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  1. Article ; Online: Bacteriophage Infections of Biofilms of Health Care-Associated Pathogens:

    Santiago, Ariel J / Donlan, Rodney M

    EcoSal Plus

    2020  Volume 9, Issue 1

    Abstract: Members of the ... ...

    Abstract Members of the family
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/therapy ; Bacteriophages/pathogenicity ; Biofilms ; Cross Infection/microbiology ; Host Specificity ; Humans ; Klebsiella pneumoniae/virology ; Phage Therapy/methods
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-11-28
    Publishing country United States
    Document type Journal Article
    ISSN 2324-6200
    ISSN (online) 2324-6200
    DOI 10.1128/ecosalplus.ESP-0029-2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A new approach to mitigate biofilm formation on totally implantable venous access ports.

    Donlan, Rodney M

    The Journal of infectious diseases

    2014  Volume 210, Issue 9, Page(s) 1345–1346

    MeSH term(s) Animals ; Biofilms/growth & development ; Biomimetic Materials/therapeutic use ; Catheter-Related Infections/prevention & control ; Central Venous Catheters/microbiology ; Male
    Language English
    Publishing date 2014-05-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiu251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Microbial Biofilms, Second Edition

    Rodney M. Donlan

    Emerging Infectious Diseases, Vol 22, Iss 6, Pp 1142-

    2016  Volume 1142

    Keywords Microbial biofilm ; bacterial biofilm ; fungal biofilm ; biofilm methods ; genomic ; metagenomic ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2016-06-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Supplemental nutrients stimulate the amplification of carbapenemase-producing

    Burgos-Garay, María L / Santiago, Ariel J / Kartforosh, Leila / Kotay, Shireen / Donlan, Rodney M

    Biofouling

    2021  Volume 37, Issue 5, Page(s) 465–480

    Abstract: Liquid wastes (LW) disposed in hospital handwashing sinks may affect colonization of sink P-traps by carbapenemase- ... ...

    Abstract Liquid wastes (LW) disposed in hospital handwashing sinks may affect colonization of sink P-traps by carbapenemase-producing
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacterial Proteins ; Biofilms ; Humans ; Klebsiella Infections ; Klebsiella pneumoniae ; Nutrients ; beta-Lactamases
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2021-07-01
    Publishing country England
    Document type Journal Article
    ISSN 1029-2454
    ISSN (online) 1029-2454
    DOI 10.1080/08927014.2021.1915998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bacteriophage treatment of carbapenemase-producing

    Santiago, Ariel J / Burgos-Garay, Maria L / Kartforosh, Leila / Mazher, Mustafa / Donlan, Rodney M

    AIMS microbiology

    2020  Volume 6, Issue 1, Page(s) 43–63

    Abstract: The p-traps of hospital handwashing sinks represent a potential reservoir for antimicrobial-resistant organisms of major public health concern, such as carbapenemase-producing KPC+ ...

    Abstract The p-traps of hospital handwashing sinks represent a potential reservoir for antimicrobial-resistant organisms of major public health concern, such as carbapenemase-producing KPC+
    Language English
    Publishing date 2020-02-26
    Publishing country United States
    Document type Journal Article
    ISSN 2471-1888
    ISSN (online) 2471-1888
    DOI 10.3934/microbiol.2020003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Biofilm elimination on intravascular catheters: important considerations for the infectious disease practitioner.

    Donlan, Rodney M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2011  Volume 52, Issue 8, Page(s) 1038–1045

    Abstract: The presence of biofilms on intravascular catheters and their role in catheter-related bloodstream infections is well accepted. The tolerance of catheter-associated biofilm organisms toward systemic antimicrobial treatments and the potential for ... ...

