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  1. Book: Best 2022 Clinical Cases in Intensive Care Medicine

    Pérez-Torres, David / Schaller, Stefan J. / Martínez-Martínez, María

    From the ESICM NEXT Committee Clinical Case Contest

    (Lessons from the ICU)

    2023  

    Author's details Series Editors § Maurizio Cecconi is Head of Department Anaesthesia and Intensive Care Units, IRCCS Istituto Clinico Humanitas, Rozzano (MI), Italy and Professor of Anaesthesia and Intensive Care, Humanitas University, Pieve Emanuele (MI), Italy. His main fields of research are haemodynamic monitoring, haemodynamic optimisation and physiology of the critically ill patient. He has published extensively and has specific interest in haemodynamic monitoring and fluid management of the critically ill. Daniel De Backer is Professor of Intensive Care at the Université Libre de Bruxelles, Brussels, Belgium Head of Intensive Care Departments of CHIREC Hospitals (Brussels and Braine l'Alleud-Waterloo). His main fields of investigation are severe sepsis, organ dysfunction, acute circulatory failure and its treatment (in particular vasoactive agents), haemodynamic monitoring, hepato-splanchnic circulation and microcirculatory disorders. §§ Volume Editors David Pérez-Torres is a Consultant in In
    Series title Lessons from the ICU
    Keywords severe infections and sepsis ; Respiratory Medicine ; Cardiovascular Medicine ; neurocritical care and severe trauma ; Differential diagnosis ; treatment ; Outcome ; respiratory medicine ; cardiovascular medicine ; differential diagnosis ; outcome
    Language English
    Size 648 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_24
    Format 173 x 246 x 41
    ISBN 9783031363979 ; 3031363973
    Database PDA

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  2. Article ; Online: Physiological response and photoacclimation capacity of Caulerpa prolifera (Forsskål) J.V. Lamouroux and Cymodocea nodosa (Ucria) Ascherson meadows in the Mar Menor lagoon (SE Spain).

    García-Sánchez, Marta / Korbee, Nathalie / Pérez-Ruzafa, Isabel M A / Marcos, Concepción / Domínguez, Belén / Figueroa, Félix L / Pérez-Ruzafa, Ángel

    Marine environmental research

    2012  Volume 79, Page(s) 37–47

    Abstract: The macroalga Caulerpa prolifera colonized the Mar Menor coastal lagoon after the enlargement ...

    Abstract The macroalga Caulerpa prolifera colonized the Mar Menor coastal lagoon after the enlargement of the main inlet in 1972, coexisting now with the previous Cymodocea nodosa meadows. The physiological response and the photoacclimation capacity of both species were studied. For this purpose in vivo chlorophyll a fluorescence, photoprotective mechanisms and oxidative stress were measured in both species in summer 2010 and exposure-recovery experiments were conducted to determine the acclimation capacity of both species. The results suggest that C. prolifera behaves as a shade-adapted species with a low photoprotective capacity, light being one of the main factors governing its distribution in the lagoon. The high photosynthetic capacity and lack of photoinhibition found in C. nodosa suggest that this species is highly photoprotected. It also possesses a high concentration of lutein and a high de-epoxidation degree, related to a much higher NPQ(max) value.
    MeSH term(s) Acclimatization/physiology ; Antioxidants/metabolism ; Bays ; Carbon/analysis ; Caulerpa/physiology ; Chlorophyll/metabolism ; Chlorophyta/physiology ; Light ; Lipid Peroxidation ; Nitrogen/analysis ; Photosynthesis/physiology ; Photosynthesis/radiation effects ; Spain
    Chemical Substances Antioxidants ; Chlorophyll (1406-65-1) ; Carbon (7440-44-0) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2012-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1502505-6
    ISSN 1879-0291 ; 0141-1136
    ISSN (online) 1879-0291
    ISSN 0141-1136
    DOI 10.1016/j.marenvres.2012.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Technologies and Applications for Big Data Value

    Curry, Edward / Auer, Sören / Berre, Arne J. / Metzger, Andreas / Perez, Maria S. / Zillner, Sonja

    2022  

    Author's details edited by Edward Curry, Sören Auer, Arne J. Berre, Andreas Metzger, Maria S. Perez, Sonja Zillner
    Keywords Data mining ; Big data ; Quantitative research ; Application software ; Expert systems (Computer science)
    Subject code 006.312
    Language English
    Size 1 Online-Ressource (XXIV, 544 p. 176 illus., 164 illus. in color)
    Edition 1st ed. 2022
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT021360785
    ISBN 978-3-030-78307-5 ; 9783030783068 ; 9783030783082 ; 9783030783099 ; 3-030-78307-3 ; 3030783065 ; 3030783081 ; 303078309X
    DOI 10.1007/978-3-030-78307-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: Technologies and Applications for Big Data Value

    Curry, Edward / Auer, Sören / Berre, Arne J. / Metzger, Andreas / Perez, Maria S. / Zillner, Sonja

