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Book ; Online ; Thesis: Antimicrobial biomaterials for treatment of bone and implant infections

2020

Author's details	Magdalena Anna Czuban
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	English
Publisher	Freie Universität Berlin
Publishing place	Berlin
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article: Release of different amphotericin B formulations from PMMA bone cements and their activity against Candida biofilm

Czuban, Magdalena / Wulsten, Dag / Wang, Lei / Di Luca, Mariagrazia / Trampuz, Andrej

Colloids and surfaces. 2019 July 29,

2019

Abstract: Amphotericin B is used for local delivery from polymethylmethacrylate to treat fungal prosthetic joint infections. The optimal amphotericin B formulation and the influence of different poragens in the bone cements are unknown. To investigate the ... ...

Abstract	Amphotericin B is used for local delivery from polymethylmethacrylate to treat fungal prosthetic joint infections. The optimal amphotericin B formulation and the influence of different poragens in the bone cements are unknown. To investigate the necessary amount of amphotericin B in the bone cement to prevent Candida biofilm several amphotericin B formulations were studied: non-liposomal and liposomal with or without poragen gentamicin. For the non-liposomal formulation, standard bile salt, the sodium deoxycholate, was used and additionally N-methyl-D-glucamine/palmitate was applied. The activity of the released amphotericin B was tested against C. albicans, C. glabrata, C. parapsilosis and C. krusei biofilms with application of the isothermal calorimeter and standard microbiological methods. Compressive strength was measured before and after antifungal elution from the cements. There is less aggregated N-methyl-D-glucamine/palmitate amphotericin B released but its antifungal activity is equivalent with the deoxycholate amphotericin B. The minimum quantity of antifungal preventing theCandida biofilm formation is 12.5 mg in gram of polymer powder for both non-liposomal formulations. The addition of gentamicin reduced the release of sodium deoxycholate amphotericin B. Gentamicin can be added to N-methyl-D-glucamine/palmitate amphotericin B in order to boost the antifungal release. When using liposomal amphotericin B more drug is released. All amphotericin B formulations were active against Candida biofilms. Although compressive strength slightly decreased, the obtained values were above the level of strength recommended for the implant fixation. The finding of this work might be beneficial for the treatment of the prosthetic joint infections caused by Candida spp.
Keywords	Candida albicans ; Candida glabrata ; Candida krusei ; Candida parapsilosis ; amphotericin B ; antifungal properties ; bile salts ; biofilm ; calorimeters ; cement ; compression strength ; deoxycholic acid ; drugs ; fungi ; gentamicin ; palmitates ; polymethylmethacrylate ; prostheses
Language	English
Dates of publication	2019-0729
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2019.110406
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Release of different amphotericin B formulations from PMMA bone cements and their activity against Candida biofilm.

Czuban, Magdalena / Wulsten, Dag / Wang, Lei / Di Luca, Mariagrazia / Trampuz, Andrej

