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  1. Article: Clinical Features and Outcomes of Persistent Candidemia Caused by

    Kitaya, Shiori / Kanamori, Hajime / Katori, Yukio / Tokuda, Koichi

    Microorganisms

    2023  Volume 11, Issue 4

    Abstract: The clinical distinctions among variations ... ...

    Abstract The clinical distinctions among variations in
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11040928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Clinical Characteristics and Outcomes of Persistent Staphylococcal Bacteremia in a Tertiary Care Hospital.

    Kitaya, Shiori / Kanamori, Hajime / Katori, Yukio / Tokuda, Koichi

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Clinical outcomes of persistent staphylococcal bacteremia vary depending on the causative organism. This secondary data analysis study compared the clinical characteristics of ... ...

    Abstract Clinical outcomes of persistent staphylococcal bacteremia vary depending on the causative organism. This secondary data analysis study compared the clinical characteristics of persistent
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12030454
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  3. Article: Preoperative Evaluation for Carotid Endarterectomy Using CT and MRI Fusion Images Without Contrast Media.

    Hashiguchi, Akihito / Tonegawa, Takeshi / Tashima, Kozo / Moroki, Koichi / Tokuda, Hajime

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54321

    Abstract: The usefulness of carotid endarterectomy (CEA) for carotid artery stenosis has been established even in the era of endovascular treatment. Digital subtraction angiography (DSA) and three-dimensional computed tomography angiography (3D-CTA) are used for ... ...

    Abstract The usefulness of carotid endarterectomy (CEA) for carotid artery stenosis has been established even in the era of endovascular treatment. Digital subtraction angiography (DSA) and three-dimensional computed tomography angiography (3D-CTA) are used for preoperative evaluation of CEA; however, contrast agents cannot be used in patients with renal dysfunction or contrast agent allergy. Since the introduction of a three-dimensional image analysis software, SYNAPSE VINCENT (Fujifilm, Tokyo, Japan) in February 2016, we initially fused cervical CT, carotid three-dimensional time-of-flight magnetic resonance angiography, and carotid plaque imaging using 1.5 T magnetic resonance imaging to evaluate carotid artery stenosis in patients with renal dysfunction. Since then, we have gradually accumulated several cases, and at present, this fusion imaging is our first choice for preoperative evaluation of CEA instead of DSA or 3D-CTA. This evaluation method has many advantages over DSA and 3D-CTA, including the fact that it does not require contrast media. We report its usefulness, limitations, and cautions.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54321
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  4. Article: Subarachnoid Hemorrhage From Ruptured Aneurysms at the Internal Carotid Artery-Posterior Communicating Artery Bifurcation Not Detectable on Preoperative Imaging Studies.

    Hashiguchi, Akihito / Tashima, Kozo / Tonegawa, Takeshi / Moroki, Koichi / Tokuda, Hajime

    Cureus

    2024  Volume 16, Issue 2, Page(s) e53691

    Abstract: Since subarachnoid hemorrhage (SAH) due to the re-rupture of cerebral aneurysms severely worsens the prognosis, an accurate initial diagnosis is essential. Computed tomography (CT) and magnetic resonance imaging (MRI) usually detect aneurysmal ... ...

    Abstract Since subarachnoid hemorrhage (SAH) due to the re-rupture of cerebral aneurysms severely worsens the prognosis, an accurate initial diagnosis is essential. Computed tomography (CT) and magnetic resonance imaging (MRI) usually detect aneurysmal subarachnoid hemorrhage (aSAH). However, in rare cases, its identification on CT- and MRI scans is difficult, and a cerebrospinal fluid (CSF) examination is required. We present preoperative imaging and intraoperative findings in patients whose aSAH detection necessitated a CSF examination. Of 225 aSAH patients who underwent preoperative imaging studies at our institution between April 2010 and August 2019, 3 females (1.3%, mean age 57.3 years) harbored undetectable aSAH due to the rupture of an internal carotid artery-posterior communicating artery (ICA-PcomA) aneurysm. The aneurysmal orientation was inferolateral. Intraoperatively, the anterior petroclinoid ligament hampered the detection of the aneurysms that firmly adhered to the surrounding arachnoid membrane. Sustained arterial pulsation and successive minor hemorrhage can lead to the gradual adhesion of an ICA-PcomA aneurysm to the surrounding arachnoid membrane and explain their atypical rupture undetectable on imaging studies and the development of acute subdural hematoma without SAH.
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Impact of Persistent Multidrug-Resistant Gram-Negative Bacteremia on Clinical Outcome and Mortality.

