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Article: Kinetics of SARS-CoV-2 Serum Antibodies Through the Alpha, Delta, and Omicron Surges Among Vaccinated Health Care Workers at a Boston Hospital.

Dodge, Maura C / Ye, Lei / Duffy, Elizabeth R / Cole, Manisha / Gawel, Susan H / Werler, Martha M / Daghfal, David / Andry, Chris / Kataria, Yachana

Open forum infectious diseases

2023 Volume 10, Issue 7, Page(s) ofad266

Abstract: Background: Longitudinal serology studies can assist in analyzing the kinetics of antibodies to SARS-CoV-2, helping to inform public health decision making. Our study aims to characterize circulating antibody trends over 18 months in vaccinated ... ...

Abstract	Background: Longitudinal serology studies can assist in analyzing the kinetics of antibodies to SARS-CoV-2, helping to inform public health decision making. Our study aims to characterize circulating antibody trends over 18 months in vaccinated participants with and without evidence of COVID-19 infection. Methods: A cohort of health care workers employed at Boston Medical Center was followed to collect serum samples and survey data over 6 time points from July 2020 through December 2021 (N = 527). History of SARS-CoV-2 infection, vaccination, and booster status were confirmed, where possible, through electronic medical records. Serum was assessed for the qualitative and semiquantitative detection of IgG antibody levels (anti-nucleoprotein [anti-N] and anti-spike [anti-S], respectively). Piecewise regression models were utilized to characterize antibody kinetics over time. Results: Anti-S IgG titers remained above the positivity threshold following infection and/or vaccination throughout the 18-month follow-up. Among participants with no evidence of COVID-19 infection, titers declined significantly faster in the initial 90 days after full vaccination (β = -0.056) from December 2020 to March 2021 as compared with the decline observed following booster dose uptake (β = -0.023, Conclusions: These findings provide novel 18-month kinetics of anti-S IgG antibodies and highlight the durability of hybrid immunity, underlining the strong humoral response stimulated by combined infection and vaccination.
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad266
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lepidoptera of Canada.

Pohl, Gregory R / Andry, Jean-François / Schmidt, B Chris / deWaard, Jeremy R

ZooKeys

2019 , Issue 819, Page(s) 463–505

Abstract: The known Lepidoptera (moths and butterflies) of the provinces and territories of Canada are summarised, and current knowledge is compared to the state of knowledge in 1979. A total of 5405 species are known to occur in Canada in 81 families, and a ... ...

Abstract	The known Lepidoptera (moths and butterflies) of the provinces and territories of Canada are summarised, and current knowledge is compared to the state of knowledge in 1979. A total of 5405 species are known to occur in Canada in 81 families, and a further 50 species have been reported but are unconfirmed. This represents an increase of 1348 species since 1979. The DNA barcodes available for Canadian Lepidoptera are also tabulated, based on a dataset of 148,314 specimens corresponding to 5842 distinct clusters. A further yet-undiscovered 1400 species of Lepidoptera are estimated to occur in Canada. The Gelechioidea are the most poorly known major lineage of Lepidoptera in Canada. Nunavut, Prince Edward Island, and British Columbia are thought to show the greatest deficit in our knowledge of Lepidoptera. The unglaciated portions of the Yukon (Beringia), and the Pacific Maritime, Montane Cordillera, and Western Interior Basin ecozones of British Columbia are also identified as hotbeds of undescribed biodiversity.
Language	English
Publishing date	2019-01-24
Publishing country	Bulgaria
Document type	Journal Article ; Review
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.819.27259
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Is the Felixer cat control device safe for marsupial carnivores?

Rickards, Holly / Read, John L. / Johnson, Chris N. / Jones, Menna E. / Pauza, Matthew D. / Bentley, Joss / Sculthorpe, Andry / Humphrey, Morgan / Hamer, Rowena

Wildlife Research. 2022, v. 50, no. 5 p.356-365

2022

Abstract: Context The Felixer grooming device (‘Felixer’) is a lethal method of feral cat control designed to be cost-effective and target specific. Aims This study aims to test the target specificity of the Felixer in Tasmania, with a particular focus on ... ...

