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Article ; Online: Bleeding Risk in Asian Patients: Potential for Thrombin Amplification Pathway Blockade Using Factor XI Inhibitors.

Liang, Yan / Yang, Qing / Zhu, Jun / Eikelboom, John

JACC. Asia

2024 Volume 4, Issue 2, Page(s) 163–165

Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Editorial
ISSN	2772-3747
ISSN (online)	2772-3747
DOI	10.1016/j.jacasi.2023.11.014
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Article ; Online: One case of surgical treatment of coagulation factor XI deficiency complicated with esophageal cancer: a case report.

Tian, Yang / Zheng, Zhaowei / Song, Nannan / Wang, Jun

Journal of cardiothoracic surgery

2024 Volume 19, Issue 1, Page(s) 40

Abstract: Background: Coagulation factor XI deficiency is an autosomal recessive hereditary disease ... of esophageal cancer still dominates.: Case presentation: We report a case of an Asian patient with XI factor ... abnormal bleeding during and after the operation.: Conclusions: Coagulation factor XI deficiency is ...

Abstract	Background: Coagulation factor XI deficiency is an autosomal recessive hereditary disease with a low incidence. It usually occurs after surgery or trauma; Esophageal cancer is a common malignant tumor of the digestive tract in China. But so far, surgery-based comprehensive treatment of esophageal cancer still dominates. Case presentation: We report a case of an Asian patient with XI factor deficiency and lower esophageal squamous cell carcinoma who was admitted to our hospital recently. After active preoperative preparation, the operation was successfully performed, and there was no obvious abnormal bleeding during and after the operation. Conclusions: Coagulation factor XI deficiency is a relatively rare disease, and patients with the disease will face a greater risk of bleeding during the perioperative period. The encouraging perioperative outcome enables us to have a deeper understanding of surgical treatment strategies for patients with Coagulation factor XI deficiency.
MeSH term(s)	Humans ; Esophageal Neoplasms/complications ; Esophageal Neoplasms/surgery ; Esophageal Squamous Cell Carcinoma/complications ; Esophageal Squamous Cell Carcinoma/surgery ; Factor XI ; Factor XI Deficiency/complications ; Hemorrhage/etiology ; Male ; Aged
Chemical Substances	Factor XI (9013-55-2)
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-024-02494-4
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Article: [New perspective of anticoagulation in intensive care unit: basic and clinical advances in coagulation factor XII and XI inhibitors].

Wang, Ruihua / Yang, Zhiyun / Ma, Shaolin / Zhu, Feng

Zhonghua wei zhong bing ji jiu yi xue

2024 Volume 36, Issue 1, Page(s) 16–22

Abstract: ... Hemophilia B, identified in 1953, manifests as a deficiency in coagulation factor XI (FXI), which focused ...

Abstract	Anticoagulation therapy stands as a key treatment for thrombotic diseases. The consequential bleeding risk tied to existing anticoagulation methods significantly impacts patient prognosis. In the intensive care unit (ICU), patients often necessitate organ support, leading to the inevitable placement of artificial devices in blood vessels, thereby requiring anticoagulation treatment to avert clot formation that might impede organ support. Nevertheless, these patients commonly encounter a heightened risk of bleeding. Hemophilia B, identified in 1953, manifests as a deficiency in coagulation factor XI (FXI), which focused people's perspective on the endogenous coagulation pathway, that is, the contact pathway. Upon interaction between the surface of artificial devices and FXII, FXII activates, subsequently triggering FXI and initiating the "coagulation cascade" within the contact pathway. Inhibitors targeting the contact pathway encompass two primary categories: FXII inhibitors and FXI inhibitors, capable of impeding this process. This article reviews the role of FXII and FXI in activating the contact pathway, seeking to illuminate their contributions to thrombus formation. By listing the relatively mature drugs and their indications, clinicians are familiar with this new anticoagulant.
MeSH term(s)	Humans ; Factor XII/metabolism ; Factor XII/pharmacology ; Blood Coagulation ; Factor XI/metabolism ; Factor XI/pharmacology ; Thrombosis/drug therapy ; Anticoagulants/therapeutic use
Chemical Substances	Factor XII (9001-30-3) ; Factor XI (9013-55-2) ; Anticoagulants
Language	Chinese
Publishing date	2024-02-26
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.cn121430-20230917-00794
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Article: Collagen XI Alpha 1 Chain, a Novel Therapeutic Target for Cancer Treatment.

