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  1. Book ; Online ; Thesis: Minderjährige unbegleitete Flüchtlinge in Hamburg

    Stolle, Martin

    kinder- und jugendpsychiatrische Auffälligkeiten unter besonderer Berücksichtigung der asylrechtlichen Anhörung und des Aufenthaltsstatus

    2001  

    Author's details vorgelegt von Martin Stolle
    Language German
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Hamburg, Univ., Diss., 2001
    Note Open Access
    HBZ-ID HT013810671
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: The activities of the Institute of Fruit and Vegetable Growing at the Martin-Luther-University Halle-Wittenberg - Tradition and prospects -

    Stolle, G.

    Kuehn-Archiv (Germany)

    1994  

    Abstract: Ausgangspunkt für die Gründung des Institutes war der Gedanke von ROEMER, daß die Fachgebiete Obstbau und Gemüsebau in einer Landwirtschaftlichen Fakultät in Lehre und Forschung einen festen Platz haben müssen. Gemüsebau und Obstbau wurden von ROEMER als ...

    Institution Halle Univ. (Germany). Landwirtschaftliche Fakultaet. Inst. fuer Obstbau und Gemuesebau
    Abstract Ausgangspunkt für die Gründung des Institutes war der Gedanke von ROEMER, daß die Fachgebiete Obstbau und Gemüsebau in einer Landwirtschaftlichen Fakultät in Lehre und Forschung einen festen Platz haben müssen. Gemüsebau und Obstbau wurden von ROEMER als Teile von Landwirtschaftsbetrieben angesehen. Dieser Gesichtspunkt war bis heute auch bestimmend für die Aufgaben in Forschung und Lehre.
    Keywords Obstbau ; Gemuesebau ; Gartenbau ; Deutschland ; Universitaet ; Forschung ; Versuch
    Language German
    Edition v. 88(2) p. 3-8
    Document type Article
    ISSN 0940-3507
    Database ELFIS - Nutrition, agriculture and forestry information system

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  3. Article ; Online: Defective mitochondria remodelling in B cells leads to an aged immune response.

    Iborra-Pernichi, Marta / Ruiz García, Jonathan / Velasco de la Esperanza, María / Estrada, Belén S / Bovolenta, Elena R / Cifuentes, Claudia / Prieto Carro, Cristina / González Martínez, Tamara / García-Consuegra, José / Rey-Stolle, María Fernanda / Rupérez, Francisco Javier / Guerra Rodriguez, Milagros / Argüello, Rafael J / Cogliati, Sara / Martín-Belmonte, Fernando / Martínez-Martín, Nuria

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2569

    Abstract: The B cell response in the germinal centre (GC) reaction requires a unique bioenergetic supply. Although mitochondria are remodelled upon antigen-mediated B cell receptor stimulation, mitochondrial function in B cells is still poorly understood. To gain ... ...

    Abstract The B cell response in the germinal centre (GC) reaction requires a unique bioenergetic supply. Although mitochondria are remodelled upon antigen-mediated B cell receptor stimulation, mitochondrial function in B cells is still poorly understood. To gain a better understanding of the role of mitochondria in B cell function, here we generate mice with B cell-specific deficiency in Tfam, a transcription factor necessary for mitochondrial biogenesis. Tfam conditional knock-out (KO) mice display a blockage of the GC reaction and a bias of B cell differentiation towards memory B cells and aged-related B cells, hallmarks of an aged immune response. Unexpectedly, blocked GC reaction in Tfam KO mice is not caused by defects in the bioenergetic supply but is associated with a defect in the remodelling of the lysosomal compartment in B cells. Our results may thus describe a mitochondrial function for lysosome regulation and the downstream antigen presentation in B cells during the GC reaction, the dysruption of which is manifested as an aged immune response.
    MeSH term(s) Mice ; Animals ; Mitochondria/genetics ; B-Lymphocytes ; Germinal Center ; Mice, Knockout ; Lymphocyte Activation
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46763-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Peripheral nerve injuries in children-prevalence, mechanisms and concomitant injuries: a major trauma center's experience.

