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Article: Toxicity evaluation of novel antidiabetic compound (11-methoxy-2-methyltridecane-4-ol) from marine macro alga, Gracilaria edulis

Vijayaraj, R. / Sri Kumaran, N. / Altaff, K.

Journal of Biologically Active Products from Nature. 2022 May 04, v. 12, no. 3

2022

Abstract: Diabetic mellitus is considered to be a global public health issue with high prevalence in Asian countries including India. Pharmaceutical approach using a wide range of existing drugs is problematic because of their side effects, toxicity and resistance. ...

Abstract	Diabetic mellitus is considered to be a global public health issue with high prevalence in Asian countries including India. Pharmaceutical approach using a wide range of existing drugs is problematic because of their side effects, toxicity and resistance. Natural ingredients are promising for the treatment of Diabetic mellitus including seaweeds. This study evaluates the toxicity and safety of a novel antidiabetic compound 11-methoxy-2-methyltridecane-4-ol extracted and isolated from the marine macroalgae Gracilaria edulis. The toxicity impact of this compound was assessed using Artemia franciscana model, Red Blood Cells hemolysis assay (RBC), cytotoxicity assay using 3T3-L1 mouse preadipocytes cell line models and in vivo acute toxicity tests using rat (Rattus norvegicus) model. The cytotoxicity tests with 1000 µg/mL concentration of 11-methoxy-2-methyltridecane-4-ol compound on A. franciscana, red blood cell hemolysis and 3T3-L1 mouse preadipocytes cell line did not show any adverse effects. Acute toxicity study on hematological and biochemical parameters of experimental and control rats (Rattus norvegicus) at a dose of 500 mg/kg body weight recorded values within the normal range. The results of present study are indicative of the nontoxic nature and safety of this bioactive compound suggesting its utilization as a novel drug for long term treatment of Diabetes mellitus.
Keywords	Artemia franciscana ; Gracilaria ; Rattus norvegicus ; acute toxicity ; bioactive compounds ; body weight ; cell lines ; cytotoxicity ; diabetes mellitus ; drugs ; erythrocytes ; hemolysis ; macroalgae ; mice ; models ; public health ; rats ; toxicity testing ; India
Language	English
Dates of publication	2022-0504
Size	p. 223-231.
Publishing place	Taylor & Francis
Document type	Article
ISSN	2231-1874
DOI	10.1080/22311866.2022.2069153
Database	NAL-Catalogue (AGRICOLA)

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Article: Anterior Cruciate Ligament (ACL) Reconstruction and Extra-Articular Tenodesis in a Contralateral Above-Knee Amputee Following Complex Trauma: A Case Report.

Vijayaraj, R M / Balakumaran, M / Ahmad, A R / Solayar, G N

Malaysian orthopaedic journal

2022 Volume 16, Issue 1, Page(s) 119–121

Abstract: We report the outcome following arthroscopic ACL reconstruction combined with a Modified LeMaire procedure in a patient who underwent multiple surgeries following an open ipsilateral femoral fracture and an above knee amputation of the contralateral limb ...

Abstract	We report the outcome following arthroscopic ACL reconstruction combined with a Modified LeMaire procedure in a patient who underwent multiple surgeries following an open ipsilateral femoral fracture and an above knee amputation of the contralateral limb at the time of initial trauma. This case highlights the importance of achieving ligamental stability in the contra-lateral limb in aiding proper rehabilitation following amputation and the potential pitfalls of retrograde femoral nailing.
Language	English
Publishing date	2022-04-20
Publishing country	Malaysia
Document type	Case Reports
ZDB-ID	2621480-5
ISSN	1985-2533
ISSN	1985-2533
DOI	10.5704/MOJ.2203.018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: What Women Want: Mental Health in the Context of Violence Against Women in Sri Lanka-A Qualitative Study of Priorities and Capacities for Care.

Palfreyman, Alexis / Vijayaraj, Kavitha / Riyaz, Safiya / Rizwan, Zahrah / Sivayokan, Sambasivamoorthy / Thenakoon, T H Samanmalee / Dayabandara, Madhubashinee / Hanwella, Raveen / Devakumar, Delan

Violence against women

2024 , Page(s) 10778012241230326

Abstract: Insufficient evidence guides mental health service development for survivors of violence against women in Sri Lanka. Provider and survivor perspectives on (1) what constitutes mental health, (2) quality of care, and (3) priority areas and stakeholders ... ...

