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Article: History and Clinical Development of Nanomedicines, Nanostructure, and Nanoscale Sciences.

Nazir, Taha / Ahmed, Marya / Mirza, Hameed / Taha, Nida

Alternative therapies in health and medicine

2023 Volume 29, Issue 6, Page(s) 25–29

Abstract: Context: Extraordinary advances in the fields of polymer nanoparticle (nano) drug technology, nanomedicines, nanostructures, and nanoscale sciences have played a key role in the healthcare system. New nanodrug complexes have exceptional pharmacological ... ...

Abstract	Context: Extraordinary advances in the fields of polymer nanoparticle (nano) drug technology, nanomedicines, nanostructures, and nanoscale sciences have played a key role in the healthcare system. New nanodrug complexes have exceptional pharmacological properties with large surface areas that encourage a formulated medication to distribute, absorb, and produce the desired clinical effects. Objective: The current study aimed to review the latest development in the field of nanodrug particles, theranostic, use of noninvasive techniques, and enhancement of retention of nano-theranostic formulations. That helps to develop the innovative pharmaceutical dosage forms. Setting: The latest published data extracted from search engines PubMed, Scopus, Medline, Wolfram Alpha, BASE, Science.gov, Semantic Scholar, Education Resources Information Center, Microsoft Academic, ResearchGate, RefSeek, WorldWideScience, arXiv, Microsoft Academic Search, Google Books, JSTOR, Scirus, Social Science Research Network, Bioline International, SciELO, MetaCrawler, PLOS One, Google Scholar, and Infotopia. Design: The metadata of clinical trials, retrospective, prospective and case control studies collected from the peer review research/ review articles. The aforesaid search engines used to explore the latest information published in ≤200 research studies. the key words Nanomedicines, nanostructure, nanoscale sciences and clinical development run into the system to obtain more specific information. The final data was analyzed, interpreted and narrated for his study. Result: The precisely use of nanodrug for targeted disease produced considerable clinical results. Particularly the designed therapeutic nanoparticle formulations help to reduce the excretion, prolong blood circulation to increase accumulation at a targeted site and increase the therapeutic effects. Conclusions: The nanodrug complexes are successfully translated into several modern medications. The new and innovative nanodrug can potentially be used precisely and correctly to diagnose and treat the terminally ill patients. However, the developed nanodrug complexes, whether they are carriers or therapeutic agents, need thorough physiochemical, pharmacological, and immunological characterization before actual use in clinical practice in different human population of the world.
MeSH term(s)	Humans ; Nanomedicine ; Retrospective Studies ; Prospective Studies ; Nanostructures ; Nanoparticles/therapeutic use
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Role of Pro-Inflammatory Mediator Interleukin-32 in Osteoclast Differentiation.

Nazir, Taha / Taha, Nida / Islam, Azharul / Rabbi, Ishtiaq / Shah, Pervaiz Akhter

Turkish journal of pharmaceutical sciences

2023 Volume 20, Issue 2, Page(s) 121–125

Abstract: The recently explained cytokine, which is produced after the stimulation of interferon (IFN)-c, interleukin (IL)-2, and IL-18 is IL-32, has pro-inflammatory IFN-c, IL-2 and IL-18 are IL-32 mediator's properties that are generally entailed in many ... ...

Abstract	The recently explained cytokine, which is produced after the stimulation of interferon (IFN)-c, interleukin (IL)-2, and IL-18 is IL-32, has pro-inflammatory IFN-c, IL-2 and IL-18 are IL-32 mediator's properties that are generally entailed in many diseases, including infections, cancer, and chronic inflammation. After the initial statement in 2005, it promoted the osteoclast precursor's differentiation into TRAcP plus VNR plus multinucleated cells that express explicit osteoclast indicators. Furthermore, the loss of bone resorption might be accredited because of the collapse of the multinucleated cells, which are produced of the reaction to IL-32 to direct factoring that is ultimately essential for attaching the cells for bone resorption. Thus, in conclusion, IL-32, the pro-inflammatory mediator, has an important and indirect role in regulating osteoclast differentiation. In bone disorder's pathophysiology, critical role of IL-32 needs more scientific evidence to develop a rational treatment protocol. IL-32 can become a potent mediator of active osteoclast generation in the presence of receptor activator of NF-κB ligand (RANKL). This novel cytokine can introduce more favorable conditions for osteoclastogenesis in the rheumatic arthritis by increasing the RANKL and osteoprotegerin ratio in fibroblast-like synoviocytes.
Language	English
Publishing date	2023-05-09
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2238484-4
ISSN	2148-6247 ; 2148-6247
ISSN (online)	2148-6247
ISSN	2148-6247
DOI	10.4274/tjps.galenos.2022.69922
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Differentiating Acute-on-Chronic Subdural Hematoma and Acute Subdural Hematohygroma.

