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  1. Article ; Online: The U-shaped curve predicting cognitive vulnerability to delirium severity.

    Lennertz, Richard C / Sanders, Robert D

    Brain : a journal of neurology

    2023  Volume 146, Issue 5, Page(s) 1743–1744

    MeSH term(s) Humans ; Delirium ; Cognition ; Research Design
    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awad115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Brain Injury in Postoperative Delirium: Lessons from Neurofilament Light.

    Payne, Thomas / Lennertz, Richard C / Sanders, Robert D

    Anesthesiology

    2024  Volume 140, Issue 5, Page(s) 884–886

    MeSH term(s) Humans ; Emergence Delirium ; Intermediate Filaments ; Brain Injuries
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 'Where there's smoke': longitudinal cognitive disintegration after postoperative delirium?

    Matar, Elie / Sanders, Robert D

    British journal of anaesthesia

    2023  Volume 131, Issue 1, Page(s) 1–5

    Abstract: Postoperative delirium is an important complication of surgery and is associated with poor long-term cognitive outcomes, although the neural basis underlying this relationship is poorly understood. Neuroimaging studies and network-based approaches play ... ...

    Abstract Postoperative delirium is an important complication of surgery and is associated with poor long-term cognitive outcomes, although the neural basis underlying this relationship is poorly understood. Neuroimaging studies and network-based approaches play an important role in our understanding of the mechanism by which delirium relates to longitudinal cognitive decline. A recent resting state functional MRI study is reviewed, which shows reduced global connectivity up to 3 months after delirium, supporting recent models of delirium and opening the door for applying this approach to understanding the complex inter-relationship between delirium and dementia.
    MeSH term(s) Humans ; Cognition ; Cognitive Dysfunction/etiology ; Delirium ; Emergence Delirium ; Neuroimaging ; Postoperative Complications
    Language English
    Publishing date 2023-03-27
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.02.025
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  4. Article ; Online: Does Delta Connectivity Differentiate Sleep and Anesthesia?

    Sanders, Robert D

    Anesthesiology

    2020  Volume 133, Issue 4, Page(s) 700–701

    MeSH term(s) Anesthesia ; Electroencephalography ; Propofol ; Sleep
    Chemical Substances Propofol (YI7VU623SF)
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000003478
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  5. Article ; Online: Critical Care and the Postintensive Care Syndrome.

    Long, Micah T / Sanders, Robert D / Preiser, Jean-Charles

    JAMA network open

    2023  Volume 6, Issue 2, Page(s) e230391

    MeSH term(s) Humans ; Critical Illness/therapy ; Critical Care
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.0391
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  6. Article ; Online: Depth of amnesia monitoring. Response to Br J Anaesth 2023; 131: e145-7.

    Sanders, Robert D / McCulloch, Timothy J

    British journal of anaesthesia

    2023  Volume 132, Issue 2, Page(s) 421–422

    MeSH term(s) Humans ; Amnesia ; Memory
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.11.010
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  7. Article ; Online: Depth of anaesthesia monitoring: time to reject the index?

    McCulloch, Timothy J / Sanders, Robert D

    British journal of anaesthesia

    2023  Volume 131, Issue 2, Page(s) 196–199

    Abstract: Depth of anaesthesia monitors can fail to detect consciousness under anaesthesia, primarily because they rely on the frontal EEG, which does not arise from a neural correlate of consciousness. A study published in a previous issue of the British Journal ... ...

    Abstract Depth of anaesthesia monitors can fail to detect consciousness under anaesthesia, primarily because they rely on the frontal EEG, which does not arise from a neural correlate of consciousness. A study published in a previous issue of the British Journal of Anaesthesia showed that indices produced by the different commercial monitors can give highly discordant results when analysing changes in the frontal EEG. Anaesthetists could benefit from routinely assessing the raw EEG and its spectrogram, rather than relying solely on an index produced by a depth of anaesthesia monitor.
    MeSH term(s) Humans ; Anesthesia ; Consciousness Monitors ; Consciousness ; Electroencephalography/methods
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.04.016
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  8. Article ; Online: Plasma HMGB1 levels in postoperative delirium.

    Kunkel, David / Parker, Margaret / Pearce, Robert A / Sanders, Robert D / Lennertz, Richard C

    British journal of anaesthesia

    2023  Volume 130, Issue 5, Page(s) e449–e451

    MeSH term(s) Humans ; Emergence Delirium ; HMGB1 Protein ; Cognition Disorders ; Cognitive Dysfunction ; Postoperative Complications
    Chemical Substances HMGB1 Protein
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.02.002
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  9. Article ; Online: Similarities in consciousness occurring during sleep and sedation.

    Turner, Andrew J F / Wehrman, Jordan / Sanders, Robert D

    British journal of anaesthesia

    2023  Volume 131, Issue 4, Page(s) 632–633

    Abstract: The subjective experiences of sedation or anaesthesia are underexplored. A recent study by Valli and colleagues (Br J Anaesth 2023; 131: 348-59) found similar frequency and content of recalled experiences after both non-rapid eye movement sleep and ... ...

    Abstract The subjective experiences of sedation or anaesthesia are underexplored. A recent study by Valli and colleagues (Br J Anaesth 2023; 131: 348-59) found similar frequency and content of recalled experiences after both non-rapid eye movement sleep and target-controlled infusions of propofol or dexmedetomidine titrated to verbal unresponsiveness. The authors find that the phenomenological similarities between consciousness during sleep and sedation mirror their physiological similarities. Intriguingly, in this small sample, conscious experience did not show a dose-dependent response suggesting other factors are important in determining the propensity for consciousness under sedation.
    MeSH term(s) Humans ; Consciousness ; Anesthesia ; Sleep ; Anesthesiology ; Conscious Sedation
    Language English
    Publishing date 2023-09-18
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.07.019
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  10. Article ; Online: Neurofilament Light and Cognition after Cardiac Surgery: Comment.

    Miles, Lachlan F / Lankadeva, Yugeesh R / Sanders, Robert D / Ayton, Scott

    Anesthesiology

    2023  Volume 138, Issue 6, Page(s) 662–663

    MeSH term(s) Intermediate Filaments ; Cognition ; Cardiac Surgical Procedures/adverse effects ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004485
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