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  1. Article ; Online: Unfulfilled Expectations Open New Horizons: What Have We Learned about Volume-Regulated Anion Channels in the Kidney?

    Pochynyuk, Oleh / Palygin, Oleg

    Journal of the American Society of Nephrology : JASN

    2022  Volume 33, Issue 8, Page(s) 1437–1439

    MeSH term(s) Anions ; Cell Size ; Kidney ; Membrane Proteins ; Motivation
    Chemical Substances Anions ; Membrane Proteins
    Language English
    Publishing date 2022-07-15
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2022050588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Modus operandi

    Stavniichuk, Anna / Pyrshev, Kyrylo / Tomilin, Viktor N / Kordysh, Mariya / Zaika, Oleg / Pochynyuk, Oleh

    Biomolecules

    2023  Volume 13, Issue 1

    Abstract: The renal collecting duct is known to play a critical role in many physiological processes, including systemic water-electrolyte homeostasis, acid-base balance, and the salt sensitivity of blood pressure. ClC-K2 (ClC-Kb in humans) is a ... ...

    Abstract The renal collecting duct is known to play a critical role in many physiological processes, including systemic water-electrolyte homeostasis, acid-base balance, and the salt sensitivity of blood pressure. ClC-K2 (ClC-Kb in humans) is a Cl
    MeSH term(s) Humans ; Kidney/metabolism ; Bartter Syndrome/genetics ; Bartter Syndrome/metabolism ; Cell Membrane ; Electrolytes/metabolism
    Chemical Substances Electrolytes
    Language English
    Publishing date 2023-01-14
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13010177
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  3. Article ; Online: Independent regulation of Piezo1 activity by principal and intercalated cells of the collecting duct.

    Pyrshev, Kyrylo / Atamanchuk-Stavniichuk, Anna / Kordysh, Mariya / Zaika, Oleg / Tomilin, Viktor N / Pochynyuk, Oleh

    The Journal of biological chemistry

    2023  Volume 300, Issue 1, Page(s) 105524

    Abstract: The renal collecting duct is continuously exposed to a wide spectrum of fluid flow rates and osmotic gradients. Expression of a mechanoactivated Piezo1 channel is the most prominent in the collecting duct. However, the status and regulation of Piezo1 in ... ...

    Abstract The renal collecting duct is continuously exposed to a wide spectrum of fluid flow rates and osmotic gradients. Expression of a mechanoactivated Piezo1 channel is the most prominent in the collecting duct. However, the status and regulation of Piezo1 in functionally distinct principal and intercalated cells (PCs and ICs) of the collecting duct remain to be determined. We used pharmacological Piezo1 activation to quantify Piezo1-mediated [Ca
    MeSH term(s) Cell Membrane ; Kidney Tubules, Collecting/cytology ; Kidney Tubules, Collecting/metabolism ; Pyrazines/pharmacology ; Thiadiazoles/pharmacology ; Water/metabolism ; Ion Channels/agonists ; Ion Channels/metabolism ; Animals ; Mice ; Calcium/metabolism
    Chemical Substances Pyrazines ; Thiadiazoles ; Water (059QF0KO0R) ; yoda-1 ; Ion Channels ; Piezo1 protein, mouse ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105524
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  4. Article ; Online: A peek into Epac physiology in the kidney.

    Tomilin, Viktor N / Pochynyuk, Oleh

    American journal of physiology. Renal physiology

    2019  Volume 317, Issue 5, Page(s) F1094–F1097

    Abstract: cAMP is a critical second messenger of numerous endocrine signals affecting water-electrolyte transport in the renal tubule. Exchange protein directly activated by cAMP (Epac) is a relatively recently discovered downstream effector of cAMP, having the ... ...

