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Article ; Online: Constitutive internalisation of EP2 differentially regulates G protein signalling.

Walker, Abigail R / Parkin, Holly Ann / Kim, Sung Hye / Terzidou, Vasso / Woodward, David F / Bennett, Phillip R / Hanyaloglu, Aylin C

Journal of molecular endocrinology

2024

Abstract: The prostanoid G protein-coupled receptor (GPCR) EP2 is widely expressed and implicated in endometriosis, osteoporosis, obesity, pre-term labour, and cancer. Internalisation and intracellular trafficking are critical for shaping GPCR activity, yet little ...

Abstract	The prostanoid G protein-coupled receptor (GPCR) EP2 is widely expressed and implicated in endometriosis, osteoporosis, obesity, pre-term labour, and cancer. Internalisation and intracellular trafficking are critical for shaping GPCR activity, yet little is known regarding spatial programming of EP2 signalling and whether this can be exploited pharmacologically. Using three EP2-selective ligands that favour activation of different EP2 pathways, we show that EP2 undergoes limited agonist-driven internalisation but is constitutively internalised via dynamin-dependent, β-arrestin-independent pathways. EP2 was constitutively trafficked to early and very early endosomes (VEE) which was not altered by ligand activation. APPL1, a key adaptor and regulatory protein of the VEE, did not impact EP2 agonist-mediated cAMP. Internalisation was required for ~70% of the acute butaprost- and AH13205-mediated cAMP signalling, yet PGN9856i, a Gαs biased agonist, was less dependent on receptor internalisation for its cAMP signalling, particularly in human term pregnant myometrial cells that endogenously express EP2. Inhibition of EP2 internalisation partially reduced calcium signalling activated by butaprost or AH13205 and had no effect on PGE2 secretion. This indicates an agonist-dependent differential spatial requirement for Gαs and Gαq/11 signalling and a role for plasma membrane initiated Gαq/11-Ca2+-mediated PGE2 secretion. These findings reveal a key role for EP2 constitutive internalisation in its signalling and potential spatial bias in mediating its downstream functions. This in turn could highlight important considerations for future selective targeting of EP2 signalling pathways.
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	645012-x
ISSN	1479-6813 ; 0952-5041
ISSN (online)	1479-6813
ISSN	0952-5041
DOI	10.1530/JME-23-0153
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Article ; Online: Long-Term Performance Assessment of a Geosynthetic-Reinforced Railway Substructure

Ahmet F. Esen / Peter K. Woodward / Omar Laghrouche / David P. Connolly

Sustainability, Vol 15, Iss 9364, p

2023 Volume 9364

Abstract: Significant savings in carbon emissions, cost, and time could be achieved via the reduction in maintenance frequency, capital costs of track construction, and land used. Geosynthetic-reinforced soils offer such sustainable solutions. The experimental ... ...

Abstract	Significant savings in carbon emissions, cost, and time could be achieved via the reduction in maintenance frequency, capital costs of track construction, and land used. Geosynthetic-reinforced soils offer such sustainable solutions. The experimental work presented in this paper investigates the long-term performance of a Geosynthetic-Reinforced Soil Retaining Wall (GRS-RW) system as an alternative to the conventional railway embankment. Full-scale testing was carried out on three sleeper sections of ballasted and slab tracks by simulating train loads cyclically, phased to 360 km/h. The tracks were supported by either a low-level fully confined conventional embankment or a GRS-RW substructure. The substructures were formed of a 1.2 m deep subgrade and frost protection layer, in accordance with high-speed railway design standards. The overall aim was to assess the performance of the tracks, in terms of transient displacements and total settlements. It was observed that once the GRS-RW system reached its active state, it deformed in a very similar way to a conventional embankment despite the fact that the GRS-RW system is less confined than the conventional embankment. The results indicate that the cumulative settlement of the slab track, which is due to the plastic deformation of the soil, is significantly less than that of the ballasted track, which is primarily caused by the movement of the ballast particles.
Keywords	full-scale testing ; railway track settlement ; geosynthetic-reinforced soil ; ballasted track ; slab track ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Broken Machines or Active Bodies? Part 1. Ways of Talking About Health and Why It Matters.

