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Article ; Online: Association of Sexual Orientation with Exposure to Suicide and Related Emotional Distress among US Adults.

Clark, Kirsty A / Sexton, Joseph F / McKay, Tara

Archives of suicide research : official journal of the International Academy for Suicide Research

2022 Volume 27, Issue 4, Page(s) 1363–1372

Abstract: Objective: Suicide bereavement is a significant public health concern. Using nationally representative survey data, we quantify sexual orientation differences in frequency of suicide exposure and suicide exposure-related emotional distress among US ... ...

Abstract	Objective: Suicide bereavement is a significant public health concern. Using nationally representative survey data, we quantify sexual orientation differences in frequency of suicide exposure and suicide exposure-related emotional distress among US adults. Methods: We used cross-sectional data from the 2016 General Social Survey (GSS) and included sexual minority (i.e., lesbian, gay, bisexual; ( Results: Sexual minorities reported a similar number of lifetime suicide exposures and were not significantly different from heterosexuals on other suicide exposure characteristics. However, sexual minority, compared to heterosexual, respondents experienced 3.14 greater odds of severe emotional distress related to suicide exposure (95% CI = 1.42-6.94, Conclusion: Perhaps due to stigmatizing mourning experiences, sexual minority adults are particularly vulnerable to severe suicide exposure-related emotional distress. Future research to understand the scope of sexual minority-specific bereavement support services and public policies (e.g., bereavement leave) as well as intervention development to support sexual minority adults' coping in the wake of suicide exposure is warranted. HIGHLIGHTSApproximately half of sexual minority US adults report a lifetime suicide exposureSexual minority adults experience more severe suicide exposure-related emotional distressPostvention care should be tailored to meet the needs of sexual minority adults.
Language	English
Publishing date	2022-09-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1283671-0
ISSN	1543-6136 ; 1381-1118
ISSN (online)	1543-6136
ISSN	1381-1118
DOI	10.1080/13811118.2022.2127386
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Article ; Online: A comparative probabilistic analysis of human and chimpanzee rotator cuff functional capacity.

MacLean, Kathleen F E / Langenderfer, Joseph E / Dickerson, Clark R

Journal of anatomy

2023 Volume 243, Issue 3, Page(s) 431–447

Abstract: Computational musculoskeletal modeling represents a valuable approach to examining biological systems in physical anthropology. Probabilistic modeling builds on computational musculoskeletal models by associating mathematical distributions of specific ... ...

Abstract	Computational musculoskeletal modeling represents a valuable approach to examining biological systems in physical anthropology. Probabilistic modeling builds on computational musculoskeletal models by associating mathematical distributions of specific musculoskeletal features within known ranges of biological variability with functional outcomes. The purpose of this study was to determine if overlap in rotator cuff muscle force predictions would occur between species during the performance of an evolutionarily relevant horizontal bimanual arm suspension task. This necessitated creating novel probabilistic models of the human and chimpanzee glenohumeral joint through augmentation of previously published deterministic models. Glenohumeral musculoskeletal features of anthropological interest were probabilistically modeled to produce distributions of predicted human and chimpanzee rotator cuff muscle force that were representative of the specific anatomical manipulations. Musculoskeletal features modeled probabilistically included rotator cuff origins and deltoid insertion, glenoid inclination, and joint stability. Predicted human rotator cuff muscle force distributions were mostly limited to alternating between infraspinatus and teres minor, with both 100% and 0% muscle force predicted for both muscles. The chimpanzee model predicted low-to-moderate muscle force across all rotator cuff muscles. Rotator cuff muscle force predictions were most sensitive to changes of muscle origins and insertions. Results indicate that functional rotator cuff overlap is unlikely between chimpanzees and humans without greater modifications of the glenohumeral musculoskeletal phenotypes. The results also highlight the low efficacy of the human upper extremity in overhead, weight-bearing tasks, and propensity for rotator cuff injury.
MeSH term(s)	Humans ; Animals ; Rotator Cuff/physiology ; Pan troglodytes ; Shoulder Joint/physiology ; Rotator Cuff Injuries ; Scapula ; Biomechanical Phenomena
Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2955-5
ISSN	1469-7580 ; 0021-8782
ISSN (online)	1469-7580
ISSN	0021-8782
DOI	10.1111/joa.13882
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Article ; Online: Volumetric analysis of hippocampal subregions and subfields in left and right semantic dementia.