Abstract	Insufficient evidence guides mental health service development for survivors of violence against women in Sri Lanka. Provider and survivor perspectives on (1) what constitutes mental health, (2) quality of care, and (3) priority areas and stakeholders for intervention were identified through framework analysis of 53 in-depth interviews. Desired care is chiefly psychosocial-not psychological-prioritizing socioeconomic, parenting, and safe environment needs in non-clinical community settings. Our evidence points strongly to the need to strengthen non-mental health community-based providers as "first contacts" and reassessment of health system-centric interventions which neglect preferred community responses and more holistic approaches accounting for women's full circumstances.
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2031375-5
ISSN	1552-8448 ; 1077-8012
ISSN (online)	1552-8448
ISSN	1077-8012
DOI	10.1177/10778012241230326
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Article ; Online: Parallel and Distributed Computing for High-Performance Applications

Vijayaraj M / Vizhi R. Malar / Chandrakala P. / Alzubaidi Laith H. / Muzaffar Khasanov / Senthilkumar R

E3S Web of Conferences, Vol 399, p

2023 Volume 04039

Abstract: The study of parallel and distributed computing has become an important area in computer science because it makes it possible to create high-performance software that can effectively handle challenging computational tasks. In terms of their use in the ... ...

Abstract	The study of parallel and distributed computing has become an important area in computer science because it makes it possible to create high-performance software that can effectively handle challenging computational tasks. In terms of their use in the world of high-performance applications, parallel and distributed computing techniques are given a thorough introduction in this study. The partitioning of computational processes into smaller subtasks that may be completed concurrently on numerous processors or computers is the core idea underpinning parallel and distributed computing. This strategy enables quicker execution times and enhanced performance in general. Parallel and distributed computing are essential for high-performance applications like scientific simulations, data analysis, and artificial intelligence since they frequently call for significant computational resources. High-performance apps are able to effectively handle computationally demanding tasks thanks in large part to parallel and distributed computing. This article offers a thorough review of the theories, methods, difficulties, and developments in parallel and distributed computing for high-performance applications. Researchers and practitioners may fully utilize the potential of parallel and distributed computing to open up new vistas in computational science and engineering by comprehending the underlying concepts and utilizing the most recent breakthroughs.
Keywords	Environmental sciences ; GE1-350
Subject code	006
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bioactive compounds from marine resources against novel corona virus (2019-nCoV): in silico study for corona viral drug

Vijayaraj, R. / Altaff, K. / Rosita, A. Sherlin / Ramadevi, S. / Revathy, J.

Natural Product Research. 2021 Dec. 2, v. 35, no. 23 p.5525-5529

2021

Abstract: Present research reports the molecular docking analysis of 2019-nCoV inhibition by antiviral compounds from marine natural resources. For this study, the structure of ligand (antiviral compound) and 2019-nCoV main protease (Mᵖʳᵒ) was received from the ... ...

Abstract	Present research reports the molecular docking analysis of 2019-nCoV inhibition by antiviral compounds from marine natural resources. For this study, the structure of ligand (antiviral compound) and 2019-nCoV main protease (Mᵖʳᵒ) was received from the databases of PubChem and Protein Data Bank (PDB), respectively. Molecular Docking was performed by Autodock version 4.2.6 software. Eight antiviral compounds identified showed inhibitory activities against novel 2019-nCoV protease. Of these compounds, Esculetin ethyl ester (-8.42 kcal/mol) from Marine Sponges Axinella cf. corrugata, has the strongest interaction with the protease enzyme of 2019-nCoV and it may be considered as an effective 2019-nCoV antiprotease drug.
Keywords	Severe acute respiratory syndrome coronavirus 2 ; antiviral agents ; computer simulation ; computer software ; databases ; ligands ; proteinases ; research ; viruses ; 2019-nCoV ; Antiviral drug ; Bioactive Compounds ; Esculetin ethyl ester
Language	English
Dates of publication	2021-1202
Size	p. 5525-5529.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2020.1791115
Database	NAL-Catalogue (AGRICOLA)

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Article: Advancing cancer theranostics through biomimetics: A comprehensive review.

Anitha, Kuttiappan / Chenchula, Santenna / Surendran, Vijayaraj / Shvetank, Bhatt / Ravula, Parameswar / Milan, Rhythm / Chikatipalli, Radhika / R, Padmavathi

Heliyon

2024 Volume 10, Issue 6, Page(s) e27692

Abstract: Nanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation of diagnostics and therapeutics, known as cancer theranostics, represents a promising strategy in ... ...