Abstract	Context The Felixer grooming device (‘Felixer’) is a lethal method of feral cat control designed to be cost-effective and target specific. Aims This study aims to test the target specificity of the Felixer in Tasmania, with a particular focus on Tasmanian devil and quoll species due to the overlap in size, habitats and behaviour between these native carnivores and feral cats. Methods Our study deployed Felixer devices set in a non-lethal mode in nine field sites in Tasmania, one field site in New South Wales and two Tasmanian wildlife sanctuaries. Key results Our study recorded 4376 passes by identifiable vertebrate species including 528 Tasmanian devil passes, 507 spotted-tailed quoll passes and 154 eastern quoll passes. Our data showed that the Felixer can successfully differentiate quoll species from feral cats with spotted-tailed quolls and eastern quolls targeted in 0.19% and 0% of passes, respectively. However, Tasmanian devils and common wombats were targeted in 23.10% and 12% of passes, respectively, although sample size was low for common wombats (n =25). Conclusions The Felixer could not reliably identify Tasmanian devils and possibly common wombats as non-target species. Further data is needed to confirm the potential for impacts on the common wombat and other potential non-target species in Tasmania, and the likelihood of the toxin being ingested by falsely targeted individuals. Implications Our study suggest that the Felixer device is safe for use in the presence of two species of conservation concern, the eastern and spotted-tailed quoll. It also supports evidence from previous studies that the Felixer is unlikely to impact bettongs and potoroos. Use of Felixer devices across much of Tasmania would have to balance the conservation or economic benefits of cat control against potential impacts on Tasmanian devils. We suggest that active Felixer deployments be preceded by surveys to establish the range of species present at the control site, and the season of control considered carefully to minimise potential impacts on more susceptible juvenile animals. In addition, modifications to the Felixer device such as the proposed incorporation of AI technology should be tested against the Tasmanian devil and other non-target species.
Keywords	Sarcophilus harrisii ; cost effectiveness ; juveniles ; nontarget organisms ; research ; sample size ; toxins ; vertebrates ; wildlife ; Tasmania ; feline control ; Felis catus ; feral cats ; grooming trap ; lethal control ; management ; Sarcophilus harrishii* ; target specificity ; Tasmanian carnivores</kwd>*
Language	English
Size	p. 356-365.
Publishing place	CSIRO Publishing
Document type	Article ; Online
ZDB-ID	1070380-9
ISSN	1035-3712
ISSN	1035-3712
DOI	10.1071/WR21175
Database	NAL-Catalogue (AGRICOLA)

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Article: Lepidoptera of Canada

Pohl, Gregory R / andry, Jean-François / Schmidt, B. Chris / deWaard, Jeremy R

ZooKeys. 2019 Jan. 24, v. 819

2019

Abstract	The known Lepidoptera (moths and butterflies) of the provinces and territories of Canada are summarised, and current knowledge is compared to the state of knowledge in 1979. A total of 5405 species are known to occur in Canada in 81 families, and a further 50 species have been reported but are unconfirmed. This represents an increase of 1348 species since 1979. The DNA barcodes available for Canadian Lepidoptera are also tabulated, based on a dataset of 148,314 specimens corresponding to 5842 distinct clusters. A further yet-undiscovered 1400 species of Lepidoptera are estimated to occur in Canada. The Gelechioidea are the most poorly known major lineage of Lepidoptera in Canada. Nunavut, Prince Edward Island, and British Columbia are thought to show the greatest deficit in our knowledge of Lepidoptera. The unglaciated portions of the Yukon (Beringia), and the Pacific Maritime, Montane Cordillera, and Western Interior Basin ecozones of British Columbia are also identified as hotbeds of undescribed biodiversity.
Keywords	DNA barcoding ; Lepidoptera ; basins ; biodiversity ; data collection ; ecological zones ; British Columbia ; Nunavut ; Prince Edward Island ; Yukon Territory
Language	English
Dates of publication	2019-0124
Size	p. 463-505.
Publishing place	Pensoft Publishers
Document type	Article
Note	NAL-light
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.819.27259
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts.

Kataria, Yachana / Cole, Manisha / Duffy, Elizabeth / de la Cena, Kyle / Schechter-Perkins, Elissa M / Bouton, Tara C / Werler, Martha M / Pierre, Cassandra / Ragan, Elizabeth J / Weber, Sarah E / Jacobson, Karen R / Andry, Chris

Scientific reports

2021 Volume 11, Issue 1, Page(s) 9694

Abstract: Healthcare workers (HCWs) are at an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that causes Coronavirus Disease (COVID-19). We aim to assess the seroprevalence of SARS-CoV-2 IgG among healthcare workers ... ...

