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Article: [A method for determination of Neisseria meningitidis serogroup A, B, C and W by real-time PCR].

Mironov, K O / Platonov, A E / Dribnokhodova, O P / Kuseva, V I / Shipulin, G A

Zhurnal mikrobiologii, epidemiologii i immunobiologii

2015 , Issue 6, Page(s) 35–42

Abstract: ... serogroup A, B, C and W DNA.: Materials and methods: Reference strains and 187 samples ... of clinical CSF samples: A--in 103 samples (55%), B--in 45 (24%), C--in 30 (16%), W--in 5 (3%). Only DNA ... A menincococci as well as DNA of 5 group W meningococci and 4 ungroupable was carried out.: Conclusion ...

Abstract	Aim: Development and testing of a real-time PCR method for detection of Neisseria meningitiis serogroup A, B, C and W DNA. Materials and methods: Reference strains and 187 samples of cerebrospinal fluid (CSF) from meningocci meningitis patients were used in the study. Multiplex PCR was carried out in an instrument with 5 channels of fluorescent detection: Results: Analysis of specific serogroup loci of the genome and design of oligonucleotides for the detection of DNA of all the capsule meningococci and 4 serogroups in particular was carried out. PCR conditions were optimized; specificity was shown and analytical sensitivity was evaluated using reference strains. DNA of the following serogroups was detected during study of clinical CSF samples: A--in 103 samples (55%), B--in 45 (24%), C--in 30 (16%), W--in 5 (3%). Only DNA of meningococci capstle gene ctrA was found in 4 samples; presumably, they contained DNA of other serogroups. Multilocus sequence-typing and detection of antigenic determinants of PorA and FetA genes for 27 DNA samples of group A menincococci as well as DNA of 5 group W meningococci and 4 ungroupable was carried out. Conclusion: The method proposed allows to carry out serogrouping of no less than 95% of strains or DNA samples isolated from CSF of meningococci infection patients. Combined with other recommended non-cultural methods of genotyping, it may be useful for complex characteristics of pathogenic meningococci.
MeSH term(s)	Bacterial Capsules/genetics ; Bacterial Outer Membrane Proteins/genetics ; DNA, Bacterial/genetics ; Gene Expression ; Genetic Loci ; Genome, Bacterial ; Genotype ; Humans ; Meningitis, Meningococcal/cerebrospinal fluid ; Meningitis, Meningococcal/microbiology ; Multilocus Sequence Typing ; Multiplex Polymerase Chain Reaction ; Neisseria meningitidis/classification ; Neisseria meningitidis/genetics ; Neisseria meningitidis/isolation & purification ; Porins/genetics ; Serogroup ; Serotyping
Chemical Substances	Bacterial Outer Membrane Proteins ; DNA, Bacterial ; FrpB protein, bacteria ; Porins ; porin protein, Neisseria
Language	Russian
Publishing date	2015-04-01
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	218354-7
ISSN	0372-9311 ; 0049-8726 ; 0372-8714
ISSN	0372-9311 ; 0049-8726 ; 0372-8714
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Zs.B 745: Show issues

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Article: Predicting Disparity between ASF-Managed Areas and Wild Boar Habitats: A Case of South Korea.

Ko, Chanwoo / Ko, Dongwook W / Cho, Wonhee

Animals : an open access journal from MDPI

2023 Volume 13, Issue 22

Abstract: African swine fever (ASF) is a highly contagious viral disease affecting both domestic and wild boars. Since its first outbreak in South Korea in 2019, substantial efforts have been made to prevent ASF transmission by reducing the wild boar population ... ...

Abstract	African swine fever (ASF) is a highly contagious viral disease affecting both domestic and wild boars. Since its first outbreak in South Korea in 2019, substantial efforts have been made to prevent ASF transmission by reducing the wild boar population and eliminating infected carcasses; however, the persistence of ASF transmission has posed challenges to these efforts. To improve ASF management strategies, the limitations of current management strategies must be identified by considering disparities between wild boar habitats and ASF-managed areas with environmental and anthropogenic characteristics of wild boars and their management strategies. Here, ensemble species distribution models were used to estimate wild boar habitats and potential ASF-managed areas, with elevation, distance to urban areas, and Normalized Difference Vegetation Index as important variables. Binary maps of wild boar habitats and potential ASF-managed areas were generated using the maxSSS as the threshold criterion. Disparity areas of ASF management were identified by overlying regions evaluated as wild boar habitats with those not classified as ASF-managed areas. Dense forests near urban regions like Chungcheongbuk-do, Gyeongsangbuk-do, and Gyeongsangnam-do were evaluated as disparity areas having high risk of ASF transmission. These findings hold significant potential for refining ASF management strategies and establishing proactive control measures.
Language	English
Publishing date	2023-11-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13223482
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Article ; Online: Social Determinants of Health in Cardiovascular Disease: A Call to Action.

Ko, Dennis T / Brophy, James M / Mamas, Mamas A / McCrindle, Brian W / Wijeysundera, Harindra C

The Canadian journal of cardiology

2024

Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Editorial
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2024.04.011
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Zs.A 2150: Show issues

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Article: Radiosensitivity index as a predictive biomarker for radiotherapy de-intensification in nasopharyngeal carcinoma: abridged secondary publication.

Chiang, C L / Lee, W M A / Choi, C W H / Ngan, K C R / Ng, W T / Lee, H F V / Lam, T C / Lam, K O / Tsang, K C / Wong, W H J

Hong Kong medical journal = Xianggang yi xue za zhi

2024 Volume 30 Suppl 1, Issue 1, Page(s) 27–28

MeSH term(s)	Humans ; Nasopharyngeal Carcinoma/radiotherapy ; Nasopharyngeal Neoplasms/radiotherapy ; Carcinoma ; Biomarkers ; Radiation Tolerance ; Cell Line, Tumor
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-02-27
Publishing country	China
Document type	Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
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Zs.A 4347: Show issues

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Article ; Online: Relapse patterns of two-jaw surgical correction in patients with skeletal Class III malocclusion and different vertical facial types.

Kuo, J J-C / Lin, C-H / Ko, E W-C

International journal of oral and maxillofacial surgery

2022 Volume 51, Issue 12, Page(s) 1587–1595

Abstract: The aim of this study was to evaluate postoperative relapse after the surgical correction of skeletal Class III deformities of various facial patterns as a guide to surgical planning. A retrospective cohort study of 90 consecutive patients with skeletal ... ...

Abstract	The aim of this study was to evaluate postoperative relapse after the surgical correction of skeletal Class III deformities of various facial patterns as a guide to surgical planning. A retrospective cohort study of 90 consecutive patients with skeletal Class III malocclusion who underwent bimaxillary surgery was performed. The surgical outcomes and postoperative stability were compared. The primary predictor variable was vertical facial type, which was classified into three groups according to the Frankfort mandibular plane angle (FMA). The primary outcome of angular and linear measurements was obtained using serial cone beam computed tomography scans obtained at time points of preoperative, 1 week after surgery, and orthodontic debonding. No significant difference in skeletal relapse was observed in patients with the different vertical facial types. The mandible displayed a forward and upward relapse in all three groups postoperatively. The patients with a low FMA exhibited a more consistent mandibular relapse pattern than those with a normal or high FMA. These findings suggest that bimaxillary surgery is clinically stable for mandibular prognathism regardless of the vertical facial pattern. However, 1-1.5 mm of overcorrection in the mandible setback should be considered in patients with a low FMA, because of the greater facial depth and consistent forward and upward mandibular relapse pattern.
MeSH term(s)	Humans ; Osteotomy, Le Fort/methods ; Retrospective Studies ; Vertical Dimension ; Cephalometry/methods ; Maxilla/surgery ; Follow-Up Studies ; Malocclusion, Angle Class III/diagnostic imaging ; Malocclusion, Angle Class III/surgery ; Mandible/diagnostic imaging ; Mandible/surgery ; Recurrence ; Orthognathic Surgical Procedures/methods
Language	English
Publishing date	2022-06-21
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2022.05.016
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Zs.A 931: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 401: Show issues

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Article ; Online: TRPS1 is a promising marker for all subtypes of breast cancer.

Lui, Joshua W / Tsang, Julia Y / Li, Joshua / Ko, Chun-Wai / Tam, Fiona / Loong, Thomson C-W / Tse, Gary M

Histopathology

2024 Volume 84, Issue 5, Page(s) 822–836

Abstract: Aims: Trichorhinophalangeal syndrome-1 (TRPS1) has been proposed as a novel breast marker with equally high expression in breast cancer (BC) subtypes, making it a useful diagnostic tool. Here, its expression was evaluated alongside other commonly used ... ...

Abstract	Aims: Trichorhinophalangeal syndrome-1 (TRPS1) has been proposed as a novel breast marker with equally high expression in breast cancer (BC) subtypes, making it a useful diagnostic tool. Here, its expression was evaluated alongside other commonly used markers [GATA3, GCDFP15, mammaglobin (MGB) and SOX10] in a large cohort of BCs (n = 1852) and their corresponding nodal metastases. Its usefulness as a diagnostic tool and its correlation with clinicopathological features were assessed. Methods and results: TRPS1 was expressed at 75.8% overall in the BC cohort, with at least 58% expression among BC subtypes. It was less sensitive than GATA3 for luminal and HER2-overexpressing (HER2-OE) cancers (luminal A: 82 versus 97%; luminal B: 80 versus 95%; HER2-OE: 62 versus 76%), but it was the most sensitive for TNBC (60 versus ≤ 41%). It showed a stable expression in nodal metastases (primary tumour 76 versus nodal metastasis 78%), unlike a reduced nodal expression for GATA3 (86 versus 77%). TRPS1 outperformed GATA3 in detecting non-luminal cancers when paired with other breast markers. TRPS1 and GCDFP15 was the most sensitive combination in TNBC detection, with a 76% detection rate. For TRPS1-negative and GCDFP15-negative TNBCs, SOX10 was more sensitive than GATA3 (29 versus 24%). Conclusions: TRPS1 is a highly sensitive marker for all breast cancer subtypes, outperforming GATA3 in non-luminal cancers and displaying the highest sensitivity for TNBC detection when combined with GCDFP15. It is a valuable addition to the breast marker panel for accurate identification of BC.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Triple Negative Breast Neoplasms/pathology ; Biomarkers, Tumor/metabolism ; Carrier Proteins ; Mammaglobin A/metabolism ; Breast/pathology ; GATA3 Transcription Factor/metabolism ; Repressor Proteins/metabolism
Chemical Substances	Biomarkers, Tumor ; Carrier Proteins ; Mammaglobin A ; GATA3 Transcription Factor ; TRPS1 protein, human ; Repressor Proteins
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/his.15126
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Zs.A 1328: Show issues

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Article ; Online: Response to Tembhre et al.: 'Enhanced expression of angiotensin-converting enzyme 2 in psoriatic skin and its upregulation in keratinocytes by interferon-γ: implication of inflammatory milieu in skin tropism of SARS-CoV-2'.

Gehlhausen, J R / Ko, C J / Damsky, W

The British journal of dermatology

2021 Volume 184, Issue 5, Page(s) 984

MeSH term(s)	Angiotensin-Converting Enzyme 2 ; COVID-19 ; Humans ; Interferon-gamma ; Keratinocytes ; SARS-CoV-2 ; Tropism ; Up-Regulation
Chemical Substances	Interferon-gamma (82115-62-6) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-02-01
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.19714
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Article: Simulating Hunting Effects on the Wild Boar Population and African Swine Fever Expansion Using Agent-Based Modeling.

Ko, Chanwoo / Cho, Wonhee / Hwang, Byungmook / Chang, Byungwoo / Kang, Wanmo / Ko, Dongwook W

Animals : an open access journal from MDPI

2023 Volume 13, Issue 2

Abstract: African swine fever (ASF) is a viral hemorrhagic fever fatal to animals of the Suidae family. It has spread from Africa to Europe and Asia, causing significant damage to wildlife and domesticated pig production. Since the first confirmed case in South ... ...

Abstract	African swine fever (ASF) is a viral hemorrhagic fever fatal to animals of the Suidae family. It has spread from Africa to Europe and Asia, causing significant damage to wildlife and domesticated pig production. Since the first confirmed case in South Korea in September 2019, the number of infected wild boars has continued to increase, despite quarantine fences and hunting operations. Hence, new strategies are needed for the effective control of ASF. We developed an agent-based model (ABM) to estimate the ASF expansion area and the efficacy of infection control strategies. In addition, we simulated the agents' (wild boars) behavior and daily movement range based on their ecological and behavioral characteristics, by applying annual hunting scenarios from past three years (2019.09-2022.08). The results of the simulation based on the annual changes in the number of infected agents and the ASF expansion area showed that the higher the hunting intensity, the smaller the expansion area (24,987 km
Language	English
Publishing date	2023-01-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13020298
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Article ; Online: Subtyping of triple-negative breast cancers: its prognostication and implications in diagnosis of breast origin.

Hu, H / Tong, K / Tsang, J Y / Ko, C W / Tam, F / Loong, T C / Tse, G M

ESMO open

2024 Volume 9, Issue 4, Page(s) 102993

Abstract: Background: Triple-negative breast cancer (TNBC) subtyping by gene profiling has provided valuable clinical information. Here, we aimed to evaluate the relevance of TNBC subtyping using immunohistochemistry (IHC), which could be a more clinically ... ...

Abstract	Background: Triple-negative breast cancer (TNBC) subtyping by gene profiling has provided valuable clinical information. Here, we aimed to evaluate the relevance of TNBC subtyping using immunohistochemistry (IHC), which could be a more clinically practical approach, for prognostication and applications in patient management. Methods: A total of 123 TNBC cases were classified using androgen receptor (AR), CD8, Forkhead box C1 protein (FOXC1), and doublecortin-like kinase 1 (DCLK1) into luminal androgen receptor (LAR), basal-like immunosuppressive (BLIS), mesenchymal-like (MES), and immunomodulatory (IM) subtypes. The IM cases were further divided into the IM-excluded and IM-inflamed categories by CD8 spatial distribution. Their clinicopathological and biomarker profiles and prognoses were evaluated. Results: LAR (28.6%) and MES (11.2%) were the most and least frequent subtypes. The IHC-TNBC subtypes demonstrated distinct clinicopathological features and biomarker profiles, corresponding to the reported features in gene profiling studies. IM-inflamed subtype had the best outcome, while BLIS had a significantly poorer survival. Differential breast-specific marker expressions were found. Trichorhinophalangeal syndrome type 1 (TRPS1) was more sensitive for IM-inflamed and BLIS, GATA-binding protein 3 (GATA3) for IM-excluded and MES, and gross cystic disease fluid protein 15 (GCDFP15) for LAR subtypes. Conclusions: Our findings demonstrated the feasibility of IHC surrogates to stratify TNBC subtypes with distinct features and prognoses. The IM subtype can be refined by its CD8 spatial pattern. Breast-specific marker expression varied among the subtypes. Marker selection should be tailored accordingly.
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ISSN	2059-7029
ISSN (online)	2059-7029
DOI	10.1016/j.esmoop.2024.102993
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Article: Risk Factors Associated with Chemotherapy-Induced Nausea and Vomiting Among Women with Breast Cancer Receiving Highly Emetogenic Chemotherapy: Individual Patient-Based Analysis of Three Prospective Antiemetic Trials.

Yeo, Winnie / Ngai, Nicole T Y / Yip, Christopher C H / Mo, Frankie K F / Yeo, Victoria A / Ko, Jonathan W H / Li, Leung V / Lau, Thomas K H / Lai, Kwai Tung / Pang, Elizabeth / Yip, Claudia H W / Yeo, Horatio L / Kwok, Carol Chi Hei / Ko, Stephanie W Y / Molassiotis, Alex

Cancer management and research

2024 Volume 16, Page(s) 283–297

Abstract: Purpose: Although risk factors related to chemotherapy-induced nausea and vomiting (CINV) have been identified in previous studies, only a few studies have evaluated the risk factors associated with contemporary antiemetic prophylaxis, including ... ...

Abstract	Purpose: Although risk factors related to chemotherapy-induced nausea and vomiting (CINV) have been identified in previous studies, only a few studies have evaluated the risk factors associated with contemporary antiemetic prophylaxis, including olanzapine/aprepitant- or NEPA-containing regimens. This study aimed to identify the risk factors associated with CINV development in Chinese breast cancer patients receiving doxorubicin and cyclophosphamide chemotherapy. Methods: Data from 304 patients enrolled in 3 previously reported prospective antiemetic studies were included. Multivariate logistic regression models were used to predict risk factors associated with CINV occurrence. Additionally, the likelihood of treatment failure in relation to the number of risk factors in individual patients was evaluated. Results: Multivariate analysis of the entire study group revealed that obesity status (defined as body mass index/= 25.0 kg/m2) and the use of olanzapine/aprepitant- or NEPA-containing anti-emetic regimens were associated with a high likelihood, while a history of motion sickness was associated with a lower likelihood, complete response (CR), and "no nausea" in the overall phase. A history of vomiting during pregnancy was also associated with a lower likelihood of an overall CR. Patients with an increasing number of risk factors had a higher likelihood of treatment failure and shorter time to first vomiting. Those who did not achieve CR and "no nausea" in the first cycle were less likely to achieve these parameters in the subsequent cycle of chemotherapy. Conclusion: The present study confirmed previously reported risk factors for CINV in Chinese breast cancer patients receiving doxorubicin and cyclophosphamide. Further optimization of CINV control is required for patients with identifiable risk factors; olanzapine/aprepitant- or NEPA- containing prophylaxis are the preferred contemporary anti-emetics regimens for Chinese breast cancer patients undergoing doxorubicin and cyclophosphamide chemotherapy.
Language	English
Publishing date	2024-04-08
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508013-1
ISSN	1179-1322
ISSN	1179-1322
DOI	10.2147/CMAR.S447546
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