Bunzli, Samantha / Taylor, Nicholas F / O'Brien, Penny / Wallis, Jason A / Caneiro, J P / Woodward-Kron, Robyn / Hunter, David J / Choong, Peter F / Dowsey, Michelle M / Shields, Nora

The Journal of orthopaedic and sports physical therapy

2023 Volume 53, Issue 5, Page(s) 236–238

Abstract: SYNOPSIS: ...

Abstract	SYNOPSIS:
MeSH term(s)	Humans ; Osteoarthritis/therapy ; Health Knowledge, Attitudes, Practice ; Communication ; Health Promotion/methods
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Editorial
ZDB-ID	604640-x
ISSN	1938-1344 ; 0190-6011
ISSN (online)	1938-1344
ISSN	0190-6011
DOI	10.2519/jospt.2023.11879
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Article ; Online: Broken Machines or Active Bodies? Part 3. Five Recommendations to Shift the Way Clinicians Communicate With People Who Are Seeking Care for Osteoarthritis.

Bunzli, Samantha / Taylor, Nicholas F / O'Brien, Penny / Wallis, Jason A / Caneiro, J P / Woodward-Kron, Robyn / Hunter, David J / Choong, Peter F / Dowsey, Michelle M / Shields, Nora

The Journal of orthopaedic and sports physical therapy

2023 Volume 53, Issue 7, Page(s) 375–380

Abstract: SYNOPSIS: ...

Abstract	SYNOPSIS:
MeSH term(s)	Humans ; Osteoarthritis/therapy ; Exercise ; Healthy Lifestyle
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	604640-x
ISSN	1938-1344 ; 0190-6011
ISSN (online)	1938-1344
ISSN	0190-6011
DOI	10.2519/jospt.2023.11881
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Article ; Online: Bimatoprost promotes satiety and attenuates body weight gain in rats fed standard or obesity-promoting diets.

Spada, Clayton / Vu, Chau / Raymond, Iona / Tong, Warren / Chuang, Chia-Lin / Walker, Christopher / Loomes, Kerry / Woodward, David F / Poloso, Neil J

Prostaglandins, leukotrienes, and essential fatty acids

2022 Volume 187, Page(s) 102511

Abstract: Bimatoprost is a synthetic prostamide F ...

Abstract	Bimatoprost is a synthetic prostamide F
MeSH term(s)	Rats ; Animals ; Bimatoprost ; Weight Gain ; Obesity/drug therapy ; Diet ; Adipogenesis
Chemical Substances	Bimatoprost (QXS94885MZ)
Language	English
Publishing date	2022-11-11
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	286714-x
ISSN	1532-2823 ; 0952-3278
ISSN (online)	1532-2823
ISSN	0952-3278
DOI	10.1016/j.plefa.2022.102511
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Article ; Online: Comparing Water Absorption of Food and Drug Administration-Approved Hyaluronic Acid Fillers.

Woodward, Julie / Ranjit-Reeves, Roshni / Katz, David F / Bernardini, Francesco P / Fagien, Steven

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2021 Volume 47, Issue 9, Page(s) 1237–1242

Abstract: Background: To compare the water absorption of 12 FDA-approved hyaluronic acid (HA) facial fillers in vitro in conditions relevant to in vivo injection.: Objective: The goal of this study was to provide long-term insight into an improved, tailored ... ...

Abstract	Background: To compare the water absorption of 12 FDA-approved hyaluronic acid (HA) facial fillers in vitro in conditions relevant to in vivo injection. Objective: The goal of this study was to provide long-term insight into an improved, tailored facial rejuvenation approach and to understand sequelae that could affect preoperative surgical planning. Methods: In 2 experiments, 12 FDA-approved HA fillers were loaded into test tubes with nonpreserved normal saline and then placed in a 94.5°F-96°F environment for 1 month to allow water absorption by passive diffusion. The test tubes were centrifuged so that the hydrated filler could pass to the bottom of the tube. The tubes were centrifuged for 12 minutes at 1,200 revolutions per minute in the first experiment and for 7 minutes in the second experiment. A blue dye was then instilled to demarcate the filler/saline interface. Results: There was variation in the water absorption of different HAs. Low absorption occurred in non-animal-stabilized hyaluronic acid. Conclusion: The pattern of water absorption was similar in the 2 experiments. The results inform us about in vivo conditions and provide guidance for filler selection.
MeSH term(s)	Cosmetic Techniques ; Dermal Fillers/chemistry ; Hyaluronic Acid/chemistry ; Rejuvenation ; United States ; United States Food and Drug Administration ; Water/chemistry
Chemical Substances	Dermal Fillers ; Water (059QF0KO0R) ; Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2021-08-05
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000003108
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Article ; Online: Hypertriglyceridemia: rationale, design and implementation of the Australian Hypertriglyceridemia Registry.