Abstract	Nanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation of diagnostics and therapeutics, known as cancer theranostics, represents a promising strategy in modern oncology. Biomimetics, inspired by nature, offers a multidisciplinary avenue with potential in advancing cancer theranostics. This review comprehensively analyses recent progress in biomimetics-based cancer theranostics, emphasizing its role in overcoming current treatment challenges, with a focus on breast, prostate, and skin cancers. Biomimetic approaches have been explored to address multidrug resistance (MDR), emphasizing their role in immunotherapy and photothermal therapy. The specific areas covered include biomimetic drug delivery systems bypassing MDR mechanisms, biomimetic platforms for immune checkpoint blockade, immune cell modulation, and photothermal tumor ablation. Pretargeting techniques enhancing radiotherapeutic agent uptake are discussed, along with a comprehensive review of clinical trials of global nanotheranostics. This review delves into biomimetic materials, nanotechnology, and bioinspired strategies for cancer imaging, diagnosis, and targeted drug delivery. These include imaging probes, contrast agents, and biosensors for enhanced specificity and sensitivity. Biomimetic strategies for targeted drug delivery involve the design of nanoparticles, liposomes, and hydrogels for site-specific delivery and improved therapeutic efficacy. Overall, this current review provides valuable information for investigators, clinicians, and biomedical engineers, offering insights into the latest biomimetics applications in cancer theranostics. Leveraging biomimetics aims to revolutionize cancer diagnosis, treatment, and patient outcomes.
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27692
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Activity-based protein profiling of rice (Oryza sativa L.) bran serine hydrolases.

Dolui, Achintya Kumar / Vijayakumar, Arun Kumar / Rajasekharan, Ram / Vijayaraj, Panneerselvam

Scientific reports

2020 Volume 10, Issue 1, Page(s) 15191

Abstract: Rice bran is an underutilized agricultural by-product with economic importance. The unique phytochemicals and fatty acid compositions of bran have been targeted for nutraceutical development. The endogenous lipases and hydrolases are responsible for the ... ...

Abstract	Rice bran is an underutilized agricultural by-product with economic importance. The unique phytochemicals and fatty acid compositions of bran have been targeted for nutraceutical development. The endogenous lipases and hydrolases are responsible for the rapid deterioration of rice bran. Hence, we attempted to provide the first comprehensive profiling of active serine hydrolases (SHs) present in rice bran proteome by activity-based protein profiling (ABPP) strategy. The active site-directed fluorophosphonate probe (rhodamine and biotin-conjugated) was used for the detection and identification of active SHs. ABPP revealed 55 uncharacterized active-SHs and are representing five different known enzyme families. Based on motif and domain analyses, one of the uncharacterized and miss annotated SHs (Os12Ssp, storage protein) was selected for biochemical characterization by overexpressing in yeast. The purified recombinant protein authenticated the serine protease activity in time and protein-dependent studies. Os12Ssp exhibited the maximum activity at a pH between 7.0 and 8.0. The protease activity was inhibited by the covalent serine protease inhibitor, which suggests that the ABPP approach is indeed reliable than the sequence-based annotations. Collectively, the comprehensive knowledge generated from this study would be useful in expanding the current understanding of rice bran SHs and paves the way for better utilization/stabilization of rice bran.
MeSH term(s)	Dietary Fiber/metabolism ; Dietary Supplements ; Food Storage ; Hydrolases/genetics ; Hydrolases/metabolism ; Molecular Sequence Annotation ; Oryza ; Plant Proteins, Dietary/metabolism ; Protein Array Analysis ; Serine/genetics ; Serine/metabolism ; Yeasts
Chemical Substances	Dietary Fiber ; Plant Proteins, Dietary ; Serine (452VLY9402) ; Hydrolases (EC 3.-)
Language	English
Publishing date	2020-09-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-72002-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Green synthesis of silver nanoparticles using sustainable bio-fertilizer (Panchakavyam) for the selective oxidation of propylene glycol and veratryl alcohol

V. Devanathan / P. Tamizhdurai / V.L. Mangesh / C. Kavitha / R. Mythily / M. Vanjinathan / A. Vijayaraj / R. Kumaran

Results in Chemistry, Vol 6, Iss , Pp 101159- (2023)

2023

Abstract: This study demonstrates the selective oxidation of propylene glycol and veratryl alcohol utilizing silver oxide nanoparticles. This work adopted employing Panchakavyam, a medicinally rich bio-fertilizer for synthesizing silver oxide nanoparticles. In the ...