Carlos, Arenn F / Weigand, Stephen D / Duffy, Joseph R / Clark, Heather M / Utianski, Rene L / Machulda, Mary M / Botha, Hugo / Thu Pham, Nha Trang / Lowe, Val J / Schwarz, Christopher G / Whitwell, Jennifer L / Josephs, Keith A

Brain communications

2024 Volume 6, Issue 2, Page(s) fcae097

Abstract: Two variants of semantic dementia are recognized based on the laterality of temporal lobe involvement: a left-predominant variant associated with verbal knowledge impairment and a right-predominant variant associated with behavioural changes and non- ... ...

Abstract	Two variants of semantic dementia are recognized based on the laterality of temporal lobe involvement: a left-predominant variant associated with verbal knowledge impairment and a right-predominant variant associated with behavioural changes and non-verbal knowledge loss. This cross-sectional clinicoradiologic study aimed to assess whole hippocampal, subregion, and/or subfield volume loss in semantic dementia versus controls and across its variants. Thirty-five semantic dementia participants and 15 controls from the Neurodegenerative Research Group at Mayo Clinic who had completed 3.0-T volumetric magnetic resonance imaging and
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcae097
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Article ; Online: Histologic tau lesions and magnetic resonance imaging biomarkers differ across two progressive supranuclear palsy variants.

Orlandi, Francesca / Carlos, Arenn F / Ali, Farwa / Clark, Heather M / Duffy, Joseph R / Utianski, Rene L / Botha, Hugo / Machulda, Mary M / Stephens, Yehkyoung C / Schwarz, Christopher G / Senjem, Matthew L / Jack, Clifford R / Agosta, Federica / Filippi, Massimo / Dickson, Dennis W / Josephs, Keith A / Whitwell, Jennifer L

Brain communications

2024 Volume 6, Issue 2, Page(s) fcae113

Abstract: Progressive supranuclear palsy is a neurodegenerative disease characterized by the deposition of four-repeat tau in neuronal and glial lesions in the brainstem, cerebellar, subcortical and cortical brain regions. There are varying clinical presentations ... ...

Abstract	Progressive supranuclear palsy is a neurodegenerative disease characterized by the deposition of four-repeat tau in neuronal and glial lesions in the brainstem, cerebellar, subcortical and cortical brain regions. There are varying clinical presentations of progressive supranuclear palsy with different neuroimaging signatures, presumed to be due to different topographical distributions and burden of tau. The classic Richardson syndrome presentation is considered a subcortical variant, whilst progressive supranuclear palsy with predominant speech and language impairment is considered a cortical variant, although the pathological underpinnings of these variants are unclear. In this case-control study, we aimed to determine whether patterns of regional tau pathology differed between these variants and whether tau burden correlated with neuroimaging. Thirty-three neuropathologically confirmed progressive supranuclear palsy patients with either the Richardson syndrome (
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcae113
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Article: Epidemiological Characteristics of Foot and Ankle Injuries in 2 Professional Ballet Companies: A 3-Season Cohort Study of 588 Medical Attention Injuries and 255 Time-Loss Injuries.

Katakura, Mai / Kedgley, Angela E / Shaw, Joseph W / Mattiussi, Adam M / Kelly, Shane / Clark, Richard / Allen, Nick / Calder, James D F

Orthopaedic journal of sports medicine

2023 Volume 11, Issue 2, Page(s) 23259671221134131

Abstract: Background: The foot and ankle are often reported as the most common sites of injury in professional ballet dancers; however, epidemiological research focusing on foot and ankle injuries in isolation and investigating specific diagnoses is limited.: ... ...

