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  1. Book ; Online ; E-Book: Conditionally toxic proteins

    Schein, Catherine H.

    2024  

    Abstract: Human health depends upon access to high-quality proteins for our diet and pharmaceutical use. This book deals with the nature of toxicity as it applies to proteins in food and drugs. ...

    Author's details Catherine H. Schein
    Abstract Human health depends upon access to high-quality proteins for our diet and pharmaceutical use. This book deals with the nature of toxicity as it applies to proteins in food and drugs.
    Keywords Proteins/Immunology ; Proteins/Toxicology
    Subject code 664
    Language English
    Size 1 online resource (176 pages)
    Edition 1st ed.
    Publisher CRC Press
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-000-95980-5 ; 9781032366944 ; 978-1-000-95980-2 ; 103236694X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Identifying Similar Allergens and Potentially Cross-Reacting Areas Using Structural Database of Allergenic Proteins (SDAP) Tools and D-Graph.

    Schein, Catherine H

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2717, Page(s) 269–284

    Abstract: The Structural Database of Allergenic Proteins (SDAP) provides rapid search tools to identify similarities among allergens, their IgE epitopes, and to determine the potential allergenicity of any novel protein. Many labs have identified IgE-binding ... ...

    Abstract The Structural Database of Allergenic Proteins (SDAP) provides rapid search tools to identify similarities among allergens, their IgE epitopes, and to determine the potential allergenicity of any novel protein. Many labs have identified IgE-binding proteins and their antibody binding or T cell epitopes using dotspots or microarrays. This chapter describes how to determine the relationship of these proteins and peptides to known allergens using the tools implemented in SDAP. One can also search with these smaller peptide similarity search tool implemented in SDAP to find similar sequences with low property distance (PD) values in the over 1500 sequences of allergens. The sequences can be compared by mapping on the surface of the protein structures provided for nearly all the allergens in SDAP. Once the user has a unique list of similar sequences, they can be graphed in 2D according to interpeptide PD values calculated automatically by the D-graph program. This chapter provides a step-by-step description of how to do this, starting from a protein similar to the Ole e 1 (olive pollen) allergen family.
    MeSH term(s) Allergens ; Databases, Factual ; Epitopes, T-Lymphocyte ; Galectin 3 ; Immunoglobulin E
    Chemical Substances Allergens ; Epitopes, T-Lymphocyte ; Galectin 3 ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3453-0_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Distinguishing Curable from Progressive Dementias for Defining Cancer Care Options.

    Schein, Catherine H

    Cancers

    2023  Volume 15, Issue 4

    Abstract: The likelihood of a diagnosis of dementia increases with a person's age, as is also the case for many cancers, including melanoma and multiple myeloma, where the median age of diagnosis is above 60 years. However, patients diagnosed with dementia are ... ...

    Abstract The likelihood of a diagnosis of dementia increases with a person's age, as is also the case for many cancers, including melanoma and multiple myeloma, where the median age of diagnosis is above 60 years. However, patients diagnosed with dementia are less likely to be offered invasive curative therapies for cancer. Together with analysis of diet and medication history, advanced imaging methods and genetic profiling can now indicate more about syndromes causing the neurological symptoms. Cachexia, malnutrition, dehydration, alcohol consumption, and even loneliness can all accentuate or cause the "3Ds" of dementia, delirium and depression. Many common drugs, especially in the context of polypharmacy, can cause cognitive difficulties resembling neurodegenerative disease. These syndromes may be reversed by diet, social and caregiver changes, and stopping potentially inappropriate medications (PIMs). More insidious are immune reactions to many different autoantigens, some of which are related to cancers and tumors. These can induce movement and cognitive difficulties that mimic Alzheimer's and Parkinson's diseases and other ataxias associated with aging. Paraneoplastic neurological syndromes may be reversed by directed immunotherapies if detected in their early stages but are best treated by removal of the causative tumor. A full genetic workup should be done for all individuals as soon as possible after diagnosis, to guide less invasive treatments suitable for frail individuals. While surgical interventions may be contraindicated, genetic profile guided immunotherapies, oral treatments, and radiation may be equally curative in a significant number of cancers.
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Repurposing approved drugs for cancer therapy.

