LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article: Bioinformatics analysis reveals molecular connections between non-alcoholic fatty liver disease (NAFLD) and COVID-19.

    Abolfazli, Pouria / Aghajanzadeh, Taha / Ghaderinasrabad, Melina / Apue Nchama, Cristina Nkene / Mokhlesi, Amir / Talkhabi, Mahmood

    Journal of cell communication and signaling

    2022  Volume 16, Issue 4, Page(s) 609–619

    Abstract: The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has devastatingly impacted people's lives. Non-alcoholic fatty liver disease (NAFLD) is fatal comorbidity of COVID-19 seen with potential risk factors to develop severe ... ...

    Abstract The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has devastatingly impacted people's lives. Non-alcoholic fatty liver disease (NAFLD) is fatal comorbidity of COVID-19 seen with potential risk factors to develop severe symptoms. This research focuses on determining and elucidating the molecular factors and connections that might contribute to the severity of SARS-CoV-2 infection in NAFLD patients. Here, we comprehensively inspected the genes involved in NAFLD and SARS-CoV-2 entry factors (SCEFs) found by searching through the DisGeNet database and literature review, respectively. Further, we identified the SCEFs-related proteins through protein-protein interaction (PPI) network construction, MCODE, and Cytohubba. Next, the shared genes involved in NAFLD and SARS-CoV-2 entry, and hub gene were determined, followed by the GO and KEGG pathways analysis. X2K database was used to construct the upstream regulatory network of hub genes, as well as to identify the top ten candidates of transcription factors (TFs) and protein kinases (PKs). PPI analysis identified connections between 4 top SCEFs, including ACE, ADAM17, DPP4, and TMPRSS2 and NAFLD-related genes such as ACE, DPP4, IL-10, TNF, and AKT1. GO and KEGG analysis revealed the top ten biological processes and pathways, including cytokine-mediated signaling, PI3K-Akt, AMPK, and mTOR signaling pathways. The upstream regulatory network revealed that AKT1 and MAPK14 as important PKs and HIF1A and SP1 as important TFs associated with AKT1, IL-10, and TNF. The molecular connections identified between COVID-19 and NAFLD may shed light on discovering the causes of the severity of SARS-CoV-2 infected NAFLD patients.
    Language English
    Publishing date 2022-05-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2299380-0
    ISSN 1873-961X ; 1873-9601
    ISSN (online) 1873-961X
    ISSN 1873-9601
    DOI 10.1007/s12079-022-00678-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Performance analysis of a micro-scale integrated hydrogen production system by analytical approach, machine learning, and response surface methodology

    Pourali, Mostafa / Esfahani, Javad Abolfazli

    Energy. 2022 Sept. 15, v. 255

    2022  

    Abstract: Parametric study of micro-scale integrated hydrogen production systems requires great computational efforts due to complex phenomena such as reaction kinetics. In the present study, an innovative combined approach, including machine learning for data ... ...

    Abstract Parametric study of micro-scale integrated hydrogen production systems requires great computational efforts due to complex phenomena such as reaction kinetics. In the present study, an innovative combined approach, including machine learning for data generation (pre-processing), analytical techniques (processing), and response surface methodology (post-processing) is developed to investigate an integrated hydrogen production system. In the pre-processing step, appropriate correlations are provided for the species’ net rate, mixture properties, and the heat of reactions considering the detailed reaction mechanism of methane steam reforming and combustion, using the decision tree algorithm. A 2D steady-state model for heat and mass transfer is employed to analytically solve the conservation equations in a thermally coupled micro-combustor and catalytic micro-reformer. The post-processing step investigates the effects of seven main operational parameters on CH₄ conversion, system efficiency, and quenching distance. It is found that the wall thickness is the most influential parameter in CH₄ conversion and system efficiency. Also, the combustor height is the most critical parameter to sustain combustion in the integrated system. The achievements can be employed as guidelines for the initial design of an integrated hydrogen production system. Finally, five optimized designs of the integrated system are suggested for the first time to construct experimental prototypes.
    Keywords algorithms ; analytical methods ; combustion ; decision support systems ; energy ; heat ; hydrogen production ; mass transfer ; methane ; models ; reaction kinetics ; reaction mechanisms ; response surface methodology ; steam
    Language English
    Dates of publication 2022-0915
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2019804-8
    ISSN 0360-5442 ; 0360-5442
    ISSN (online) 0360-5442
    ISSN 0360-5442
    DOI 10.1016/j.energy.2022.124553
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Amyotrophic lateral sclerosis progression: Iran-ALS clinical registry, a multicentre study.