Abstract	Healthcare workers (HCWs) are at an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that causes Coronavirus Disease (COVID-19). We aim to assess the seroprevalence of SARS-CoV-2 IgG among healthcare workers and compare risk-factors between seropositive and seronegative HCWs. In this observational study, serum samples were collected from HCWs between July 13th to 26th, 2020 at Boston Medical Center (BMC). Samples were subsequently tested for SARS-CoV-2 IgG antibody using the Abbott SARS-CoV-2 IgG assay. Participants also answered a questionnaire capturing data on demographics, history of COVID-19 symptoms, occupation, infection prevention and control measures. Overall, 95 of 1743 (5.5%) participants tested positive for SARS-CoV-2 IgG. Of these, 1.8% of the participants had mild or no COVID-19 symptoms and did not require a diagnostic test. Seropositivity was not associated with gender, occupation, hand hygiene and personal protective equipment (PPE) practices amongst HCWs. However, lack of physical distancing among health care workers in work areas and break room was associated with seropositivity (p = 0.05, p = 0.003, respectively). The majority of the HCWs are negative for SARS-CoV-2 IgG. This data highlights the need to promote infection prevention measures, and the importance of distance amongst co-workers to help mitigate infection rates.
MeSH term(s)	Adult ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Boston/epidemiology ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19 Testing ; Female ; Health Personnel ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Male ; Middle Aged ; Risk Factors ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Seroepidemiologic Studies ; Young Adult
Chemical Substances	Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2021-05-06
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-89107-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Implementation and Preliminary Results of an Emergency Department Nontargeted, Opt-out Hepatitis C Virus Screening Program.

Schechter-Perkins, Elissa M / Miller, Nancy S / Hall, Jon / Hartman, Joshua J / Dorfman, David H / Andry, Chris / Linas, Benjamin P

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

2018 Volume 25, Issue 11, Page(s) 1216–1226

Abstract: Background: Emergency department (ED) visits provide an opportunity for hepatitis C virus (HCV) screening for patients who otherwise might not be tested. We report on a novel nontargeted, opt-out HCV screening and linkage-to-care (LTC) program ... ...

Abstract	Background: Emergency department (ED) visits provide an opportunity for hepatitis C virus (HCV) screening for patients who otherwise might not be tested. We report on a novel nontargeted, opt-out HCV screening and linkage-to-care (LTC) program implemented in an urban ED. Methods: This is a descriptive analysis from 3 months (November 2016-January 2017) of a nontargeted, opt-out ED HCV screening and LTC program among patients at least 13 years old undergoing phlebotomy for clinical purposes. A multipurpose best practice advisory (BPA) alerted providers to the program and generated order labels. For patients who authorized testing, specimens were drawn in the ED for HCV antibody (Ab) and reflex confirmatory RNA tests. Public health navigators attempted to contact RNA-positive patients and arrange outpatient visits. Results: HCV Ab tests were performed on 3,808 patients, a 6,950% increase from preprogram. The proportion of HCV Ab test positivity was 13.2% (504/3,808, 95% confidence interval [CI] = 12.2%-14.3%) and of those 97.8% (493/504) had a follow-up RNA test performed. A total of 292 were confirmed positive for active infection, for an overall RNA positivity rate of 7.7% (95% CI = 6.8%-8.5%). Of those with active infection, 155 (53%) were outside the Centers for Disease Control and Prevention birth cohort for increased risk for HCV including 46 (15.8%, 95% CI = 11.8%-20.4%) who also did not report injection drug use. Linkage attempts were documented on 223 (76.4%) patients and appointments were scheduled for 102 (38% of attempted). Sixty-six patients attended their LTC visit (22.5% of all RNA-positive patients, 30% of linkage-eligible patients). Conclusions: Nontargeted opt-out HCV testing can be successfully implemented in an ED setting. A number of patients diagnosed were outside traditional risk groups. Once diagnosed, an ED population may be difficult to engage in care, but a structured interdisciplinary program can successfully link patients to HCV care.
MeSH term(s)	Adolescent ; Adult ; Emergency Service, Hospital/statistics & numerical data ; Female ; Hepatitis C/blood ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Hepatitis C Antibodies/blood ; Humans ; Male ; Mass Screening/methods ; Middle Aged ; Program Development ; Risk Factors ; United States ; Young Adult
Chemical Substances	Hepatitis C Antibodies
Language	English
Publishing date	2018-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1329813-6
ISSN	1553-2712 ; 1069-6563
ISSN (online)	1553-2712
ISSN	1069-6563
DOI	10.1111/acem.13484
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Biobanking-Budgets and the Role of Pathology Biobanks in Precision Medicine.