    Aman, Martin / Zimmermann, Kim S / Boecker, Arne H / Thielen, Mirjam / Falkner, Florian / Daeschler, Simeon / Stolle, Annette / Kneser, Ulrich / Harhaus, Leila

    European journal of medical research

    2023  Volume 28, Issue 1, Page(s) 116

    Abstract: Background: Peripheral nerve injuries are severe conditions with potential lifelong impairment, which is especially meaningful for the pediatric population. Knowledge on prevalence, injury mechanisms and concomitant injuries is, therefore, of utmost ... ...

    Abstract Background: Peripheral nerve injuries are severe conditions with potential lifelong impairment, which is especially meaningful for the pediatric population. Knowledge on prevalence, injury mechanisms and concomitant injuries is, therefore, of utmost importance to increase clinician awareness and enable early diagnosis and treatment. As current literature on pediatric nerve lesions and concomitant injuries is scarce, we aimed to analyze all details of our patient population.
    Methods: A total of 110 667 patients treated at our level 1 trauma center from 2012 to 2021 were evaluated for pediatric peripheral nerve injuries, causes, concomitant injuries and assessed for lesion classification (in continuity, partial lesion, dissection) and further relevant intraoperative findings.
    Results: We found 5026 patients of all ages with peripheral nerve lesions, whereof 288 were pediatric, resulting in a prevalence of 5.7% of pediatric patients with nerve injuries. Mean age was 12.4 ± 4.6 years. Most common lesions were digital nerves (48.2%), followed by median (14.9%), ulnar (14.6%), radial (8.8%), peroneal nerve (5.2%) and brachial plexus injuries (2.1%). Of all pediatric nerve injuries, 3.8% were iatrogenic, only 30.2% had preserved continuity and 47.3% a concomitant vessel injury. Fractures were accompanied in 22.6%.
    Discussion: We observed that a large proportion of injures had complete transections, often accompanied by concomitant vessel injuries especially in distally located injuries, highlighting the importance of early surgical exploration. Radial, ulnar and lower extremity nerve injuries were often associated with fractures. Early surgical nerve repair is key to improve motor and sensory outcomes. Knowledge on mechanisms and concomitant injuries facilitates timely diagnosis and treatment, thereby potentially preventing lifelong impairment.
    MeSH term(s) Humans ; Child ; Adolescent ; Peripheral Nerve Injuries/surgery ; Prevalence ; Trauma Centers ; Fractures, Bone ; Extremities ; Retrospective Studies
    Language English
    Publishing date 2023-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-023-01082-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Modern MRI Diagnostics of Upper-Extremity-Related Nerve Injuries-A Prospective Multi-Center Study Protocol for Diagnostics and Follow Up of Peripheral Nerve Injuries.

    Aman, Martin / Schwarz, Daniel / Stolle, Annette / Bergmeister, Konstantin Davide / Boecker, Arne H / Daeschler, Simeon / Bendszus, Martin / Kneser, Ulrich / Harhaus, Leila

    Journal of personalized medicine

    2022  Volume 12, Issue 10

    Abstract: 1) Background: Peripheral nerve injuries are severe injuries with potentially devastating impairment of extremity function. Correct and early diagnosis as well as regular regeneration observation is of utmost importance for individualized reconstruction ...

