LIVIVO - Search results -

Search results

Result 1 - 10 of total 13766

Search options

Article: Correction: Pu et al. Exosome miRNA Expression in Umbilical Cord Blood of High-Parity Sows Regulates Their Reproductive Potential.

Pu, Qiang / Chai, Jie / Chen, Li / Liu, Changbao / Yang, Changfeng / Huang, Yongfu / Luo, Jia

Animals : an open access journal from MDPI

2024 Volume 14, Issue 2

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14020345
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Book ; Online: Split-PU

Xu, Chengming / Liu, Chen / Yang, Siqian / Wang, Yabiao / Zhang, Shijie / Jia, Lijie / Fu, Yanwei

Hardness-aware Training Strategy for Positive-Unlabeled Learning

2022

Abstract: Positive-Unlabeled (PU) learning aims to learn a model with rare positive samples and abundant ... unlabeled samples. Compared with classical binary classification, the task of PU learning is much more ...

Abstract	Positive-Unlabeled (PU) learning aims to learn a model with rare positive samples and abundant unlabeled samples. Compared with classical binary classification, the task of PU learning is much more challenging due to the existence of many incompletely-annotated data instances. Since only part of the most confident positive samples are available and evidence is not enough to categorize the rest samples, many of these unlabeled data may also be the positive samples. Research on this topic is particularly useful and essential to many real-world tasks which demand very expensive labelling cost. For example, the recognition tasks in disease diagnosis, recommendation system and satellite image recognition may only have few positive samples that can be annotated by the experts. These methods mainly omit the intrinsic hardness of some unlabeled data, which can result in sub-optimal performance as a consequence of fitting the easy noisy data and not sufficiently utilizing the hard data. In this paper, we focus on improving the commonly-used nnPU with a novel training pipeline. We highlight the intrinsic difference of hardness of samples in the dataset and the proper learning strategies for easy and hard data. By considering this fact, we propose first splitting the unlabeled dataset with an early-stop strategy. The samples that have inconsistent predictions between the temporary and base model are considered as hard samples. Then the model utilizes a noise-tolerant Jensen-Shannon divergence loss for easy data; and a dual-source consistency regularization for hard data which includes a cross-consistency between student and base model for low-level features and self-consistency for high-level features and predictions, respectively.
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2022-11-30
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Meta-PU

Ye, Shuquan / Chen, Dongdong / Han, Songfang / Wan, Ziyu / Liao, Jing

An Arbitrary-Scale Upsampling Network for Point Cloud

2021

Abstract: ... in this work, we propose a novel method called ``Meta-PU" to firstly support point cloud upsampling ... of arbitrary scale factors with a single model. In the Meta-PU method, besides the backbone network consisting ... Together, these two blocks enable our Meta-PU to continuously upsample the point cloud with arbitrary scale ...

Abstract	Point cloud upsampling is vital for the quality of the mesh in three-dimensional reconstruction. Recent research on point cloud upsampling has achieved great success due to the development of deep learning. However, the existing methods regard point cloud upsampling of different scale factors as independent tasks. Thus, the methods need to train a specific model for each scale factor, which is both inefficient and impractical for storage and computation in real applications. To address this limitation, in this work, we propose a novel method called ``Meta-PU" to firstly support point cloud upsampling of arbitrary scale factors with a single model. In the Meta-PU method, besides the backbone network consisting of residual graph convolution (RGC) blocks, a meta-subnetwork is learned to adjust the weights of the RGC blocks dynamically, and a farthest sampling block is adopted to sample different numbers of points. Together, these two blocks enable our Meta-PU to continuously upsample the point cloud with arbitrary scale factors by using only a single model. In addition, the experiments reveal that training on multiple scales simultaneously is beneficial to each other. Thus, Meta-PU even outperforms the existing methods trained for a specific scale factor only. Comment: To appear at TVCG
Keywords	Computer Science - Graphics
Subject code	310
Publishing date	2021-02-08
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: PC$^2$-PU

Long, Chen / Zhang, Wenxiao / Li, Ruihui / Wang, Hao / Dong, Zhen / Yang, Bisheng

Patch Correlation and Point Correlation for Effective Point Cloud Upsampling

2021

Abstract: ... patches. In this paper, we present a novel method PC$^2$-PU, which explores patch-to-patch and point ... at \url{https://github.com/chenlongwhu/PC2-PU.git}. ... Comment: Accepted to ACM MM 2022 ...