Abstract	This study demonstrates the selective oxidation of propylene glycol and veratryl alcohol utilizing silver oxide nanoparticles. This work adopted employing Panchakavyam, a medicinally rich bio-fertilizer for synthesizing silver oxide nanoparticles. In the present study, panchakavyam was prepared as a supporting material for the synthesis of silver oxide nanoparticles (Ag2O NPs). The traditional source of panchakavyam makes it cost effective, eco-friendly and the positive alteration of structure and shape of the catalyst enabled to deliver high yield of value added products. The synthesized silver oxide nanoparticle’s structure, shape, reactivity, stability, nature of the catalyst, thermal behaviour were studied and analysed through standard catalyst characterization techniques. Post synthesis of nanoparticles, selective oxidation reaction was carried out by confining the silver oxide nanoparticles as a nano catalyst. The tert-butyl hydroperoxide was chosen as the solvent for the oxidation studies of propylene glycol and veratryl alcohol. This study was performed by varying the reaction parameters such as temperature, pressure, time, WHSV−1 etc., to obtain the maximum yield of most desired product. The study involving conversion of propylene glycol(PG) to hydroxy acetone(HA) showed a conversion and selectivity of 100 and 99%, respectively. Similarly conversion of veratryl alcohol(VAOL) to veratraldehyde(VAL) showed a conversion and selectivity of 100 and 97.8%, respectively. The result of the study provides a path to explore the adoption of sustainable catalyst in the conversion of propylene glycol and veratryl alcohol to an industrially important products.
Keywords	Panchakavyam ; Silver nanoparticles ; Green synthesis ; Propylene Glycol ; Hydroxy Acetone ; Veratryl alcohol ; Chemistry ; QD1-999
Subject code	660 ; 540
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bioactive compounds from marine resources against novel corona virus (2019-nCoV):

Vijayaraj, R / Altaff, K / Rosita, A Sherlin / Ramadevi, S / Revathy, J

Natural product research

2020 Volume 35, Issue 23, Page(s) 5525–5529

Abstract	Present research reports the molecular docking analysis of 2019-nCoV inhibition by antiviral compounds from marine natural resources. For this study, the structure of ligand (antiviral compound) and 2019-nCoV main protease (M
MeSH term(s)	COVID-19 ; Humans ; Molecular Docking Simulation ; Pharmaceutical Preparations ; Protease Inhibitors/pharmacology ; SARS-CoV-2
Chemical Substances	Pharmaceutical Preparations ; Protease Inhibitors
Keywords	covid19
Language	English
Publishing date	2020-07-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2020.1791115
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fe-Ni bimetallic supported on mordenite catalyst for selective oxidation of veratryl alcohol in a continuous reactor

N. Gayathri / P. Tamizhdurai / C. Kavitha / V.L. Mangesh / P. Santhana Krishnan / A. Vijayaraj / R. Kumaran / Nadavala Siva Kumar / Ahmed S. Al-Fatesh / Salwa B. Alreshaidan

Arabian Journal of Chemistry, Vol 17, Iss 2, Pp 105506- (2024)

2024

Abstract: Veratryl alcohol (VA) is preferentially oxidized to veratraldehyde (VADE) using a heterogeneous catalyst, which is more favoured in industries. Commercial mordenite (Ca,Na2,K2) Al2Si10O24·7H2O) was desilicated with NaOH and loaded with nickel and iron ... ...

Abstract	Veratryl alcohol (VA) is preferentially oxidized to veratraldehyde (VADE) using a heterogeneous catalyst, which is more favoured in industries. Commercial mordenite (Ca,Na2,K2) Al2Si10O24·7H2O) was desilicated with NaOH and loaded with nickel and iron bimetal by the wet impregnation method. The synthesised Mordenite-Fe(5 %)/Ni(5–20 %) bimetallic catalyst, possessing active Bronsted acid sites, was employed to selectively oxidize the veratryl alcohol reaction. FT-IR, XRD, BET, HR-SEM, HR-TEM, and TPD were employed to determine the catalyst's textural attributes, morphology, chemical properties, and stability. Selective oxidation was performed over the catalysts using TBHP as an oxidant in a continuous reactor. To examine the most active catalyst among the four and to maximise the conversion and yield, the reaction conditions are optimised for various reaction parameters The reaction conditions were optimized by attaining 100 % conversion at temperature (90° C) for time (2 hr) and a maximum conversion of 97 % and a selectivity of 99 % at 10 bar pressure, WHSV (1.0 h−1) with acetonitrile solvent. The result of the study display that Fe (5 %) and Ni(15 %) impregnated on mordenite exhibits excellent catalytic stability with conversion (100 %) and selectivity (99 %) among the other catalysts. During regeneration, the conversion rate declined from 99.5 to 92.4.7 % and selectivity declined from 100 % to 96.2 % at the end of the seventh cycle. The high selectivity and stability of MOR-Fe(5 %)/Ni(15 %) imply that they might function properly as appropriate catalysts for the oxidation of aromatic alcohols. The advantages of the current synthesis are its cost-efficiency and eco-friendliness.
Keywords	Mordenite ; Veratryl alcohol (VA) ; Selective oxidation ; Continuous reactor ; Veratraldehyde (VADE) ; Chemistry ; QD1-999
Subject code	660 ; 540
Language	English
Publishing date	2024-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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