    2022  

    Keywords Data mining ; Databases ; Probability & statistics ; Information technology: general issues ; Expert systems / knowledge-based systems ; Big Data ; Data Management ; Data Processing ; Data Analytics ; Data Visualisation and User Interaction ; Knowledge Discovery ; Information Retrieval
    Language 0|e
    Size 1 electronic resource (544 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021614181
    ISBN 9783030783075 ; 3030783073
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article: Physiological response and photoacclimation capacity of Caulerpa prolifera (Forsskål) J.V. Lamouroux and Cymodocea nodosa (Ucria) Ascherson meadows in the Mar Menor lagoon (SE Spain)

    García-Sánchez, Marta / Korbee, Nathalie / Pérez-Ruzafa, Isabel M(a) / Marcos, Concepción / Domínguez, Belén / Figueroa, Félix L / Pérez-Ruzafa, Ángel

    Marine environmental research. 2012 Aug., v. 79

    2012  

    Abstract: The macroalga Caulerpa prolifera colonized the Mar Menor coastal lagoon after the enlargement ...

    Abstract The macroalga Caulerpa prolifera colonized the Mar Menor coastal lagoon after the enlargement of the main inlet in 1972, coexisting now with the previous Cymodocea nodosa meadows. The physiological response and the photoacclimation capacity of both species were studied. For this purpose in vivo chlorophyll a fluorescence, photoprotective mechanisms and oxidative stress were measured in both species in summer 2010 and exposure-recovery experiments were conducted to determine the acclimation capacity of both species. The results suggest that C. prolifera behaves as a shade-adapted species with a low photoprotective capacity, light being one of the main factors governing its distribution in the lagoon. The high photosynthetic capacity and lack of photoinhibition found in C. nodosa suggest that this species is highly photoprotected. It also possesses a high concentration of lutein and a high de-epoxidation degree, related to a much higher NPQmax value.
    Keywords Caulerpa ; acclimation ; chlorophyll ; fluorescence ; lutein ; macroalgae ; meadows ; oxidative stress ; photoinhibition ; physiological response ; summer ; Spain
    Language English
    Dates of publication 2012-08
    Size p. 37-47.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1502505-6
    ISSN 1879-0291 ; 0141-1136
    ISSN (online) 1879-0291
    ISSN 0141-1136
    DOI 10.1016/j.marenvres.2012.05.001
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Redox-mediated activation of ATG3 promotes ATG8 lipidation and autophagy progression in Chlamydomonas reinhardtii.

    Mallén-Ponce, Manuel J / Pérez-Pérez, María Esther

    Plant physiology

    2023  Volume 194, Issue 1, Page(s) 359–375

    Abstract: Autophagy is one of the main degradative pathways used by eukaryotic organisms to eliminate useless or damaged intracellular material to maintain cellular homeostasis under stress conditions. Mounting evidence indicates a strong interplay between the ... ...

    Abstract Autophagy is one of the main degradative pathways used by eukaryotic organisms to eliminate useless or damaged intracellular material to maintain cellular homeostasis under stress conditions. Mounting evidence indicates a strong interplay between the generation of reactive oxygen species and the activation of autophagy. Although a tight redox regulation of autophagy has been shown in several organisms, including microalgae, the molecular mechanisms underlying this control remain poorly understood. In this study, we have performed an in-depth in vitro and in vivo redox characterization of ATG3, an E2-activating enzyme involved in ATG8 lipidation and autophagosome formation, from 2 evolutionary distant unicellular model organisms: the green microalga Chlamydomonas (Chlamydomonas reinhardtii) and the budding yeast Saccharomyces cerevisiae. Our results indicated that ATG3 activity from both organisms is subjected to redox regulation since these proteins require reducing equivalents to transfer ATG8 to the phospholipid phosphatidylethanolamine. We established the catalytic Cys of ATG3 as a redox target in algal and yeast proteins and showed that the oxidoreductase thioredoxin efficiently reduces ATG3. Moreover, in vivo studies revealed that the redox state of ATG3 from Chlamydomonas undergoes profound changes under autophagy-activating stress conditions, such as the absence of photoprotective carotenoids, the inhibition of fatty acid synthesis, or high light irradiance. Thus, our results indicate that the redox-mediated activation of ATG3 regulates ATG8 lipidation under oxidative stress conditions in this model microalga.
    MeSH term(s) Chlamydomonas reinhardtii/genetics ; Chlamydomonas reinhardtii/metabolism ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Autophagy/physiology ; Chlamydomonas/metabolism ; Oxidation-Reduction ; Saccharomyces cerevisiae Proteins/metabolism ; Ubiquitin-Conjugating Enzymes/metabolism ; Autophagy-Related Protein 8 Family/genetics ; Autophagy-Related Protein 8 Family/metabolism
    Chemical Substances Autophagy-Related Proteins ; ATG3 protein, S cerevisiae (EC 6.3.2.-) ; Saccharomyces cerevisiae Proteins ; Ubiquitin-Conjugating Enzymes (EC 2.3.2.23) ; ATG8 protein, S cerevisiae ; Autophagy-Related Protein 8 Family
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1093/plphys/kiad520
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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  7. Article ; Online: Bile-acid-induced cell injury and protection.