Abstract	Point cloud upsampling is to densify a sparse point set acquired from 3D sensors, providing a denser representation for the underlying surface. Existing methods divide the input points into small patches and upsample each patch separately, however, ignoring the global spatial consistency between patches. In this paper, we present a novel method PC$^2$-PU, which explores patch-to-patch and point-to-point correlations for more effective and robust point cloud upsampling. Specifically, our network has two appealing designs: (i) We take adjacent patches as supplementary inputs to compensate the loss structure information within a single patch and introduce a Patch Correlation Module to capture the difference and similarity between patches. (ii) After augmenting each patch's geometry, we further introduce a Point Correlation Module to reveal the relationship of points inside each patch to maintain the local spatial consistency. Extensive experiments on both synthetic and real scanned datasets demonstrate that our method surpasses previous upsampling methods, particularly with the noisy inputs. The code and data are at \url{https://github.com/chenlongwhu/PC2-PU.git}. Comment: Accepted to ACM MM 2022
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2021-09-20
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Expression profile of PU.1 in CD4

Xiang, Nan / Fang, Xuan / Sun, Xiao-Ge / Zhou, Ying-Bo / Ma, Yan / Zhu, Chen / Li, Xiang-Pei / Wang, Guo-Sheng / Tao, Jin-Hui / Li, Xiao-Mei

Clinical and experimental medicine

2021 Volume 21, Issue 4, Page(s) 621–632

Abstract: ... predisposing factors involved. PU.1 is an important member of the ETS transcription factors family which has diverse ... cytokines. Previous studies preliminary explored the relation between PU.1 and SLE. To further explain ... the potential role of PU.1 in the pathogenesis of SLE, 40 SLE patients and 20 age-sex matched healthy controls ...

Abstract	Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complex genetic predisposing factors involved. PU.1 is an important member of the ETS transcription factors family which has diverse functions such as regulating the proliferation, differentiation of immune cells and multiple inflammatory cytokines. Previous studies preliminary explored the relation between PU.1 and SLE. To further explain the potential role of PU.1 in the pathogenesis of SLE, 40 SLE patients and 20 age-sex matched healthy controls (HC) were recruited in this study. Flow cytometry was used to test the percentages of CD4
MeSH term(s)	CD4-Positive T-Lymphocytes ; Cytokines ; Flow Cytometry ; Humans ; Leukocytes, Mononuclear ; Lupus Erythematosus, Systemic ; Proto-Oncogene Proteins ; T-Lymphocytes ; Trans-Activators
Chemical Substances	Cytokines ; Proto-Oncogene Proteins ; Trans-Activators ; proto-oncogene protein Spi-1
Language	English
Publishing date	2021-05-08
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-021-00717-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5481: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book ; Online: CAD-PU

Lin, Jiehong / Shi, Xian / Gao, Yuan / Chen, Ke / Jia, Kui

A Curvature-Adaptive Deep Learning Solution for Point Set Upsampling

2020

Abstract: ... we propose a novel design of Curvature-ADaptive Point set Upsampling network (CAD-PU), the core of which is ... a module of curvature-adaptive feature expansion. To train CAD-PU, we follow the same motivation and ... curvature minimization objective, which gives a practically effective learning of CAD-PU. We conduct ...