Abstract	Background: The foot and ankle are often reported as the most common sites of injury in professional ballet dancers; however, epidemiological research focusing on foot and ankle injuries in isolation and investigating specific diagnoses is limited. Purpose: To investigate the incidence rate, severity, burden, and mechanisms of foot and ankle injuries that (1) required visiting a medical team (medical attention foot and ankle injuries; MA-FAIs) and (2) prevented a dancer from fully participating in all dance-related activities for at least 24 hours after the injury (time-loss foot and ankle injuries; TL-FAIs) in 2 professional ballet companies. Study design: Descriptive epidemiological study. Methods: Foot and ankle injury data across 3 seasons (2016-2017 to 2018-2019) were extracted from the medical databases of 2 professional ballet companies. Injury-incidence rate (per dancer-season), severity, and burden were calculated and reported with reference to the mechanism of injury. Results: A total of 588 MA-FAIs and 255 TL-FAIs were observed across 455 dancer-seasons. The incidence rates of MA-FAIs and TL-FAIs were significantly higher in women (1.20 MA-FAIs and 0.55 TL-FAIs per dancer-season) than in men (0.83 MA-FAIs and 0.35 TL-FAIs per dancer-season) (MA-FAIs, Conclusion: The results of this study highlight the importance of further investigation of injury prevention strategies targeting
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2706251-X
ISSN	2325-9671
ISSN	2325-9671
DOI	10.1177/23259671221134131
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Medicines optimization prior to discharge in patients admitted to hospital with heart failure.

Cuthbert, Joseph J / Brown, Oliver I / Pellicori, Pierpaolo / Dobbs, Karen / Bulemfu, Jeanne / Kazmi, Syed / Sokoreli, Ioanna / Pauws, Steffan C / Riistama, Jarno M / Cleland, John G F / Clark, Andrew L

ESC heart failure

2024 Volume 11, Issue 2, Page(s) 950–961

Abstract: Aims: Approximately half of patients with heart failure and a reduced ejection fraction (HeFREF) are discharged from hospital on triple therapy [angiotensin-converting enzyme inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), beta-blockers ( ... ...

Abstract	Aims: Approximately half of patients with heart failure and a reduced ejection fraction (HeFREF) are discharged from hospital on triple therapy [angiotensin-converting enzyme inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), beta-blockers (BBs), and mineralocorticoid receptor antagonists (MRAs)]. We investigated what proportion of patients are on optimal doses prior to discharge and how many might be eligible for initiation of sacubitril-valsartan or sodium-glucose co-transporter-2 inhibitors (SGLT2Is). Methods and results: Between 2012 and 2017, 1277 patients admitted with suspected heart failure were enrolled at a single hospital serving a local community around Kingston upon Hull, UK. Eligibility for sacubitril-valsartan or SGLT2I was based on entry criteria for the PIONEER-HF, DAPA-HF, and EMPEROR-Reduced trials. Four hundred fifty-five patients had HeFREF with complete data on renal function, heart rate, and systolic blood pressure (SBP) prior to discharge. Eighty-three per cent of patients were taking an ACE-I or ARB, 85% a BB, and 63% an MRA at discharge. More than 60% of patients were eligible for sacubitril-valsartan and >70% for SGLT2I. Among those not already receiving a prescription, 37%, 28%, and 49% were eligible to start ACE-I or ARB, BB, and MRA, respectively. Low SBP (≤105 mmHg) was the most frequent explanation for failure to initiate or up-titrate therapy. Conclusions: Most patients admitted for heart failure are eligible for initiation of life-prolonging medications prior to discharge. A hospital admission may be a common missed opportunity to improve treatment for patients with HeFREF.
MeSH term(s)	Humans ; Patient Discharge ; Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Tetrazoles/therapeutic use ; Treatment Outcome ; Stroke Volume/physiology ; Heart Failure ; Hospitals
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Tetrazoles
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14638
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Article ; Online: Influence of serum transferrin concentration on diagnostic criteria for iron deficiency in chronic heart failure.

Graham, Fraser J / Pellicori, Pierpaolo / Masini, Gabriele / Cuthbert, Joseph J / Clark, Andrew L / Cleland, John G F

ESC heart failure

2023 Volume 10, Issue 5, Page(s) 2826–2836

Abstract: Aims: Transferrin saturation (TSAT), a marker of iron deficiency, reflects both serum concentrations of iron (SIC) and transferrin (STC). TSAT is susceptible to changes in each of these biomarkers. Little is known about determinants of STC and its ... ...

Abstract	Aims: Transferrin saturation (TSAT), a marker of iron deficiency, reflects both serum concentrations of iron (SIC) and transferrin (STC). TSAT is susceptible to changes in each of these biomarkers. Little is known about determinants of STC and its influence on TSAT and mortality in patients with heart failure. Accordingly, we studied the relationship of STC to clinical characteristics, to markers of iron deficiency and inflammation and to mortality in chronic heart failure (CHF). Methods and results: Prospective cohort of patients with CHF attending a clinic serving a large local population. A total of 4422 patients were included (median age 75 (68-82) years; 40% women; 32% with left ventricular ejection fraction ≤40%). STC ≤ 2.3 g/L (lowest quartile) was associated with older age, lower SIC and haemoglobin and higher high-sensitivity C-reactive protein, ferritin and N-terminal pro-brain natriuretic peptide compared with those with STC > 2.3 g/L. In the lowest STC quartile, 624 (52%) patients had SIC ≤13 μmol/L, of whom 38% had TSAT ≥20%. For patients in the highest STC quartile, TSAT was <20% when SIC was >13 μmol/L in 185 (17%) patients. STC correlated inversely with ferritin (r = -0.52) and high-sensitivity C-reactive protein (r = -0.17) and directly with albumin (r = 0.29); all P < 0.001. In models adjusted for age, N-terminal pro-brain natriuretic peptide and haemoglobin, both higher SIC (hazard ratio 0.87 [95% CI: 0.81-0.95]) and STC (hazard ratio 0.82 [95% CI: 0.73-0.91]) were associated with lower mortality. SIC was more strongly associated with both anaemia and mortality than either STC or TSAT. Conclusions: Many patients with CHF and a low STC have low SIC even when TSAT is >20% and serum ferritin >100 μg/L; such patients have a high prevalence of anaemia and a poor prognosis and might have iron deficiency but are currently excluded from clinical trials of iron repletion.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Anemia ; Anemia, Iron-Deficiency/complications ; Anemia, Iron-Deficiency/diagnosis ; C-Reactive Protein ; Chronic Disease ; Ferritins/metabolism ; Heart Failure/complications ; Heart Failure/diagnosis ; Hemoglobins ; Iron/metabolism ; Iron Deficiencies ; Prospective Studies ; Stroke Volume ; Transferrin/metabolism ; Ventricular Function, Left ; Aged, 80 and over
Chemical Substances	C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2) ; Hemoglobins ; Iron (E1UOL152H7) ; Transferrin
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14438
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Creatine and creatine phosphate

Conway, Michael A. / Clark, Joseph F.

scientific and clinical perspectives

1996

Author's details	Michael A. Conway and Joseph F. Clark
Keywords	Creatine ; Phosphocreatine ; Kreatinkinase ; Herzmuskel ; Muskelstoffwechsel ; Biochemie ; Kreatin
Subject	Biologische Chemie ; Creatin ; CAS 57-00-1 ; Kreatinphosphatkinase ; CPK ; Creatinkinase ; CK ; Muskel ; Herzmuskeln ; Herzmuskulatur ; Myokard ; Myocard ; Myocardium ; Herzmuskelgewebe
Language	English
Size	XII, 242 S. : graph. Darst.
Publisher	Academic Press
Publishing place	San Diego u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT007450199
ISBN	0-12-186340-9 ; 978-0-12-186340-1
Database	Catalogue ZB MED Medicine, Health

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Book: Manual of pediatric gastroenterology

Fitzgerald, Joseph F. / Clark, Joseph H.

1988

Author's details	Joseph F. Fitzgerald ; Joseph H. Clark
Keywords	Gastrointestinal Diseases / in infancy & childhood
Size	VIII, 216 S. : Ill., graph. Darst.
Publisher	Churchill Livingstone
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT003368939
ISBN	0-443-08538-2 ; 978-0-443-08538-3
Database	Catalogue ZB MED Medicine, Health

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1989 B 1544	order for loan	Magazin

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Article ; Online: Disabilities Reporting in Cardiac Clinical Trials: How Are We Doing?

Lan, Roy H / Rice, Eli N / Nunes, Julio C / Shah, Rushil / Igwe, Joseph-Kevin / Clark, Kira / Periyakoil, Vyjeyanthi S / Chen, Jonathan H / Lin, Bryant / Awad, Christopher / Idris, Muhammed / Cruz, Erin Rose / Lewis, Eldrin F / Johnson, Cati Brown / Wang, Paul J

Journal of the American Heart Association

2023 , Page(s) e029726

Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.029726
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