Colloids and surfaces. B, Biointerfaces

2019 Volume 183, Page(s) 110406

Abstract	Amphotericin B is used for local delivery from polymethylmethacrylate to treat fungal prosthetic joint infections. The optimal amphotericin B formulation and the influence of different poragens in the bone cements are unknown. To investigate the necessary amount of amphotericin B in the bone cement to prevent Candida biofilm several amphotericin B formulations were studied: non-liposomal and liposomal with or without poragen gentamicin. For the non-liposomal formulation, standard bile salt, the sodium deoxycholate, was used and additionally N-methyl-D-glucamine/palmitate was applied. The activity of the released amphotericin B was tested against C. albicans, C. glabrata, C. parapsilosis and C. krusei biofilms with application of the isothermal calorimeter and standard microbiological methods. Compressive strength was measured before and after antifungal elution from the cements. There is less aggregated N-methyl-D-glucamine/palmitate amphotericin B released but its antifungal activity is equivalent with the deoxycholate amphotericin B. The minimum quantity of antifungal preventing the Candida biofilm formation is 12.5 mg in gram of polymer powder for both non-liposomal formulations. The addition of gentamicin reduced the release of sodium deoxycholate amphotericin B. Gentamicin can be added to N-methyl-D-glucamine/palmitate amphotericin B in order to boost the antifungal release. When using liposomal amphotericin B more drug is released. All amphotericin B formulations were active against Candida biofilms. Although compressive strength slightly decreased, the obtained values were above the level of strength recommended for the implant fixation. The finding of this work might be beneficial for the treatment of the prosthetic joint infections caused by Candida spp.
MeSH term(s)	Amphotericin B/analogs & derivatives ; Amphotericin B/chemistry ; Amphotericin B/pharmacology ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Biofilms/drug effects ; Biofilms/growth & development ; Bone Cements/analysis ; Bone Cements/chemistry ; Candida albicans/drug effects ; Candida albicans/growth & development ; Candida glabrata/drug effects ; Candida glabrata/growth & development ; Candida parapsilosis/drug effects ; Candida parapsilosis/growth & development ; Compressive Strength ; Deoxycholic Acid/chemistry ; Deoxycholic Acid/pharmacology ; Drug Combinations ; Drug Liberation ; Gentamicins/pharmacology ; Kinetics ; Materials Testing ; Microbial Sensitivity Tests ; Polymethyl Methacrylate/analysis ; Polymethyl Methacrylate/chemistry ; Porosity
Chemical Substances	Antifungal Agents ; Bone Cements ; Drug Combinations ; Gentamicins ; liposomal amphotericin B ; Deoxycholic Acid (005990WHZZ) ; amphoglucamine (58722-78-4) ; Amphotericin B (7XU7A7DROE) ; amphotericin B, deoxycholate drug combination (87687-70-5) ; Polymethyl Methacrylate (9011-14-7)
Language	English
Publishing date	2019-08-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2019.110406
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of selenium status from dried blood spots by total-reflection X-ray fluorescence analysis

Magdalena Czuban / Sarah Blasig / Lutz Schomburg

Perspectives in Science, Vol 3, Iss 1, Pp 32-

2015 Volume 33

Keywords	Science ; Q ; Science (General) ; Q1-390
Language	English
Publishing date	2015-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Real-Time Antimicrobial Susceptibility Assay of Planktonic and Biofilm Bacteria by Isothermal Microcalorimetry.

Butini, Maria Eugenia / Gonzalez Moreno, Mercedes / Czuban, Magdalena / Koliszak, Anna / Tkhilaishvili, Tamta / Trampuz, Andrej / Di Luca, Mariagrazia

Advances in experimental medicine and biology

2018 Volume 1214, Page(s) 61–77

Abstract: Most antimicrobials currently used in the clinical practice are tested as growth inhibitors against free-floating microorganisms in a liquid suspension, rather than against sessile cells constituting biofilms. Hence, reliable, fast, and reproducible ... ...

Abstract	Most antimicrobials currently used in the clinical practice are tested as growth inhibitors against free-floating microorganisms in a liquid suspension, rather than against sessile cells constituting biofilms. Hence, reliable, fast, and reproducible methods for assessing biofilm susceptibility to antimicrobials are strongly needed. Isothermal microcalorimetry (IMC) is a nondestructive sensitive technique that allows for the real-time monitoring of microbial viability in the presence or absence of antimicrobial compounds. Therefore, the efficacy of specific antimicrobials, alone or in combination, may be promptly validated supporting the development of new drugs and avoiding the administration of ineffective therapies. Furthermore, the susceptibility of both planktonic and biofilm cells to antimicrobials can be conveniently assessed without the need for elaborated staining procedures and under nontoxic working conditions. Quantitative data regarding the antimicrobial effect against different strains might be collected by monitoring the microbial cell replication, and, more importantly, a dose-dependent activity can be efficiently detected by measuring the delay and decrease in the heat flow peak of the treated samples. A limitation of IMC for anti-biofilm susceptibility test is the inability to directly quantify the non-replicating cells in the biofilm or the total biomass. However, as IMC is a nondestructive method, the samples can be also analyzed by using different techniques, acquiring more information complementary to calorimetric data. IMC finds application also for the investigation of antibiotic eluting kinetics from different biomaterials, as well as for studying bacteriophages activity against planktonic and biofilm bacteria. Thus, the wide applicability of this ultra-sensitive and automated technique provides a further advance in the field of clinical microbiology and biomedical sciences.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Biofilms/drug effects ; Calorimetry ; Microbial Sensitivity Tests ; Plankton/drug effects ; Plankton/microbiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2018-11-08
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/5584_2018_291
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Titanium coating with mussel inspired polymer and bio-orthogonal chemistry enhances antimicrobial activity against Staphylococcus aureus.