    Abstract cAMP is a critical second messenger of numerous endocrine signals affecting water-electrolyte transport in the renal tubule. Exchange protein directly activated by cAMP (Epac) is a relatively recently discovered downstream effector of cAMP, having the same affinity to the second messenger as protein kinase A, the classical cAMP target. Two Epac isoforms, Epac1 and Epac2, are abundantly expressed in the renal epithelium, where they are thought to regulate water and electrolyte transport, particularly in the proximal tubule and collecting duct. Recent characterization of renal phenotype in mice lacking Epac1 and Epac2 revealed a critical role of the Epac signaling cascade in urinary concentration as well as in Na
    MeSH term(s) Animals ; Cyclic AMP ; Gene Expression Regulation ; Guanine Nucleotide Exchange Factors/metabolism ; Humans ; Kidney/metabolism ; Protein Isoforms
    Chemical Substances Guanine Nucleotide Exchange Factors ; Protein Isoforms ; Cyclic AMP (E0399OZS9N)
    Language English
    Publishing date 2019-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00373.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: TRPV4 functional status in cystic cells regulates cystogenesis in autosomal recessive polycystic kidney disease during variations in dietary potassium.

    Pyrshev, Kyrylo / Stavniichuk, Anna / Tomilin, Viktor N / Khayyat, Naghmeh Hassanzadeh / Ren, Guohui / Kordysh, Mariya / Zaika, Oleg / Mamenko, Mykola / Pochynyuk, Oleh

    Physiological reports

    2023  Volume 11, Issue 6, Page(s) e15641

    Abstract: Mechanosensitive TRPV4 channel plays a dominant role in maintaining [ ... ...

    Abstract Mechanosensitive TRPV4 channel plays a dominant role in maintaining [Ca
    MeSH term(s) Animals ; Humans ; Rats ; Aquaporin 2 ; Functional Status ; Kidney/metabolism ; Polycystic Kidney, Autosomal Recessive ; Potassium, Dietary/metabolism ; TRPV Cation Channels/genetics ; Disease Models, Animal
    Chemical Substances Aquaporin 2 ; Potassium, Dietary ; TRPV Cation Channels ; Trpv4 protein, rat
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: TRPV4 expression in the renal tubule is necessary for maintaining whole body K

    Stavniichuk, Anna / Pyrshev, Kyrylo / Zaika, Oleg / Tomilin, Viktor N / Kordysh, Mariya / Lakk, Monika / Križaj, David / Pochynyuk, Oleh

    American journal of physiology. Renal physiology

    2023  Volume 324, Issue 6, Page(s) F603–F616

    Abstract: ... The ... ...

    Abstract The Ca
    MeSH term(s) Animals ; Mice ; Adenosine Triphosphatases ; Homeostasis ; Hypokalemia/metabolism ; Kidney Tubules/metabolism ; Kidney Tubules, Distal/metabolism ; Mice, Knockout ; Mice, Transgenic ; Potassium Deficiency/metabolism ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism
    Chemical Substances Adenosine Triphosphatases (EC 3.6.1.-) ; TRPV Cation Channels ; Trpv4 protein, mouse
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00278.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Evolving concepts of TRPV4 in controlling flow-sensitivity of the renal nephron.

    Pyrshev, Kyrylo / Stavniichuk, Anna / Tomilin, Viktor N / Zaika, Oleg / Pochynyuk, Oleh

    Current topics in membranes

    2022  Volume 89, Page(s) 75–94

    Abstract: Kidneys are central for whole body water and electrolyte balance by first filtering plasma at the glomeruli and then processing the filtrate along the renal nephron until the final urine is produced. Renal nephron epithelial cells mediate transport of ... ...

