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Article ; Online: Optimal graft size for pediatric liver transplantation: Revisited rules.

Chardot, Christophe

2023 Volume 27, Issue 7, Page(s) e14539

Language	English
Publishing date	2023-06-12
Publishing country	Denmark
Document type	Editorial
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14539
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Article: Surgical and Medical Aspects of the Initial Treatment of Biliary Atresia: Position Paper.

Davenport, Mark / Madadi-Sanjani, Omid / Chardot, Christophe / Verkade, Henkjan J / Karpen, Saul J / Petersen, Claus

Journal of clinical medicine

2022 Volume 11, Issue 21

Abstract: Biliary atresia, a fibro-obliterative disease of the newborn, is usually initially treated by Kasai portoenterostomy, although there are many variations in technique and different options for post-operative adjuvant medical therapy. A questionnaire on ... ...

Abstract	Biliary atresia, a fibro-obliterative disease of the newborn, is usually initially treated by Kasai portoenterostomy, although there are many variations in technique and different options for post-operative adjuvant medical therapy. A questionnaire on such topics (e.g., open vs. laparoscopic; the need for liver mobilisation; use of post-operative steroids; use of post-operative anti-viral therapy, etc.) was circulated to delegates (
Language	English
Publishing date	2022-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11216601
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pediatric Liver and Transplant Surgery: Results of an International Survey and Expert Consensus Recommendations.

Lemoine, Caroline P / Madadi-Sanjani, Omid / Petersen, Claus / Chardot, Christophe / de Ville de Goyet, Jean / Superina, Riccardo

Journal of clinical medicine

2023 Volume 12, Issue 9

Abstract: Background: Pediatric liver surgery is a complex and challenging procedure and can be associated with major complications, including mortality. Best practices are not established. The aims of this study were to evaluate surgeons' individual and ... ...

Abstract	Background: Pediatric liver surgery is a complex and challenging procedure and can be associated with major complications, including mortality. Best practices are not established. The aims of this study were to evaluate surgeons' individual and institutional practices in pediatric liver surgery and make recommendations applicable to the management of children who require liver surgery. Methods: A web-based survey was developed, focusing on the surgical management of children with liver conditions. It was distributed to 34 pediatric surgery faculty members of the Biliary Atresia and Related Disorders (BARD) consortium and 28 centers of the European Reference Network-Rare Liver. Using the Delphi method, a series of questions was then created to develop ideas about potential future developments in pediatric liver surgery. Results: The overall survey response rate was 70.6% (24/34), while the response rate for the Delphi questionnaire was 26.5% (9/34). In centers performing pediatric liver surgery, most pediatric subspecialties were present, although pediatric oncology was the least present (79.2%). Nearly all participants surveyed agreed that basic and advanced imaging modalities (including ERCP) should be available in those centers. Most pediatric liver surgeries were performed by pediatric surgeons (69.6%). A majority of participants agreed that centers treating pediatric liver tumors should include a pediatric transplant program (86%) able to perform technical variant grafts and living donor liver transplantation. Fifty-six percent of responders believe pediatric liver transplantation should be performed by specialized pediatric surgeons. Conclusion: Pediatric liver surgery should be performed by specialized pediatric surgeons and should be centralized in regional centers of excellence where all pediatric subspecialists are present. Pediatric hepatobiliary and transplant training needs to be better promoted amongst pediatric surgery fellows to increase this subspecialized workforce.
Language	English
Publishing date	2023-04-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12093229
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Article ; Online: Endoscopic retrograde cholangiopancreatography in patients with neonatal cholestasis: an additional diagnostic tool for selected indications.

Chardot, Christophe

Journal of pediatric gastroenterology and nutrition

2009 Volume 49, Issue 4, Page(s) 380–381

MeSH term(s)	Biliary Atresia/complications ; Biliary Atresia/diagnosis ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Cholestasis/etiology ; Humans ; Infant, Newborn
Language	English
Publishing date	2009-10
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0b013e3181a87135
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Article ; Online: Preservation of native sigmoid colon for secondary continent cystostomy after multivisceral transplantation for chronic intestinal pseudo-obstruction.