Abstract	Point set is arguably the most direct approximation of an object or scene surface, yet its practical acquisition often suffers from the shortcoming of being noisy, sparse, and possibly incomplete, which restricts its use for a high-quality surface recovery. Point set upsampling aims to increase its density and regularity such that a better surface recovery could be achieved. The problem is severely ill-posed and challenging, considering that the upsampling target itself is only an approximation of the underlying surface. Motivated to improve the surface approximation via point set upsampling, we identify the factors that are critical to the objective, by pairing the surface approximation error bounds of the input and output point sets. It suggests that given a fixed budget of points in the upsampling result, more points should be distributed onto the surface regions where local curvatures are relatively high. To implement the motivation, we propose a novel design of Curvature-ADaptive Point set Upsampling network (CAD-PU), the core of which is a module of curvature-adaptive feature expansion. To train CAD-PU, we follow the same motivation and propose geometrically intuitive surrogates that approximate discrete notions of surface curvature for the upsampled point set. We further integrate the proposed surrogates into an adversarial learning based curvature minimization objective, which gives a practically effective learning of CAD-PU. We conduct thorough experiments that show the efficacy of our contributions and the advantages of our method over existing ones. Our implementation codes are publicly available at https://github.com/JiehongLin/CAD-PU.
Keywords	Computer Science - Computer Vision and Pattern Recognition
Publishing date	2020-09-10
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Effects of Geographical Origin and Tree Age on the Stable Isotopes and Multi-Elements of Pu-erh Tea.

Chen, Ming-Ming / Liao, Qiu-Hong / Qian, Li-Li / Zou, Hai-Dan / Li, Yan-Long / Song, Yan / Xia, Yu / Liu, Yi / Liu, Hong-Yan / Liu, Ze-Long

Foods (Basel, Switzerland)

2024 Volume 13, Issue 3

Abstract: Pu-erh tea is a famous tea worldwide, and identification of the geographical origin of Pu-erh tea ... may also influence the fingerprints of Pu-erh tea. In order to study the effects of the geographical origin ... and tree age on the interactions of stable isotopes and multi-elements of Pu-erh tea, 53 Pu-erh tea ...

Abstract	Pu-erh tea is a famous tea worldwide, and identification of the geographical origin of Pu-erh tea can not only protect manufacture's interests, but also boost consumers' confidence. However, tree age may also influence the fingerprints of Pu-erh tea. In order to study the effects of the geographical origin and tree age on the interactions of stable isotopes and multi-elements of Pu-erh tea, 53 Pu-erh tea leaves with three different age stages from three different areas in Yunnan were collected in 2023. The δ
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13030473
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages.

Virgilio, Maria C / Ramnani, Barkha / Chen, Thomas / Disbennett, W Miguel / Lubow, Jay / Welch, Joshua D / Collins, Kathleen L

bioRxiv : the preprint server for biology

2024

Abstract: ... transcriptomic changes by targeting PU.1, a transcription factor necessary for expression of host ... innate immune response genes, including those that target Env. Consistent with this, we find silencing PU.1 in infected ... macrophages lacking Vpr rescues Env. Vpr downmodulates PU.1 through a proteasomal degradation pathway ...

Abstract	HIV-1 Vpr promotes efficient spread of HIV-1 from macrophages to T cells by transcriptionally downmodulating restriction factors that target HIV-1 Envelope protein (Env). Here we find that Vpr induces broad transcriptomic changes by targeting PU.1, a transcription factor necessary for expression of host innate immune response genes, including those that target Env. Consistent with this, we find silencing PU.1 in infected macrophages lacking Vpr rescues Env. Vpr downmodulates PU.1 through a proteasomal degradation pathway that depends on physical interactions with PU.1 and DCAF1, a component of the Cul4A E3 ubiquitin ligase. The capacity for Vpr to target PU.1 is highly conserved across primate lentiviruses. In addition to impacting infected cells, we find that Vpr suppresses expression of innate immune response genes in uninfected bystander cells, and that virion-associated Vpr can degrade PU.1. Together, we demonstrate Vpr counteracts PU.1 in macrophages to blunt antiviral immune responses and promote viral spread.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.21.533528
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Metabolites and metagenomic analysis reveals the quality of Pu-erh "tea head".