    Abstract Kidneys are central for whole body water and electrolyte balance by first filtering plasma at the glomeruli and then processing the filtrate along the renal nephron until the final urine is produced. Renal nephron epithelial cells mediate transport of water and solutes which is under the control of systemic hormones as well as local mechanical stimuli arising from alterations in fluid flow. TRPV4 is a mechanosensitive Ca
    MeSH term(s) Albumins ; Hormones ; Kidney ; Nephrons ; Reactive Oxygen Species ; TRPV Cation Channels ; Water
    Chemical Substances Albumins ; Hormones ; Reactive Oxygen Species ; TRPV Cation Channels ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1063-5823
    ISSN 1063-5823
    DOI 10.1016/bs.ctm.2022.06.001
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  8. Article ; Online: Adenosine inhibits the basolateral Cl

    Zaika, Oleg / Tomilin, Viktor N / Pochynyuk, Oleh

    American journal of physiology. Renal physiology

    2020  Volume 318, Issue 4, Page(s) F870–F877

    Abstract: Adenosine plays an important role in various aspects of kidney physiology, but the specific targets and mechanisms of actions are not completely understood. The collecting duct has the highest expression of adenosine receptors, particularly adenosine ... ...

    Abstract Adenosine plays an important role in various aspects of kidney physiology, but the specific targets and mechanisms of actions are not completely understood. The collecting duct has the highest expression of adenosine receptors, particularly adenosine A
    MeSH term(s) Adenosine/pharmacology ; Adenosine A1 Receptor Agonists/pharmacology ; Animals ; Anion Transport Proteins/antagonists & inhibitors ; Anion Transport Proteins/metabolism ; Calcium Signaling/drug effects ; Cells, Cultured ; Chloride Channels/antagonists & inhibitors ; Chloride Channels/metabolism ; Chlorides/metabolism ; Kidney Tubules, Collecting/cytology ; Kidney Tubules, Collecting/drug effects ; Kidney Tubules, Collecting/metabolism ; Male ; Membrane Potentials/drug effects ; Mice, Inbred C57BL ; Receptor, Adenosine A1/drug effects ; Receptor, Adenosine A1/metabolism ; Renal Reabsorption/drug effects
    Chemical Substances Adenosine A1 Receptor Agonists ; Anion Transport Proteins ; Chloride Channels ; Chlorides ; Clcnka protein, mouse ; Clcnkb protein, mouse ; Receptor, Adenosine A1 ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2020-01-27
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00572.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Polymodal roles of TRPC3 channel in the kidney.

    Khayyat, Naghmeh Hassanzadeh / Tomilin, Viktor N / Zaika, Oleg / Pochynyuk, Oleh

    Channels (Austin, Tex.)

    2020  Volume 14, Issue 1, Page(s) 257–267

    Abstract: TRPC3 is a ... ...

    Abstract TRPC3 is a Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Humans ; Kidney/metabolism ; Kidney/pathology ; Osmolar Concentration ; Signal Transduction ; TRPC Cation Channels/genetics ; TRPC Cation Channels/metabolism
    Chemical Substances TRPC Cation Channels ; TRPC3 cation channel ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2262854-X
    ISSN 1933-6969 ; 1933-6969
    ISSN (online) 1933-6969
    ISSN 1933-6969
    DOI 10.1080/19336950.2020.1804153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Angiotensin II increases activity of the ClC-K2 Cl

    Khayyat, Naghmeh Hassanzadeh / Zaika, Oleg / Tomilin, Viktor N / Pyrshev, Kyrylo / Pochynyuk, Oleh

    The Journal of biological chemistry

    2021  Volume 296, Page(s) 100347

    Abstract: The renal collecting duct plays a critical role in setting urinary volume and composition, with principal cells transporting ... ...

    Abstract The renal collecting duct plays a critical role in setting urinary volume and composition, with principal cells transporting Na
    MeSH term(s) Angiotensin II/metabolism ; Animals ; Anion Transport Proteins/metabolism ; Chloride Channels/metabolism ; Kidney Tubules, Collecting/metabolism ; Male ; Mice, Inbred C57BL ; Reactive Oxygen Species/metabolism ; Mice
    Chemical Substances Anion Transport Proteins ; Chloride Channels ; Clcnkb protein, mouse ; Reactive Oxygen Species ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2021-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2021.100347
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