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Article ; Online: Cytomegalovirus infection and disease in pediatric liver transplantation: Burden of disease under a preemptive therapy approach.

Arroyo-Orvañanos, Jorge / Hernández-Plata, José-Alejandro / Erro-Aboytia, Rosa / Nieto-Zermeño, Jaime / Reyes-López, Alfonso / Varela-Fascinetto, Gustavo

Pediatric transplantation

2022 Volume 27, Issue 1, Page(s) e14356

Abstract: Background: CMV remains a frequent complication after liver transplantation. Few studies exist in children reporting the epidemiology and outcomes of CMV after LT with current prevention strategies. Our goal is to report the incidence of CMV infection ... ...

Abstract	Background: CMV remains a frequent complication after liver transplantation. Few studies exist in children reporting the epidemiology and outcomes of CMV after LT with current prevention strategies. Our goal is to report the incidence of CMV infection and disease in pediatric LT recipients under preemptive therapy, identify risk factors, complications, and adverse reactions to treatment. Methods: All pediatric LT recipients from a single center (1998-2018) were included. Antigenemia pp65 (1998-2003) and QNAT or both were used to inform preemptive therapy. Cutoff value for starting treatment was Agpp65 > 10 + cells/200 000 or QNAT >1500 copies/ml or any value in high-risk recipients (D+/R-). Results: One hundred eighteen LT were analyzed. CMV infection was detected in 67% of patients, only 44 (37%) required treatment, and 5 (4%) developed CMV disease. All patients responded well to treatment, and no graft or patients were lost to CMV effects. There were no differences in mortality, CMV indirect effects, or other complications between those who required treatment and those who did not. Thirty-two percent of the patients who received antivirals developed an adverse hematological reaction. Risk factors associated with CMV infection requiring treatment were D+/R- (OR 13.9, p = .01) and fulminant hepatitis (OR 4.8, p = .02). Conclusions: Preemptive therapy for CMV in children is safe and effective, yields low CMV infection rates that require treatment, and minimal rates of CMV disease, without increasing CMV-related complications. Using this strategy, 63% of our patients did not receive treatment. Therefore, drug exposure, adverse reactions, and resistance risk were minimized.
MeSH term(s)	Humans ; Child ; Liver Transplantation ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/etiology ; Cytomegalovirus Infections/drug therapy ; Antiviral Agents/therapeutic use ; Risk Factors ; Cost of Illness ; Ganciclovir/therapeutic use
Chemical Substances	Antiviral Agents ; Ganciclovir (P9G3CKZ4P5)
Language	English
Publishing date	2022-07-17
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14356
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Article ; Online: Esophagitis caused by L-arginine capsule retention: Presentation of four cases.

Blanco-Rodríguez, G / Reyes-Retana, R / Varela-Fascinetto, G / Graham-Pontones, S

Revista de gastroenterologia de Mexico (English)

2017 Volume 83, Issue 2, Page(s) 196–197

Title translation	Esofagitis causada por la retención de cápsulas de L-arginina. Presentación de 4 casos.
MeSH term(s)	Adolescent ; Arginine/adverse effects ; Capsules ; Child ; Esophagitis/chemically induced ; Esophagitis/diagnostic imaging ; Esophagoscopy ; Female ; Humans ; Male
Chemical Substances	Capsules ; Arginine (94ZLA3W45F)
Language	Spanish
Publishing date	2017-03-17
Document type	Case Reports ; Letter
ISSN	2255-534X
ISSN (online)	2255-534X
DOI	10.1016/j.rgmx.2016.09.003
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Article ; Online: Pediatric transplantation case conference: Update on cytomegalovirus.

Pellett Madan, Rebecca / Allen, Upton D / Green, Michael / Höcker, Britta / Michaels, Marian G / Varela-Fascinetto, Gustavo / Danziger-Isakov, Lara

Pediatric transplantation

2018 Volume 22, Issue 7, Page(s) e13276

Abstract: The prevention and management of cytomegalovirus (CMV) remain challenging in children who have undergone solid organ transplantation, despite the availability of effective antiviral medications and sensitive diagnostic assays. The primary objective of ... ...