    Schein, Catherine H

    British medical bulletin

    2021  Volume 137, Issue 1, Page(s) 13–27

    Abstract: Background: Many drugs approved for other indications can control the growth of tumor cells and limit adverse events (AE).: Data sources: Literature searches with keywords 'repurposing and cancer' books, websites: https://clinicaltrials.gov/, for ... ...

    Abstract Background: Many drugs approved for other indications can control the growth of tumor cells and limit adverse events (AE).
    Data sources: Literature searches with keywords 'repurposing and cancer' books, websites: https://clinicaltrials.gov/, for drug structures: https://pubchem.ncbi.nlm.nih.gov/.
    Areas of agreement: Introducing approved drugs, such as those developed to treat diabetes (Metformin) or inflammation (Thalidomide), identified to have cytostatic activity, can enhance chemotherapy or even replace more cytotoxic drugs. Also, anti-inflammatory compounds, cytokines and inhibitors of proteolysis can be used to control the side effects of chemo- and immuno-therapies or as second-line treatments for tumors resistant to kinase inhibitors (KI). Drugs specifically developed for cancer therapy, such as interferons (IFN), the tyrosine KI abivertinib TKI (tyrosine kinase inhibitor) and interleukin-6 (IL-6) receptor inhibitors, may help control symptoms of Covid-19.
    Areas of controversy: Better knowledge of mechanisms of drug activities is essential for repurposing. Chemotherapies induce ER stress and enhance mutation rates and chromosome alterations, leading to resistance that cannot always be related to mutations in the target gene. Metformin, thalidomide and cytokines (IFN, tumor necrosis factor (TNF), interleukin-2 (IL-2) and others) have pleiomorphic activities, some of which can enhance tumorigenesis. The small and fragile patient pools available for clinical trials can cloud the data on the usefulness of cotreatments.
    Growing points: Better understanding of drug metabolism and mechanisms should aid in repurposing drugs for primary, adjuvant and adjunct treatments.
    Areas timely for developing research: Optimizing drug combinations, reducing cytotoxicity of chemotherapeutics and controlling associated inflammation.
    MeSH term(s) Drug Repositioning ; Humans ; Neoplasms/drug therapy ; COVID-19 Drug Treatment
    Language English
    Publishing date 2021-01-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 213294-1
    ISSN 1471-8391 ; 0007-1420
    ISSN (online) 1471-8391
    ISSN 0007-1420
    DOI 10.1093/bmb/ldaa045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Peptide immunotherapy for aeroallergens.

    Midoro-Horiuti, Terumi / Schein, Catherine H

    Allergy and asthma proceedings

    2023  Volume 44, Issue 4, Page(s) 237–243

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Animals ; Humans ; Epitopes, T-Lymphocyte ; Antibodies, Blocking ; Immunoglobulin E ; Allergens ; Desensitization, Immunologic/methods ; Immunotherapy ; Peptides/therapeutic use
    Chemical Substances Epitopes, T-Lymphocyte ; Antibodies, Blocking ; Immunoglobulin E (37341-29-0) ; Allergens ; Peptides
    Language English
    Publishing date 2023-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1312445-6
    ISSN 1539-6304 ; 1088-5412
    ISSN (online) 1539-6304
    ISSN 1088-5412
    DOI 10.2500/aap.2023.44.230028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1804: Show issues Location:
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  6. Article ; Online: Repurposing approved drugs on the pathway to novel therapies.

    Schein, Catherine H

    Medicinal research reviews

    2019  Volume 40, Issue 2, Page(s) 586–605

    Abstract: The time and cost of developing new drugs have led many groups to limit their search for therapeutics to compounds that have previously been approved for human use. Many "repurposed" drugs, such as derivatives of thalidomide, antibiotics, and antivirals ... ...