    Perez, Maria-J / Briz, Oscar

    World journal of gastroenterology

    2009  Volume 15, Issue 14, Page(s) 1677–1689

    Abstract: Several studies have characterized the cellular and molecular mechanisms of hepatocyte injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs may disrupt cell membranes through their detergent action on lipid ... ...

    Abstract Several studies have characterized the cellular and molecular mechanisms of hepatocyte injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs may disrupt cell membranes through their detergent action on lipid components and can promote the generation of reactive oxygen species that, in turn, oxidatively modify lipids, proteins, and nucleic acids, and eventually cause hepatocyte necrosis and apoptosis. Several pathways are involved in triggering hepatocyte apoptosis. Toxic BAs can activate hepatocyte death receptors directly and induce oxidative damage, thereby causing mitochondrial dysfunction, and induce endoplasmic reticulum stress. When these compounds are taken up and accumulate inside biliary cells, they can also cause apoptosis. Regarding extrahepatic tissues, the accumulation of BAs in the systemic circulation may contribute to endothelial injury in the kidney and lungs. In gastrointestinal cells, BAs may behave as cancer promoters through an indirect mechanism involving oxidative stress and DNA damage, as well as acting as selection agents for apoptosis-resistant cells. The accumulation of BAs may have also deleterious effects on placental and fetal cells. However, other BAs, such as ursodeoxycholic acid, have been shown to modulate BA-induced injury in hepatocytes. The major beneficial effects of treatment with ursodeoxycholic acid are protection against cytotoxicity due to more toxic BAs; the stimulation of hepatobiliary secretion; antioxidant activity, due in part to an enhancement in glutathione levels; and the inhibition of liver cell apoptosis. Other natural BAs or their derivatives, such as cholyl-N-methylglycine or cholylsarcosine, have also aroused pharmacological interest owing to their protective properties.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Bile Acids and Salts/chemistry ; Bile Acids and Salts/metabolism ; Bile Acids and Salts/pharmacology ; Biliary Tract Diseases/physiopathology ; Cell Membrane/drug effects ; Cholestasis/metabolism ; Cytoprotection/physiology ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Humans ; Molecular Structure ; Oxidative Stress
    Chemical Substances Bile Acids and Salts
    Language English
    Publishing date 2009-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.15.1677
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Successful treatment of sebaceous adenitis with oclacitinib and low-dose prednisolone in a dog.

    Pérez-Aranda, María / Yotti, César / Pérez, Judith / Ginel, Pedro J

    Veterinary dermatology

    2023  Volume 35, Issue 2, Page(s) 238–241

    Abstract: Finding an effective and well-tolerated treatment for canine idiopathic sebaceous adenitis (ISA) can be challenging. This case report describes an 8-year-old male Rottweiler with ISA successfully treated with a combination of oclacitinib and low doses of ...

    Abstract Finding an effective and well-tolerated treatment for canine idiopathic sebaceous adenitis (ISA) can be challenging. This case report describes an 8-year-old male Rottweiler with ISA successfully treated with a combination of oclacitinib and low doses of prednisolone.
    MeSH term(s) Male ; Dogs ; Animals ; Prednisolone/therapeutic use ; Pyrimidines/therapeutic use ; Sulfonamides/therapeutic use ; Dermatitis/drug therapy ; Dermatitis/veterinary ; Dog Diseases/drug therapy ; Lymphadenitis/drug therapy ; Lymphadenitis/veterinary
    Chemical Substances Prednisolone (9PHQ9Y1OLM) ; oclacitinib (99GS5XTB51) ; Pyrimidines ; Sulfonamides
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Case Reports
    ZDB-ID 2011122-8
    ISSN 1365-3164 ; 0959-4493
    ISSN (online) 1365-3164
    ISSN 0959-4493
    DOI 10.1111/vde.13216
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  9. Article: Maintaining excellent outcomes: the impact of age cutoff reclassification on reduced therapy for neuroblastoma patients.

    Pérez-García, María J / Segura, Miguel F

    Translational pediatrics

    2023  Volume 12, Issue 11, Page(s) 1926–1930

    Language English
    Publishing date 2023-11-23
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-23-391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: A third assessment of global marine fisheries discards

    Pérez Roda, Maria Amparo / Gilman, Eric / Huntington, Tim / Kennelly, Steven J. / Suuronen, Petri / Chaloupka, Milani / Medley, Paul A. H.

    (FAO fisheries and aquaculture technical paper ; 633)

    2019  

    Institution FAO
    Author's details by Maria Amparo Pérez Roda, Eric Gilman, Tim Huntington, Steven J. Kennelly, Petri Suuronen, Milani Chaloupka and Paul A. H. Medley
    Series title FAO fisheries and aquaculture technical paper ; 633
    Collection
    Language English
    Size 1 Online-Ressource (xvi, 58 Seiten), Diagramme, Karten
    Publisher Food and Agriculture Organization of the United Nations
    Publishing place Rome
    Publishing country Italy
    Document type Book ; Online
    Note Includes bibliographical references ; Open Access
    HBZ-ID HT020064115
    ISBN 9789251312261 ; 9251312265
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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