Wu, Yi-Hui / Chou, Cheng-Yang

Frontiers in oncology

2022 Volume 12, Page(s) 925165

Abstract: ... the most abundant component in ECM, and is involved in the biological formation of cancer. Although type XI ... collagen is a minor fibrillar collagen, collagen XI alpha 1 chain (COL11A1) expression has been found to be ...

Abstract	The extracellular matrix (ECM) plays an important role in the progression of cancer. Collagen is the most abundant component in ECM, and is involved in the biological formation of cancer. Although type XI collagen is a minor fibrillar collagen, collagen XI alpha 1 chain (COL11A1) expression has been found to be upregulated in a variety of human cancers including colorectal, esophagus, glioma, gastric, head and neck, lung, ovarian, pancreatic, salivary gland, and renal cancers. High levels of COL11A1 usually predict poor prognosis, owing to its association with angiogenesis, invasion, and drug resistance in cancer. However, little is known about the specific mechanism through which COL11A1 regulates tumor progression. Here, we have organized and summarized recent developments regarding the interactions between COL11A1 and intracellular signaling pathways and selected therapeutic agents targeting COL11A1, as these indicate its potential as a target for treatment of cancers, especially epithelial ovarian cancer.
Language	English
Publishing date	2022-06-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.925165
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Article ; Online: Female naïve human pluripotent stem cells carry X chromosomes with Xa-like and Xi-like folding conformations.

Patterson, Benjamin / Yang, Bing / Tanaka, Yoshiaki / Kim, Kun-Yong / Cakir, Bilal / Xiang, Yangfei / Kim, Jonghun / Wang, Siyuan / Park, In-Hyun

Science advances

2023 Volume 9, Issue 31, Page(s) eadf2245

Abstract: ... chromosome (Xi) in somatic cells. However, naïve X chromosomes do not exhibit the chromatin compaction ...

Abstract	Three-dimensional (3D) genomics shows immense promise for studying X chromosome inactivation (XCI) by interrogating changes to the X chromosomes' 3D states. Here, we sought to characterize the 3D state of the X chromosome in naïve and primed human pluripotent stem cells (hPSCs). Using chromatin tracing, we analyzed X chromosome folding conformations in these cells with megabase genomic resolution. X chromosomes in female naïve hPSCs exhibit folding conformations similar to the active X chromosome (Xa) and the inactive X chromosome (Xi) in somatic cells. However, naïve X chromosomes do not exhibit the chromatin compaction typically associated with these somatic X chromosome states. In H7 naïve human embryonic stem cells,
MeSH term(s)	Humans ; Female ; Epigenesis, Genetic ; Chromosomes, Human, X/genetics ; RNA, Long Noncoding/genetics ; Pluripotent Stem Cells ; Chromatin/genetics
Chemical Substances	RNA, Long Noncoding ; Chromatin
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adf2245
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Book ; Online: Tests of $CP$ symmetry in the entangled $\Xi^0-\bar{\Xi}^0$ Pairs

BESIII Collaboration / Ablikim, M. / Achasov, M. N. / Adlarson, P. / Ai, X. C. / Aliberti, R. / Amoroso, A. / An, M. R. / An, Q. / Bai, Y. / Bakina, O. / Balossino, I. / Ban, Y. / Batozskaya, V. / Begzsuren, K. / Berger, N. / Berlowski, M. / Bertani, M. / Bettoni, D. /

