higher adjusted HR (aHR) of MH-related ED visits than non-veterans (aHR, 1.97, 95% CI, 1.70 to 2.29). A stronger effect was observed among females (aHR, 3.29; 95% CI, 1.96 to 5.53) than males (aHR, 1.78; 95% CI, 1.57 to 2.01). Veterans who served for 5-9 years had a higher rate of use than non-veterans (aHR, 3.76; 95% CI, 2.34 to 6.02) while veterans who served for 30+ years had a lower rate compared to non-veterans (aHR, 0.60; 95% CI, 0.42 à 0.84). Conclusions: Rates of MH-related ED visits are higher among veterans overall compared to members of the Ontario general population, but usage is influenced by sex and length of service. These findings indicate that certain subpopulations of veterans, including females and those with fewer years of service, may have greater acute mental healthcare needs and/or reduced access to primary mental healthcare.
MeSH term(s)	Female ; Male ; Humans ; Ontario/epidemiology ; Veterans/psychology ; Retrospective Studies ; Mental Health ; Emergency Room Visits ; Cohort Studies ; Emergency Service, Hospital
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	304227-3
ISSN	1497-0015 ; 0008-4824 ; 0706-7437
ISSN (online)	1497-0015
ISSN	0008-4824 ; 0706-7437
DOI	10.1177/07067437231223328
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Article ; Online: Comparing approaches to determining poor oral health among older adults in a national survey.

Horncastle, Alice J / Gauld, Taylor D / Smith, Moira B / Thomson, W Murray

Gerodontology

2023

Abstract: Objectives: To compare the clinical validity of the three approaches in residential care facility residents.: Background: In NZ residential care facilities, the interRAI assessment tool is used by trained registered nurses for assessing oral status ... ...

Abstract	Objectives: To compare the clinical validity of the three approaches in residential care facility residents. Background: In NZ residential care facilities, the interRAI assessment tool is used by trained registered nurses for assessing oral status when new residents are admitted, but its validity has been questioned. Although Locker's global oral health item has been used to measure oral health in surveys and health services research, it is not routinely used in care facilities, yet its clinical validity has been demonstrated in population-based samples. Self-perceived oral health need may also be useful. Materials and methods: Using a secondary analysis of clinical and self-reported data from a national survey of nursing home residents (the 2012 New Zealand Older People's Oral Health Survey, or OPOHS), we compared the validity of Locker's item, the interRAI tool and self-reported treatment need for identifying three key clinical indicators of poor oral health among dentate older adults; those were coronal caries (3+ teeth affected), root caries (1+ teeth affected) and xerostomia. Analyses were conducted using STATA, and survey weighting was used to obtain estimates for a source population of 25-843 individuals. Results: The prevalence of 3+ teeth with coronal caries was 28.7% (23.9, 34.0), the prevalence of 1+ teeth with root caries was 33.7% (28.7, 39.0), the prevalence of xerostomia was 23.1% (18.4, 28.3). Marked gradients in prevalence risk ratio were seen across different categories of Locker's global oral health item and the interRAI assessment tooth for coronal caries and xerostomia. Locker's global oral health item gave a better fitting model and was more discriminative in detecting coronal caries than the interRAI assessment tool (Lockers AIC = 0.76, interRAI AIC = 0.81). None of the approaches was particularly discriminative for root surface caries experience. Conclusion: Self-reported approaches are discriminative for poor oral health. Standardised assessment tools used in residential care facilities should consider including a self-assessment component such as Locker's global oral health item.
Language	English
Publishing date	2023-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	604810-9
ISSN	1741-2358 ; 0734-0664
ISSN (online)	1741-2358
ISSN	0734-0664
DOI	10.1111/ger.12729
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Article ; Online: Getting back to that point of balance

John R. Oberholzer Dent / Carolyn Smith / M. Cristina Gonzales / Alice B. Lincoln-Cook

Ecology and Society, Vol 28, Iss 1, p

Indigenous environmental justice and the California Indian Basketweavers’ Association

2023 Volume 14

Abstract: Emerging theories of Indigenous environmental justice reframe environmental problems and solutions using Indigenous onto-epistemologies, emphasizing the agency of non-human relations and influence of colonialism. The California Indian Basketweavers’ ... ...