Pang, Jing / Li, Stephen C H / Chan, Dick C / Sullivan, David R / Woodward, Ann-Marie / Watts, Gerald F

Current opinion in endocrinology, diabetes, and obesity

2022 Volume 29, Issue 2, Page(s) 131–140

Abstract: Purpose of review: Hypertriglyceridemia (HTG) is a risk factor for atherosclerotic cardiovascular disease (ASCVD), aortic stenosis, hepatic steatosis and pancreatitis. We briefly review the aetiology and treatment of HTG and familial chylomicronemia ... ...

Abstract	Purpose of review: Hypertriglyceridemia (HTG) is a risk factor for atherosclerotic cardiovascular disease (ASCVD), aortic stenosis, hepatic steatosis and pancreatitis. We briefly review the aetiology and treatment of HTG and familial chylomicronemia syndrome (FCS), as well as the implementation of a clinical quality registry for improving care, the Australian Hypertriglyceridemia (AUSTRIG) Registry. Recent findings: There is a need to improve the detection of individuals with severe HTG and FCS, who could benefit from more intense and novel treatments to prevent end-organ damage. Patient registries provide valuable data for advancing care of individuals with severe HTG at high risk of acute pancreatitis, steatohepatitis and ASCVD. However, there is a paucity of registries of such patients. We outline the design and implementation of the AUSTRIG Registry. Summary: Clinical registries can be employed in many ways for improving outcomes for patients with HTG, through the collation and analysis of data for enabling health service planning, clinical trials and audits, and for better informing and empowering registrants.
MeSH term(s)	Acute Disease ; Atherosclerosis/complications ; Atherosclerosis/epidemiology ; Australia/epidemiology ; Humans ; Hyperlipoproteinemia Type I ; Hypertriglyceridemia/epidemiology ; Hypertriglyceridemia/therapy ; Pancreatitis/diagnosis ; Pancreatitis/epidemiology ; Pancreatitis/therapy ; Registries ; Triglycerides
Chemical Substances	Triglycerides
Language	English
Publishing date	2022-02-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2272017-0
ISSN	1752-2978 ; 1752-296X
ISSN (online)	1752-2978
ISSN	1752-296X
DOI	10.1097/MED.0000000000000715
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Article ; Online: Panretinal Optical Coherence Tomography.

Ni, Shuibin / Nguyen, Thanh-Tin P / Ng, Ringo / Woodward, Mani / Ostmo, Susan / Jia, Yali / Chiang, Michael F / Huang, David / Skalet, Alison H / Campbell, J Peter / Jian, Yifan

IEEE transactions on medical imaging

2023 Volume 42, Issue 11, Page(s) 3219–3228

Abstract: We introduce a new concept of panoramic retinal (panretinal) optical coherence tomography (OCT) imaging system with a 140° field of view (FOV). To achieve this unprecedented FOV, a contact imaging approach was used which enabled faster, more efficient, ... ...

Abstract	We introduce a new concept of panoramic retinal (panretinal) optical coherence tomography (OCT) imaging system with a 140° field of view (FOV). To achieve this unprecedented FOV, a contact imaging approach was used which enabled faster, more efficient, and quantitative retinal imaging with measurement of axial eye length. The utilization of the handheld panretinal OCT imaging system could allow earlier recognition of peripheral retinal disease and prevent permanent vision loss. In addition, adequate visualization of the peripheral retina has a great potential for better understanding disease mechanisms regarding the periphery. To the best of our knowledge, the panretinal OCT imaging system presented in this manuscript has the widest FOV among all the retina OCT imaging systems and offers significant values in both clinical ophthalmology and basic vision science.
MeSH term(s)	Tomography, Optical Coherence/methods ; Retina/diagnostic imaging
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	622531-7
ISSN	1558-254X ; 0278-0062
ISSN (online)	1558-254X
ISSN	0278-0062
DOI	10.1109/TMI.2023.3278269
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Article ; Online: Broken Machines or Active Bodies? Part 2. How People Talk About Osteoarthritis and Why Clinicians Need to Change the Conversation.