Bianchi, F. / Bianco, E. / Bortone, A. / Boyko, I. / Briere, R. A. / Brueggemann, A. / Cai, H. / Cai, X. / Calcaterra, A. / Cao, G. F. / Cao, N. / Cetin, S. A. / Chang, J. F. / Chang, T. T. / Chang, W. L. / Che, G. R. / Chelkov, G. / Chen, C. / Chen, Chao / Chen, G. / Chen, H. S. / Chen, M. L. / Chen, S. J. / Chen, S. M. / Chen, T. / Chen, X. R. / Chen, X. T. / Chen, Y. B. / Chen, Y. Q. / Chen, Z. J. / Cheng, W. S. / Choi, S. K. / Chu, X. / Cibinetto, G. / Coen, S. C. / Cossio, F. / Cui, J. J. / Dai, H. L. / Dai, J. P. / Dbeyssi, A. / de Boer, R. E. / Dedovich, D. / Deng, Z. Y. / Denig, A. / Denysenko, I. / Destefanis, M. / De Mori, F. / Ding, B. / Ding, X. X. / Ding, Y. / Dong, J. / Dong, L. Y. / Dong, M. Y. / Dong, X. / Du, M. C. / Du, S. X. / Duan, Z. H. / Egorov, P. / Fan, Y. L. / Fang, J. / Fang, S. S. / Fang, W. X. / Fang, Y. / Farinelli, R. / Fava, L. / Feldbauer, F. / Felici, G. / Feng, C. Q. / Feng, J. H. / Fischer, K / Fritsch, M. / Fritzsch, C. / Fu, C. D. / Fu, J. L. / Fu, Y. W. / Gao, H. / Gao, Y. N. / Gao, Yang / Garbolino, S. / Garzia, I. / Ge, P. T. / Ge, Z. W. / Geng, C. / Gersabeck, E. M. / Gilman, A / Goetzen, K. / Gong, L. / Gong, W. X. / Gradl, W. / Gramigna, S. / Greco, M. / Gu, M. H. / Gu, Y. T. / Guan, C. Y / Guan, Z. L. / Guo, A. Q. / Guo, L. B. / Guo, M. J. / Guo, R. P. / Guo, Y. P. / Guskov, A. / Han, T. T. / Han, W. Y. / Hao, X. Q. / Harris, F. A. / He, K. K. / He, K. L. / Heinsius, F. H. H. / Heinz, C. H. / Heng, Y. K. / Herold, C. / Holtmann, T. / Hong, P. C. / Hou, G. Y. / Hou, X. T. / Hou, Y. R. / Hou, Z. L. / Hu, H. M. / Hu, J. F. / Hu, T. / Hu, Y. / Huang, G. S. / Huang, K. X. / Huang, L. Q. / Huang, X. T. / Huang, Y. P. / Hussain, T. / Hüsken, N / Imoehl, W. / Irshad, M. / Jackson, J. / Jaeger, S. / Janchiv, S. / Jeong, J. H. / Ji, Q. / Ji, Q. P. / Ji, X. B. / Ji, X. L. / Ji, Y. Y. / Jia, X. Q. / Jia, Z. K. / Jiang, P. C. / Jiang, S. S. / Jiang, T. J. / Jiang, X. S. / Jiang, Y. / Jiao, J. 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H. / Liu, Fang / Liu, Feng / Liu, G. M. / Liu, H. / Liu, H. B. / Liu, H. M. / Liu, Huanhuan / Liu, Huihui / Liu, J. B. / Liu, J. L. / Liu, J. Y. / Liu, K. / Liu, K. Y. / Liu, Ke / Liu, L. / Liu, L. C. / Liu, Lu / Liu, M. H. / Liu, P. L. / Liu, Q. / Liu, S. B. / Liu, T. / Liu, W. K. / Liu, W. M. / Liu, X. / Liu, Y. / Liu, Y. B. / Liu, Z. A. / Liu, Z. Q. / Lou, X. C. / Lu, F. X. / Lu, H. J. / Lu, J. G. / Lu, X. L. / Lu, Y. / Lu, Y. P. / Lu, Z. H. / Luo, C. L. / Luo, M. X. / Luo, T. / Luo, X. L. / Lyu, X. R. / Lyu, Y. F. / Ma, F. C. / Ma, H. L. / Ma, J. L. / Ma, L. L. / Ma, M. M. / Ma, Q. M. / Ma, R. Q. / Ma, R. T. / Ma, X. Y. / Ma, Y. / Ma, Y. M. / Maas, F. E. / Maggiora, M. / Malde, S. / Malik, Q. A. / Mangoni, A. / Mao, Y. J. / Mao, Z. P. / Marcello, S. / Meng, Z. X. / Messchendorp, J. G. / Mezzadri, G. / Miao, H. / Min, T. J. / Mitchell, R. E. / Mo, X. H. / Muchnoi, N. Yu. / Nefedov, Y. / Nerling, F. / Nikolaev, I. B. / Ning, Z. / Nisar, S. / Niu, Y. / Olsen, S. L. / Ouyang, Q. / Pacetti, S. / Pan, X. / Pan, Y. / Pathak, A. / Patteri, P. / Pei, Y. P. / Pelizaeus, M. / Peng, H. P. / Peters, K. / Ping, J. L. / Ping, R. G. / Plura, S. / Pogodin, S. / Prasad, V. / Qi, F. Z. / Qi, H. / Qi, H. R. / Qi, M. / Qi, T. Y. / Qian, S. / Qian, W. B. / Qiao, C. F. / Qin, J. J. / Qin, L. Q. / Qin, X. P. / Qin, X. S. / Qin, Z. H. / Qiu, J. F. / Qu, S. Q. / Redmer, C. F. / Ren, K. J. / Rivetti, A. / Rodin, V. / Rolo, M. / Rong, G. / Rosner, Ch. / Ruan, S. N. / Salone, N. / Sarantsev, A. / Schelhaas, Y. / Schoenning, K. / Scodeggio, M. / Shan, K. Y. / Shan, W. / Shan, X. Y. / Shangguan, J. F. / Shao, L. G. / Shao, M. / Shen, C. P. / Shen, H. F. / Shen, W. H. / Shen, X. Y. / Shi, B. A. / Shi, H. C. / Shi, J. L. / Shi, J. Y. / Shi, Q. Q. / Shi, R. S. / Shi, X. / Song, J. J. / Song, T. Z. / Song, W. M. / Song, Y. J. / Song, Y. X. / Sosio, S. / Spataro, S. / Stieler, F. / Su, Y. J. / Sun, G. B. / Sun, G. X. / Sun, H. / Sun, H. K. / Sun, J. 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2023