Andry, Chris / Duffy, Elizabeth / Moskaluk, Christopher A / McCall, Shannon / Roehrl, Michael H A / Remick, Daniel

Academic pathology

2017 Volume 4, Page(s) 2374289517702924

Abstract: Biobanks have become an important component of the routine practice of pathology. At the 2016 meeting of the Association of Pathology Chairs, a series of presentations covered several important aspects of biobanking. An often overlooked aspect of ... ...

Abstract	Biobanks have become an important component of the routine practice of pathology. At the 2016 meeting of the Association of Pathology Chairs, a series of presentations covered several important aspects of biobanking. An often overlooked aspect of biobanking is the fiscal considerations. A biobank budget must address the costs of consenting, procuring, processing, and preserving high-quality biospecimens. Multiple revenue streams will frequently be necessary to create a sustainable biobank; partnering with other key stakeholders has been shown to be successful at academic institutions which may serve as a model. Biobanking needs to be a deeply science-driven and innovating process so that specimens help transform patient-centered clinical and basic research (ie, fulfill the promise of precision medicine). Pathology's role must be at the center of the biobanking process. This ensures that optimal research samples are collected while guaranteeing that clinical diagnostics are never impaired. Biobanks will continue to grow as important components in the mission of pathology, especially in the era of precision medicine.
Language	English
Publishing date	2017-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819382-9
ISSN	2374-2895
ISSN	2374-2895
DOI	10.1177/2374289517702924
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A computational solution to improve biomarker reproducibility during long-term projects.

Feng, Feng / Thompson, Morgan P / Thomas, Beena E / Duffy, Elizabeth R / Kim, Jiyoun / Kurosawa, Shinichiro / Tashjian, Joseph Y / Wei, Yibing / Andry, Chris / Stearns-Kurosawa, D J

PloS one

2019 Volume 14, Issue 4, Page(s) e0209060

Abstract: Biomarkers are fundamental to basic and clinical research outcomes by reporting host responses and providing insight into disease pathophysiology. Measuring biomarkers with research-use ELISA kits is universal, yet lack of kit standardization and ... ...

Abstract	Biomarkers are fundamental to basic and clinical research outcomes by reporting host responses and providing insight into disease pathophysiology. Measuring biomarkers with research-use ELISA kits is universal, yet lack of kit standardization and unexpected lot-to-lot variability presents analytic challenges for long-term projects. During an ongoing two-year project measuring plasma biomarkers in cancer patients, control concentrations for one biomarker (PF) decreased significantly after changes in ELISA kit lots. A comprehensive operations review pointed to standard curve shifts with the new kits, an analytic variable that jeopardized data already collected on hundreds of patient samples. After excluding other reasonable contributors to data variability, a computational solution was developed to provide a uniform platform for data analysis across multiple ELISA kit lots. The solution (ELISAtools) was developed within open-access R software in which variability between kits is treated as a batch effect. A defined best-fit Reference standard curve is modelled, a unique Shift factor "S" is calculated for every standard curve and data adjusted accordingly. The averaged S factors for PF ELISA kit lots #1-5 ranged from -0.086 to 0.735, and reduced control inter-assay variability from 62.4% to <9%, within quality control limits. S factors calculated for four other biomarkers provided a quantitative metric to monitor ELISAs over the 10 month study period for quality control purposes. Reproducible biomarker measurements are essential, particularly for long-term projects with valuable patient samples. Use of research-use ELISA kits is ubiquitous and judicious use of this computational solution maximizes biomarker reproducibility.
MeSH term(s)	Algorithms ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/blood ; Enzyme-Linked Immunosorbent Assay/methods ; Enzyme-Linked Immunosorbent Assay/standards ; Humans ; Neoplasms/blood ; Neoplasms/diagnosis ; Quality Control ; Reagent Kits, Diagnostic/standards ; Reference Standards ; Reproducibility of Results ; Software ; Time Factors
Chemical Substances	Biomarkers, Tumor ; Reagent Kits, Diagnostic
Language	English
Publishing date	2019-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0209060
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: HCV screening, linkage to care, and treatment patterns at different sites across one academic medical center.