Abstract	Emerging theories of Indigenous environmental justice reframe environmental problems and solutions using Indigenous onto-epistemologies, emphasizing the agency of non-human relations and influence of colonialism. The California Indian Basketweavers’ Association (CIBA) embodies this paradigm in its work to expand access to gathering areas, revitalize cultural burning, and stop pesticide use. Through our different positionalities as CIBA members, California Indian basketweavers, and researchers, we construct a case study of Indigenous environmental justice that articulates environmental stewardship as intrinsically linked with cultural and spiritual practice. Through education, information sharing, relationship building, lobbying, and collective action among its membership and land management agencies, CIBA has expanded basketweavers’ access to safe and successful gathering. By sustaining millennia of tradition, CIBA builds Indigenous sovereignty and shifts California’s land management paradigm toward environmental justice and global survival.
Keywords	basketweaving ; california indians ; indigenous environmental justice ; indigenous people ; natural resource management ; pesticides ; prescribed fire ; reciprocal relations ; settler colonialism ; traditional ecological knowledge ; Biology (General) ; QH301-705.5 ; Ecology ; QH540-549.5
Subject code	333 ; 390
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Resilience Alliance
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction to: Considerations for establishing and maintaining international research collaboration: the example of chemotherapy‑induced peripheral neurotoxicity (CIPN)-a white paper.

Alberti, Paola / Argyriou, Andreas A / Bruna, Jordi / Damaj, M Imad / Faithfull, Sara / Harding, Alice / Hoke, Ahmet / Knoerl, Robert / Kolb, Noah / Li, Tiffany / Park, Susanna B / Staff, Nathan P / Tamburin, Stefano / Thomas, Simone / Smith, Ellen Lavoie

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2024 Volume 32, Issue 3, Page(s) 175

Language	English
Publishing date	2024-02-21
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-024-08382-w
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Article ; Online: Machine Learning Potentials with the Iterative Boltzmann Inversion: Training to Experiment.

Matin, Sakib / Allen, Alice E A / Smith, Justin / Lubbers, Nicholas / Jadrich, Ryan B / Messerly, Richard / Nebgen, Benjamin / Li, Ying Wai / Tretiak, Sergei / Barros, Kipton

Journal of chemical theory and computation

2024 Volume 20, Issue 3, Page(s) 1274–1281

Abstract: Methodologies for training machine learning potentials (MLPs) with quantum-mechanical simulation data have recently seen tremendous progress. Experimental data have a very different character than simulated data, and most MLP training procedures cannot ... ...

Abstract	Methodologies for training machine learning potentials (MLPs) with quantum-mechanical simulation data have recently seen tremendous progress. Experimental data have a very different character than simulated data, and most MLP training procedures cannot be easily adapted to incorporate both types of data into the training process. We investigate a training procedure based on iterative Boltzmann inversion that produces a pair potential correction to an existing MLP using equilibrium radial distribution function data. By applying these corrections to an MLP for pure aluminum based on density functional theory, we observe that the resulting model largely addresses previous overstructuring in the melt phase. Interestingly, the corrected MLP also exhibits improved performance in predicting experimental diffusion constants, which are not included in the training procedure. The presented method does not require autodifferentiating through a molecular dynamics solver and does not make assumptions about the MLP architecture. Our results suggest a practical framework for incorporating experimental data into machine learning models to improve the accuracy of molecular dynamics simulations.
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ISSN	1549-9626
ISSN (online)	1549-9626
DOI	10.1021/acs.jctc.3c01051
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Article ; Online: The Short-term Effects of Artificial Tears on the Tear Film Assessed by a Novel High-Resolution Tear Film Imager: A Pilot Study.

Antman, Gal / Tessone, Isaac / Rios, Hernan A / Verticchio, Alice / Sidoti, Paul A / King-Smith, P Ewen / Suchowski, Haim / Beitner, Daniel / Eckert, George / Siesky, Brent / Rosen, Richard B / Chen, Masako

Cornea

2024

Abstract: Purpose: The purpose of this study was to investigate the effects of artificial tears (AT) on the sublayers of the tear film assessed by a novel tear film imaging (TFI) device.: Methods: The mucoaqueous layer thickness (MALT) and lipid layer ... ...