Elghamudi, Taha Abdulhakim / Khan, Mohammed Nazir

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2021 Volume 50, Issue 1, Page(s) 133–134

MeSH term(s)	Humans ; Hematoma, Subdural, Chronic ; Hematoma, Subdural, Acute ; Subdural Space
Language	English
Publishing date	2021-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2021.240
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Article ; Online: Dementia challenges in Africa: Journeying through forgetfulness.

Kantawala, Burhan / Zahra, Najwa / Oseili, Taha / Jawad, Ali / Ouardouz, Souhail / Nazir, Abubakar / Wojtara, Magda / Uwishema, Olivier

Health science reports

2023 Volume 6, Issue 9, Page(s) e1561

Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Journal Article
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.1561
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Article: Formulation, evaluation and in vitro characterization of gastroretentive floating tablet of diclofenac sodium.

Shehzad, Muhammad Qaiser / Nazir, Taha / Nazir, Saeed-Ur-Rashid / Taha, Nida / Jamil, Tahir / Akram, Muhammad Abdullah

Pakistan journal of pharmaceutical sciences

2020 Volume 32, Issue 6, Page(s) 2573–2578

Abstract: Currently a variety of tools and techniques are used to deliver complex medicines. Whereas, certain advanced methods assure the safety and usefulness by regulating the pharmacokinetic and pharmacodynamic. Thus, we aimed this study to develop a novel ... ...

Abstract	Currently a variety of tools and techniques are used to deliver complex medicines. Whereas, certain advanced methods assure the safety and usefulness by regulating the pharmacokinetic and pharmacodynamic. Thus, we aimed this study to develop a novel gastro retentive floating tablets. The formulation was designed to provide the desired controlled and complete release of drug for prolonged period of time. The formulations were evaluated for physical characterization. The obtained results of hardness (4.6-5.1), friability (0.20-0.43%), weight variation (350 ±2 - 350±5) and in vitro buoyancy were found within official limits of United Stated Pharmacopoeia (USP). Whereas, the F-7 showed most optimized intra gastric floating characteristics and exhibited 93.87% release of diclofenac sodium in 9 hours. The Floating Lag Time of 8 minutes and Total Floating Time >12 hours were recorded. In-vitro drug release kinetics evaluated using the linear regression method was found to follow the Zero Order and Peppas model for the release of both the drugs. DSC thermograph and FTIR spectra depicted that there was no chemical incompatibility between drugs and polymers. In conclusion the desgined tablet can be use in clinical practice as model drug. Because, the pre-compression and post-compression parameters were satisfactory and within desired limits.
MeSH term(s)	Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/pharmacokinetics ; Diclofenac/administration & dosage ; Diclofenac/pharmacokinetics ; Drug Compounding/methods ; Drug Liberation ; Humans ; Spectroscopy, Fourier Transform Infrared ; Tablets
Chemical Substances	Delayed-Action Preparations ; Tablets ; Diclofenac (144O8QL0L1)
Language	English
Publishing date	2020-01-22
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article: Biochemical Dynamics and Clinical Features of Novel Corona Virus (2019-nCoV).

Nazir, Taha / Nazir, Saeed Ur Rashid / Sultana, Misbah / Taha, Nida / Riaz, Humayun / Islam, Azharul / Rasheed Kayani, Ruqaiya / Manzoor, Saba

Alternative therapies in health and medicine

2020 Volume 26, Issue S2, Page(s) 50–53

Abstract: Context: The novel Corona Virus (nCoV-19) was initially reported in Wuhan, China during December 2019, and later people with nCoV-19 were identified in different parts of the world. Infected people had shown symptoms resembling pneumonia, but about 50% ... ...