He, Shiqiang / Deng, Xinyi / Han, Yuxin / Gong, Zhengli / Wang, Jian / Tao, Xiaoqi / Tong, Huarong / Chen, Yingjuan

Food chemistry

2023 Volume 429, Page(s) 136992

Abstract: Tea head, a derivative product of Pu-erh tea, are tight tea lumps formed during pile-fermentation ... communities between ripened Pu-erh tea (PE-21) and tea heads (CT-21). Compared with PE-21, CT-21 showed a more ... distinct flavor of Pu-erh. ...

Abstract	Tea head, a derivative product of Pu-erh tea, are tight tea lumps formed during pile-fermentation. The aim of this study was to reveal the differences of quality-related metabolites and microbial communities between ripened Pu-erh tea (PE-21) and tea heads (CT-21). Compared with PE-21, CT-21 showed a more mellow and smooth taste with slight bitterness and astringency, and can withstand multiple infusions. Metabolites analysis indicated CT-21 had more abundant water-soluble substances (47.39%) and showed significant differences with PE-21 in the main compositions of amino acids, catechins and saccharides which contributed to the viscosity of tea liquor, mellow taste and the tight tea lumps formation. Microbial communities and COG annotation analysis revealed CT-21 had lower abundance of Bacteria (84.05%), and higher abundance of Eukaryota (15.10%), carbohydrate transport and metabolism (8.28%) and glycoside hydrolases (37.36%) compared with PE-21. The different microbial communities may cause metabolites changes, forming distinct flavor of Pu-erh.
MeSH term(s)	Tea/chemistry ; Microbiota ; Bacteria/genetics ; Catechin ; Fermentation
Chemical Substances	Tea ; Catechin (8R1V1STN48)
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.136992
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 3634: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: PU.1 induces tumor-associated macrophages promoting glioma progression through BTK-mediated Akt/mTOR pathway activation.

Song, Gu / Zhang, Zeyu / Chen, Yan / Hou, Weiliang / Zhong, Weiwei / Zhou, Yuhang / Zhang, Anke / Xu, Yuanzhi

American journal of cancer research

2024 Volume 14, Issue 3, Page(s) 1139–1156

Abstract: ... remain elusive. In this study, we investigated the role of PU.1, a crucial transcription factor involved ... and analysis of clinical glioma samples demonstrated a positive correlation between PU.1 expression ... that the expression of PU.1 is increased in glioma cells vs. control cells. Importantly, PU.1-overexpressing ...

Abstract	Glioma, the most common primary malignant brain tumor, is characterized by infiltrating immune cells that contribute to tumor progression and therapeutic resistance. Tumor-associated macrophages (TAMs) constitute a significant proportion of these infiltrating immune cells and have been implicated in glioma progression. However, the underlying molecular mechanisms by which TAMs promote glioma progression remain elusive. In this study, we investigated the role of PU.1, a crucial transcription factor involved in myeloid cell development, in glioma-associated macrophage polarization and activation. First, bioinformatics and analysis of clinical glioma samples demonstrated a positive correlation between PU.1 expression in TAMs and disease severity. Further experiments using in vitro coculture systems revealed that the expression of PU.1 is increased in glioma cells vs. control cells. Importantly, PU.1-overexpressing macrophages exhibited a protumorigenic phenotype characterized by enhanced migration, invasion, and proliferation. Mechanistically, we found that PU.1-induced activation of the Bruton tyrosine kinase (BTK) signaling pathway led to Akt/mTOR pathway activation in macrophages, which further enhanced their protumorigenic functions. Furthermore, pharmacological inhibition of the BTK or Akt/mTOR pathway reversed the protumorigenic effects of macrophages in vitro and impaired their ability to promote glioma progression in vivo. In conclusion, our study elucidates a novel mechanism by which PU.1 induces the polarization and activation of TAMs in the glioma microenvironment. We highlight the significance of BTK-mediated Akt/mTOR pathway activation in driving the protumorigenic functions of TAMs. Targeting PU.1 and its downstream signaling pathways in TAMs may provide a promising therapeutic strategy to suppress glioma progression and improve patient outcomes.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
DOI	10.62347/USAJ2794
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito