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  1. Article ; Online: Cytotoxic naphtho- and benzofurans from an endophytic fungus Epicoccum nigrum Ann-B-2 associated with Annona squamosa fruits.

    Elnaggar, Mohamed S / Fayez, Shaimaa / Anwar, Alaa / Ebada, Sherif S

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4940

    Abstract: Chemical exploration of the total extract derived from Epicoccum nigrum Ann-B-2, an endophyte associated with Annona squamosa fruits, afforded two new metabolites, epicoccofuran A (1) and flavimycin C (2), along with four known compounds namely, ... ...

    Abstract Chemical exploration of the total extract derived from Epicoccum nigrum Ann-B-2, an endophyte associated with Annona squamosa fruits, afforded two new metabolites, epicoccofuran A (1) and flavimycin C (2), along with four known compounds namely, epicocconigrone A (3), epicoccolide B (4), epicoccone (5) and 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (6). Structures of the isolated compounds were elucidated using extensive 1D and 2D NMR along with HR-ESI-MS. Flavimycin C (2) was isolated as an epimeric mixture of its two diastereomers 2a and 2b. The new compounds 1 and 2 displayed moderate activity against B. subtilis, whereas compounds (2, 3, 5, and 6) showed significant antiproliferative effects against a panel of seven different cancer cell lines with IC
    MeSH term(s) Annona/chemistry ; Fruit ; Benzofurans/pharmacology ; Ascomycota/chemistry ; Antineoplastic Agents/chemistry ; Molecular Structure
    Chemical Substances Benzofurans ; Antineoplastic Agents
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55168-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytotoxic Polyhydroxy-Isoprenoids from

    Pripdeevech, Patcharee / Khruengsai, Sarunpron / Tanapichatsakul, Chutima / Afifi, Wael M / Sum, Winnie Chemutai / Hyde, Kevin D / Ebada, Sherif S

    Journal of natural products

    2024  Volume 87, Issue 2, Page(s) 349–357

    Abstract: Fungal-derived natural products continue to play a pivotal role in the discovery of drug agents for human, veterinary, and general agricultural use. The ... ...

    Abstract Fungal-derived natural products continue to play a pivotal role in the discovery of drug agents for human, veterinary, and general agricultural use. The fungus
    MeSH term(s) Male ; Female ; Humans ; Terpenes ; Antineoplastic Agents/pharmacology ; Ascomycota ; Cell Line ; Candida albicans
    Chemical Substances Terpenes ; Antineoplastic Agents
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c01094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Diaporphasines E and F: New Polyketides from the Saprotrophic Fungus

    Phutthacharoen, Kunthida / Khalid, Syeda J / Schrey, Hedda / Hyde, Kevin D / Stadler, Marc / Ebada, Sherif S

    ACS omega

    2023  Volume 8, Issue 44, Page(s) 41689–41695

    Abstract: Chemical investigation for the mycelial extract of a saprotrophic ... ...

    Abstract Chemical investigation for the mycelial extract of a saprotrophic fungus
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c05984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bioprospection of Tenellins Produced by the Entomopathogenic Fungus

    Toshe, Rita / Charria-Girón, Esteban / Khonsanit, Artit / Luangsa-Ard, Janet Jennifer / Khalid, Syeda Javariya / Schrey, Hedda / Ebada, Sherif S / Stadler, Marc

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 1

    Abstract: Fungi are known as prolific producers of bioactive secondary metabolites with applications across various fields, including infectious diseases, as well as in biological control. However, some of the well-known species are still underexplored. Our ... ...

    Abstract Fungi are known as prolific producers of bioactive secondary metabolites with applications across various fields, including infectious diseases, as well as in biological control. However, some of the well-known species are still underexplored. Our current study evaluated the production of secondary metabolites by the entomopathogenic fungus
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10010069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lasiodipline G and other diketopiperazine metabolites produced by

    Khruengsai, Sarunpron / Pripdeevech, Patcharee / Tanapichatsakul, Chutima / Sum, Winnie Chemutai / Ibrahim, Mahmoud A A / Stadler, Marc / Ebada, Sherif S

    RSC advances

    2023  Volume 13, Issue 28, Page(s) 19373–19378

    Abstract: ... ...

    Abstract Lasiodiplodia
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra03242f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Quinoisobutyride A, an acyclic antibacterial tetrapeptide incorporating an unprecedented heterocyclic amino acid residue from the hypersaline lake-derived fungus Penicillium simplicissimum strain WSH17

    Ebada, Sherif S / Ebrahim, Weaam

    Phytochemical Society of Europe Phytochemistry letters. 2020 Apr., v. 36

    2020  

    Abstract: ... s derivatization method along with biogenetic considerations were used to determine the absolute ...

    Abstract Chromatographic refining of the EtOAc extract of a solid rice culture of the hypersaline lake-derived fungus Penicillium simplicissimum strain WSH17 afforded a new linear antibacterial peptide quinoisobutyride A (1) along with three known metabolites (2-4). The chemical structure of 1 was unambiguously determined based on extensive 1D and 2D NMR spectroscopic analyses together with HRESIMS. In addition, Marfey’s derivatization method along with biogenetic considerations were used to determine the absolute configuration of its amino acids’ entities. Interestingly, in this study we distinguished a new unusual heterocyclic amino acid which is comprised as a unit of compound 1. Among the isolated compounds, only 1 revealed a promising antibacterial activity against Staphylococcus aureus (ATCC700699) with a MIC value of 2.72 μM (2.0 μg/mL). Moreover, citrinamide A (3) was the only isolated compound that showed a cytotoxic activity against human epithelial colorectal adenocarcinoma (Caco-2) cell line with an IC50 value of 12.76 μM (5.5 μg/mL).
    Keywords Penicillium simplicissimum ; Staphylococcus aureus ; adenocarcinoma ; amino acids ; antibacterial properties ; antimicrobial peptides ; chemical structure ; chromatography ; cytotoxicity ; derivatization ; epithelium ; ethyl acetate ; fungi ; heterocyclic compounds ; human cell lines ; hypersalinity ; inhibitory concentration 50 ; metabolites ; neoplasm cells ; nuclear magnetic resonance spectroscopy ; refining ; rice ; spectral analysis
    Language English
    Dates of publication 2020-04
    Size p. 95-98.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2020.01.022
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Two new lanostanoid glycosides isolated from a Kenyan polypore

    Sum, Winnie Chemutai / Ebada, Sherif S / Gonkhom, Didsanutda / Decock, Cony / Teponno, Rémy Bertrand / Matasyoh, Josphat Clement / Stadler, Marc

    Beilstein journal of organic chemistry

    2023  Volume 19, Page(s) 1161–1169

    Abstract: Chemical exploration of solid-state cultures of the ... ...

    Abstract Chemical exploration of solid-state cultures of the polypore
    Language English
    Publishing date 2023-08-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.19.84
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Penicacids H-J, three new mycophenolic acid derivatives from the marine-derived fungus

    Pilevneli, Amine Dilara / Ebada, Sherif S / Kaşkatepe, Banu / Konuklugil, Belma

    RSC advances

    2021  Volume 11, Issue 55, Page(s) 34938–34944

    Abstract: Chemical investigation of secondary metabolites in crude methanol extract of a solid rice medium of a marine-derived fungus, ...

    Abstract Chemical investigation of secondary metabolites in crude methanol extract of a solid rice medium of a marine-derived fungus,
    Language English
    Publishing date 2021-11-01
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra07196c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Omnipolyphilins A and B: Chlorinated Cyclotetrapeptides and Naphtho-α-pyranones from the Plant Nematode-Derived Fungus

    Wennrich, Jan-Peer / Ebada, Sherif S / Sepanian, Ellen / Holzenkamp, Caren / Khalid, Syeda J / Schrey, Hedda / Maier, Wolfgang / Mándi, Attila / Kurtán, Tibor / Ashrafi, Samad / Stadler, Marc

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 13, Page(s) 6998–7009

    Abstract: Chemical exploration for two isolates of the recently described ascomycete ... ...

    Abstract Chemical exploration for two isolates of the recently described ascomycete species
    MeSH term(s) Humans ; Animals ; Staphylococcus aureus ; Ascomycota ; Bacillus subtilis ; Tylenchoidea ; Molecular Structure
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.4c00572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: Antimicrobial Metabolites from Extremophilic Fungus Botryotrichum piluliferum Strain WESH19

    Ebrahim, Weaam / Ebada, Sherif S.

    Chemistry of natural compounds. 2021 July, v. 57, no. 4

    2021  

    Abstract: Chromatographic analysis of a crude ethyl acetate (EtOAc) extract derived from a solid rice culture incubated at 40°C to mimic the natural ecological niche of the extremophilic fungus Botryotrichum piluliferum strain WESH19 yielded a new natural ... ...

    Abstract Chromatographic analysis of a crude ethyl acetate (EtOAc) extract derived from a solid rice culture incubated at 40°C to mimic the natural ecological niche of the extremophilic fungus Botryotrichum piluliferum strain WESH19 yielded a new natural butenolide compound (1) together with three known metabolites (2–4). Chemical structures of the isolated metabolites were confirmed by HR-ESI-MS along with 1D and 2D NMR spectroscopic analyses. Compounds 1–3 revealed pronounced antimicrobial activities against Staphylococcus aureus (ATCC 700699), Enterococcus faecalis (ATCC 29212), and Enterococcus faecium (ATCC 35667), while their antifungal activities were assessed against the extremophilic fungus Penicillium simplicissimum strain WSH17 (GenBank Acc. No. MN055685). This study adds another example of how extreme environmental conditions may influence secondary metabolism of the inhabiting fungi.
    Keywords Enterococcus faecalis ; Enterococcus faecium ; Penicillium simplicissimum ; Staphylococcus aureus ; chromatography ; ethyl acetate ; fungi ; metabolism ; metabolites ; niches ; rice
    Language English
    Dates of publication 2021-07
    Size p. 654-658.
    Publishing place Springer US
    Document type Article
    ZDB-ID 213866-9
    ISSN 0009-3130
    ISSN 0009-3130
    DOI 10.1007/s10600-021-03443-6
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3107: Show issues Location:
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