Abstract	Context: The novel Corona Virus (nCoV-19) was initially reported in Wuhan, China during December 2019, and later people with nCoV-19 were identified in different parts of the world. Infected people had shown symptoms resembling pneumonia, but about 50% of patients were asymptomatic. Objective: The study intended to examine the data from studies on nCoV-19. Design: The research team performed a literature review, searching relevant literature databases. The sources of data included bioRxiv, medRxiv, Google Scholar, Embase, PsychINFO, WanFang Data and PubMed. The search terms were novel Corona Virus, and nCoV-19 structure. Setting: The study took place in the main library of the University of Sargodha, Sargodha, Pakistan. Results: The study identified 22 studies that had reported and confirmed over 2000 cases of nCoV-19 by January 26, 2020. The studies found that the virus was transmitted through respiratory droplets. The virus has two serotypes, OC43 and 229E. Conclusions: No specific curative therapy is available for CoVid-19. However, certain precautionary measures may potentially reduce the transmission, including washing hands, using sanitizers frequently, avoiding public gatherings, and quarantining or isolating patients. This virus has spread globally and immunocompromised individuals, and especially older individuals, are at significant risk. Community and healthcare professionals have a positive role to play in controlling the spread of the disease.
MeSH term(s)	Betacoronavirus/classification ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Serogroup
Keywords	covid19
Language	English
Publishing date	2020-07-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Characteristics and outcome of critically ill patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to a tertiary care center in the United Arab Emirates during the first wave of the SARS-CoV-2 pandemic. A retrospective analysis.

Ismail, Khaled / Bensasi, Hatim / Taha, Ahmed / Nazir, Aamir / Abdelkhalek, Mohamed / Mohamed, Walid / Lodhe, Dipak / Buschbeck, Samuel / Bauer, Michael / Sakr, Yasser

PloS one

2021 Volume 16, Issue 10, Page(s) e0251687

Abstract: Background: The aim of this study was to describe the clinical characteristics and outcome of patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to an intensive care unit (ICU) of a tertiary care center in the United Arab Emirates (UAE) ...

Abstract	Background: The aim of this study was to describe the clinical characteristics and outcome of patients with coronavirus disease-2019 (COVID-19) pneumonia admitted to an intensive care unit (ICU) of a tertiary care center in the United Arab Emirates (UAE) and to identify early risk factors for in-hospital mortality in these patients. Methods: A total of 371 adult patients (>18 years) admitted to the ICU of Al Ain Hospital between March 16 and July 19, 2020 with SARS-CoV-2 infection confirmed using real-time reverse transcription polymerase chain reaction (rt-PCR) on nasopharyngeal swabs were included. Results: The mean patient age was 53 years (standard deviation = 13). Patients were mostly male (n = 314 [84.6%]) and of South Asian origin (n = 231 [62.3%]). Invasive mechanical ventilation was required in 182 (49.1%) patients for a median of 11 days (25-75% interquartile range: 6-17). During the ICU stay, renal replacement therapy was required in 87 (23.5%) and vasopressor therapy in 190 (51.2%) patients. ICU and hospital lengths of stay were 9 (IQ: 5-17) and 18 (IQ: 13-29) days, respectively and ICU and hospital mortality rates were both 20.2%. In a multivariable analysis with in-hospital mortality as the dependent variable, greater Acute Physiology and Chronic Health Evaluation II score on ICU admission, diarrhea prior to hospital admission, greater, admission from hospital ward, and higher lactate dehydrogenase levels and neutrophil:lymphocyte ratio on admission to the ICU were independently associated with higher risk of in-hospital mortality. Conclusion: In this cohort of patients admitted to the ICU of a tertiary hospital in the UAE, COVID-19 pneumonia was associated with high morbidity and mortality rates. Identifying patients at high risk of death may help detect future therapeutic targets.
MeSH term(s)	Adult ; Aged ; COVID-19/mortality ; COVID-19/therapy ; Critical Care ; Critical Illness ; Female ; Hospital Mortality ; Humans ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Tertiary Care Centers ; United Arab Emirates/epidemiology
Language	English
Publishing date	2021-10-22
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0251687
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Machine Learning for Intrusion Detection in Industrial Control Systems

Umer, Muhammad Azmi / Junejo, Khurum Nazir / Jilani, Muhammad Taha / Mathur, Aditya P.

Applications, Challenges, and Recommendations

2022

Abstract: Methods from machine learning are being applied to design Industrial Control Systems resilient to cyber-attacks. Such methods focus on two major areas: the detection of intrusions at the network-level using the information acquired through network ... ...