    Abstract (1) Background: Peripheral nerve injuries are severe injuries with potentially devastating impairment of extremity function. Correct and early diagnosis as well as regular regeneration observation is of utmost importance for individualized reconstruction and the best possible results. Currently, diagnoses and follow-up examinations are based on clinical examinations supported with electroneurography, which often causes delays in treatment and can result in impaired healing. However, there is currently no diagnostic device that can reliably correlate the anatomic-pathological parameters with the functional-pathological changes initially and during therapy. With new technologies such as MR neurography (MRN), precise visualization of potential nerve damage and visualization of the reinnervation processes is assumed to accelerate clinical decision making and accompaniment of individualized treatment. (2) Methods/Design: This prospective clinical study will examine 60 patients after peripheral nerve lesion aged 18-65 years from trauma timepoint onward. Patients should be observed over a period of 18-24 months with regular clinical examinations, electroneurography, and ultrasound to compare the potential of MRN to current gold-standard diagnostic tools. Furthermore, 20 patients with the same inclusion criteria stated above, with an internal fixation and osteosyntheses of humerus fractures, will be examined to determine the visibility of peripheral nerve structures in close proximity to metal. (3) Discussion: Peripheral nerve injuries are often accompanied with severe, expensive, and long-lasting impairment of extremity function. An early and precise diagnosis of the nerve lesion, as well as the healing course, is crucial to indicate the right therapy as soon as possible to save valuable time for nerve regeneration. Here, new technologies such as MRN aim to visualize nerve injuries on fascicular level, providing not only early diagnosis and therapy decisions, but also providing a precise tool for monitoring of reinnervation processes. As severe injuries of a nerve are often accompanied with bone fractures and internal fixation, we also aim to evaluate the visualization feasibility of nerves in close proximity to metal, and ultimately improve the outcome and extremity function of patients after a peripheral nerve injury.
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12101548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Conference proceedings: MODERN: Eine prospektive Multicenterstudie zum outcome-Monitoring von Stammnervenverletzungen der oberen Extremität

    Aman, Martin / Schwarz, Daniel / Stolle, Annette / Pindur, Lukas / Bendszus, Martin / Kneser, Ulrich / Harhaus, Leila

    2021  , Page(s) 21dgh66

    Event/congress 61. Kongress der Deutschen Gesellschaft für Handchirurgie; Münster; Deutsche Gesellschaft für Handchirurgie; 2021
    Keywords Medizin, Gesundheit ; MRT ; Nervenchirurgie
    Publishing date 2021-08-27
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21dgh66
    Database German Medical Science

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  7. Article ; Online: Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach.

    Barker-Tejeda, Tomás Clive / Zubeldia-Varela, Elisa / Macías-Camero, Andrea / Alonso, Lola / Martín-Antoniano, Isabel Adoración / Rey-Stolle, María Fernanda / Mera-Berriatua, Leticia / Bazire, Raphaëlle / Cabrera-Freitag, Paula / Shanmuganathan, Meera / Britz-McKibbin, Philip / Ubeda, Carles / Francino, M Pilar / Barber, Domingo / Ibáñez-Sandín, María Dolores / Barbas, Coral / Pérez-Gordo, Marina / Villaseñor, Alma

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3004

    Abstract: The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development ... ...

    Abstract The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development of the gut microbiota. Fecal samples from 200 individuals, including infants (0-12 months old; 55% females, 45% males) and their respective mothers and grandmothers, were analyzed using two independent metabolomics platforms and metagenomics. For metabolomics, gas chromatography and capillary electrophoresis coupled to mass spectrometry were applied. For metagenomics, both 16S rRNA gene and shotgun sequencing were performed. Here we show that infants greatly vary from their elders in fecal microbiota populations, function, and metabolome. Infants have a less diverse microbiota than adults and present differences in several metabolite classes, such as short- and branched-chain fatty acids, which are associated with shifts in bacterial populations. These findings provide innovative biochemical insights into the shaping of the gut microbiome within the same generational line that could be beneficial in improving childhood health outcomes.
    MeSH term(s) Infant ; Male ; Adult ; Female ; Humans ; Child ; Aged ; Infant, Newborn ; Gastrointestinal Microbiome/genetics ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/metabolism ; Multiomics ; Metabolome ; Feces/microbiology ; Mothers
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47182-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: An Algorithm for Elective Amputation Combined with Targeted Muscle Reinnervation in Complex Regional Pain Syndrome-A Perspective.

    Aman, Martin / Biglari, Bahram / Thielen, Mirjam / Boecker, Arne H / Stolle, Annette / Schwarz, Daniel / Gazyakan, Emre / Kneser, Ulrich / Harhaus, Leila

    Journal of personalized medicine

    2022  Volume 12, Issue 7

    Abstract: Complex regional pain syndrome (CRPS) can result in a devastating condition. For a small number of patients, there is a non-response to any existing multimodal therapies and they ultimately request amputation. Such a drastic and final decision is not ... ...

    Abstract Complex regional pain syndrome (CRPS) can result in a devastating condition. For a small number of patients, there is a non-response to any existing multimodal therapies and they ultimately request amputation. Such a drastic and final decision is not easy to take for both the patient and the surgeon and requires careful and interdisciplinary assessments and considerations. Furthermore, new surgical procedures, such as targeted muscle reinnervation (TMR) and hybrid prosthetic fitting, and multidisciplinary board advice should be included when considering amputation. In order to help other therapeutic teams in decision making for such rare but more than demanding cases, we aimed to propose an advanced algorithm for amputation indications in CRPS patients combining all these new factors. This algorithm consists of extensive pre-operative psychiatric assessment, diagnostic hybrid prosthetic fitting including fMRI analyses, multidisciplinary board advice as well as targeted muscle reinnervation and amputation procedures with final prosthetic fitting and rehabilitation. By involving multiple disciplines, this algorithm should provide optimized and individualized patient treatment on the one hand and a reliable base for decision making for therapists on the other.
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12071169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Conference proceedings: Ein-Jahres-Follow-up einer prospektiven Multicenterstudie zum Outcome-Monitoring von Stammnervenverletzungen der oberen Extremität

    Aman, Martin / Schwarz, Daniel / Stolle, Annette / Böcker, Arne / Pindur, Lukas / Bendszus, Martin / Kneser, Ulrich / Harhaus, Leila

    2022  , Page(s) 22dgh26

    Event/congress 62. Kongress der Deutschen Gesellschaft für Handchirurgie; Garmisch-Partenkirchen; Deutsche Gesellschaft für Handchirurgie; 2022
    Keywords Medizin, Gesundheit ; Nerven ; MRT ; Nervenrekonstruktion
    Publishing date 2022-10-06
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dgh26
    Database German Medical Science

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  10. Article ; Online: Modern MRI Diagnostics of Upper-Extremity-Related Nerve Injuries—A Prospective Multi-Center Study Protocol for Diagnostics and Follow Up of Peripheral Nerve Injuries

    Martin Aman / Daniel Schwarz / Annette Stolle / Konstantin Davide Bergmeister / Arne H. Boecker / Simeon Daeschler / Martin Bendszus / Ulrich Kneser / Leila Harhaus

    Journal of Personalized Medicine, Vol 12, Iss 1548, p

    2022  Volume 1548

    Abstract: 1) Background: Peripheral nerve injuries are severe injuries with potentially devastating impairment of extremity function. Correct and early diagnosis as well as regular regeneration observation is of utmost importance for individualized reconstruction ...

    Abstract (1) Background: Peripheral nerve injuries are severe injuries with potentially devastating impairment of extremity function. Correct and early diagnosis as well as regular regeneration observation is of utmost importance for individualized reconstruction and the best possible results. Currently, diagnoses and follow-up examinations are based on clinical examinations supported with electroneurography, which often causes delays in treatment and can result in impaired healing. However, there is currently no diagnostic device that can reliably correlate the anatomic–pathological parameters with the functional–pathological changes initially and during therapy. With new technologies such as MR neurography (MRN), precise visualization of potential nerve damage and visualization of the reinnervation processes is assumed to accelerate clinical decision making and accompaniment of individualized treatment. (2) Methods/Design: This prospective clinical study will examine 60 patients after peripheral nerve lesion aged 18–65 years from trauma timepoint onward. Patients should be observed over a period of 18–24 months with regular clinical examinations, electroneurography, and ultrasound to compare the potential of MRN to current gold-standard diagnostic tools. Furthermore, 20 patients with the same inclusion criteria stated above, with an internal fixation and osteosyntheses of humerus fractures, will be examined to determine the visibility of peripheral nerve structures in close proximity to metal. (3) Discussion: Peripheral nerve injuries are often accompanied with severe, expensive, and long-lasting impairment of extremity function. An early and precise diagnosis of the nerve lesion, as well as the healing course, is crucial to indicate the right therapy as soon as possible to save valuable time for nerve regeneration. Here, new technologies such as MRN aim to visualize nerve injuries on fascicular level, providing not only early diagnosis and therapy decisions, but also providing a precise tool for monitoring of ...
    Keywords plastic surgery ; reconstructive surgery ; microsurgery ; nerve damage ; MRI ; neurosonography ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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