Czuban, Magdalena / Kulka, Michaël W / Wang, Lei / Koliszak, Anna / Achazi, Katharina / Schlaich, Christoph / Donskyi, Ievgen S / Di Luca, Mariagrazia / Mejia Oneto, Jose M / Royzen, Maksim / Haag, Rainer / Trampuz, Andrej

Materials science & engineering. C, Materials for biological applications

2020 Volume 116, Page(s) 111109

Abstract: Implant-associated infections present severe and difficult-to-treat complications after surgery, related to implant biofilm colonization. Systemic administration of antibiotics cannot reach sufficient concentrations at the infected site and may be toxic. ...

Abstract	Implant-associated infections present severe and difficult-to-treat complications after surgery, related to implant biofilm colonization. Systemic administration of antibiotics cannot reach sufficient concentrations at the infected site and may be toxic. Here we describe how mussel-inspired dendritic material coated on a titanium surface can locally activate a prodrug of daptomycin (pro-dapto) to treat methicillin-resistant Staphylococcus aureus. The mechanism of the prodrug activation is based on bio-orthogonal click chemistry between a tetrazine (Tz) and trans-cyclooctene (TCO). The former is attached to the dendritic polymer, while the later converts daptomycin into a prodrug. Characterization of the material's properties revealed that it is hydrophobic, non-toxic, and stable for a prolonged period of time. We envision that the titanium coated dendritic material will be able to improve the treatment of implant-associated infections by concentrating systemically administered antibiotic prodrugs, thus converting them into active localized medicines.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Biofilms ; Coated Materials, Biocompatible/pharmacology ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Polymers ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus ; Titanium/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Coated Materials, Biocompatible ; Polymers ; Titanium (D1JT611TNE)
Language	English
Publishing date	2020-05-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012160-X
ISSN	1873-0191 ; 0928-4931
ISSN (online)	1873-0191
ISSN	0928-4931
DOI	10.1016/j.msec.2020.111109
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Electro-responsive graphene oxide hydrogels for skin bandages: The outcome of gelatin and trypsin immobilization.

di Luca, Mariagrazia / Vittorio, Orazio / Cirillo, Giuseppe / Curcio, Manuela / Czuban, Magdalena / Voli, Florida / Farfalla, Annafranca / Hampel, Silke / Nicoletta, Fiore Pasquale / Iemma, Francesca

International journal of pharmaceutics

2018 Volume 546, Issue 1-2, Page(s) 50–60

Abstract: A free radical polymerization method was adopted for the fabrication of hybrid hydrogel films based on acrylamide and polyethylene glycol dimethacrylate as plasticizing and crosslinking agents, respectively, to be employed as smart skin bandages. Electro- ...

Abstract	A free radical polymerization method was adopted for the fabrication of hybrid hydrogel films based on acrylamide and polyethylene glycol dimethacrylate as plasticizing and crosslinking agents, respectively, to be employed as smart skin bandages. Electro-sensitivity, biocompatibility and proteolytic properties were conferred to the final polymer networks by introducing graphene oxide (0.5% w/w), gelatin or trypsin (10% w/w) in the polymerization feed. The physical chemical and mechanical characterization of hybrid materials was performed by means of determination of protein content, Raman spectroscopy, thermogravimetric analysis and measurement of tensile strength. The evaluation of both water affinity and curcumin release profiles (analyzed by suitable mathematical modelling) upon application of an external electric stimulation in the 0-48 voltage range, confirmed the possibility to modulate the release kinetics. Proper proteolytic tests showed that the trypsin enzymatic activity was retained by 80% upon immobilization. Moreover, for all samples, we observed a viability higher than 94% in normal human fibroblast cells (MRC-5), while a reduction of methicillin-resistant Staphylococcus aureus CFU mL
MeSH term(s)	Acrylamide/administration & dosage ; Acrylamide/chemistry ; Bandages ; Cell Line ; Cell Survival/drug effects ; Curcumin/administration & dosage ; Curcumin/chemistry ; Drug Liberation ; Fibroblasts/drug effects ; Gelatin/administration & dosage ; Gelatin/chemistry ; Graphite/administration & dosage ; Graphite/chemistry ; Humans ; Hydrogels/administration & dosage ; Hydrogels/chemistry ; Methacrylates/administration & dosage ; Methacrylates/chemistry ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/growth & development ; Oxides/administration & dosage ; Oxides/chemistry ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/chemistry ; Polymerization ; Spectrum Analysis, Raman ; Tensile Strength ; Thermogravimetry ; Trypsin/administration & dosage ; Trypsin/chemistry
Chemical Substances	Hydrogels ; Methacrylates ; Oxides ; poly(ethylene glycol)-dimethacrylate ; Acrylamide (20R035KLCI) ; Polyethylene Glycols (30IQX730WE) ; Graphite (7782-42-5) ; Gelatin (9000-70-8) ; Trypsin (EC 3.4.21.4) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2018-05-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2018.05.027
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against