Abstract	Purpose: The purpose of this study was to investigate the effects of artificial tears (AT) on the sublayers of the tear film assessed by a novel tear film imaging (TFI) device. Methods: The mucoaqueous layer thickness (MALT) and lipid layer thickness (LLT) of 198 images from 11 healthy participants, 9 of whom had meibomian gland disease, were prospectively measured before and after exposure to 3 different AT preparations (Refresh Plus; Retaine [RTA]; Systane Complete PF [SYS]), using a novel nanometer resolution TFI device (AdOM, Israel). Participants were assessed at baseline and at 1, 5, 10, 30, and 60 minutes after instilling 1 drop of AT during 3 sessions on separate days. Repeated-measures analysis of variances were used for comparisons with P < 0.05 considered significant. Results: For all ATs, the mean MALT was greatest 1 minute after drop instillation, with an increase of 67%, 55%, and 11% above the baseline for SYS, Refresh Plus, and RTA, respectively. The SYS formulation demonstrated the highest percentage increases in mean MALT and LLT at most postdrop time points. The MALT differences were significantly higher in the SYS than in the RTA (P = 0.014). After 60 minutes, no AT group demonstrated statistically significant changes in MALT or LLT compared with baseline. Conclusions: We report, for the first time, the effects of AT on MALT and LLT using a high-resolution TFI. A substantial acute mean MALT increase occurs 1 minute after AT instillation with all agents tested, but there were clear differences in response and durability, suggesting the benefits of choosing specific AT according to the needs of each patient.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0000000000003505
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Zs.A 1790: Show issues

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Article ; Online: Protecting Human and Animal Health: The Road from Animal Models to New Approach Methods.

Kaplan, Barbara L F / Hoberman, Alan M / Slikker, William / Smith, Mary Alice / Corsini, Emanuela / Knudsen, Thomas B / Marty, M Sue / Sobrian, Sonya K / Fitzpatrick, Suzanne C / Ratner, Marcia H / Mendrick, Donna L

Pharmacological reviews

2024 Volume 76, Issue 2, Page(s) 251–266

Abstract: Animals and animal models have been invaluable for our current understanding of human and animal biology, including physiology, pharmacology, biochemistry, and disease pathology. However, there are increasing concerns with continued use of animals in ... ...

Abstract	Animals and animal models have been invaluable for our current understanding of human and animal biology, including physiology, pharmacology, biochemistry, and disease pathology. However, there are increasing concerns with continued use of animals in basic biomedical, pharmacological, and regulatory research to provide safety assessments for drugs and chemicals. There are concerns that animals do not provide sufficient information on toxicity and/or efficacy to protect the target population, so scientists are utilizing the principles of replacement, reduction, and refinement (the 3Rs) and increasing the development and application of new approach methods (NAMs). NAMs are any technology, methodology, approach, or assay used to understand the effects and mechanisms of drugs or chemicals, with specific focus on applying the 3Rs. Although progress has been made in several areas with NAMs, complete replacement of animal models with NAMs is not yet attainable. The road to NAMs requires additional development, increased use, and, for regulatory decision making, usually formal validation. Moreover, it is likely that replacement of animal models with NAMs will require multiple assays to ensure sufficient biologic coverage. The purpose of this manuscript is to provide a balanced view of the current state of the use of animal models and NAMs as approaches to development, safety, efficacy, and toxicity testing of drugs and chemicals. Animals do not provide all needed information nor do NAMs, but each can elucidate key pieces of the puzzle of human and animal biology and contribute to the goal of protecting human and animal health. SIGNIFICANCE STATEMENT: Data from traditional animal studies have predominantly been used to inform human health safety and efficacy. Although it is unlikely that all animal studies will be able to be replaced, with the continued advancement in new approach methods (NAMs), it is possible that sometime in the future, NAMs will likely be an important component by which the discovery, efficacy, and toxicity testing of drugs and chemicals is conducted and regulatory decisions are made.
MeSH term(s)	Animals ; Humans ; Toxicity Tests/methods ; Models, Animal
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	209898-2
ISSN	1521-0081 ; 0031-6997
ISSN (online)	1521-0081
ISSN	0031-6997
DOI	10.1124/pharmrev.123.000967
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Article: Disseminated tuberculosis in a lung transplant recipient presenting as tenosynovitis, subcutaneous nodules, and liver abscesses.

Vargas Barahona, Lilian / Henao-Cordero, José / Smith, Joshua / Gray, Alice / Marshall, Carrie B / Scherger, Sias / Bajrovic, Valida / Koullias, Yiannis

Therapeutic advances in infectious disease

2022 Volume 9, Page(s) 20499361221132153

Abstract: Tuberculosis is of particular concern in lung transplant recipients. We present the case of a patient who received a double lung transplant from a deceased donor from Mexico and developed disseminated tuberculosis 60 days post-transplant manifested as ... ...