Abstract: The $J/\psi \to \Xi^0 \bar{\Xi}^{0}$ process and subsequent decays are investigated using $(10087 ... of $\Xi^0$ and $\bar{\Xi}^0$ are measured with greatly improved precision over previous measurements to be ... alpha_{\Xi} = -0.3750 \pm 0.0034 \pm 0.0016$, $\bar{\alpha}_{\Xi} = 0.3790 \pm 0.0034 \pm 0.0021$, $\phi ...

Abstract	The $J/\psi \to \Xi^0 \bar{\Xi}^{0}$ process and subsequent decays are investigated using $(10087 \pm 44)\times 10^6$ $J/\psi$ events collected at the BESIII experiment. The decay parameters of $\Xi^0$ and $\bar{\Xi}^0$ are measured with greatly improved precision over previous measurements to be $\alpha_{\Xi} = -0.3750 \pm 0.0034 \pm 0.0016$, $\bar{\alpha}_{\Xi} = 0.3790 \pm 0.0034 \pm 0.0021$, $\phi_{\Xi} = 0.0051 \pm 0.0096 \pm 0.0018$~rad, $\bar{\phi}_{\Xi} = -0.0053 \pm 0.0097 \pm 0.0019$~rad, where the first and the second uncertainties are statistical and systematic, respectively. From these measurements, precise $CP$ symmetry tests in $\Xi^0$ decay are performed, and $A^{\Xi}_{CP} = (-5.4 \pm 6.5 \pm 3.1) \times 10^{-3}$ and $\Delta\phi^{\Xi}_{CP} = (-0.1 \pm 6.9 \pm 0.9) \times 10^{-3}$~rad are consistent with $CP$ conservation. The sequential decay also enables a separation of weak and strong phase differences, which are found for the first time to be $\xi_{P}-\xi_{S} = (0.0 \pm 1.7 \pm 0.2) \times 10^{-2}$~rad and $\delta_{P}-\delta_{S} = (-1.3 \pm 1.7 \pm 0.4)\times 10^{-2}$~rad, respectively. In addition, we measure the $\Lambda$ decay parameters and test $CP$ symmetry in $\Lambda$ decays.
Keywords	High Energy Physics - Experiment
Subject code	612
Publishing date	2023-05-16
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Metabolomic Analysis on the Petal of 'Chen Xi' Rose with Light-Induced Color Changes.