    Abstract The presence of biofilms on intravascular catheters and their role in catheter-related bloodstream infections is well accepted. The tolerance of catheter-associated biofilm organisms toward systemic antimicrobial treatments and the potential for development of antimicrobial resistance in the health care environment underscores the importance of alternative treatment strategies. Biofilms are microbial communities that exhibit unique characteristics that must be considered when evaluating the potential of biofilm prevention or control strategies. Because biofilm-associated infections do not respond consistently to therapeutically achievable concentrations of many antimicrobial agents, treatments that are more effective against slowly growing biofilm cells or combination treatments that can penetrate the biofilm matrix may be more effective. Alternative strategies that do not incorporate antimicrobial drugs have also been investigated. These approaches have the potential to prevent or eradicate biofilms on indwelling intravascular catheters and prevent or resolve catheter-related infections.
    MeSH term(s) Biofilms/drug effects ; Biofilms/growth & development ; Catheter-Related Infections/prevention & control ; Catheters, Indwelling/microbiology ; Cross Infection/prevention & control ; Disinfection/methods ; Humans ; Infection Control/methods
    Language English
    Publishing date 2011-04-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/cir077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 480: Show issues

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  7. Article ; Online: Bacteriophage-mediated control of a two-species biofilm formed by microorganisms causing catheter-associated urinary tract infections in an in vitro urinary catheter model.

    Lehman, Susan M / Donlan, Rodney M

    Antimicrobial agents and chemotherapy

    2015  Volume 59, Issue 2, Page(s) 1127–1137

    Abstract: Microorganisms from a patient or their environment may colonize indwelling urinary catheters, forming biofilm communities on catheter surfaces and increasing patient morbidity and mortality. This study investigated the effect of pretreating hydrogel- ... ...

    Abstract Microorganisms from a patient or their environment may colonize indwelling urinary catheters, forming biofilm communities on catheter surfaces and increasing patient morbidity and mortality. This study investigated the effect of pretreating hydrogel-coated silicone catheters with mixtures of Pseudomonas aeruginosa and Proteus mirabilis bacteriophages on the development of single- and two-species biofilms in a multiday continuous-flow in vitro model using artificial urine. Novel phages were purified from sewage, characterized, and screened for their abilities to reduce biofilm development by clinical isolates of their respective hosts. Our screening data showed that artificial urine medium (AUM) is a valid substitute for human urine for the purpose of evaluating uropathogen biofilm control by these bacteriophages. Defined phage cocktails targeting P. aeruginosa and P. mirabilis were designed based on the biofilm inhibition screens. Hydrogel-coated catheters were pretreated with one or both cocktails and challenged with approximately 1×10(3) CFU/ml of the corresponding pathogen(s). The biofilm growth on the catheter surfaces in AUM was monitored over 72 to 96 h. Phage pretreatment reduced P. aeruginosa biofilm counts by 4 log10 CFU/cm2 (P≤0.01) and P. mirabilis biofilm counts by >2 log10 CFU/cm2 (P≤0.01) over 48 h. The presence of P. mirabilis was always associated with an increase in lumen pH from 7.5 to 9.5 and with eventual blockage of the reactor lines. The results of this study suggest that pretreatment of a hydrogel urinary catheter with a phage cocktail can significantly reduce mixed-species biofilm formation by clinically relevant bacteria.
    MeSH term(s) Bacteriophages/metabolism ; Bacteriophages/physiology ; Biofilms/growth & development ; Proteus mirabilis/physiology ; Proteus mirabilis/virology ; Pseudomonas aeruginosa/physiology ; Pseudomonas aeruginosa/virology ; Urinary Catheterization/adverse effects ; Urinary Catheters/microbiology
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.03786-14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 809: Show issues Location:
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    Einzelsignatur: Show issues

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  8. Article: Preventing biofilms of clinically relevant organisms using bacteriophage.

    Donlan, Rodney M

    Trends in microbiology

    2009  Volume 17, Issue 2, Page(s) 66–72

    Abstract: Biofilms might result in healthcare-associated infections and substantially impact healthcare delivery. Bacteriophage (phage) has been used to treat infectious diseases in humans and there is interest in phage to control biofilms. Phages propagate in ... ...