Czuban, Magdalena / Srinivasan, Sangeetha / Yee, Nathan A / Agustin, Edgar / Koliszak, Anna / Miller, Ethan / Khan, Irfan / Quinones, Ilenis / Noory, Hasina / Motola, Christopher / Volkmer, Rudolf / Di Luca, Mariagrazia / Trampuz, Andrej / Royzen, Maksim / Mejia Oneto, Jose M

ACS central science

2018 Volume 4, Issue 12, Page(s) 1624–1632

Abstract: Systemic administration of antibiotics can cause severe side-effects such as liver and kidney toxicity, destruction of healthy gut bacteria, as well as multidrug resistance. Here, we present a bio-orthogonal chemistry-based strategy toward local prodrug ... ...

Abstract	Systemic administration of antibiotics can cause severe side-effects such as liver and kidney toxicity, destruction of healthy gut bacteria, as well as multidrug resistance. Here, we present a bio-orthogonal chemistry-based strategy toward local prodrug concentration and activation. The strategy is based on the inverse electron-demand Diels-Alder chemistry between
Language	English
Publishing date	2018-12-12
Publishing country	United States
Document type	Journal Article
ISSN	2374-7943
ISSN	2374-7943
DOI	10.1021/acscentsci.8b00344
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections

Magdalena Czuban / Sangeetha Srinivasan / Nathan A. Yee / Edgar Agustin / Anna Koliszak / Ethan Miller / Irfan Khan / Ilenis Quinones / Hasina Noory / Christopher Motola / Rudolf Volkmer / Mariagrazia Di Luca / Andrej Trampuz / Maksim Royzen / Jose M. Mejia Oneto

ACS Central Science, Vol 4, Iss 12, Pp 1624-

2018 Volume 1632

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

Stepien, Magdalena / Jenab, Mazda / Freisling, Heinz / Becker, Niels-Peter / Czuban, Magdalena / Tjønneland, Anne / Olsen, Anja / Overvad, Kim / Boutron-Ruault, Marie-Christine / Mancini, Francesca Romana / Savoye, Isabelle / Katzke, Verena / Kühn, Tilman / Boeing, Heiner / Iqbal, Khalid / Trichopoulou, Antonia / Bamia, Christina / Orfanos, Philippos / Palli, Domenico /

Carcinogenesis

2017 Volume 38, Issue 7, Page(s) 699–707

Abstract: Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be ... ...

Abstract	Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to investigate the association between circulating levels of copper and zinc, and their calculated ratio, with risk of CRC development. Copper and zinc levels were measured by reflection X-ray fluorescence spectrometer in 966 cases and 966 matched controls. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression and are presented for the fifth versus first quintile. Higher circulating concentration of copper was associated with a raised CRC risk (OR = 1.50; 95% CI: 1.06, 2.13; P-trend = 0.02) whereas an inverse association with cancer risk was observed for higher zinc levels (OR = 0.65; 95% CI: 0.43, 0.97; P-trend = 0.07). Consequently, the ratio of copper/zinc was positively associated with CRC (OR = 1.70; 95% CI: 1.20, 2.40; P-trend = 0.0005). In subgroup analyses by follow-up time, the associations remained statistically significant only in those diagnosed within 2 years of blood collection. In conclusion, these data suggest that copper or copper levels in relation to zinc (copper to zinc ratio) become imbalanced in the process of CRC development. Mechanistic studies into the underlying mechanisms of regulation and action are required to further examine a possible role for higher copper and copper/zinc ratio levels in CRC development and progression.
MeSH term(s)	Aged ; Biomarkers, Tumor/blood ; Case-Control Studies ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/pathology ; Copper/blood ; Female ; Humans ; Male ; Middle Aged ; Oxidative Stress/drug effects ; Prospective Studies ; Risk Factors ; White People ; Zinc/blood
Chemical Substances	Biomarkers, Tumor ; Copper (789U1901C5) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2017-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/bgx051
Database	MEDical Literature Analysis and Retrieval System OnLINE

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