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Book ; Online ; Thesis: Autolog zellbesiedelte Matrix zum Verschluss gastraler Inzisionen: Eine Machbarkeitsstudie im Schweinemodell

Schlesinger, Tobias [Verfasser] / Metzger, Marco [Gutachter]

2024

Author's details	Tobias Schlesinger ; Gutachter: Marco Metzger
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universität Würzburg
Publishing place	Würzburg
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Postoperative nausea and vomiting: risk factors, prediction tools, and algorithms.

Schlesinger, Tobias / Meybohm, Patrick / Kranke, Peter

Current opinion in anaesthesiology

2022 Volume 36, Issue 1, Page(s) 117–123

Abstract: Purpose of review: Postoperative/postdischarge nausea and vomiting (PONV/PDNV) remain relevant issues in perioperative care. Especially in ambulatory surgery, PONV can prevent discharge or lead to unplanned readmission.: Recent findings: The evidence ...

Abstract	Purpose of review: Postoperative/postdischarge nausea and vomiting (PONV/PDNV) remain relevant issues in perioperative care. Especially in ambulatory surgery, PONV can prevent discharge or lead to unplanned readmission. Recent findings: The evidence for the management of PONV is now quite good but is still inadequately implemented. A universal, multimodal rather than risk-adapted approach for PONV prophylaxis is now recommended. The evidence on PDNV is insufficient. Summary: PDNV management is based primarily on consequent prophylaxis and therapy of PONV.
MeSH term(s)	Humans ; Postoperative Nausea and Vomiting/diagnosis ; Postoperative Nausea and Vomiting/epidemiology ; Postoperative Nausea and Vomiting/prevention & control ; Antiemetics/therapeutic use ; Aftercare ; Patient Discharge ; Risk Factors ; Algorithms
Chemical Substances	Antiemetics
Language	English
Publishing date	2022-12-02
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	645203-6
ISSN	1473-6500 ; 0952-7907
ISSN (online)	1473-6500
ISSN	0952-7907
DOI	10.1097/ACO.0000000000001220
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Article ; Online: Postoperative/postdischarge nausea and vomiting: evidence-based prevention and treatment.

Schlesinger, Tobias / Weibel, Stephanie / Kranke, Peter

Current opinion in anaesthesiology

2022 Volume 36, Issue 1, Page(s) 109–116

Abstract: Purpose of review: Postoperative/postdischarge nausea and vomiting (PONV/PDNV) remains a relevant issue in perioperative care. Especially in outpatient surgery, PONV can prevent discharge or lead to unplanned readmission.: Recent findings: Evidence ... ...

Abstract	Purpose of review: Postoperative/postdischarge nausea and vomiting (PONV/PDNV) remains a relevant issue in perioperative care. Especially in outpatient surgery, PONV can prevent discharge or lead to unplanned readmission. Recent findings: Evidence on prophylaxis and treatment of PONV is growing, but implementation remains poor. Summary: A liberal, universal PONV management is now endorsed by the guidelines. Specific evidence concerning prevention and (at-home) treatment of PDNV is still scarce.
MeSH term(s)	Humans ; Postoperative Nausea and Vomiting/prevention & control ; Postoperative Nausea and Vomiting/drug therapy ; Antiemetics/therapeutic use ; Aftercare ; Patient Discharge
Chemical Substances	Antiemetics
Language	English
Publishing date	2022-10-10
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	645203-6
ISSN	1473-6500 ; 0952-7907
ISSN (online)	1473-6500
ISSN	0952-7907
DOI	10.1097/ACO.0000000000001200
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Article ; Online: Drugs in anesthesia: preventing postoperative nausea and vomiting.

Schlesinger, Tobias / Weibel, Stephanie / Meybohm, Patrick / Kranke, Peter

Current opinion in anaesthesiology

2021 Volume 34, Issue 4, Page(s) 421–427

Abstract: Purpose of review: Postoperative nausea and vomiting (PONV) continues to be a burden for patients, medical staff and healthcare facilities because of inadequate adherence to available recommendations. This review gives an overview on recent ... ...

Abstract	Purpose of review: Postoperative nausea and vomiting (PONV) continues to be a burden for patients, medical staff and healthcare facilities because of inadequate adherence to available recommendations. This review gives an overview on recent recommendations, new evidence and remaining issues in the field of PONV management. Recent findings: A wide range of drugs is available for the management of PONV including corticosteroids, 5-HT3-antagonists, dopamine-antagonists, neurokinin-receptor-1 (NK1)-antagonists, antihistamines and anticholinergics. The updated PONV guidelines from 2020 recommend a universal multimodal strategy for PONV prophylaxis, which is an important paradigm shift to improve implementation of the existing evidence. A recent Cochrane network meta-analysis ranked single drugs and drug combinations for PONV prophylaxis in terms of efficacy and safety. Notably, NK1-antagonists and new 5-HT3-antagonists ranged among the most effective drugs. However, safety data on antiemetics are generally scarce. Summary: Numerous drug (combinations) and strategies are available for PONV management. New and very effective (single) drugs could result in a simplification compared with a combination of several drugs, and thus lead to better implementation.
MeSH term(s)	Anesthesia/adverse effects ; Antiemetics/adverse effects ; Humans ; Pharmaceutical Preparations ; Postoperative Nausea and Vomiting/prevention & control
Chemical Substances	Antiemetics ; Pharmaceutical Preparations
Language	English
Publishing date	2021-04-12
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	645203-6
ISSN	1473-6500 ; 0952-7907
ISSN (online)	1473-6500
ISSN	0952-7907
DOI	10.1097/ACO.0000000000001010
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Article ; Online: Coronavirus Threatens Blood Supply: Patient Blood Management Now!