Su, Mengyue / Damaris, Rebecca Njeri / Hu, Zhengrong / Yang, Pingfang / Deng, Jiao

Plants (Basel, Switzerland)

2021 Volume 10, Issue 10

Abstract: ... their ornamental value. The color of the "Chen Xi" rose can change from yellow to red during flower blooming ...

Abstract	Flower color is one of the most prominent traits of rose flowers and determines their ornamental value. The color of the "Chen Xi" rose can change from yellow to red during flower blooming. In the present study, the flavonoid metabolites were investigated by the UPLC-ESI-MS/MS from the petals of four successive flower development stages under natural conditions. In total, 176 flavonoid components, including 49 flavones, 59 flavonols, 12 flavanones, 3 isoflavones, 12 anthocyanins, and 41 proanthocyanidins were identified, with some of them being detected for the first time in this study. Additionally, there were 56 compounds that showed differences among comparison groups, mainly being enriched in pathways of isoflavone, flavonoid, flavone, flavonol, phenylpropanoids, and anthocyanin. Among them, it is anthocyanins that allow the rose flower to turn red when exposed to sunlight. To verify this result, compounds from rose petal with shading treatment (S2D) was also detected but could be clearly separated from the four samples under light by clustering and principal component analyses (PCA). Consistent with low anthocyanins accumulation, the flower with shading could not turn red. Moreover, it provides a foundation for further research on the light-induced color modification of flower.
Language	English
Publishing date	2021-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10102065
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Article ; Online: Practice Model of Xi Jinping Thought on Ecological Civilization

Kaizhong YANG

Chinese Journal of Urban and Environmental Studies, Vol 09, Iss

2021 Volume 04

Abstract: ... between man and nature. Xi Jinping Thought on Ecological Civilization offers answers to such theoretical ... of building an ecological civilization. It is a structural and operable approach for implementing Xi Jinping Thought ... between Xi Jinping Thought on Ecological Civilization and eco-civilization construction, the practice ...

Abstract	Ecological development is essentially the process of building a resource-efficient, environment-friendly and ecologically-safe society, and of achieving modernization that features harmonious coexistence between man and nature. Xi Jinping Thought on Ecological Civilization offers answers to such theoretical and practical questions as why to build an ecological civilization, what the goal is and how to achieve it. Its practice model focuses on explaining the norms, content, paths and methods of building an ecological civilization. It is a structural and operable approach for implementing Xi Jinping Thought on Ecological Civilization and guiding the construction of ecological civilization. As an intermediate link between Xi Jinping Thought on Ecological Civilization and eco-civilization construction, the practice model is not only an indispensable part of the former, but also the key to combine the theory and practice concerning the two.
Keywords	Xi Jinping Thought on Ecological Civilization ; practice model ; construction of ecological civilization ; Urbanization. City and country ; HT361-384 ; Environmental sciences ; GE1-350
Subject code	300
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	World Scientific Publishing Co. Pte Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Short-term outcomes of da Vinci SP versus Xi for colon cancer surgery: a propensity-score matching analysis of multicenter cohorts.

Jung, Jin-Min / Kim, Young Il / Yoon, Yong Sik / Yang, Songsoo / Kim, Min Hyun / Lee, Jong Lyul / Kim, Chan Wook / Park, In Ja / Lim, Seok-Byung / Yu, Chang Sik

Journal of robotic surgery

2023 Volume 17, Issue 6, Page(s) 2911–2917

Abstract: ... the perioperative outcomes of colon cancer surgeries conducted using the da Vinci SP and Xi systems. Patients ... difference between the SP and Xi groups (7.5% vs. 13.2%). Robotic-assisted colon cancer surgery using the da ... Vinci SP system is feasible and demonstrates favorable short-term outcomes. Compared to the Xi system ...

