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Article: Mifepristone and PGF

Smallman, Mary A / Filtz, Theresa M / Stormshak, Fredrick

2021 Volume 153, Page(s) 106538

Abstract: Two experiments were conducted to determine whether mifepristone (RU486) and ... ...

Abstract	Two experiments were conducted to determine whether mifepristone (RU486) and PGF
MeSH term(s)	Animals ; Corpus Luteum ; Female ; Hydrolysis ; Mifepristone ; Phosphatidylinositols ; Progesterone ; Sheep
Chemical Substances	Phosphatidylinositols ; Mifepristone (320T6RNW1F) ; Progesterone (4G7DS2Q64Y)
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1426962-4
ISSN	2212-196X ; 1098-8823 ; 0090-6980
ISSN (online)	2212-196X
ISSN	1098-8823 ; 0090-6980
DOI	10.1016/j.prostaglandins.2021.106538
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Article ; Online: Optimal dose of PG600 when given to progestogen-synchronized ewes during anestrus as affected by day of the year and temperature.

Cross, Lucy J / Cross, Robin M / Stormshak, Fredrick

Translational animal science

2018 Volume 3, Issue 1, Page(s) 433–442

Abstract: The objective of this long-term study was to improve the out-of-season breeding rates for ewes by examining effectiveness of dose levels of PG600, a combination of 80-IU/mL pregnant mare serum gonadotropin and 40-IU/mL human chorionic gonadotropin. Each ... ...

Abstract	The objective of this long-term study was to improve the out-of-season breeding rates for ewes by examining effectiveness of dose levels of PG600, a combination of 80-IU/mL pregnant mare serum gonadotropin and 40-IU/mL human chorionic gonadotropin. Each week, during the anestrous season from 1998 through 2016, mature ewes were inserted with 1 of 2 progestogen devices. After 9 to 13 d, at removal of the device, ewes were injected intramuscularly with a specific dose of PG600. A total of 1,402 ewes were treated in this study, with weekly treatment groups ranging from 3 to 12 ewes. Ewes were assigned randomly in equal numbers to 1 of 2 ram pens with one fertile ram in each pen. Rams were fitted with a marking harness. Between 36 and 48 h after removal of the device, rams were switched. Ewes were checked for crayon marks (indicative of estrus) at 36, 48, and 96 h after removal of synchronizing devices. Rams were removed after 1 wk. Pregnancy status was diagnosed at 90 d of gestation using radiography and verified at 120 d or at lambing. To explore the impact of dose level, daylight, and temperature on pregnancy rate, we formulated an ordered multinomial probit model. The model controls statistically for dose level, synchronization device type, device reuse, and natural variation in minimum daily temperature and day of the year (
Language	English
Publishing date	2018-08-29
Publishing country	England
Document type	Journal Article
ISSN	2573-2102
ISSN (online)	2573-2102
DOI	10.1093/tas/txy092
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Article: Steroid regulation of uterine function in domestic animals: an introduction.

Stormshak, Fredrick

Biology of reproduction

2004 Volume 71, Issue 1, Page(s) 1

MeSH term(s)	Animals ; Animals, Domestic/physiology ; Female ; Steroids/physiology ; Uterus/physiology
Chemical Substances	Steroids
Language	English
Publishing date	2004-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1095/biolreprod.104.031336
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Article ; Online: Cassida Award Winner Response: impact of modern technology on graduate education in animal sciences.

Stormshak, Fredrick

Journal of animal science

2004 Volume 82 E-Suppl, Page(s) E1–3

MeSH term(s)	Animal Husbandry/education ; Animal Husbandry/trends ; Animals ; Awards and Prizes ; Computers/trends ; Education, Graduate/trends ; Societies ; Technology/trends ; United States ; Writing/standards
Language	English
Publishing date	2004
Publishing country	United States
Document type	Lectures
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.2527/2004.8213_supplE1x
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Article: Impact of modern technology on graduate education in animal sciences.

Stormshak, Fredrick

Journal of animal science

2004 Volume 82, Issue 9, Page(s) 2815–2817

MeSH term(s)	Animal Husbandry/education ; Awards and Prizes ; Communication ; Computer Communication Networks/trends ; Education, Graduate/methods ; Education, Graduate/standards ; Forecasting ; Humans ; Information Science ; Research Design ; Technology/trends ; Technology Assessment, Biomedical ; United States
Language	English
Publishing date	2004-09
Publishing country	United States
Document type	Lectures
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.2527/2004.8292815x
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Article ; Online: Biochemical and endocrine aspects of oxytocin production by the mammalian corpus luteum.