Abstract	The prevention and management of cytomegalovirus (CMV) remain challenging in children who have undergone solid organ transplantation, despite the availability of effective antiviral medications and sensitive diagnostic assays. The primary objective of this invited commentary is to provide an updated and multidisciplinary approach to persistently challenging CMV cases that commonly occur in pediatric transplantation candidates and recipients, including cases for which published data are frequently lacking.
MeSH term(s)	Child, Preschool ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/etiology ; Cytomegalovirus Infections/therapy ; Female ; Humans ; Infant ; Male ; Organ Transplantation ; Postoperative Complications/diagnosis ; Postoperative Complications/therapy
Language	English
Publishing date	2018-09-10
Publishing country	Denmark
Document type	Case Reports ; Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.13276
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Article ; Online: Tolerability of up to 200 days of prophylaxis with valganciclovir oral solution and/or film-coated tablets in pediatric kidney transplant recipients at risk of cytomegalovirus disease.

Varela-Fascinetto, G / Benchimol, C / Reyes-Acevedo, R / Genevray, M / Bradley, D / Ives, J / Silva, H T

Pediatric transplantation

2017 Volume 21, Issue 1

Abstract: This multicenter, open-label study evaluated the tolerability of extended prophylaxis with valganciclovir in pediatric kidney transplant recipients at risk of CMV disease. Fifty-six patients aged 4 months to 16 years received once-daily valganciclovir ... ...

Abstract	This multicenter, open-label study evaluated the tolerability of extended prophylaxis with valganciclovir in pediatric kidney transplant recipients at risk of CMV disease. Fifty-six patients aged 4 months to 16 years received once-daily valganciclovir oral solution and/or tablets, dosed by BSA and renal function, for up to 200 days. The most common AEs on treatment were upper respiratory tract infection (33.9%), urinary tract infection (33.9%), diarrhea (32.1%), leukopenia (25.0%), neutropenia (23.2%), and headache (21.4%). There were fewer AEs during days 101-228 vs days 1-100. Twenty-seven patients (48.2%) had treatment-related AEs during valganciclovir treatment, most commonly leukopenia (21.4%), neutropenia (19.6%), anemia (7.1%), and tremor (5.4%). Treatment-related serious AEs were reported for nine patients (16.1%) and six withdrew due to AEs. Viremia was centrally confirmed in 10 patients; there was no confirmed CMV disease. One patient tested positive for a resistance mutation (UL97 L595F). Biopsy-proven acute rejection occurred in six patients (10.7%), but no graft loss or deaths occurred. In conclusion, up to 200 days of valganciclovir prophylaxis in pediatric kidney allograft recipients showed a safety profile consistent with that established in adult transplant patients.
MeSH term(s)	Administration, Oral ; Adolescent ; Antiviral Agents/administration & dosage ; Biopsy ; Child ; Child, Preschool ; Cytomegalovirus Infections/prevention & control ; Drug Administration Schedule ; Female ; Ganciclovir/administration & dosage ; Ganciclovir/analogs & derivatives ; Graft Rejection/prevention & control ; Humans ; Infant ; Kidney Transplantation/methods ; Male ; Mutation ; Tablets, Enteric-Coated/administration & dosage ; Transplant Recipients ; Treatment Outcome
Chemical Substances	Antiviral Agents ; Tablets, Enteric-Coated ; valganciclovir (GCU97FKN3R) ; Ganciclovir (P9G3CKZ4P5)
Language	English
Publishing date	2017-02
Publishing country	Denmark
Document type	Clinical Trial, Phase IV ; Journal Article ; Multicenter Study
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.12833
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Article ; Online: Mutational spectrum of Mexican patients with tyrosinemia type 1: In silico modeling and predicted pathogenic effect of a novel missense FAH variant.

Ibarra-González, Isabel / Fernández-Lainez, Cynthia / Alcántara-Ortigoza, Miguel Angel / González-Del Angel, Ariadna / Fernández-Henández, Liliana / Guillén-López, Sara / Belmont-Martínez, Leticia / López-Mejía, Lizbeth / Varela-Fascinetto, Gustavo / Vela-Amieva, Marcela

Molecular genetics & genomic medicine

2019 Volume 7, Issue 12, Page(s) e937

Abstract: Background: Tyrosinemia type 1 (HT1, MIM#276700) is caused by a deficiency in fumarylacetoacetate hydrolase (FAH) and it is associated with severe liver and renal disfunction. At present, the mutational FAH (15q25.1, MIM*613871) spectrum underlying HT1 ... ...

Abstract	Background: Tyrosinemia type 1 (HT1, MIM#276700) is caused by a deficiency in fumarylacetoacetate hydrolase (FAH) and it is associated with severe liver and renal disfunction. At present, the mutational FAH (15q25.1, MIM613871) spectrum underlying HT1 in the Mexican population is unknown. The objective of this study was to determine the FAH genotypes in eight nonrelated Mexican patients with HT1, who were diagnosed clinically. Methods:* Sequencing of FAH and their exon-intron boundaries and in silico protein modeling based on the crystallographic structure of mouse FAH. Results: We identified pathogenic variants in 15/16 studied alleles (93.8%). Nine different variants were found. The most commonly detected HT1-causing allele was NM_000137.2(FAH):c.3G > A or p.(?) [rs766882348] (25%, n = 4/16). We also identified a novel missense variant NM_000137.2(FAH):c.36C > A or p.(Phe12Leu) in a homozygous patient with an early and fatal acute form. The latter was classified as a likely pathogenic variant and in silico protein modeling showed that Phe-12 residue substitution for Leu, produces a repulsion in all possible Leu rotamers, which in turn would lead to a destabilization of the protein structure and possible loss-of-function. Conclusion: HT1 patients had a heterogeneous mutational and clinical spectrum and no genotype-phenotype correlation could be established.
MeSH term(s)	Alleles ; Child, Preschool ; Exons ; Female ; Genotype ; Humans ; Hydrolases/genetics ; Hydrolases/metabolism ; Infant ; Introns ; Liver/pathology ; Male ; Mexico/epidemiology ; Mutation, Missense ; Tyrosinemias/enzymology ; Tyrosinemias/genetics ; Tyrosinemias/pathology
Chemical Substances	Hydrolases (EC 3.-) ; fumarylacetoacetase (EC 3.7.1.2)
Language	English
Publishing date	2019-09-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2734884-2
ISSN	2324-9269 ; 2324-9269
ISSN (online)	2324-9269
ISSN	2324-9269
DOI	10.1002/mgg3.937
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Article ; Online: CYP3A5 Genotype and Time to Reach Tacrolimus Therapeutic Levels in Renal Transplant Children.

Alvarez-Elías, A C / García-Roca, P / Velásquez-Jones, L / Valverde, S / Varela-Fascinetto, G / Medeiros, M

Transplantation proceedings

2016 Volume 48, Issue 2, Page(s) 631–634

Abstract: Background: CYP3A5 gene polymorphism rs776746 has been associated with lower tacrolimus dose requirements and bioavailability in both adults and children. This variant causes a loss of CYP3A5 activity owing to a splice site variant leading to a ... ...