Abstract	Recent advancements in robotic systems have led to the introduction of the da Vinci SP system, which allows surgeons to perform colon cancer surgery through fewer ports. This study aimed to evaluate the perioperative outcomes of colon cancer surgeries conducted using the da Vinci SP and Xi systems. Patients who underwent robotic colon cancer surgeries between November 2020 and December 2022 at two tertiary referral centers were considered for inclusion. Following propensity-score matching, short-term outcomes between the two systems were retrospectively analyzed. Out of 189 patients included in the study, 106 from 53 propensity-score matched pairs were analyzed. Patients operated on with the SP system exhibited smaller incision lengths (5.0 cm vs. 9.4 cm, p < 0.001) experienced less pain at 8 h (3.0 vs. 3.5, p < 0.001) and at 24 h post-operation (2.9 vs. 3.3, p = 0.001) and had a shorter duration of hospital stay (5 days vs. 6 days, p = 0.002). The overall rate of postoperative complications was 10.4%, with no significant difference between the SP and Xi groups (7.5% vs. 13.2%). Robotic-assisted colon cancer surgery using the da Vinci SP system is feasible and demonstrates favorable short-term outcomes. Compared to the Xi system, the SP system offers advantages in terms of cosmesis, postoperative pain, and recovery duration for colon cancer patients.
MeSH term(s)	Humans ; Retrospective Studies ; Robotic Surgical Procedures/methods ; Colonic Neoplasms/surgery ; Digestive System Surgical Procedures ; Treatment Outcome
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2268283-1
ISSN	1863-2491 ; 1863-2483
ISSN (online)	1863-2491
ISSN	1863-2483
DOI	10.1007/s11701-023-01727-3
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Article ; Online: Detection and Gene Mutation Analysis of Three Variations in Two Unrelated Chinese Hereditary Coagulation Factor XI Deficiency Families.

Yang, Ting / Zhu, Jin / Chen, Xiuhua / Wang, Fengping / Zheng, Xiaoyan / Cheng, Xiaoli

Acta haematologica

2022 Volume 145, Issue 6, Page(s) 611–618

Abstract: ... Chinese families with coagulation factor XI deficiency, and their possible pathogenesis was elucidated ...

Abstract	Introduction: Three variations including a novel F11 gene variation were detected in two unrelated Chinese families with coagulation factor XI deficiency, and their possible pathogenesis was elucidated. Methods: The genomic DNA of the probands' pedigrees was extracted, and all exons and flanking sequences of F11 gene were subjected to PCR amplification and Sanger sequencing. ClustalX-2.1-win, Mutation Taster, and Swiss-Pdb Viewer software were used to analyze the conservation and impact of the variations on protein function and structure. Results: DNA sequencing showed that the proband one had p.Gly350Glu and p.Trp501stop complex heterozygous variations, while the proband two took p.Pro338Leu and p.Trp501stop compound heterozygous variations. Conservation, structural, and functional analysis of variant amino acids indicated that these three variations were harmful and probably affected the structure and function of the variable protein. Conclusions: Three variations including p.Pro338Leu, p.Gly350Glu, and p.Trp501stop responsible for the reduction of the FXI activities were herein detected. Notably, the p.Pro338Leu variation was discovered for the first time in the world. Furthermore, the p.Gly350Glu was first reported in China.
MeSH term(s)	Humans ; Factor XI/genetics ; Factor XI Deficiency/diagnosis ; Factor XI Deficiency/genetics ; Heterozygote ; Pedigree ; Mutation
Chemical Substances	Factor XI (9013-55-2)
Language	English
Publishing date	2022-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	80008-9
ISSN	1421-9662 ; 0001-5792
ISSN (online)	1421-9662
ISSN	0001-5792
DOI	10.1159/000526043
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