Calner, Paul / Sperring, Heather / Ruiz-Mercado, Glorimar / Miller, Nancy S / Andry, Chris / Battisti, Leandra / Scrudder, Katy / Shea, Fiona / Chan, Angelica / Schechter-Perkins, Elissa M

PloS one

2019 Volume 14, Issue 7, Page(s) e0218388

Abstract: Background: It is unclear whether sites that screen large numbers of patients for Hepatitis C Virus but achieve limited follow-up are more or less effective at having patients succeed through linkage and treatment than lower volume sites that have ... ...

Abstract	Background: It is unclear whether sites that screen large numbers of patients for Hepatitis C Virus but achieve limited follow-up are more or less effective at having patients succeed through linkage and treatment than lower volume sites that have higher linkage percentages. The objective was to compare the rates of HCV identification, linkage to care, and treatment success between different study sites including the Emergency Department, 3 outpatient clinics with unique patients, and the inpatient setting at one medical center. Methods: This is a descriptive analysis of 2 years of data from a protocol that integrated HCV screening and treatment into clinical services throughout multiple departments in one medical center. The program used a best practice advisory to prompt testing at all sites, with different triggers for it to fire at each site, and one central navigation program that attempted to link all patients diagnosed with hepatitis C virus to outpatient care. Outcomes included volume of tests performed in each site, Antibody and RNA rates at each site, demographic data, navigation and linkage outcomes, and post-linkage treatment completion. Results: 28,435 patients were screened across 5 clinical locations. RNA+ rates and absolute numbers linked to MD (linkage rates among all RNA+) were: ED 7.2% RNA+, 224 (22.6%) linked; Inpatient 14.8% RNA+, 27 (17.6%) linked, General Internal Medicine 3.9% RNA+, 269 (65.8%) linked, Infectious Diseases 4.0% RNA+, 34(70.8%) linked, Family Medicine 2.0% RNA+, 28 (75.7%) linked. Demographics, linkage barriers, and treatment initiation rates were different at all sites. Conclusion: Among sites there were differences in the sociodemographic characteristics of patients diagnosed with HCV, as well as differences in the success linking patients to outpatient care. At this medical center, the ED screened the most patients, the inpatient area had the highest RNA positivity rate, the FM clinic had the highest linkage rate, GIM linked the most patients by absolute number, and GIM also had the highest number of patients start treatment.
MeSH term(s)	Academic Medical Centers ; Adolescent ; Adult ; Aged ; Ambulatory Care ; Diagnostic Tests, Routine ; Disease Management ; Female ; Hepacivirus/isolation & purification ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Hepatitis C/therapy ; Humans ; Male ; Mass Screening ; Middle Aged ; Young Adult
Language	English
Publishing date	2019-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0218388
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts

Yachana Kataria / Manisha Cole / Elizabeth Duffy / Kyle de la Cena / Elissa M. Schechter-Perkins / Tara C. Bouton / Martha M. Werler / Cassandra Pierre / Elizabeth J. Ragan / Sarah E. Weber / Karen R. Jacobson / Chris Andry

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 9

Abstract: Abstract Healthcare workers (HCWs) are at an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that causes Coronavirus Disease (COVID-19). We aim to assess the seroprevalence of SARS-CoV-2 IgG among healthcare ... ...

Abstract	Abstract Healthcare workers (HCWs) are at an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that causes Coronavirus Disease (COVID-19). We aim to assess the seroprevalence of SARS-CoV-2 IgG among healthcare workers and compare risk-factors between seropositive and seronegative HCWs. In this observational study, serum samples were collected from HCWs between July 13th to 26th, 2020 at Boston Medical Center (BMC). Samples were subsequently tested for SARS-CoV-2 IgG antibody using the Abbott SARS-CoV-2 IgG assay. Participants also answered a questionnaire capturing data on demographics, history of COVID-19 symptoms, occupation, infection prevention and control measures. Overall, 95 of 1743 (5.5%) participants tested positive for SARS-CoV-2 IgG. Of these, 1.8% of the participants had mild or no COVID-19 symptoms and did not require a diagnostic test. Seropositivity was not associated with gender, occupation, hand hygiene and personal protective equipment (PPE) practices amongst HCWs. However, lack of physical distancing among health care workers in work areas and break room was associated with seropositivity (p = 0.05, p = 0.003, respectively). The majority of the HCWs are negative for SARS-CoV-2 IgG. This data highlights the need to promote infection prevention measures, and the importance of distance amongst co-workers to help mitigate infection rates.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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