    Shamshiri, Hosein / Fatehi, Farzad / Davoudi, Farnoush / Mir, Elham / Pourmirza, Behin / Abolfazli, Roya / Etemadifar, Masoud / Harirchian, Mohammad Hossein / Gharagozli, Koroush / Ayromlou, Hormoz / Basiri, Keivan / Zamani, Babak / Rohani, Mohammad / Sedighi, Behnaz / Roudbari, Ali / Delavar Kasmaei, Hossein / Nikkhah, Karim / Ranjbar Naeini, Alireza / Nafissi, Shahriar

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2015  Volume 16, Issue 7-8, Page(s) 506–511

    Abstract: This study was designed to evaluate ALS progression among different subgroups of Iranian patients. Three hundred and fifty-eight patients from centres around the country were registered and their progression rate was evaluated using several scores ... ...

    Abstract This study was designed to evaluate ALS progression among different subgroups of Iranian patients. Three hundred and fifty-eight patients from centres around the country were registered and their progression rate was evaluated using several scores including Manual Muscle Test scoring (MMT) and the revised ALS Functional Rating Scale (ALSFRS-R). Progression rate was analysed separately in subgroups regarding gender, onset site, stage of disease and riluzole consumption. A significant difference in MMT deterioration rate (p = 0.01) was noted between those who used riluzole and those who did not. No significant difference was observed in progression rates between male/female and bulbar-onset/limb-onset groups using riluzole. In conclusion, riluzole has a significant effect on muscle force deterioration rate but not functional scale. Progression rate was not influenced by site of onset or gender.
    MeSH term(s) Adult ; Amyotrophic Lateral Sclerosis/complications ; Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/physiopathology ; Bulbar Palsy, Progressive/etiology ; Bulbar Palsy, Progressive/physiopathology ; Disease Progression ; Extremities/physiopathology ; Female ; Humans ; Iran ; Male ; Middle Aged ; Muscle Weakness/etiology ; Muscle Weakness/physiopathology ; Neuroprotective Agents/therapeutic use ; Prospective Studies ; Registries ; Riluzole/therapeutic use
    Chemical Substances Neuroprotective Agents ; Riluzole (7LJ087RS6F)
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.3109/21678421.2015.1074698
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5874: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Safety and Efficacy of MLC601 in Iranian Patients after Stroke: A Double-Blind, Placebo-Controlled Clinical Trial.

    Harandi, A A / Abolfazli, R / Hatemian, A / Ghragozlee, K / Ghaffar-Pour, M / Karimi, M / Shahbegi, S / Pakdaman, H / Tabasi, M / Tabatabae, A L / Nourian, A

    Stroke research and treatment

    2011  Volume 2011, Page(s) 721613

    Abstract: Objective. To investigate the safety and efficacy of MLC601 (NeuroAid) as a traditional Chinese medicine on motor recovery after ischemic stroke. Methods. This study was a double-blind, placebo-controlled clinical trial on 150 patients with a recent ( ... ...

    Abstract Objective. To investigate the safety and efficacy of MLC601 (NeuroAid) as a traditional Chinese medicine on motor recovery after ischemic stroke. Methods. This study was a double-blind, placebo-controlled clinical trial on 150 patients with a recent (less than 3 month) ischemic stroke. All patients were given either MLC601 (100 patients) or placebo (50 patients), 4 capsules 3 times a day, as an add-on to standard stroke treatment for 3 months. Results. Sex, age, elapsed time from stroke onset, and risk factors in the treatment group were not significantly different from placebo group at baseline (P > .05). Repeated measures analysis showed that Fugl-Meyer assessment was significantly higher in the treatment group during 12 weeks after stroke (P < .001). Good tolerability to treatment was shown, and adverse events were mild and transient. Conclusion. MLC601 showed better motor recovery than placebo and was safe on top of standard ischemic stroke medications especially in the severe and moderate cases.
    Language English
    Publishing date 2011-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573724-7
    ISSN 2042-0056 ; 2090-8105
    ISSN (online) 2042-0056
    ISSN 2090-8105
    DOI 10.4061/2011/721613
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Safety and Efficacy of MLC601 in Iranian Patients after Stroke

    A. Nourian / A. L. Tabatabae / H. Pakdaman / M. Tabasi / M. Karimi / S. Shahbegi / M. Ghaffar-Pour / A. Hatemian / A. A. Harandi / K. Ghragozlee / R. Abolfazli

    Stroke Research and Treatment , Vol

    A Double-Blind, Placebo-Controlled Clinical Trial

    2011  Volume 2011

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top