Bunzli, Samantha / Taylor, Nicholas F / O'Brien, Penny / Wallis, Jason A / Caneiro, J P / Woodward-Kron, Robyn / Hunter, David J / Choong, Peter F / Dowsey, Michelle M / Shields, Nora

The Journal of orthopaedic and sports physical therapy

2022 Volume 53, Issue 6, Page(s) 325–330

Abstract: SYNOPSIS: ...

Abstract	SYNOPSIS:
MeSH term(s)	Humans ; Osteoarthritis, Knee/therapy ; Life Style ; Communication
Language	English
Publishing date	2022-09-13
Publishing country	United States
Document type	Systematic Review ; Editorial
ZDB-ID	604640-x
ISSN	1938-1344 ; 0190-6011
ISSN (online)	1938-1344
ISSN	0190-6011
DOI	10.2519/jospt.2023.11880
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Article ; Online: Diagnosis, treatment, and survival from kidney cancer: real-world National Health Service England data between 2013 and 2019.

Conroy, Samantha / Catto, James W F / Bex, Axel / Brown, Janet E / Cartledge, Jon / Fielding, Alison / Jones, Rob J / Khoo, Vincent / Nicol, David / Stewart, Grant D / Sullivan, Mark / Tran, Maxine G B / Woodward, Rose / Cumberbatch, Marcus G

BJU international

2023 Volume 132, Issue 5, Page(s) 541–553

Abstract: Objectives: To report the NHS Digital (NHSD) data for patients diagnosed with kidney cancer (KC) in England. We explore the incidence, route to diagnosis (RTD), treatment, and survival patterns from 2013 to 2019.: Materials and methods: Data was ... ...

Abstract	Objectives: To report the NHS Digital (NHSD) data for patients diagnosed with kidney cancer (KC) in England. We explore the incidence, route to diagnosis (RTD), treatment, and survival patterns from 2013 to 2019. Materials and methods: Data was extracted from the Cancer Data NHSD portal for International Classification of Diseases, 10th edition coded KC; this included Cancer Registry data, Hospital Episode Statistics, and cancer waiting times data. Results: Registrations included 66 696 individuals with KC. Incidence of new KC diagnoses increased (8998 in 2013, to 10 232 in 2019), but the age-standardised rates were stable (18.7-19.4/100 000 population). Almost half of patients (30 340 [45.5%]) were aged 0-70 years and the cohort were most frequently diagnosed with Stage 1-2 KC (n = 26 297 [39.4%]). Most patients were diagnosed through non-urgent general practitioner referrals (n = 16 814 [30.4%]), followed by 2-week-wait (n = 15 472 [28.0%]) and emergency routes (n = 11 796 [21.3%]), with older patients (aged ≥70 years), Stage 4 KCs, and patients with non-specified renal cell carcinoma being significantly more likely to present through the emergency route (all P < 0.001). Invasive treatment (surgery or ablation), radiotherapy, or systemic anti-cancer therapy use varied with disease stage, patient factors, and treatment network (Cancer Alliance). Survival outcomes differed by Stage, histological subtype, and social deprivation class (P < 0.001). Age-standardised mortality rates did not change over the study duration, although immunotherapy usage is likely not captured in this study timeline. Conclusion: The NHSD resource provides useful insight about the incidence, diagnostic pathways, treatment, and survival of patients with KC in England and a useful benchmark for the upcoming commissioned National Kidney Cancer Audit. The RTD data may be limited by incidental diagnoses, which could confound the high proportion of 'emergency' diagnoses. Importantly, survival outcomes remained relatively unchanged.
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/bju.16128
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