Abstract	Background: CYP3A5 gene polymorphism rs776746 has been associated with lower tacrolimus dose requirements and bioavailability in both adults and children. This variant causes a loss of CYP3A5 activity owing to a splice site variant leading to a truncated inactive enzyme. The aim of this study was to determine if the rs776746 gene polymorphism is related to the time to reach tacrolimus therapeutic levels in renal transplant children. Methods: A prospective study was performed in renal transplant children receiving tacrolimus as part of their immunosuppressive regime. CYP3A5 genotype was determined by direct sequencing. Tacrolimus trough levels and serum creatinine at 1 week and 1 month after renal transplantation was obtained from clinical chart. Results: A total of 42 patients were included; 19 (45.2%) were female, 23 (54.8%) received living-donor transplants, and 21 patients expressed CYP3A51/1 or CYP3A51/3. Tacrolimus dose was higher in expressers at week 1 (0.13 vs 0.10 mg/kg/d; P = .011), and week 4 after transplantation (0.17 vs 0.09 mg/kg/d; P < .0001). At 4 weeks after renal transplantation, only 9 patients from the expressers group (42.8%) had levels ≥7 ng/mL, in contrast to 18 in the nonexpressers group (85.7%; Fisher exact P = .008). Conclusions: Tacrolimus dose was significant higher in functional CYP3A5 expressers. Only 42.8% of such expressers had tacrolimus trough levels ≥7 ng/mL at 1 month after transplantation despite dose adjustments. Long-term follow up is needed to address the consequences of early post-transplantation bioavailability differences due to CYP3A5 genotype.
MeSH term(s)	Adolescent ; Alternative Splicing/genetics ; Biological Availability ; Child ; Cytochrome P-450 CYP3A/genetics ; Dose-Response Relationship, Drug ; Female ; Genotype ; Graft Rejection/blood ; Graft Rejection/genetics ; Graft Survival/genetics ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/pharmacokinetics ; Kidney Transplantation ; Male ; Polymorphism, Genetic/genetics ; Prospective Studies ; Tacrolimus/administration & dosage ; Tacrolimus/pharmacokinetics ; Tissue Donors
Chemical Substances	Immunosuppressive Agents ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2016.02.024
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Article ; Online: Simultaneous Detection of Beta and Gamma Human Herpesviruses by Multiplex qPCR Reveals Simple Infection and Coinfection Episodes Increasing Risk for Graft Rejection in Solid Organ Transplantation.

Sánchez-Ponce, Yessica / Varela-Fascinetto, Gustavo / Romo-Vázquez, José Carlos / López-Martínez, Briceida / Sánchez-Huerta, José Luis / Parra-Ortega, Israel / Fuentes-Pananá, Ezequiel M / Morales-Sánchez, Abigail

Viruses

2018 Volume 10, Issue 12

Abstract: Herpesviruses are common components of the human microbiome that become clinically relevant when a competent immunosurveillance is compromised, such as in transplantation. Members of the beta and gamma subfamilies are associated with a wide diversity of ... ...

Abstract	Herpesviruses are common components of the human microbiome that become clinically relevant when a competent immunosurveillance is compromised, such as in transplantation. Members of the beta and gamma subfamilies are associated with a wide diversity of pathologies, including end-organ disease and cancer. In this study, we developed a multiplex qPCR technique with high specificity, sensitivity, efficiency and predictability that allowed the simultaneous detection and quantification of beta and gamma human herpesviruses. The technique was tested in a cohort of 34 kidney- or liver-transplanted pediatric patients followed up for up to 12 months post-transplant. Viral load was determined in 495 leukocyte-plasma paired samples collected bi-weekly or monthly. Human herpesvirus (HHV) 7 was the herpesvirus most frequently found in positive samples (39%), followed by Epstein-Barr virus (EBV) (20%). Also, EBV and HHV7 were present in the majority of coinfection episodes (62%). The share of positive samples exclusively detected either in leukocytes or plasma was 85%, suggesting that these herpesviruses tended to take a latent or lytic path in an exclusive manner. Infection by human cytomegalovirus (HCMV) and HHV6, as well as coinfection by EBV/HHV7 and EBV/HHV6/HHV7, were associated with graft rejection (RR = 40.33 (
MeSH term(s)	Adolescent ; Child ; Coinfection/diagnosis ; Coinfection/virology ; DNA Primers/genetics ; DNA, Viral/blood ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/virology ; Female ; Graft Rejection/etiology ; Graft Rejection/virology ; Herpesvirus 4, Human/genetics ; Herpesvirus 6, Human/genetics ; Herpesvirus 7, Human/genetics ; Humans ; Male ; Multiplex Polymerase Chain Reaction ; Organ Transplantation/adverse effects ; Prospective Studies ; Roseolovirus Infections/diagnosis ; Roseolovirus Infections/virology ; Sensitivity and Specificity ; Viral Load
Chemical Substances	DNA Primers ; DNA, Viral
Language	English
Publishing date	2018-12-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v10120730
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Article: A Novel c.91dupG

Reyes-de la Rosa, Alejandra Del Pilar / Varela-Fascinetto, Gustavo / García-Delgado, Constanza / Vázquez-Martínez, Edgar Ricardo / Valencia-Mayoral, Pedro / Cerbón, Marco / Morán-Barroso, Verónica Fabiola

Case reports in genetics

2018 Volume 2018, Page(s) 1369413

Abstract: Alagille syndrome (MIM 118450) is an autosomal dominant disorder characterized by paucity of intrahepatic bile ducts, chronic cholestasis, pulmonary stenosis, butterfly-like vertebrae, posterior embryotoxon, and dysmorphic facial features. Most cases are ...

Abstract	Alagille syndrome (MIM 118450) is an autosomal dominant disorder characterized by paucity of intrahepatic bile ducts, chronic cholestasis, pulmonary stenosis, butterfly-like vertebrae, posterior embryotoxon, and dysmorphic facial features. Most cases are caused by
Language	English
Publishing date	2018-06-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2664417-4
ISSN	2090-6552 ; 2090-6544
ISSN (online)	2090-6552
ISSN	2090-6544
DOI	10.1155/2018/1369413
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Article ; Online: Is Your Kid Actin Out? A Series of Six Patients With Inherited Actin-Related Protein 2/3 Complex Subunit 1B Deficiency and Review of the Literature.

Vásquez-Echeverri, Estefanía / Yamazaki-Nakashimada, Marco Antonio / Venegas Montoya, Edna / Scheffler Mendoza, Selma Cecilia / Castano-Jaramillo, Lina Maria / Medina-Torres, Edgar Alejandro / González-Serrano, Maria Edith / Espinosa-Navarro, Melissa / Bustamante Ogando, Juan Carlos / González-Villarreal, María Guadalupe / Ortega Cisneros, Margarita / Valencia Mayoral, Pedro Francisco / Consuelo Sanchez, Alejandra / Varela-Fascinetto, Gustavo / Ramírez-Uribe, Rosa María Nideshda / Salazar Gálvez, Yuridia / Bonifaz Alonzo, Laura Cecilia / Fuentes-Pananá, Ezequiel Moisés / Gómez Hernández, Noemí /

Rojas Maruri, César Mauricio / Casanova, Jean-Laurent / Espinosa-Padilla, Sara Elva / Staines Boone, Aidé Tamara / López-Velázquez, Gabriel / Boisson, Bertrand / Lugo Reyes, Saul Oswaldo

The journal of allergy and clinical immunology. In practice

2023 Volume 11, Issue 4, Page(s) 1261–1280.e8

Abstract: Background: Hereditary actin-related protein 2/3 complex subunit 1B deficiency is characterized clinically by ear, skin, and lung infections, bleeding, eczema, food allergy, asthma, skin vasculitis, colitis, arthritis, short stature, and lymphadenopathy. ...

Abstract	Background: Hereditary actin-related protein 2/3 complex subunit 1B deficiency is characterized clinically by ear, skin, and lung infections, bleeding, eczema, food allergy, asthma, skin vasculitis, colitis, arthritis, short stature, and lymphadenopathy. Objective: We aimed to describe the clinical, laboratory, and genetic features of six patients from four Mexican families. Methods: We performed exome sequencing in patients of four families with suspected actinopathy, collected their data from medical records, and reviewed the literature for reports of other patients with actin-related protein 2/3 complex subunit 1B deficiency. Results: Six patients from four families were included. All had recurrent infections, mainly bacterial pneumonia, and cellulitis. A total of 67% had eczema whereas 50% had food allergies, failure to thrive, hepatomegaly, and bleeding. Eosinophilia was found in all; 84% had thrombocytopenia, 67% had abnormal-size platelets and anemia. Serum levels of IgG, IgA, and IgE were highly increased in most; IgM was normal or low. T cells were decreased in 67% of patients, whereas B and NK cells were increased in half of patients. Two of the four probands had compound heterozygous variants. One patient was successfully transplanted. We identified 28 other patients whose most prevalent features were eczema, recurrent infections, failure to thrive, bleeding, diarrhea, allergies, vasculitis, eosinophilia, platelet abnormalities, high IgE/IgA, low T cells, and high B cells. Conclusion: Actin-related protein 2/3 complex subunit 1B deficiency has a variable and heterogeneous clinical spectrum, expanded by these cases to include keloid scars and Epstein-Barr virus chronic hepatitis. A novel deletion in exon 8 was shared by three unrelated families and might be the result of a founder effect.
MeSH term(s)	Humans ; Actin-Related Protein 2 ; Actins ; Eczema ; Eosinophilia ; Epstein-Barr Virus Infections ; Failure to Thrive ; Herpesvirus 4, Human ; Immunoglobulin A ; Immunoglobulin E ; Reinfection ; Vasculitis ; Actin-Related Protein 3/metabolism
Chemical Substances	Actin-Related Protein 2 ; Actins ; Immunoglobulin A ; Immunoglobulin E (37341-29-0) ; Actin-Related Protein 3
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2022.12.045
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Article ; Online: Correlation between viral load of cytomegalovirus and tacrolimus and sirolimus levels in transplanted pediatric patients.

Reyes-Pérez, Herlinda / Sánchez-Huerta, José Luis / Varela-Fascinetto, Gustavo / Romo-Vázquez, José Carlos / Morales-Sánchez, Abigail / Fuentes-Pananá, Ezequiel M / Parra-Ortega, Israel / Ramírez-Ramírez, Graciela / López-Martínez, Briceida

Boletin medico del Hospital Infantil de Mexico

2016 Volume 73, Issue 1, Page(s) 4–9

Abstract: Introduction: Survival of transplant patients and grafts depends largely on the use of immunosuppressive drugs. However, a balance remains to be established among immunosuppression, transplant rejection and cytomegalovirus (CMV) infection, which results ...

Abstract	Introduction: Survival of transplant patients and grafts depends largely on the use of immunosuppressive drugs. However, a balance remains to be established among immunosuppression, transplant rejection and cytomegalovirus (CMV) infection, which results in a high rate of morbidity and mortality. The aim of this study was to define a better strategy for monitoring transplanted patients based on the analysis of the blood concentration of sirolimus and tacrolimus and the burden of CMV. Methods: Fifty five post-transplant (kidney and liver) pediatric patients, nine treated with sirolimus and 46 treated with tacrolimus, were included. A total of 541 measurements were obtained. In each measurement the concentration of immunosuppressant in whole blood and CMV viral load in plasma and whole blood was quantified by real-time PCR. Pearson correlation coefficient (r) was estimated. Results: Values of r ≤0.0747 were found for the relationship between dose and concentration of immunosuppressant; r = 0.9406 for the relationship between viral load in whole blood and plasma, and r ≤0.4616 for the relationship between concentration of immunosuppressant and viral load. Conclusions: These data support that the doses of immunosuppressive drugs do not correlate with the levels of the same in whole blood. Therefore, systemic levels of immunosuppressant should be constantly monitored together with CMV load. Meanwhile, a high correlation between viral load measured in whole blood and plasma was found.
Language	English
Publishing date	2016-01
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	730519-9
ISSN	1665-1146 ; 1665-1146 ; 0539-6115 ; 0539-6123
ISSN (online)	1665-1146
ISSN	1665-1146 ; 0539-6115 ; 0539-6123
DOI	10.1016/j.bmhimx.2015.12.006
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