Stormshak, Fredrick

Reproductive biology and endocrinology : RB&E

2003 Volume 1, Page(s) 92

Abstract: A review of the current state of knowledge of oxytocin production by the preovulatory follicle and corpus luteum is presented. Corpora lutea of a number of mammalian species have been found to synthesize oxytocin. However, the synthesis and secretion of ... ...

Abstract	A review of the current state of knowledge of oxytocin production by the preovulatory follicle and corpus luteum is presented. Corpora lutea of a number of mammalian species have been found to synthesize oxytocin. However, the synthesis and secretion of this nanopeptide by the corpus luteum of the ruminant has been most extensively studied because of the potential role of this peptide in facilitating luteal regression. While much information exists relative to various biochemical and endocrine factors that impact on oxytocin gene expression, this aspect about luteal synthesis of this peptide hormone remains enigmatic. Prostaglandin F-2alpha (PGF-2alpha) has been shown to be a primary endogenous hormone responsible for triggering luteal secretion of oxytocin. Details are provided regarding the PGF-2alpha-induced intracellular signal transduction pathway that ultimately results in exocytosis of luteal oxytocin. Evidence is also presented for potential autocrine/paracrine actions of oxytocin in regulating progesterone production by luteal and granulosa cells. Concluding remarks highlight aspects about luteal oxytocin production that require further research.
MeSH term(s)	Animals ; Autocrine Communication/drug effects ; Corpus Luteum/drug effects ; Corpus Luteum/metabolism ; Female ; Gene Expression Regulation/drug effects ; Oxytocin/biosynthesis ; Oxytocin/genetics ; Oxytocin/pharmacology ; Oxytocin/secretion ; Paracrine Communication/drug effects
Chemical Substances	Oxytocin (50-56-6)
Language	English
Publishing date	2003-11-10
Publishing country	England
Document type	Journal Article ; Review
ISSN	1477-7827
ISSN (online)	1477-7827
DOI	10.1186/1477-7827-1-92
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Article ; Online: Biochemical and endocrine aspects of oxytocin production by the mammalian corpus luteum

Stormshak Fredrick

Reproductive Biology and Endocrinology, Vol 1, Iss 1, p

2003 Volume 92

Abstract: Abstract A review of the current state of knowledge of oxytocin production by the preovulatory follicle and corpus luteum is presented. Corpora lutea of a number of mammalian species have been found to synthesize oxytocin. However, the synthesis and ... ...

Abstract	Abstract A review of the current state of knowledge of oxytocin production by the preovulatory follicle and corpus luteum is presented. Corpora lutea of a number of mammalian species have been found to synthesize oxytocin. However, the synthesis and secretion of this nanopeptide by the corpus luteum of the ruminant has been most extensively studied because of the potential role of this peptide in facilitating luteal regression. While much information exists relative to various biochemical and endocrine factors that impact on oxytocin gene expression, this aspect about luteal synthesis of this peptide hormone remains enigmatic. Prostaglandin F-2α (PGF-2α) has been shown to be a primary endogenous hormone responsible for triggering luteal secretion of oxytocin. Details are provided regarding the PGF-2α-induced intracellular signal transduction pathway that ultimately results in exocytosis of luteal oxytocin. Evidence is also presented for potential autocrine/paracrine actions of oxytocin in regulating progesterone production by luteal and granulosa cells. Concluding remarks highlight aspects about luteal oxytocin production that require further research.
Keywords	Physiology ; QP1-981 ; Science ; Q ; DOAJ:Physiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Language	English
Publishing date	2003-11-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Nongenomic action of progesterone inhibits oxytocin-induced phosphoinositide hydrolysis and prostaglandin F2alpha secretion in the ovine endometrium.

Bishop, Cecily V / Stormshak, Fredrick

Endocrinology

2006 Volume 147, Issue 2, Page(s) 937–942

Abstract: Experiments were conducted to characterize the nongenomic effects of progesterone (P4) on binding of oxytocin (OT) to its receptor and signal transduction in the ovine endometrium. The dose-response relationship of P4 to OT binding was examined. ... ...