Grosman, Julien / Aigrain, Yves / Goulet, Olivier / Lacaille, Florence / Capito, Carmen / Chardot, Christophe

Pediatric transplantation

2021 Volume 26, Issue 2, Page(s) e14180

Abstract: Chronic intestinal pseudo-obstruction (CIPO) is characterized by severe digestive +/- urinary dysmotility. If the conservative management fails, multivisceral transplantation (MVT) may be needed. However, urinary dysmotility remains after MVT and ... ...

Abstract	Chronic intestinal pseudo-obstruction (CIPO) is characterized by severe digestive +/- urinary dysmotility. If the conservative management fails, multivisceral transplantation (MVT) may be needed. However, urinary dysmotility remains after MVT and requires to continue urinary catheterizations and/or drainage. We report on a boy with severe CIPO complicated by (1) chronic intestinal obstruction requiring total parenteral nutrition, decompression gastrostomy, and ileostomy; (2) recurrent line infections; (3) hepatic fibrosis; and (4) distension of the bladder and upper urinary tract, and recurrent urinary infections, leading to non-continent cystostomy for urinary drainage. He underwent MVT at the age of 5 years. The transplant included the liver, stomach, duodenum and pancreas, small bowel, and right colon. The distal native sigmoid colon was preserved. Fifteen months later, he underwent a pull through of the transplanted right colon (Duhamel's procedure), together with a tube continent cystostomy (Monti's procedure) using the native sigmoid. Postoperative course was uneventful, and the remaining ileostomy was closed 3 months later. Five years post-transplant, he is alive and well. He is fed by mouth with complementary gastrostomy feeding at night. He has 3-6 stools per day, with occasional soiling. The cystostomy is used for intermittent urinary catheterization 4 times/day and continuous drainage at night. He is dry, with rare afebrile urinary infections, normal renal function, and un-dilated upper urinary tract. Conclusion: in severe CIPO with urinary involvement, preservation of the distal native sigmoid colon during MVT allows secondary creation of a continent tube cystostomy, which is useful to manage persistent urinary disease.
MeSH term(s)	Catheter-Related Infections/therapy ; Child, Preschool ; Colon, Sigmoid ; Cystostomy/methods ; Gastrostomy ; Humans ; Ileostomy ; Intestinal Obstruction/surgery ; Intestinal Pseudo-Obstruction/surgery ; Liver Cirrhosis/surgery ; Male ; Parenteral Nutrition ; Urinary Tract Infections/therapy ; Viscera/transplantation
Language	English
Publishing date	2021-11-08
Publishing country	Denmark
Document type	Case Reports
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14180
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Article ; Online: Pediatric Liver and Transplant Surgery

Caroline P. Lemoine / Omid Madadi-Sanjani / Claus Petersen / Christophe Chardot / Jean de Ville de Goyet / Riccardo Superina

Journal of Clinical Medicine, Vol 12, Iss 3229, p

Results of an International Survey and Expert Consensus Recommendations

2023 Volume 3229

Abstract	Background: Pediatric liver surgery is a complex and challenging procedure and can be associated with major complications, including mortality. Best practices are not established. The aims of this study were to evaluate surgeons’ individual and institutional practices in pediatric liver surgery and make recommendations applicable to the management of children who require liver surgery. Methods: A web-based survey was developed, focusing on the surgical management of children with liver conditions. It was distributed to 34 pediatric surgery faculty members of the Biliary Atresia and Related Disorders (BARD) consortium and 28 centers of the European Reference Network—Rare Liver. Using the Delphi method, a series of questions was then created to develop ideas about potential future developments in pediatric liver surgery. Results: The overall survey response rate was 70.6% (24/34), while the response rate for the Delphi questionnaire was 26.5% (9/34). In centers performing pediatric liver surgery, most pediatric subspecialties were present, although pediatric oncology was the least present (79.2%). Nearly all participants surveyed agreed that basic and advanced imaging modalities (including ERCP) should be available in those centers. Most pediatric liver surgeries were performed by pediatric surgeons (69.6%). A majority of participants agreed that centers treating pediatric liver tumors should include a pediatric transplant program (86%) able to perform technical variant grafts and living donor liver transplantation. Fifty-six percent of responders believe pediatric liver transplantation should be performed by specialized pediatric surgeons. Conclusion: Pediatric liver surgery should be performed by specialized pediatric surgeons and should be centralized in regional centers of excellence where all pediatric subspecialists are present. Pediatric hepatobiliary and transplant training needs to be better promoted amongst pediatric surgery fellows to increase this subspecialized workforce.
Keywords	pediatric liver surgery ; pediatric liver transplantation ; hepatoblastoma ; hepatocellular carcinoma ; pediatric surgery workforce ; subspecialization ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Outcome of Total Colonic Aganglionosis Involving the Small Bowel Depends on Bowel Length, Liver Disease, and Enterocolitis.

Payen, Elise / Talbotec, Cécile / Chardot, Christophe / Capito, Carmen / Khen-Dunlop, Naziha / Sarnacki, Sabine / Lacaille, Florence / Lambe, Cecile / Goulet, Olivier

Journal of pediatric gastroenterology and nutrition

2022 Volume 74, Issue 5, Page(s) 582–587

Abstract: Objectives: Total colonic aganglionosis involving the small bowel is a rare form of Hirschsprung disease. We aim to analyse the long-term outcomes, digestive autonomy, and complications, to suggest recommendations for prevention and treatment.: ... ...

Abstract	Objectives: Total colonic aganglionosis involving the small bowel is a rare form of Hirschsprung disease. We aim to analyse the long-term outcomes, digestive autonomy, and complications, to suggest recommendations for prevention and treatment. Methods: All patients born between 2000 and 2015 followed in our centre were retrospectively included. We analysed the length of aganglionosis, surgical procedures, growth, duration of parenteral nutrition (PN), enterocolitis, liver disease, intestinal transplantation. Results: Twenty-five patients were followed for a median of 10.9 years. Fifteen patients had less than 80 cm of ganglionic small bowel (SB) with a median of 20 cm. Ten patients had more than 80 cm of ganglionic sB with a median of 115 cm. The median PN duration was significantly shorter for patients with more than 80 cm: 0.9 versus 7.5 years in those with less than 80 cm (P < 0.001). No patient with less than 80 cm was weaned off PN, except 1 who underwent intestinal transplantation. Ten patients with less than 80 cm develop enterocolitis on the excluded segment, leading to emergency entero-colectomy in 5. Liver disease was more frequent in patients with less than 80 cm (11 vs 0). Three patients required combined liver-intestine transplantation; 2 underwent an isolated intestinal transplantation. Conclusions: Digestive autonomy was possible in most patients with more than 80 cm of ganglionic SB. The more severe complication was enterocolitis. Liver disease compromised long-term survival without transplantation. Both complications should be prevented by early diversion and enterectomy of the whole aganglionic segment. Follow-up in or together with a multidisciplinary intestinal rehabilitation centre is suggested.
MeSH term(s)	Enterocolitis/etiology ; Hirschsprung Disease/complications ; Hirschsprung Disease/surgery ; Humans ; Infant ; Intestines ; Liver Diseases/complications ; Retrospective Studies ; Short Bowel Syndrome/complications ; Short Bowel Syndrome/surgery ; Treatment Outcome
Language	English
Publishing date	2022-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003415
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Article ; Online: ASO Author Reflections: Surgical Management of Wilms Tumors with Intravenous Extension: A Multicenter Analysis of Clinical Management with Technical Insights.

Pio, Luca / Abib, Simone / Guerin, Florent / Chardot, Christophe / Blanc, Thomas / Sarrai, Nadia / Martelli, Helene / de Souza, Fernanda K M / Fanelli, Mayara C A / Tamisier, Daniel / Guilhen, José Cícero S / Le Bret, Emmanuel / Belli, Emré / Fadel, Elie / Cypriano, Monica D S / Minard, Véronique / Pasqualini, Claudia / Schleiermacher, Gudrun / Lemelle, Lauriane /

Rod, Julien / Irtan, Sabine / Pistorio, Angela / Gauthier, Frederic / Branchereau, Sophie / Sarnacki, Sabine

Annals of surgical oncology

2024

Language	English
Publishing date	2024-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-024-15325-6
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Article ; Online: Biliary atresia.

Chardot, Christophe

Orphanet journal of rare diseases

2006 Volume 1, Page(s) 28

Abstract: Biliary atresia (BA) is a rare disease characterised by a biliary obstruction of unknown origin that presents in the neonatal period. It is the most frequent surgical cause of cholestatic jaundice in this age group. BA occurs in approximately 1/18,000 ... ...

Abstract	Biliary atresia (BA) is a rare disease characterised by a biliary obstruction of unknown origin that presents in the neonatal period. It is the most frequent surgical cause of cholestatic jaundice in this age group. BA occurs in approximately 1/18,000 live births in Western Europe. In the world, the reported incidence varies from 5/100,000 to 32/100,000 live births, and is highest in Asia and the Pacific region. Females are affected slightly more often than males. The common histopathological picture is one of inflammatory damage to the intra- and extrahepatic bile ducts with sclerosis and narrowing or even obliteration of the biliary tree. Untreated, this condition leads to cirrhosis and death within the first years of life. BA is not known to be a hereditary condition. No primary medical treatment is relevant for the management of BA. Once BA suspected, surgical intervention (Kasai portoenterostomy) should be performed as soon as possible as operations performed early in life is more likely to be successful. Liver transplantation may be needed later if the Kasai operation fails to restore the biliary flow or if cirrhotic complications occur. At present, approximately 90% of BA patients survive and the majority have normal quality of life.
MeSH term(s)	Biliary Atresia/complications ; Biliary Atresia/pathology ; Biliary Atresia/surgery ; Biliary Tract/pathology ; Biliary Tract Surgical Procedures ; Cholestasis/etiology ; Female ; Humans ; Infant, Newborn ; Liver Transplantation ; Male
Language	English
Publishing date	2006-07-26
Publishing country	England
Document type	Journal Article ; Review
ISSN	1750-1172
ISSN (online)	1750-1172
DOI	10.1186/1750-1172-1-28
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Surgical and Medical Aspects of the Initial Treatment of Biliary Atresia

Mark Davenport / Omid Madadi-Sanjani / Christophe Chardot / Henkjan J. Verkade / Saul J. Karpen / Claus Petersen

Journal of Clinical Medicine, Vol 11, Iss 6601, p

Position Paper

2022 Volume 6601

Abstract	Biliary atresia, a fibro-obliterative disease of the newborn, is usually initially treated by Kasai portoenterostomy, although there are many variations in technique and different options for post-operative adjuvant medical therapy. A questionnaire on such topics (e.g., open vs. laparoscopic; the need for liver mobilisation; use of post-operative steroids; use of post-operative anti-viral therapy, etc.) was circulated to delegates ( n = 43) of an international webinar (Biliary Atresia and Related Diseases—BARD) held in June 2021. Respondents were mostly European, but included some from North America, and represented 18 different countries overall. The results of this survey are presented here, together with a commentary and review from an expert panel convened for the meeting on current trends in practice.
Keywords	biliary atresia ; Kasai operation ; adjuvant therapy ; corticosteroids ; cytomegalovirus ; ursodeoxycholic acid ; Medicine ; R
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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