Abstract	Tuberculosis is of particular concern in lung transplant recipients. We present the case of a patient who received a double lung transplant from a deceased donor from Mexico and developed disseminated tuberculosis 60 days post-transplant manifested as tenosynovitis, liver abscesses, and subcutaneous nodules with no definitive lung allograft involvement. The recipient did not have evidence of tuberculosis on explanted lungs, had a negative interferon gamma release assay pre-transplant, and did not have risk factors for this infection.
Language	English
Publishing date	2022-10-20
Publishing country	England
Document type	Case Reports
ZDB-ID	2728410-4
ISSN	2049-937X ; 2049-9361
ISSN (online)	2049-937X
ISSN	2049-9361
DOI	10.1177/20499361221132153
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Article ; Online: Engagement of individuals with serious mental illness in outpatient mental health services and telehealth use during the COVID-19 pandemic.

Bareis, Natalie / Tepper, Miriam C / Wang, Rui / Tang, Fei / Olfson, Mark / Dixon, Lisa B / Kimhy, David / Wall, Melanie M / Medalia, Alice / Finnerty, Molly T / Anderson, Adrienne / Smith, Thomas E

Psychiatry research

2023 Volume 329, Page(s) 115497

Abstract: Questions remain regarding whether the transition and continued use of telehealth was associated with changes in treatment engagement among patients with serious mental illness (SMI). Using NYS Medicaid claims, we identified 116,497 individuals with SMI ... ...

Abstract	Questions remain regarding whether the transition and continued use of telehealth was associated with changes in treatment engagement among patients with serious mental illness (SMI). Using NYS Medicaid claims, we identified 116,497 individuals with SMI receiving outpatient mental health services from September 1, 2019-February 28, 2021 and a comparison cohort of 101,995 from September 1, 2017-February 28, 2019 to account for unmeasured and seasonal variation. We characterized engagement in three 6-month increments (T
MeSH term(s)	United States/epidemiology ; Humans ; Female ; Outpatients ; Pandemics ; COVID-19 ; Ambulatory Care ; Telemedicine ; Mental Health Services ; Mental Disorders/epidemiology ; Mental Disorders/therapy
Language	English
Publishing date	2023-09-24
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2023.115497
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Article ; Online: Considerations for establishing and maintaining international research collaboration: the example of chemotherapy-induced peripheral neurotoxicity (CIPN)-a white paper.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2024 Volume 32, Issue 2, Page(s) 117

Abstract: Purpose: This white paper provides guidance regarding the process for establishing and maintaining international collaborations to conduct oncology/neurology-focused chemotherapy-induced peripheral neurotoxicity (CIPN) research.: Methods: An ... ...

Abstract	Purpose: This white paper provides guidance regarding the process for establishing and maintaining international collaborations to conduct oncology/neurology-focused chemotherapy-induced peripheral neurotoxicity (CIPN) research. Methods: An international multidisciplinary group of CIPN scientists, clinicians, research administrators, and legal experts have pooled their collective knowledge regarding recommendations for establishing and maintaining international collaboration to foster advancement of CIPN science. Results: Experts provide recommendations in 10 categories: (1) preclinical and (2) clinical research collaboration; (3) collaborators and consortiums; (4) communication; (5) funding; (6) international regulatory standards; (7) staff training; (8) data management, quality control, and data sharing; (9) dissemination across disciplines and countries; and (10) additional recommendations about feasibility, policy, and mentorship. Conclusion: Recommendations to establish and maintain international CIPN research collaboration will promote the inclusion of more diverse research participants, increasing consideration of cultural and genetic factors that are essential to inform innovative precision medicine interventions and propel scientific discovery to benefit cancer survivors worldwide. Relevance to inform research policy: Our suggested guidelines for establishing and maintaining international collaborations to conduct oncology/neurology-focused chemotherapy-induced peripheral neurotoxicity (CIPN) research set forth a challenge to multinational science, clinical, and policy leaders to (1) develop simple, streamlined research designs; (2) address logistical barriers; (3) simplify and standardize regulatory requirements across countries; (4) increase funding to support international collaboration; and (5) foster faculty mentorship.
MeSH term(s)	Humans ; Peripheral Nervous System Diseases/chemically induced ; Antineoplastic Agents/adverse effects ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/drug therapy ; Cancer Survivors ; Administrative Personnel
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2024-01-20
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-023-08301-5
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