Schlesinger, Tobias / Kranke, Peter / Zacharowski, Kai / Meybohm, Patrick

Annals of surgery

2020 Volume 272, Issue 2, Page(s) e74

MeSH term(s)	Blood Banks/supply & distribution ; Blood Transfusion/statistics & numerical data ; COVID-19 ; Coronavirus Infections/epidemiology ; Female ; Germany ; Humans ; Male ; Needs Assessment ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Risk Assessment
Keywords	covid19
Language	English
Publishing date	2020-07-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000004086
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Article ; Online: Der epidurale Blut-Patch – Goldstandard in der Therapie postpunktioneller Kopfschmerzen und originäre Aufgabe der geburtshilflichen Anästhesie.

Schlesinger, Tobias / Becke-Jakob, Karin / Girard, Thierry / Greve, Susanne / Meybohm, Patrick / Kranke, Peter

Die Anaesthesiologie

2022 Volume 71, Issue 9, Page(s) 724–726

Title translation	The epidural blood patch-Gold standard in treatment of postdural puncture headache and original task of obstetric anesthesia.
MeSH term(s)	Anesthesia, Epidural/adverse effects ; Anesthesia, Obstetrical ; Blood Patch, Epidural ; Female ; Humans ; Post-Dural Puncture Headache/therapy ; Pregnancy ; Spinal Puncture/adverse effects
Language	German
Publishing date	2022-06-23
Publishing country	Germany
Document type	Letter
ISSN	2731-6866
ISSN (online)	2731-6866
DOI	10.1007/s00101-022-01153-4
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Article ; Online: Outcome-relevante Anästhesiologie: peri- und postoperative Anämiebehandlung.

Helmer, Philipp / Kranke, Peter / Schlesinger, Tobias / Hottenrott, Sebastian / Zacharowski, Kai / Choorapoikayil, Suma / Meybohm, Patrick

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

2022 Volume 57, Issue 2, Page(s) 115–126

Abstract: Patient Blood Management (PBM) aims to diagnose and treat preoperative anaemia, avoid unnecessary blood loss, and enable rational use of blood products. Due to various limitations, treatment of preoperative anaemia has been successful in only a few ... ...

Title translation	Peri- and Postoperative Anaemia Management.
Abstract	Patient Blood Management (PBM) aims to diagnose and treat preoperative anaemia, avoid unnecessary blood loss, and enable rational use of blood products. Due to various limitations, treatment of preoperative anaemia has been successful in only a few German hospitals to date. Thus, the peri- and postoperative phase is increasingly becoming important for implementing various preventive and therapeutic measures for the treatment of (postoperative) anaemia. These will be comprehensively presented in the following.
MeSH term(s)	Anemia/diagnosis ; Anemia/therapy ; Hospitals ; Humans ; Preoperative Care
Language	German
Publishing date	2022-02-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1065682-0
ISSN	1439-1074 ; 0939-2661
ISSN (online)	1439-1074
ISSN	0939-2661
DOI	10.1055/a-1390-3581
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Zs.A 257: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: First safety outcomes for rigicon conticlassic® artificial urinary sphincter.

Wilson, Steven K / Chung, Eric / Langford, Brian / Schlesinger, Ricardo / Koca, Orhan / Simsek, Abdulmuttalip / Persu, Cristian / Pottek, Tobias / Mulcahy, John

International journal of impotence research

2023

Abstract: The Rigicon ContiClassic® is a new sphincteric device designed to treat male stress urinary incontinence. This study evaluates the surgical outcomes and safety profile of the first 116 patients who received the implant between September 2021 and April ... ...

Abstract	The Rigicon ContiClassic® is a new sphincteric device designed to treat male stress urinary incontinence. This study evaluates the surgical outcomes and safety profile of the first 116 patients who received the implant between September 2021 and April 2022. Data were collected from patient information forms completed at the time of the implant and submitted by implanting surgeons, nursing staff in the Operating Room or company representatives present during the surgery. The study analyzed patient demographics, surgical details, and etiology of incontinence. The mean age of patients was 68.3 years +/- 9.65 yrs. Minimum age was 23 and maximum age was 83. The most common reason for implantation was urinary incontinence (58.6%) after radical prostatectomy. The results showed a revision rate of 6.90%, with three cases of fluid loss, four cases of iatrogenic mistaken sizing, and one case of patient dissatisfaction. There were no reported infections. Kaplan-Meier calculation showed survival rate of 93.2% at 12 months. This study shows the early safety outcomes for the Rigicon ContiClassic® sphincter device to be comparable to others presently on the market.
Language	English
Publishing date	2023-08-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1034295-3
ISSN	1476-5489 ; 0955-9930
ISSN (online)	1476-5489
ISSN	0955-9930
DOI	10.1038/s41443-023-00748-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2910: Show issues

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Article ; Online: Risk-adjusted perioperative bridging anticoagulation reduces bleeding complications without increasing thromboembolic events in general and visceral surgery.

Döhler, Ida / Röder, Daniel / Schlesinger, Tobias / Nassen, Christian Alexander / Germer, Christoph-Thomas / Wiegering, Armin / Lock, Johan Friso

BMC anesthesiology

2023 Volume 23, Issue 1, Page(s) 56

Abstract: Background: Perioperative bridging of oral anticoagulation increases the risk of bleeding complications after elective general and visceral surgery. The aim of this study was to explore, whether an individual risk-adjusted bridging regimen can reduce ... ...

Abstract	Background: Perioperative bridging of oral anticoagulation increases the risk of bleeding complications after elective general and visceral surgery. The aim of this study was to explore, whether an individual risk-adjusted bridging regimen can reduce bleeding events, while still protecting against thromboembolic events. Methods: We performed a quality improvement study comparing bridging parameters and postoperative outcomes before (period 1) and after implementation (period 2) of a new risk-adjusted bridging regimen. The primary endpoint of the study was overall incidence of postoperative bleeding complications during 30 days postoperatively. Secondary endpoints were major postoperative bleeding, minor bleeding, thromboembolic events, postoperative red blood cell transfusion, perioperative length-of-stay (LOS) and in-hospital mortality. Results: A total of 263 patients during period 1 and 271 patients during period 2 were compared. The included elective operations covered the entire field of general and visceral surgery. The overall incidence of bleeding complications declined from 22.1% during period 1 to 10.3% in period 2 (p < 0.001). This reduction affected both major as well as minor bleeding events (8.4% vs. 4.1%; p = 0.039; 13.7% vs. 6.3%; p = 0.004). The incidence of thromboembolic events remained low (0.8% vs. 1.1%). No changes in mortality or length-of-stay were observed. Conclusion: It is important to balance the individual thromboembolic and bleeding risks in perioperative bridging management. The risk adjusted bridging regimen reduces bleeding events in general and visceral surgery while the risk of thromboembolism remains comparably low.
MeSH term(s)	Humans ; Anticoagulants/adverse effects ; Thromboembolism/epidemiology ; Thromboembolism/prevention & control ; Thromboembolism/etiology ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Postoperative Hemorrhage/epidemiology ; Digestive System Surgical Procedures/adverse effects
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-02-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-023-02017-z
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Article ; Online: Assessing the potential for precision medicine in body weight reduction with regard to type 2 diabetes mellitus therapies: A meta-regression analysis of 120 randomized controlled trials.

Vargas, Kris G / Rütten, Tobias / Siemes, Benedikt / Brockmeyer, Maximilian / Parco, Claudio / Hoss, Alexander / Schlesinger, Sabrina / Jung, Christian / Roden, Michael / Kelm, Malte / Wolff, Georg / Kuss, Oliver

Diabetes, obesity & metabolism

2024

Abstract: Aims: To assess the potential for precision medicine in type 2 diabetes by quantifying the variability of body weight as response to pharmacological treatment and to identify predictors which could explain this variability.: Methods: We used ... ...

Abstract	Aims: To assess the potential for precision medicine in type 2 diabetes by quantifying the variability of body weight as response to pharmacological treatment and to identify predictors which could explain this variability. Methods: We used randomized clinical trials (RCTs) comparing glucose-lowering drugs (including but not limited to sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists and thiazolidinediones) to placebo from four recent systematic reviews. RCTs reporting on body weight after treatment to allow for calculation of its logarithmic standard deviation (log[SD], i.e., treatment response heterogeneity) in verum (i.e., treatment) and placebo groups were included. Meta-regression analyses were performed with respect to variability of body weight after treatment and potential predictors. Results: A total of 120 RCTs with a total of 43 663 participants were analysed. A slightly larger treatment response heterogeneity was shown in the verum groups, with a median log(SD) of 2.83 compared to 2.79 from placebo. After full adjustment in the meta-regression model, the difference in body weight log(SD) was -0.026 (95% confidence interval -0.044; 0.008), with greater variability in the placebo groups. Scatterplots did not show any slope divergence (i.e., interaction) between clinical predictors and the respective treatment (verum or placebo). Conclusions: We found no major treatment response heterogeneity in RCTs of glucose-lowering drugs for body weight reduction in type 2 diabetes. The precision medicine approach may thus be of limited value in this setting.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15519
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