    Abstract Biofilms might result in healthcare-associated infections and substantially impact healthcare delivery. Bacteriophage (phage) has been used to treat infectious diseases in humans and there is interest in phage to control biofilms. Phages propagate in their bacterial host and many phages produce depolymerases that hydrolyze biofilm extracellular polymers. Drawbacks of phage to consider include narrow host range, bacterial resistance to phage and phage-encoded virulence genes that can incorporate into the host bacterial genome. The immune system might inactivate phage, and impure phage preparations could contain endotoxin. Phage mixtures or engineered phages could provide effective strategies to overcome these obstacles. Lytic bacteriophages could become a new class of anti-biofilm agents.
    MeSH term(s) Bacterial Infections/microbiology ; Bacterial Infections/prevention & control ; Bacteriophages/physiology ; Biofilms/growth & development ; Gram-Negative Bacteria/physiology ; Gram-Positive Bacteria/physiology ; Humans ; Prosthesis-Related Infections/microbiology ; Prosthesis-Related Infections/prevention & control
    Language English
    Publishing date 2009-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2008.11.002
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  9. Article ; Online: Droplet- Rather than Aerosol-Mediated Dispersion Is the Primary Mechanism of Bacterial Transmission from Contaminated Hand-Washing Sink Traps.

    Kotay, Shireen M / Donlan, Rodney M / Ganim, Christine / Barry, Katie / Christensen, Bryan E / Mathers, Amy J

    Applied and environmental microbiology

    2019  Volume 85, Issue 2

    Abstract: An alarming rise in hospital outbreaks implicating hand-washing sinks has led to widespread acknowledgment that sinks are a major reservoir of antibiotic-resistant pathogens in patient care areas. An earlier study using green fluorescent protein (GFP)- ... ...

    Abstract An alarming rise in hospital outbreaks implicating hand-washing sinks has led to widespread acknowledgment that sinks are a major reservoir of antibiotic-resistant pathogens in patient care areas. An earlier study using green fluorescent protein (GFP)-expressing
    MeSH term(s) Aerosols/analysis ; Air Microbiology ; Cross Infection/microbiology ; Cross Infection/prevention & control ; Equipment Contamination ; Escherichia coli/isolation & purification ; Escherichia coli/physiology ; Green Fluorescent Proteins/analysis ; Hand Disinfection ; Hospitals ; Humans ; Water/chemistry
    Chemical Substances Aerosols ; Water (059QF0KO0R) ; Green Fluorescent Proteins (147336-22-9)
    Keywords covid19
    Language English
    Publishing date 2019-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/AEM.01997-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: New approaches for the characterization of prosthetic joint biofilms.

    Donlan, Rodney M

    Clinical orthopaedics and related research

    2005  , Issue 437, Page(s) 12–19

    Abstract: Indwelling prosthetic joints may become colonized by microbial biofilms, although the biofilm structure, composition of the microbial community, and physiologic activity of the organisms in these devices are not well understood. New approaches that rely ... ...

    Abstract Indwelling prosthetic joints may become colonized by microbial biofilms, although the biofilm structure, composition of the microbial community, and physiologic activity of the organisms in these devices are not well understood. New approaches that rely on the use of fluorescent stain technology can be used to characterize the structure and community composition in a way that earlier methods, which relied on culturing or scanning electron microscopy, could not. Model systems incorporating parameters relevant for indwelling prosthetic joints also can be designed to evaluate the efficacy of treatments for preventing or eradicating biofilms from these devices. Effectively treating microbial biofilms on indwelling medical devices such as prosthetic joints is a challenging proposition. A clearer understanding of the process in vivo and a defined approach for evaluating treatment strategies provide the best hope for success.
    MeSH term(s) Biofilms/growth & development ; Humans ; In Vitro Techniques ; Joint Prosthesis/microbiology ; Microscopy, Electron ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/microbiology ; Prosthesis-Related Infections/prevention & control
    Language English
    Publishing date 2005-07-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/01.blo.0000175120.66051.29
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