    Kitaya, Shiori / Kanamori, Hajime / Katori, Yukio / Tokuda, Koichi

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: The clinical aspects of persistent bacteremia (PB) caused by gram-negative rods (GNRs) in terms of antimicrobial resistance (AMR) and PB clearance status are unclear. This secondary analysis of a retrospective cohort study investigated differences in PB ... ...

    Abstract The clinical aspects of persistent bacteremia (PB) caused by gram-negative rods (GNRs) in terms of antimicrobial resistance (AMR) and PB clearance status are unclear. This secondary analysis of a retrospective cohort study investigated differences in PB caused by Enterobacterales and glucose non-fermentative GNRs (NF-GNRs) based on AMR and PB clearance. We retrospectively surveyed medical records at Tohoku University Hospital. Patients for whom blood cultures were performed between January 2012 and December 2021 were recruited. PB cases were grouped based on AMR and PB clearance; the characteristics of PB due to each bacterial pathogen were examined. The main outcome variable was mortality. The late (30-90-day) mortality rate was significantly higher in the multidrug-resistant (MDR) group than in the non-MDR group for Enterobacterales. However, no significant difference was noted in mortality rates between NF-GNRs with and without AMR. Mortality rates tended to be higher in the non-PB-clearance group than in the clearance group for both Enterobacterales and NF-GNRs. Since the mortality rate was higher in the MDR group in the case of Enterobacterales PB, more careful management is necessary for this condition. Follow-up blood cultures and confirming the clearance of PB are useful for improving the survival rate.
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12020313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Tip position of peripherally inserted central venous catheters inserted without fluoroscopy.

    Ide, Kentaro / Okuwaki, Hajime / Ota, Hidehito / Tokuda, Yusuke / Nakagawa, Satoshi

    Pediatrics international : official journal of the Japan Pediatric Society

    2022  Volume 65, Issue 1, Page(s) e15432

    MeSH term(s) Humans ; Central Venous Catheters/adverse effects ; Catheterization, Central Venous/adverse effects ; Catheterization, Peripheral ; Fluoroscopy ; Catheters, Indwelling
    Language English
    Publishing date 2022-11-12
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15432
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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Pulmonary infection caused by

    Oshima, Kengo / Niinuma, Yukari / Saito, Hajime / Baba, Hiroaki / Kanamori, Hajime / Aoyagi, Tetsuji / Tokuda, Koichi / Kaku, Mitsuo

    ERJ open research

    2021  Volume 7, Issue 1

    Abstract: Mycobacterium ... ...

    Abstract Mycobacterium marinum
    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00782-2020
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  8. Article: Clinical and Epidemiological Characteristics of Persistent Bacteremia: A Decadal Observational Study.

    Kitaya, Shiori / Kanamori, Hajime / Baba, Hiroaki / Oshima, Kengo / Takei, Kentarou / Seike, Issei / Katsumi, Makoto / Katori, Yukio / Tokuda, Koichi

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12020212
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  9. Article ; Online: A web-based genome-wide association study reveals the susceptibility loci of common adverse events following COVID-19 vaccination in the Japanese population.