    Abstract The time and cost of developing new drugs have led many groups to limit their search for therapeutics to compounds that have previously been approved for human use. Many "repurposed" drugs, such as derivatives of thalidomide, antibiotics, and antivirals have had clinical success in treatment areas well beyond their original approved use. These include applications in treating antibiotic-resistant organisms, viruses, cancers and to prevent burn scarring. The major theoretical justification for reusing approved drugs is that they have known modes of action and controllable side effects. Coadministering antibiotics with inhibitors of bacterial toxins or enzymes that mediate multidrug resistance can greatly enhance their activity. Drugs that control host cell pathways, including inflammation, tumor necrosis factor, interferons, and autophagy, can reduce the "cytokine storm" response to injury, control infection, and aid in cancer therapy. An active compound, even if previously approved for human use, will be a poor clinical candidate if it lacks specificity for the new target, has poor solubility or can cause serious side effects. Synergistic combinations can reduce the dosages of the individual components to lower reactivity. Preclinical analysis should take into account that severely ill patients with comorbidities will be more sensitive to side effects than healthy trial subjects. Once an active, approved drug has been identified, collaboration with medicinal chemists can aid in finding derivatives with better physicochemical properties, specificity, and efficacy, to provide novel therapies for cancers, emerging and rare diseases.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/therapeutic use ; Drug Approval ; Drug Repositioning ; Humans ; Pharmaceutical Preparations/chemistry ; Signal Transduction
    Chemical Substances Anti-Bacterial Agents ; Pharmaceutical Preparations
    Keywords covid19
    Language English
    Publishing date 2019-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 603210-2
    ISSN 1098-1128 ; 0198-6325
    ISSN (online) 1098-1128
    ISSN 0198-6325
    DOI 10.1002/med.21627
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    Zs.A 1764: Show issues Location:
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  7. Article ; Online: The updated Structural Database of Allergenic Proteins (SDAP 2.0) provides 3D models for allergens and incorporated bioinformatics tools.

    Negi, Surendra S / Schein, Catherine H / Braun, Werner

    The journal of allergy and clinical immunology. Global

    2023  Volume 2, Issue 4, Page(s) 100162

    Abstract: Background: Allergenic proteins can cause IgE-mediated adverse reactions in sensitized individuals. Although the sequences of many allergenic proteins have been identified, bioinformatics data analysis with advanced computational methods and modeling is ...

    Abstract Background: Allergenic proteins can cause IgE-mediated adverse reactions in sensitized individuals. Although the sequences of many allergenic proteins have been identified, bioinformatics data analysis with advanced computational methods and modeling is needed to identify the basis for IgE binding and cross-reactivity.
    Objective: We aim to present the features and use of the updated Structural Database of Allergenic Proteins 2.0 (SDAP 2.0) webserver, a unique, publicly available resource to compare allergens using specially designed computational tools and new high-quality 3-D models for most known allergens.
    Methods: Previously developed and novel software tools for identifying cross-reactive allergens using sequence and structure similarity are implemented in SDAP 2.0. A comprehensive set of high-quality 3-D models of most allergens was generated with the state-of-the-art AlphaFold 2 software. A graphics tool enables the interactive visualization of IgE epitopes on experimentally determined and modeled 3-D structures.
    Results: A user can search for allergens similar to a given input sequence with the FASTA algorithm or the window-based World Health Organization/International Union of Immunological Societies (WHO/IUIS) guidelines on safety concerns of novel food products. Peptides similar to known IgE epitopes can be identified with the property distance tool and conformational epitopes by the Cross-React method. The updated database contains 1657 manually curated sequences including all allergens from the IUIS database, 334 experimentally determined X-ray or NMR structures, and 1565 3-D models. Each allergen/isoallergen is classified according to its protein family.
    Conclusions: SDAP provides access to the steadily increasing information on allergenic structures and epitopes with integrated bioinformatics tools to identify and analyze their similarities. In addition to serving the research and regulatory community, it provides clinicians with tools to identify potential coallergies in a sensitive patient and can help companies to design hypoallergenic foods and immunotherapies.
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2023.100162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Nuclease methods and protocols

    Schein, Catherine H.