Abstract	Methods from machine learning are being applied to design Industrial Control Systems resilient to cyber-attacks. Such methods focus on two major areas: the detection of intrusions at the network-level using the information acquired through network packets, and detection of anomalies at the physical process level using data that represents the physical behavior of the system. This survey focuses on four types of methods from machine learning in use for intrusion and anomaly detection, namely, supervised, semi-supervised, unsupervised, and reinforcement learning. Literature available in the public domain was carefully selected, analyzed, and placed in a 7-dimensional space for ease of comparison. The survey is targeted at researchers, students, and practitioners. Challenges associated in using the methods and research gaps are identified and recommendations are made to fill the gaps.
Keywords	Computer Science - Cryptography and Security ; Computer Science - Machine Learning
Subject code	006
Publishing date	2022-02-24
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Biochemical Dynamics and Clinical Features of Novel Corona Virus (2019-nCoV)

Nazir, Taha / Nazir, Saeed Ur Rashid / Sultana, Misbah / Taha, Nida / Riaz, Humayun / Islam, Azharul / Rasheed Kayani, Ruqaiya / Manzoor, Saba

Alternative therapies in health and medicine

Abstract: CONTEXT: The novel Corona Virus (nCoV-19) was initially reported in Wuhan, China during December 2019, and later people with nCoV-19 were identified in different parts of the world Infected people had shown symptoms resembling pneumonia, but about 50% of ...

Abstract	CONTEXT: The novel Corona Virus (nCoV-19) was initially reported in Wuhan, China during December 2019, and later people with nCoV-19 were identified in different parts of the world Infected people had shown symptoms resembling pneumonia, but about 50% of patients were asymptomatic OBJECTIVE: The study intended to examine the data from studies on nCoV-19 DESIGN: The research team performed a literature review, searching relevant literature databases The sources of data included bioRxiv, medRxiv, Google Scholar, Embase, PsychINFO, WanFang Data and PubMed The search terms were novel Corona Virus, and nCoV-19 structure SETTING: The study took place in the main library of the University of Sargodha, Sargodha, Pakistan RESULTS: The study identified 22 studies that had reported and confirmed over 2000 cases of nCoV-19 by January 26, 2020 The studies found that the virus was transmitted through respiratory droplets The virus has two serotypes, OC43 and 229E CONCLUSIONS: No specific curative therapy is available for CoVid-19 However, certain precautionary measures may potentially reduce the transmission, including washing hands, using sanitizers frequently, avoiding public gatherings, and quarantining or isolating patients This virus has spread globally and immunocompromised individuals, and especially older individuals, are at significant risk Community and healthcare professionals have a positive role to play in controlling the spread of the disease
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #679468
Database	COVID19

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Article: Monocytopenia; Induction by Vinorelbine, Cisplatin and Doxorubicin in Breast, Non-Small Cell Lung and Cervix Cancer Patients.

Nazir, Taha / Taha, Nida / Islam, Azahrul / Abraham, Suraj / Mahmood, Adeel / Mustafa, Mazhar

International journal of health sciences

2016 Volume 10, Issue 4, Page(s) 542–547

Abstract: Background: The neoplasm is still a potential threat for breast, Non-Small Cell Lung (NSCL) and cervix cancer patients. Those gradually invade into other body organs, inducing complex pathological complications. Whereas, the anticancer drugs suppress ... ...

Abstract	Background: The neoplasm is still a potential threat for breast, Non-Small Cell Lung (NSCL) and cervix cancer patients. Those gradually invade into other body organs, inducing complex pathological complications. Whereas, the anticancer drugs suppress the bone marrow, resulting serious hematological toxicities. Thus, the monocytic toxicity may the chance of infections, particularly in AID's patients. Objective: We aimed this retrospective study to investigate the monocytopenia induced by vinorelbine following chemotherapy in cancer patients. Patients and method: A total 60 adult cancer patients were divided into two groups; Group-1 patients received the treatment of Vinorelbine alone while group 2 patients received Vinorelbine based combination chemotherapy. Result: The overall comparison of mean monocyte count (×10 Conclusion: Monocytopenia is induced in both of the chemotherapy protocols allows the clinical oncologists and consultant physicians to select either of the chemotherapy protocol. The therapeutic efficacy should constitute the intervening consideration to treat the breast, cervix and NSCL (Non-Small Cell Lung's) cancers.
Language	English
Publishing date	2016-02-01
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2603595-9
ISSN	1658-3639
ISSN	1658-3639
Database	MEDical Literature Analysis and Retrieval System OnLINE

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