    Nogawa, Shun / Kanamori, Hajime / Tokuda, Koichi / Kawafune, Kaoru / Chijiiwa, Miyuki / Saito, Kenji / Takahashi, Shoko

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 20820

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly worldwide. To prevent its spread, mRNA-based vaccines made by Pfizer/BioNTech (BNT162b1) and Moderna (mRNA-1273) have been widely used, including in Japan. Various adverse events have ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly worldwide. To prevent its spread, mRNA-based vaccines made by Pfizer/BioNTech (BNT162b1) and Moderna (mRNA-1273) have been widely used, including in Japan. Various adverse events have been reported following the COVID-19 mRNA vaccination, with differences observed among individuals. However, analyses of the genetic background associated with the susceptibility to side effects have been limited. In the present study, we performed genome-wide association studies (GWAS) for self-reported adverse events of the COVID-19 mRNA vaccination in 4545 Japanese individuals and identified 14 associated loci. Among these, 6p21 was associated with 37.5 °C or higher fever, 38 °C or higher fever, and muscle pain. HLA allele association analysis revealed that various HLA alleles were associated with the adverse effects; HLA-DQA1*03:01 and HLA-A*11:01 were more reliably associated with the adverse effects. Our results may enable the preparation and management of adverse effects by identifying the susceptibility to these adverse events. Furthermore, we obtained valuable data that may lead to a better understanding of the mechanisms of action of the COVID-19 mRNA vaccines.
    MeSH term(s) Humans ; BNT162 Vaccine ; Chromosomes, Human, Pair 6/genetics ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; East Asian People/genetics ; Genome-Wide Association Study ; Histocompatibility Antigens/genetics ; Internet ; RNA, Messenger/genetics ; Vaccination/adverse effects ; Genetic Predisposition to Disease/ethnology ; Genetic Predisposition to Disease/genetics
    Chemical Substances BNT162 Vaccine ; COVID-19 Vaccines ; Histocompatibility Antigens ; RNA, Messenger
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-47632-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Dissection of an ABC transporter LolCDE function analyzed by photo-crosslinking.

    Tao, Kazuyuki / Narita, Shin-Ichiro / Okada, Ui / Murakami, Satoshi / Tokuda, Hajime

    Journal of biochemistry

    2023  Volume 175, Issue 4, Page(s) 427–437

    Abstract: The envelope of Escherichia coli contains approximately 100 different species of lipoproteins, most of which are localized to the inner leaflet of the outer membrane. The localization of lipoprotein (Lol) system, consisting of five Lol proteins, is ... ...

    Abstract The envelope of Escherichia coli contains approximately 100 different species of lipoproteins, most of which are localized to the inner leaflet of the outer membrane. The localization of lipoprotein (Lol) system, consisting of five Lol proteins, is responsible for the trafficking of lipoproteins to the outer membrane. LolCDE binds to lipoproteins destined for the outer membrane and transfers them to the periplasmic chaperone LolA. Although the cryo-EM structures of E. coli LolCDE have been reported, the mechanisms by which outer membrane lipoproteins are transferred to LolA remain elusive. In this study, we investigated the interaction between LolCDE and lipoproteins using site-specific photo-crosslinking. We introduced a photo-crosslinkable amino acid into different locations across the four helices which form the central lipoprotein-binding cavity, and identified domains that crosslink with peptidoglycan-associated lipoprotein (Pal) in vivo. Using one of the derivatives containing the photo-crosslinkable amino acid, we developed an in vitro system to analyze the binding of lipoproteins to LolCDE. Our results indicate that compound 2, a LolCDE inhibitor, does not inhibit the binding of lipoproteins to LolCDE, but rather promotes the dissociation of bound lipoproteins from LolCDE.
    MeSH term(s) Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; ATP-Binding Cassette Transporters/metabolism ; Cell Membrane/metabolism ; Lipoproteins/chemistry ; Lipoproteins/metabolism ; Amino Acids/metabolism ; Bacterial Outer Membrane Proteins/metabolism ; Periplasmic Binding Proteins/metabolism
    Chemical Substances Escherichia coli Proteins ; ATP-Binding Cassette Transporters ; Lipoproteins ; Amino Acids ; Bacterial Outer Membrane Proteins ; LolA protein, E coli ; Periplasmic Binding Proteins
    Language English
    Publishing date 2023-12-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 218073-x
    ISSN 1756-2651 ; 0021-924X
    ISSN (online) 1756-2651
    ISSN 0021-924X
    DOI 10.1093/jb/mvad118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.202: Show issues Location:
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