Abstract	Experiments were conducted to characterize the nongenomic effects of progesterone (P4) on binding of oxytocin (OT) to its receptor and signal transduction in the ovine endometrium. The dose-response relationship of P4 to OT binding was examined. Membranes from endometrial tissue of ovariectomized hormone-treated ewes were preincubated in the presence of P4 for 1 h followed by OT receptor analysis. P4 interfered with the binding of OT in a dose-dependent manner. Endometrium was then recovered from cyclic ewes and divided into explants. Treatment consisted of two dosages of P4 and two dosages of OT. Explants were analyzed for total inositol monophosphate, bisphosphate (IP(2)), and trisphosphate (IP(3)) content. Preincubation with P4 for 10 min significantly interfered with OT stimulation of IP(2) and IP(3) synthesis. Oxytocin increased monophosphate production, but there was no detectable effect of P4. In the next experiment, endometrial explants were cultured in the absence or the presence of arachidonic acid. Explants were then exposed for 1 h to medium containing vehicle or P4. After incubation, explants were challenged with OT and the media were collected and analyzed for 13,14 dihydro-15-keto prostaglandin F(2alpha) by RIA. Treatment of explants with AA increased PGF(2alpha) content compared with that of controls. Brief exposure to P4 significantly decreased OT-induced PGF(2alpha) secretion from explants previously exposed to medium or AA. Collectively, these data are interpreted to indicate that the observed reduction in OT-induced IP(2) and IP(3) production and OT-induced PGF(2alpha) secretion was due to P4 inhibition of OT binding to its receptor.
MeSH term(s)	Analysis of Variance ; Animals ; Dinoprost/secretion ; Dose-Response Relationship, Drug ; Endometrium/metabolism ; Female ; Hydrolysis ; Linear Models ; Models, Statistical ; Oxytocin/metabolism ; Phosphatidylinositols/metabolism ; Progesterone/administration & dosage ; Progesterone/physiology ; Receptors, Oxytocin/metabolism ; Sheep ; Signal Transduction/physiology
Chemical Substances	Phosphatidylinositols ; Receptors, Oxytocin ; Progesterone (4G7DS2Q64Y) ; Oxytocin (50-56-6) ; Dinoprost (B7IN85G1HY)
Language	English
Publishing date	2006-02
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	427856-2
ISSN	1945-7170 ; 0013-7227
ISSN (online)	1945-7170
ISSN	0013-7227
DOI	10.1210/en.2005-0869
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Article: Nongenomic inhibition of oxytocin binding by progesterone in the ovine uterus.

Dunlap, Kathrin A / Stormshak, Fredrick

Biology of reproduction

2004 Volume 70, Issue 1, Page(s) 65–69

Abstract: Progesterone (P4) has been reported to inhibit oxytocin (OT) binding to its receptor in isolated murine endometrial membranes. The purpose of the present research was to 1). examine the in vivo and in vitro effect of P4 on the binding of OT to its ... ...