    (Methods in molecular biology ; 160)

    2001  

    Author's details ed. by Catherine H. Schein
    Series title Methods in molecular biology ; 160
    Collection
    Keywords Nucleasen ; Molekularbiologie ; Methode
    Subject Methodik ; Verfahren ; Technik ; Methoden ; Molekulare Biologie ; Nukleasen
    Language English
    Size XVII, 525 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT013009584
    ISBN 0-89603-679-0 ; 978-0-89603-679-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 A 2427 order for loan Magazin

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  9. Article ; Online: Polyglutamine Repeats in Viruses.

    Schein, Catherine H

    Molecular neurobiology

    2018  Volume 56, Issue 5, Page(s) 3664–3675

    Abstract: This review explores the presence and functions of polyglutamine (polyQ) in viral proteins. In mammals, mutations in polyQ segments (and CAG repeats at the nucleotide level) have been linked to neural disorders and ataxias. PolyQ regions in normal human ... ...

    Abstract This review explores the presence and functions of polyglutamine (polyQ) in viral proteins. In mammals, mutations in polyQ segments (and CAG repeats at the nucleotide level) have been linked to neural disorders and ataxias. PolyQ regions in normal human proteins have documented functional roles, in transcription factors and, more recently, in regulating autophagy. Despite the high frequency of polyQ repeats in eukaryotic genomes, little attention has been given to the presence or possible role of polyQ sequences in virus genomes. A survey described here revealed that polyQ repeats occur rarely in RNA viruses, suggesting that they have detrimental effects on virus replication at the nucleotide or protein level. However, there have been sporadic reports of polyQ segments in potyviruses and in reptilian nidoviruses (among the largest RNA viruses known). Conserved polyQ segments are found in the regulatory control proteins of many DNA viruses. Variable length polyQ tracts are found in proteins that contribute to transmissibility (cowpox A-type inclusion protein (ATI)) and control of latency (herpes viruses). New longer-read sequencing methods, using original biological samples, should reveal more details on the presence and functional role of polyQ in viruses, as well as the nucleotide regions that encode them. Given the known toxic effects of polyQ repeats, the role of these segments in neurovirulent and tumorigenic viruses should be further explored.
    MeSH term(s) Amino Acid Sequence ; Autophagy ; Genome, Viral ; Peptides/genetics ; Trinucleotide Repeat Expansion/genetics ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viruses/genetics ; Viruses/pathogenicity
    Chemical Substances Peptides ; Viral Proteins ; polyglutamine (26700-71-0)
    Keywords covid19
    Language English
    Publishing date 2018-09-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-018-1269-4
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    Zs.A 2411: Show issues Location:
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  10. Article ; Online: Still SDAPing Along: 20 Years of the Structural Database of Allergenic Proteins.

    Schein, Catherine H / Negi, Surendra S / Braun, Werner

    Frontiers in allergy

    2022  Volume 3, Page(s) 863172

    Abstract: The introduction of plant extracts to mitigate the symptoms of "hay fever", about a century ago, led to discoveries beginning sixty years ago on determining the sequences and eventually structures of allergenic proteins. As more proteins were cloned, ... ...

    Abstract The introduction of plant extracts to mitigate the symptoms of "hay fever", about a century ago, led to discoveries beginning sixty years ago on determining the sequences and eventually structures of allergenic proteins. As more proteins were cloned, there was a need to rapidly identify and categorize those with significant similarity to known allergens. The Structural Database of Allergenic Proteins (SDAP) was created at the beginning of the 21st century as the first cross-referenced website to allow rapid overview of the structures and sequences of allergenic proteins. SDAP provides a way to identify sequence and functional similarities between these proteins, despite the complex nomenclature system based on the Latin names of their different sources. A rapid FASTA search simplifies grouping allergens from the same structural or functional family. SDAP also provides an overview of the rapidly expanding literature on the sequence, structure and epitopes of allergenic proteins and a way to estimate the potential allergenicity of novel proteins based on rules provided by the IUIS. Twenty years and a pandemic later, the list of allergenic proteins and their attributes continues to grow. SDAP is expanding and improving to allow rapid access to all this information.
    Language English
    Publishing date 2022-03-22
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6101
    ISSN (online) 2673-6101
    DOI 10.3389/falgy.2022.863172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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