Abstract	Progesterone (P4) has been reported to inhibit oxytocin (OT) binding to its receptor in isolated murine endometrial membranes. The purpose of the present research was to 1). examine the in vivo and in vitro effect of P4 on the binding of OT to its receptor in the ovine endometrium and 2). determine whether the endometrial plasma membranes have high-affinity binding sites for P4. Ovariectomized ewes were pretreated with a sequence of estradiol-17beta (2 days) and P4 (5 days) before being treated with estradiol-17beta plus either vehicle (corn oil), P4, or P4 + mifepristone (RU 486) for 3 consecutive days. Treatment of ewes with 10 mg P4/day for 3 days suppressed binding of OT (P < 0.01) compared with that of controls, whereas concomitant treatment with the progestin antagonist RU 486 (10 mg/day) blocked the effect of P4. Similarly, incubation of endometrial plasma membranes with P4 (5 ng/ml) inhibited binding of OT (P < 0.05), whereas this effect of P4 was blocked by the presence of RU 486 (10 ng/ml). By radioreceptor assay, the endometrial plasma membranes were found to contain a high-affinity binding site for P4 and the progestin agonist promegestone (Kd 1.2 x 10-9 and 1.74 x 10-10M, respectively). Incubation of endometrial plasma membranes with P4 (5 ng/ml) significantly increased the concentration of progestin binding sites. Binding of labeled promegestone (R 5020) was competitively inhibited by excess unlabeled R 5020, P4, RU 486, and OT but not by estradiol-17beta, cortisol, testosterone, and arginine vasopressin. These data suggest a direct suppressive action of P4 on the binding of OT to OT receptors in the ovine endometrial plasma membrane.
MeSH term(s)	Animals ; Binding Sites/drug effects ; Binding, Competitive/drug effects ; Cell Membrane/metabolism ; Endometrium/metabolism ; Female ; Hormone Antagonists/pharmacology ; In Vitro Techniques ; Mifepristone/pharmacology ; Oxytocin/metabolism ; Progesterone/pharmacology ; Promegestone/pharmacology ; Receptors, Oxytocin/metabolism ; Sheep
Chemical Substances	Hormone Antagonists ; Receptors, Oxytocin ; Mifepristone (320T6RNW1F) ; Progesterone (4G7DS2Q64Y) ; Oxytocin (50-56-6) ; Promegestone (9XE0V2SQYX)
Language	English
Publishing date	2004-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1095/biolreprod.103.020180
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Article: Changes in bovine luteal progesterone metabolism in response to exogenous prostaglandin F(2alpha).

Waite, Andrea L / Holtan, Donald W / Stormshak, Fredrick

Domestic animal endocrinology

2005 Volume 28, Issue 2, Page(s) 162–171

Abstract: An experiment was conducted to determine the effect of prostaglandin F2alpha (PGF2alpha) on luteal synthesis of progesterone (P4) and related progestins. Sixteen beef heifers were assigned in equal numbers to four groups in a 2x2 factorial arrangement of ...

Abstract	An experiment was conducted to determine the effect of prostaglandin F2alpha (PGF2alpha) on luteal synthesis of progesterone (P4) and related progestins. Sixteen beef heifers were assigned in equal numbers to four groups in a 2x2 factorial arrangement of treatments. The experiment consisted of two levels of PGF2alpha analog (0 and 500 microg) and two levels of time (4 and 24 h after injection) of corpus luteum collection. All heifers were injected intravenously with saline (2 ml) or PGF2alpha (cloprostenol) on day 8 of the estrous cycle (estrus=day 0). Jugular blood was collected at 0, 1, 2, 3, 4 and 20, 21, 22, 23, and 24 h after injection. Resulting sera were analyzed for P4 by use of radioimmunoassay. Luteal tissue was analyzed by gas chromatography/mass spectrometry for P4, 20beta-hydroxyprogesterone, pregnenolone, and allopregnanolone (3beta-hydroxy-5alpha-pregnan-20-one). Treatment with PGF2alpha reduced serum concentrations of P4 as early as 1 h after injection (P<0.005) and steroid levels remained low over 24 h. Similarly, administration of PGF2alpha caused a decline in luteal P4 (P<0.005), 20beta-hydroxyprogesterone (P<0.10), and pregnenolone (P<0.05). In contrast, treatment with PGF(2alpha) caused an increase in luteal allopregnanolone over time (time x treatment interaction; P<0.05). These data are interpreted to suggest that PGF2alpha promotes conversion of P4 to the metabolite allopregnanolone.
MeSH term(s)	Animals ; Cattle/blood ; Cattle/metabolism ; Corpus Luteum/chemistry ; Corpus Luteum/drug effects ; Corpus Luteum/metabolism ; Dinoprost/pharmacology ; Female ; Gas Chromatography-Mass Spectrometry ; Hydroxyprogesterones/blood ; Pregnanolone/blood ; Pregnenolone/blood ; Progesterone/blood ; Progesterone/metabolism ; Radioimmunoassay/veterinary ; Random Allocation
Chemical Substances	Hydroxyprogesterones ; Progesterone (4G7DS2Q64Y) ; Pregnenolone (73R90F7MQ8) ; Dinoprost (B7IN85G1HY) ; Pregnanolone (BXO86P3XXW)
Language	English
Publishing date	2005-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	594468-5
ISSN	1879-0054 ; 0739-7240
ISSN (online)	1879-0054
ISSN	0739-7240
DOI	10.1016/j.domaniend.2004.08.001
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